Article
Oncology
Xi Wang, Guangyu Gao, Zhengrong Chen, Zhihao Chen, Mingxiao Han, Xiaolu Xie, Qiyuan Jin, Hong Du, Zhifei Cao, Haifang Zhang
Summary: This study identified potential biomarkers in miRNAs and genes for colorectal cancer (CRC) by systematic bioinformatic analysis and experimental validation. A novel miRNA-mRNA network was established for CRC lymph node metastasis, which may serve as a potential biomarker in the development of lymph node metastatic CRC.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Guangyu Gao, Xinya Shi, Jiaofeng Shen
Summary: This study established a lymph node metastasis prediction model based on miRNA and mRNA, identifying hsa-miR-100 and hsa-miR-99a as potential biomarkers in lymph node metastatic colorectal cancer. The results provide new theoretical basis for clinical diagnosis and treatment.
ONCOTARGETS AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Jin Li, Peng Wang, Yang Zhou, Hong Liang, Yang Lu, Kuan Luan
Summary: An automatic classification method based on deep transfer learning was proposed, which resolved the issue of repetition of low-level features and improved the accuracy of classification of colorectal cancer lymph node metastasis.
Article
Genetics & Heredity
In Hee Lee, Gyeonghwa Kim, Sang Gyu Kwak, Dong Won Baek, Byung Woog Kang, Hye Jin Kim, Su Yeon Park, Jun Seok Park, Gyu-Seog Choi, Keun Hur, Jong Gwang Kim
Summary: The study validated candidate biomarkers for predicting LN metastasis in colon cancer patients using plasma miRNA concentrations, identifying three circulating miRNAs significantly associated with LN metastasis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Suyun Li, Zhenhui Li, Li Wang, Mimi Wu, Xiaobo Chen, Chutong He, Yao Xu, Mengyi Dong, Yanting Liang, Xin Chen, Zaiyi Liu
Summary: This study evaluated the feasibility of using clinicopathological characteristics and CT morphological features to predict lymph node metastasis in patients with T1 colorectal cancer. The presence of necrosis, irregular outer border, and heterogeneity enhancement, as well as tumor location, were found to be independent risk factors for predicting lymph node metastasis. These findings can assist doctors in making decisions about additional surgery after endoscopic resection.
EUROPEAN RADIOLOGY
(2023)
Review
Pathology
Nazila Mozammel, Mohammad Amini, Behzad Baradaran, Seyedeh Zahra Bahojb Mahdavi, Seyed Samad Hosseini, Ahad Mokhtarzadeh
Summary: MicroRNAs (miRNA) are a class of small non-coding RNAs that have significant impact on gene expression in human cancers. miR-145, a potential tumor suppressor miRNA, is downregulated in colorectal cancer and is involved in multiple processes such as cell proliferation, apoptosis, migration, and differentiation. It regulates tumor-specific signaling pathways, including KRAS and P53 signaling, through targeting various genes. This study aims to present recent findings on the functions of miR-145 and its involvement in colorectal cancer by interacting with multiple signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Yutaro Higashi, Kodai Nakamura, Ryota Takaoka, Mika Tani, Yusaku Noma, Kazuki Mori, Kota Yamashiro, Seiya Yokoyama, Tomofumi Hamada, Tsuyoshi Sugiura
Summary: Currently, there is a lack of established biomarkers for oral squamous cell carcinoma (OSCC) and imaging studies are relied upon for detecting neck lymph node metastases. This study discovered that serum microRNAs were more accurate at diagnosing primary and late neck lymph node metastases compared to serum squamous cell carcinoma antigens or pathological factors. Detection of microRNAs in OSCC patients using real-time PCR showed high diagnostic and predictive accuracy for neck lymph node metastases. The use of microRNAs can assist in personalized treatment, including follow-up, surgical methods, and postoperative management.
Article
Oncology
Yingdian Yu, Wenyuan Xue, Zefeng Liu, Shang Chen, Jun Wang, Quanzhou Peng, Linhao Xu, Xin Liu, Chunhui Cui, Jian-Bing Fan
Summary: The novel methylation marker LBX2 could be used as a simple, cost-effective, and reliable diagnostic method for lymph node metastasis of colorectal cancer, outperforming conventional diagnostic methods.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiang Li, Jing Zhai, Yuke Shen, Tiancheng Zhang, Yaohui Wang, Yani He, Qiang You, Lizong Shen
Summary: This study found that elevated pretherapeutic serum interleukin-8 (sIL-8) levels in patients with gastric cancer are associated with lymph node metastasis and poor prognosis. Gastric cancer-associated fibroblasts (CAFs) were identified as the main producers of IL-8, which in turn up-regulates PD-1 expression in CD8(+) T cells, leading to immune suppression and promoting lymph node metastasis in gastric cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Qian Liu, Meng Qiao, Zoltan Lohinai, Shiqi Mao, Yingying Pan, Yan Wang, Shuo Yang, Fei Zhou, Tao Jiang, Xianghua Yi, Shengxiang Ren, Caicun Zhou, Fred R. Hirsch
Summary: The study revealed that CCL19 is associated with lymph node metastasis and poor prognosis in SCLC patients, as its expression promotes tumor progression and metastasis while impairing the function of CD8 + T cells.
Article
Oncology
Sinan Omeroglu, Selcuk Gulmez, Orhan Uzun, Aziz Serkan Senger, Ozgur Bostanci, Onur Guven, Erdal Polat, Mustafa Duman
Summary: In this retrospective study, it was found that a metastatic lymph node (MLN) diameter greater than 1.05 cm may indicate a poorer prognosis and lower survival rate in patients with stage III colorectal cancer (CRC). Therefore, the MLN diameter may be an important indicator for predicting the prognosis of CRC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Review
Oncology
Yohann Dabi, Amelia Favier, Leo Razakamanantsoa, Stephane Suisse, Yannick Marie, Cyril Touboul, Clement Ferrier, Sofiane Bendifallah, Emile Darai
Summary: Cervical cancer (CC) is a major cause of cancer death in women, and accurate assessment of lymph node status is crucial for prognosis and treatment. Previous studies have suggested the potential value of non-coding RNA expression in CC. This review discusses the contribution of non-coding RNAs in tissue and biofluid samples to determine lymph node status in CC, with potential implications for surgical and adjuvant therapies.
FRONTIERS IN ONCOLOGY
(2023)
