Article
Multidisciplinary Sciences
Jiarong Zhou, Nishta Krishnan, Zhongyuan Guo, Christian J. Ventura, Maya Holay, Qiangzhe Zhang, Xiaoli Wei, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: This study investigates the effectiveness of a biomimetic nanotoxoid vaccine in protecting immunodeficient animals from Pseudomonas aeruginosa infection. The nanotoxoids utilize a macrophage membrane coating to sequester and present bacterial virulence factors, providing rapid and long-lasting immunity. The nanovaccine can be administered through multiple routes and effectively protects against lethal infections in pneumonia and septicemia models.
Review
Microbiology
Alexandra Grote, Ashlee M. Earl
Summary: Many bacterial pathogens can form persistent infections, and high-throughput sequencing methods have enabled the study of their genetic evolution, revealing common trends in bacterial adaptation to persistent infections.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Review
Immunology
Pamella Constantino-Teles, Albane Jouault, Lhousseine Touqui, Alessandra Mattos Saliba
Summary: Pseudomonas aeruginosa, an opportunistic pathogen, causes respiratory infections by utilizing various virulence factors, such as bacterial lipids and enzymes, and by interacting with host lipids. These mechanisms play important roles in the establishment and persistence of P. aeruginosa in the lungs, as well as in modulating host immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sara Hernando-Amado, Pablo Laborda, Jose Ramon Valverde, Jose Luis Martinez
Summary: Collateral sensitivity, a trade-off in evolution where resistance to one antibiotic leads to increased susceptibility to another, can be utilized in designing evolutionary-based approaches for treating bacterial infections. This study investigates the conservation of collateral sensitivity in different antibiotic-resistant mutants, and suggests alternating certain antibiotics as an effective strategy to eliminate these mutants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Kara R. Eichelberger, Saikat Paul, Brian M. Peters, James E. Cassat
Summary: This review highlights the impact of Candida albicans-bacteria interactions on healthy polymicrobial community structure, host immune responses, and microbial pathogenesis, and discusses the significance of these interactions in discovering novel antivirulence compounds for fungal infections.
TRENDS IN MICROBIOLOGY
(2023)
Article
Ecology
Pawel Markwitz, Cedric Lood, Tomasz Olszak, Vera van Noort, Rob Lavigne, Zuzanna Drulis-Kawa
Summary: The study found that phage-resistance emergence in bacterial populations had a key ecological impact and could be influenced by self and cross-resistance mechanisms. Using seven phages with distinct receptors to infect five Pseudomonas aeruginosa strains, significant differences were observed in resistance mechanisms between strains, which were correlated with bacterial growth rates.
Article
Multidisciplinary Sciences
Jing Yang, Qing-Ming Qin, Paul de Figueiredo
Summary: This article introduces a newly developed automated fluorescence microscopy-based imaging method, combined with high-throughput image processing and statistical analysis, which can rapidly and accurately quantify bacterial adherence to host cells. Experimental results demonstrate that this method significantly reduces experimental workloads and timelines.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Microbiology
Adrienne R. Kambouris, Jerod A. Brammer, Holly Roussey, Chixiang Chen, Alan S. Cross
Summary: The combination of burn state and infection affects gene expression in both the host and pathogen, increasing the propensity for infection. Inhibiting IL-10 signaling or co-administering arginine can improve survival rates in a burn and infection model.
Review
Microbiology
Shuaitao Wang, Juanli Cheng, Yanting Niu, Panxin Li, Xiangqian Zhang, Jinshui Lin
Summary: Zinc plays essential roles in the growth and development of plants, animals, and microorganisms, as well as in the growth and virulence of pathogenic microorganisms. Hosts sequester zinc intracellularly and extracellularly upon infection to enhance immune responses and inhibit pathogen proliferation. Conditional pathogenic Pseudomonas aeruginosa relies on various zinc uptake systems to establish infection, providing potential drug targets.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Subhash Dhital, Pankaj Deo, Isabella Stuart, Thomas Naderer
Summary: The programmed cell death pathways of pyroptosis and apoptosis protect mammals from infections by activating host cell death signaling that depends on cell surface and cytosolic receptors binding bacterial molecules or sensing their activity. Outer membrane vesicles (OMVs) released from Gram-negative bacteria deliver bacterial molecules to host cells, activating pyroptosis, apoptosis, and other inflammatory pathways.
TRENDS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Roberta Genova, Pablo Laborda, Trinidad Cuesta, Jose Luis Martinez, Fernando Sanz-Garcia
Summary: Understanding the consequences of drug resistance in bacterial physiology is crucial for exploiting its weaknesses. Collateral sensitivity, a potentially exploitable phenotype, may not be conserved among different isolates. Identifying robust and conserved collateral sensitivity patterns is important for translating this knowledge into clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Vincent Deruelle, Stephanie Bouillot, Viviana Job, Emmanuel Taillebourg, Marie-Odile Fauvarque, Ina Attree, Philippe Huber
Summary: The phospholipase ExoU from Pseudomonas aeruginosa acts on plasma membrane lipids in infected cells, causing membrane rupture and host cell necrosis. Once injected into the host cytoplasm, ExoU requires a host chaperone found on secretory vesicles to reach the plasma membrane and exert its phospholipase activity.
NATURE COMMUNICATIONS
(2021)
Article
Infectious Diseases
Katie A. Parsels, Keri A. Mastro, Jeffrey M. Steele, Stephen J. Thomas, Wesley D. Kufel
Summary: Cefiderocol is a novel siderophore cephalosporin that has shown activity against clinically relevant MDR Gram-negative bacteria. FDA-approved indications include complicated urinary tract infections and hospital-acquired bacterial pneumonia. Clinical trials have demonstrated non-inferiority to standard treatments, but higher all-cause mortality was observed in certain cases.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Xiangke Duan, Zhao Zhi Boo, Song Lin Chua, Kelvin Han Chung Chong, Ziqi Long, Renliang Yang, Yachun Zhou, Baptiste Janela, Sanjay Haresh Chotirmall, Florent Ginhoux, Qinghua Hu, Bin Wu, Liang Yang
Summary: This study reports that Pseudomonas aeruginosa induces innate immune suppression in macrophages through quorum sensing mechanism. It is found that a quorum sensing regulated product, LasB, digests the death domains of innate immune adaptors, mainly MyD88, leading to innate immune suppression.
Article
Microbiology
Erin R. Green, Joseph N. Fakhoury, Andrew J. Monteith, Hualiang Pi, David P. Giedroc, Eric P. Skaar
Summary: This study reveals that Acinetobacter baumannii causes more virulent pneumonia following desiccation and identifies the genetic requirements for desiccation. The disruption of Lon protease enhances desiccation tolerance, while bacterial hydrophilins DtpA and DtpB play a crucial role in this process.
CELL HOST & MICROBE
(2022)
Article
Agriculture, Dairy & Animal Science
Sara Mangiaterra, Anne Schmidt-Kuntzel, Laurie Marker, Alessandro Di Cerbo, Renato Piccinini, Davide Guadagnini, Maria Elena Turba, Sara Berardi, Livio Galosi, Silvia Preziuso, Matteo Cerquetella, Giacomo Rossi
Summary: This study evaluated the efficacy of a specific probiotic mixture in cheetahs, showing that high concentrations of live probiotics can help manage gastrointestinal signs in these animals.
Review
Cell Biology
Francesca Saluzzo, Luca Riberi, Barbara Messore, Nicola Ivan Lore, Irene Esposito, Elisabetta Bignamini, Virginia De Rose
Summary: Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR gene, leading to imbalances in the airway microenvironment and increased susceptibility to infections. CFTR modulators have shown promise in improving airway infections, but their long-term effects remain to be fully understood.
Review
Agriculture, Dairy & Animal Science
Lucia Biagini, Livio Galosi, Alessandra Roncarati, Anna-Rita Attili, Sara Mangiaterra, Giacomo Rossi
Summary: The use of nutraceuticals and phytonutrients in poultry nutrition has been extensively studied in recent years as a natural alternative to antibiotics in preventing and treating gastrointestinal diseases in chickens. This review summarizes the current status and effects of various substances in the prevention and treatment of four main gastrointestinal diseases in poultry, including salmonellosis, necrotic enteritis, campylobacteriosis, and coccidiosis. While some studies show promising results, further research is needed to confirm the effectiveness and practical applicability of these compounds.
Article
Medicine, Research & Experimental
Rachel M. Gittelman, Enrico Lavezzo, Thomas M. Snyder, H. Jabran Zahid, Cara L. Carty, Rebecca Elyanow, Sudeb Dalai, Ilan Kirsch, Lance Baldo, Laura Manuto, Elisa Franchin, Claudia Del Vecchio, Monia Pacenti, Caterina Boldrin, Margherita Cattai, Francesca Saluzzo, Andrea Padoan, Mario Plebani, Fabio Simeoni, Jessica Bordini, Nicola Lore, Dejan Lazarevic, Daniela M. Cirillo, Paolo Ghia, Stefano Toppo, Jonathan M. Carlson, Harlan S. Robins, Andrea Crisanti, Giovanni Tonon
Summary: This study investigates the role of T cells in the immune response to SARS-CoV-2 infection, demonstrating their importance in both clinical presentation and long-term immunity. The findings show that T cells contribute to the production of neutralizing antibodies and remain detectable up to 15 months after infection.
Article
Veterinary Sciences
Livio Galosi, Christian Falcaro, Patrizia Danesi, Claudia Zanardello, Sara Berardi, Lucia Biagini, Anna-Rita Attili, Giacomo Rossi
Summary: A retrospective study conducted in Italy reported four cases of atypical mycosis in parrots, with Mucor racemosus and M. circinelloides identified as the causative agents in lovebirds and A. alternata and Fusicladium spp. in macaws. This study provides new insights into the fungal pathogens affecting parrots.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biology
Sara Mangiaterra, Laurie Marker, Matteo Cerquetella, Livio Galosi, Andrea Marchegiani, Alessandra Gavazza, Giacomo Rossi
Summary: The decline of cheetah populations is mainly attributed to habitat destruction, predation, and illegal wildlife trade. Both wild and captive populations of cheetahs suffer from limited reproduction and disease, leading to reduced genetic diversity and increased vulnerability. Conservation programs focus on habitat protection, human-animal conflict management, and disease and genetics research. Chronic gastritis is a common disease in captive cheetahs, characterized by symptoms such as vomiting, diarrhea, anorexia, and weight loss. This review summarizes the potential causes of chronic gastritis in cheetahs.
Letter
Pharmacology & Pharmacy
Clara Sciorati, Rebecca De Lorenzo, Nicola I. Lore, Cristina Tresoldi, Daniela M. Cirillo, Fabio Ciceri, Angelo Corti, Angelo A. Manfredi, Patrizia Rovere-Querini
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Francesca Nicola, Daniela M. Cirillo, Nicola I. Lore
Summary: This article reviews the current murine models for M. abscessus lung infection and their application in studying new therapeutic approaches. The murine models can be used to validate new targets and drugs and study the combinatorial regimens and dosage and administration of existing antibiotics. Additionally, the murine models can be used to develop new therapeutic approaches to modulate the host immune response and limit immunopathological damage.
Article
Microbiology
Cristina Cigana, Ruggero Giannella, Alice Colavolpe, Beatriz Alcala-Franco, Giulia Mancini, Francesca Colombi, Chiara Bigogno, Ulla Bastrup, Giovanni Bertoni, Alessandra Bragonzi
Summary: CFTR modulators have direct antimicrobial properties and can enhance antibiotic activity against bacteria in cystic fibrosis patients. Bacterial infections can also impact the levels of CFTR modulators in the airways. Optimizing treatment regimens based on the interaction between CFTR modulators and bacterial infections may improve personalized treatment efficacy.
MICROBIOLOGY SPECTRUM
(2023)
Article
Veterinary Sciences
Matteo Cerquetella, Sara Mangiaterra, Giacomo Rossi, Alessandra Gavazza, Andrea Marchegiani, Gianni Sagratini, Massimo Ricciutelli, Simone Angeloni, Licia Fioretti, Carlotta Marini, Stefania Pucciarelli, Silvia Vincenzetti
Summary: This study used proteomic approach to investigate changes in the digestive environment of dogs suffering from acute uncomplicated diarrhea at different time points. Four groups of proteins showed significant differences, indicating a reaction of the organism to the disease. Further studies are needed for confirmation.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gabriele Brecchia, Gerald Muca, Albana Munga, Laura Menchetti, Livio Galosi, Giacomo Rossi, Olimpia Barbato, Grazia Pastorelli, Stella Agradi, Valentina Serra, Majlind Sulce, Enkeleda Ozuni, Luigj Turmalaj, Marta Castrica, Maria Rachele Ceccarini, Federica Riva, Bernard Fioretti, Alda Quattrone, Maria Laura Marongiu, Giulio Curone, Alessandra Napolitano
Summary: This study found that dietary supplementation of goji berry improves semen quality and reproductive tract histology in rabbits, but further research is needed to understand its effect on oxidative stress.
Article
Veterinary Sciences
Barbara Biancani, Livio Galosi, Adolfo Maria Tambella, Sara Berardi, Lucia Biagini, Subeide Mari, Giacomo Rossi
Summary: The bottlenose dolphin and Risso's dolphin, both belonging to the Delphinidae family, exhibit significant differences in their feeding habits. While the bottlenose dolphin prefers blue fish rich in histamine, the Risso's dolphin is strictly teutophagous, feeding on cephalopods. In captivity, both species are fed with several kilograms of fish daily, but Risso's dolphin shows sensitivity to bony fish, leading to gastrointestinal discomfort. Differences in gastric morphology and cell composition suggest that inappropriate diet could result in severe clinical signs due to gastric acidity in Risso's dolphin.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Matteo Cerquetella, Andrea Marchegiani, Giacomo Rossi, Massimo Trabalza-Marinucci, Fabrizio Passamonti, Marco Isidori, Fabrizio Rueca
Summary: This case report describes the effects of orally administered fecal microbiota transplantation (FMT) in a dog with chronic diarrhea. The results showed that FMT improved the clinical score and reduced the canine inflammatory bowel disease activity index (CIBDAI) score. Additionally, the gastrointestinal symptoms of bloating and painful defecation rapidly improved. During the 18-month follow-up, there were no serious relapses and no increase in medication dosage.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Rebecca De Lorenzo, Clara Sciorati, Giuseppe A. Ramirez, Barbara Colombo, Nicola I. Lore, Annalisa Capobianco, Cristina Tresoldi, Daniela Cirillo, Fabio M. Ciceri, Angelo Corti, Patrizia Rovere-Querini, Angelo Manfredi, Angelo A. Bio Angels for COVID-BioB Study Grp
Summary: This study found that plasma CgA levels increase in COVID-19 patients and represent an early independent predictor of mortality.