Article
Medicine, Research & Experimental
Ra-Yeong Choi, In-Woo Kim, Moongi Ji, Man-Jeong Paik, Eu-Jin Ban, Joon Ha Lee, Jae Sam Hwang, HaeYong Kweon, Minchul Seo
Summary: The ethanol extract of P. brevitarsis larvae (PBE) can inhibit RANKL-induced osteoclast formation and prevent bone loss. PBE decreases tartrate-resistant acid phosphatase activity and the expression of osteoclastogenesis-associated genes and proteins. It also inhibits the phosphorylation of p38 and NF-κB.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Amin Nikkhah, Sam Van Haute, Vesna Jovanovic, Heejung Jung, Jo Dewulf, Tanja Cirkovic Velickovic, Sami Ghnimi
Summary: Insects have been recommended as a new sustainable source of edible protein due to the importance of developing alternative protein sources. This study in South Korea used Life Cycle Assessment (LCA) to evaluate the environmental impact of a small-scale edible insect production unit, finding both beneficial and negative effects on various impact categories. By effectively managing inputs, edible insects have the potential to become an environmentally efficient food production system.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Jin Mi Chun, Hyeon-Hwa Nam, Ji Hye Lee, Young Hye Seo, Hyo Seon Kim, Byeong Cheol Moon, Jun Hong Park
Summary: This study demonstrated the effects of Protaetia brevitarsis seulensis larva (PBSL) on the progression of osteoarthritis (OA). The results showed that PBSL can inhibit the progression of OA, reduce articular cartilage damage, and suppress inflammation. This provides a new approach for the development of functional foods for OA treatment.
FOOD SCIENCE & NUTRITION
(2023)
Article
Microbiology
Miyoung Won, Parthiban Subramanian, Seunghwan Kim, Jun Heo, Hanako Naito, Tomomi Asano, Moriyuki Hamada, Soon-Wo Kwon
Summary: A novel actinobacterium strain CFWR-12T was isolated from the larval gut of Protaetia brevitarsis seulensis in Korea and was identified as a new species of the genus Agromyces based on its physiological and genetic characteristics. The strain showed high sequence similarity to Agromyces intestinalis and Agromyces protaetiae, but had distinct differences in average nucleotide identity and digital DNA-DNA hybridization. The findings suggest the presence of a new species, named Agromyces larvae.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2023)
Article
Entomology
Sejung Hwang, Kyeongrin Bang, Jiae Lee, Youngwoo Cho, Saeyoull Cho
Summary: The study identified and characterized full-length furin-like cDNAs from larvae of Protaetia brevitarsis seulensis, revealing a consensus site for proprotein convertase and a domain related to the immune system. Immune-related expression experiments showed that the mRNA levels of Psfurin-1 and 2 were significantly affected by bacterial and yeast challenges.
JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sueun Lee, Young Hye Seo, Jun Ho Song, Wook Jin Kim, Ji Hye Lee, Byeong Cheol Moon, Mary Jasmin Ang, Sung Ho Kim, Changjong Moon, Jun Lee, Joong Sun Kim
Summary: The study showed that the water extract of Protaetia brevitarsis seulensis (PBWE) has a significant therapeutic effect against trimethyltin-induced seizures and hippocampal neurodegeneration, likely through its antioxidative properties. Furthermore, six major compounds isolated from PBWE, including inosine and benzoic acid, were confirmed to have essential antioxidative activity, suggesting the potential pharmacotherapeutic use of PBWE in neurodegenerative diseases such as seizures or epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Hyeon-Hwa Nam, Sohi Kang, Yun-Soo Seo, Jun Lee, Byeong Cheol Moon, Hae June Lee, Ji Hye Lee, Bohye Kim, Sueun Lee, Joong-Sun Kim
Summary: The larvae extract of Protaetia brevitorsis seulensis protects against radiation-induced testicular injury through its antioxidative properties. This suggests its potential clinical applicability as a neoadjuvant therapy for preventing testicular damage caused by cancer radiotherapy.
FOOD SCIENCE & NUTRITION
(2022)
Article
Food Science & Technology
Ha-Yeon Song, Woo Yong Park, Jeong Moo Han, Bo-Gyeong Yoo, Bo Sun Kang, Eui-Baek Byun
Summary: The potential anticancer immunostimulatory properties of a protein-rich fraction obtained from larvae of Protaetia brevitarsis seulensis (PBLP) were investigated in CT26 colon carcinoma-bearing mice. PBLP increased the production of Th1-polarized cytokines and the phenotypic maturation of dendritic cells. Dietary PBLP inhibited tumor growth and synchronized dendritic cells and T cells for anticancer immunity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Microbiology
Huina Xuan, Peiwen Gao, Baohai Du, Lili Geng, Kui Wang, Kun Huang, Jie Zhang, Tianpei Huang, Changlong Shu
Summary: The frass of Protaetia brevitarsis larvae contains beneficial microorganisms that can promote plant growth and enhance disease resistance.
Article
Food Science & Technology
Yun-Soo Seo, Na-Rea Shin, Hyeon Hwa Nam, Jun-Ho Song, Byeong Cheol Moon, Goya Choi, In-Sik Shin, Joong-Sun Kim
Summary: The study found that P. brevitarsis significantly inhibits prostate hyperplasia in BPH animals, reduces dihydrotestosterone levels, and effectively reduces testosterone-induced prostatic epithelial cell hyperplasia.
FOOD SCIENCE & NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
B. G. Kang, S. M. Kang, S. Y. Lee, S. W. Kim, Y. J. Choi, S. S. Lim
Summary: This study aimed to assess the effect of different solvent ratios on the content of 5-hydroxyindolin-2-one (5-HI) in Protaetia brevitarsis seulensis larvae extract and to investigate its effects on the induction of cell adhesion molecules (CAMs) in human umbilical vein endothelial cells (HUVECs). A validated HPLC-DAD method was used to quantify 5-HI. The highest 5-HI content was found in the extract obtained from 70% ethanol, and the highest content was observed at 31 degrees C for 30 days. Furthermore, the extract inhibited the upregulation of CAM protein expression in TNF-a-activated HUVECs.
JOURNAL OF INSECTS AS FOOD AND FEED
(2023)
Article
Entomology
Daniele Bruno, Aurora Montali, Marzia Gariboldi, Anna Katarzyna Wronska, Agata Kaczmarek, Amr Mohamed, Ling Tian, Morena Casartelli, Gianluca Tettamanti
Summary: This study provides the first detailed characterization of black soldier fly hemocytes and reveals new insights into the cell-mediated immune response of this insect. The study identifies five hemocyte types involved in the immune response in the larva and analyzes their behavior, role, and morphofunctional changes. The results demonstrate that circulating phagocytes in black soldier fly larvae are plasmatocytes, which participate in nodulation and encapsulation with granulocytes and lamellocyte-like cells.
Article
Agriculture, Dairy & Animal Science
Tae-Kyung Kim, Hae In Yong, Samooel Jung, Jung-Min Sung, Hae Won Jang, Yun-Sang Choi
Summary: The study compared the physicochemical and rheological properties of emulsions made from three different edible insect larvae species. Tenebrio molitor was found to be the most suitable candidate for replacing meat protein based on its properties. Maintaining these properties of insect-based emulsions is essential for their successful utilization as meat replacements.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sujin Baek, Hyun Ho Noh, Chang Jo Kim, Kyungae Son, Hee-Dong Lee, Leesun Kim
Summary: The study aimed to optimize a simple extraction method combined with liquid chromatography tandem mass spectrometry to detect fungicide residues in Protaetia brevitarsis. It was found that using a specific mixture could achieve a high recovery rate of target compounds.
Article
Chemistry, Applied
Jae Hoon Lee, Tae-Kyung Kim, Yun Jeong Kim, Min-Cheol Kang, Kyung-Mo Song, Bum-Keun Kim, Yun-Sang Choi
Summary: The structural, physicochemical, and biofunctional properties of edible insect protein isolates (EPIs) extracted from Protaetia brevitarsis larvae were investigated. The results showed that EPIs have a high total essential amino acid content and β-sheet is the major secondary protein structure. The EPI protein solution was highly soluble and electrically stable. Moreover, EPIs exhibited immune-enhancing properties by activating macrophages through the MAPK and NF-xB pathways.