The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex
出版年份 2014 全文链接
标题
The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex
作者
关键词
-
出版物
PLoS One
Volume 9, Issue 7, Pages e102420
出版商
Public Library of Science (PLoS)
发表日期
2014-07-16
DOI
10.1371/journal.pone.0102420
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis
- (2013) Yu Deng et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1–PP2A protein complex
- (2013) Sybille Krauß et al. Nature Communications
- A tale of two drug targets: the evolutionary history of BACE1 and BACE2
- (2013) Christopher Southan et al. Frontiers in Genetics
- Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease
- (2012) Cora O'Neill et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation
- (2012) Jing Wang et al. Cell Stem Cell
- Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice
- (2012) Jiejie Li et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Protein Phosphatase 2A (PP2A)-specific Ubiquitin Ligase MID1 Is a Sequence-dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide-dependent Protein Kinase-1 (PDPK-1)
- (2011) Beatriz Aranda-Orgillés et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes
- (2011) Amit Gupta et al. NEUROPHARMACOLOGY
- Control of mTORC1 signaling by the Opitz syndrome protein MID1
- (2011) E. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- APP processing in Alzheimer's disease
- (2011) Yun-wu Zhang et al. Molecular Brain
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Mammalian Autophagy in Physiology and Pathophysiology
- (2010) Brinda Ravikumar et al. PHYSIOLOGICAL REVIEWS
- Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
- (2010) E. Kickstein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alzheimer's disease: synaptic dysfunction and Aβ
- (2009) Ganesh M Shankar et al. Molecular Neurodegeneration
- Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
- (2009) Y. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin signalling in the heart
- (2008) L. Bertrand et al. CARDIOVASCULAR RESEARCH
- How Insulin Receptor Substrate Proteins Regulate the Metabolic Capacity of the Liver - Implications for Health and Disease
- (2008) Louise Fritsche et al. CURRENT MEDICINAL CHEMISTRY
- The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex
- (2008) Beatriz Aranda-Orgillés et al. HUMAN GENETICS
- Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin
- (2008) C.G. Jolivalt et al. JOURNAL OF NEUROSCIENCE RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More