Article
Biochemistry & Molecular Biology
Krzysztof Jedraszek, Marta Malczewska, Karolina Parysek-Wojcik, Monika Lejman
Summary: Despite advances in medicine, acute lymphoblastic leukemia (ALL) remains a challenge for pediatric clinicians due to treatment resistance and disease relapse. This article focuses on B-cell leukemia patients and examines prognostic factors, mechanisms of resistance to therapy, and the impact of genetic factors, including TCF3::HLF translocation. It also compares treatment protocols and explores the resistance of cancer cells to innovative therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sarah Schober, Jennifer M. Rottenberger, Johannes Hilz, Evi Schmid, Martin Ebinger, Tobias Feuchtinger, Rupert Handgretinger, Peter Lang, Manon Queudeville
Summary: The immune environment plays a crucial role in various types of cancer. This study investigates the influence of Th1 cytokines on pediatric acute lymphoblastic leukemia (ALL). The findings suggest that TNF-alpha and IFN-gamma can induce apoptosis in ALL cells, though the reaction varies among different cells. The high expression of IFN-gamma receptor and subsequent activation of STAT1 are correlated with cell death.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Mateusz Gorecki, Ilona Koziol, Agnieszka Kopystecka, Julia Budzynska, Joanna Zawitkowska, Monika Lejman
Summary: The KMT2A gene is a common target for recurrent translocations in various types of leukemia, and its rearrangement has significant prognostic implications.
Review
Biochemistry & Molecular Biology
Anca Viorica Ivanov, Mirabela Smaranda Alecsa, Roxana Popescu, Magdalena Iuliana Starcea, Adriana Maria Mocanu, Cristina Rusu, Ingrith Crenguta Miron
Summary: In the past 40 years, the survival rate for pediatric cancer has greatly improved, reaching 75-80%. However, leukemia still remains a major cause of morbidity and mortality in specific patient populations. The future of leukemia treatment lies in molecular therapies, immune therapy, and cellular therapy. Recent advances in the field have led to the development of novel therapies for childhood leukemia, including targeted therapies and immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Marina Oldenburg, Nadine Ruechel, Stefan Janssen, Arndt Borkhardt, Katharina L. Goessling
Summary: The concept of holobionts emphasizes the complex interactions between a host and other species, which, if disturbed may lead to disease and premature aging. The impact of chemotherapy on the microbiome and long-term dysbiosis in survivors of acute lymphoblastic leukemia requires further research.
Review
Cell Biology
Huan Xu, Hui Yu, Runming Jin, Xiaoyan Wu, Hongbo Chen
Summary: Acute lymphoblastic leukemia is characterized by genetic and epigenetic abnormalities, with epigenetic mechanisms playing a significant role in leukemogenesis. Compared to genetic alterations, epigenetic abnormalities are relatively reversible with small molecule-based agents.
Article
Medicine, General & Internal
Jae Won Yoo, Ari Ahn, Jong-Mi Lee, Suejung Jo, Seongkoo Kim, Jae Wook Lee, Bin Cho, Yonggoo Kim, Myungshin Kim, Nack-Gyun Chung
Summary: This study investigated the mutational spectrum in pediatric acute lymphoblastic leukemia (ALL) in Korea using next-generation sequencing (NGS) technology. The most frequently mutated genes and pathways were identified in B-cell ALL and T-cell ALL, and several pairs of co-occurring mutations were found. The study also revealed the most frequent newly emerged mutation in relapsed ALL.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Hiroto Inaba, Ching-Hon Pui
Summary: Over the past five decades, the outcomes of pediatric acute lymphoblastic leukemia (ALL) have significantly improved, with 5-year survival rates exceeding 90% in high-income countries. The goal for the next decade is to further increase survival towards 100% and minimize treatment-related adverse effects. Genome-wide analyses have allowed for the classification of ALL into various subtypes, with treatment response and minimal residual disease analysis providing insights for new therapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Article
Immunology
Siyao Jin, Jiamin Xu, Yaru Zou, Xiaona Li, Boran Yu, Jiaqi Han, Xiaoling Wang, Libo Zhao
Summary: This study aimed to explore the association between the anti-inflammatory effects of 6-MP and gut microbiome changes, and their impact on inflammasome. Using a mouse model, it was proved that 6-MP has anti-tumor effects and can significantly decrease the levels of pro-inflammatory factors IL6 and TNF-α. The levels of short-chain fatty acids and the composition of gut microbiota were found to be correlated with the anti-inflammatory response of 6-MP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Gazala Abdulaziz-Opiela, Anna Sobieraj, Anna Plotka, Barbara Wieckowska, Lidia Gil, Katarzyna Derwich
Summary: The aim of this study was to compare the time intervals between different events on disease trajectory in pediatric and AYA groups suffering from ALL and lymphomas. The results confirmed that the diagnostic and treatment processes are longer for AYA patients, indicating a poorer prognosis compared to children, possibly attributed to the organization of the healthcare system.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chana L. Glasser, Jing Chen
Summary: The treatment for relapsed acute lymphoblastic leukemia (ALL) in children and young adults is constantly evolving. Immunotherapy has revolutionized the field by harnessing the patient's immune system to target and eliminate leukemia cells. Novel immunotherapies, such as blinatumomab, inotuzumab, daratumomab, and chimeric antigen receptor T-cell therapy, show promising potential to enhance outcomes while reducing toxicity.
Review
Oncology
Paulina Drozak, Lukasz Brylinski, Joanna Zawitkowska
Summary: Acute lymphoblastic leukemia (ALL) is the most common cancer among pediatric patients. Advances in treatment methods and understanding of its pathogenesis have greatly improved the survival rates of childhood ALL. The latest research in epigenetics shows promising potential for the treatment and diagnostics of this disease.
Review
Oncology
Thai Hoa Tran, Stephen P. Hunger
Summary: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and has shown significant improvement in survival rates through risk-adapted chemotherapy, prevention measures, and molecular analysis. However, challenges remain for older patients and relapsed/refractory cases.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shawn H. R. Lee, Wenjian Yang, Yoshihiro Gocho, August John, Lauren Rowland, Brandon Smart, Hannah Williams, Dylan Maxwell, Jeremy Hunt, Wentao Yang, Kristine R. R. Crews, Kathryn G. G. Roberts, Sima Jeha, Cheng Cheng, Seth E. E. Karol, Mary V. V. Relling, Gary L. L. Rosner, Hiroto Inaba, Charles G. G. Mullighan, Ching-Hon Pui, William E. E. Evans, Jun J. J. Yang
Summary: Contemporary chemotherapy for childhood acute lymphoblastic leukemia is personalized based on clinical features, leukemia genomics, and minimal residual disease. However, the pharmacological basis of these prognostic variables is unclear. A study analyzing samples from 805 children with newly diagnosed leukemia identified variations in drug response and determined that certain subtypes were more sensitive to specific agents. The findings suggest opportunities for individualizing therapy and exploring alternative strategies for childhood acute lymphoblastic leukemia.
Article
Dentistry, Oral Surgery & Medicine
Yujia Cui, Jing Xie, Linyi Cai, Demao Zhang, Jianxun Sun, Xuedong Zhou
Summary: This study suggests that berberine repairs bone destruction caused by apical periodontics by reducing osteoclast activity, promoting osteoblast differentiation, and inhibiting inflammatory response.
Review
Dentistry, Oral Surgery & Medicine
Shuxing Yu, Qizhao Ma, Yuqing Li, Jing Zou
Summary: This review summarizes the research progress of protective molecules and regulatory mechanisms of oxidative stress adaptation of S. mutans.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Peiqing Huang, Shaotang Yuan, Xin Xu, Xian Peng
Summary: This study found that Bifidobacterium lactis HN019 and Lactobacillus acidophilus NCFM exhibited excellent bacteriostatic action against pathogenic bacteria related to halitosis, and they showed remarkable inhibitory effect on the production and emission of volatile sulfur compounds.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Min Liao, Yangyang Shi, Enni Chen, Yuke Shou, Dongyue Dai, Wenpan Xian, Biao Ren, Shimeng Xiao, Lei Cheng
Summary: This study investigated the effects of bio-aging on titanium implants in the oral microenvironment. Different surface treatments were used, and biofilms were established using different bacteria and saliva from healthy individuals and patients with periodontitis. After 30 days of bio-aging, the surface morphology, chemical composition, and water contact angles were measured. The adhesion of cells and biofilms was also evaluated. The results showed that the polished samples had no significant changes, while the MAO- and SLA-treated samples showed mild corrosion. The HA-coated samples were the most vulnerable, especially when exposed to saliva from patients with periodontitis. These findings highlight the importance of oral hygiene and periodontal health for long-term implant success.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bina Yang, Bingqing Song, Jingou Liang, Xuedong Zhou, Biao Ren, Xian Peng, Qi Han, Mingyun Li, Lei Cheng
Summary: Previous studies have shown that there are microorganisms in the oral cavity that promote the occurrence of dental caries, but few studies have been conducted on anticaries materials for these 'core microbiome'. The DMAEM monomer has been found to have an inhibitory effect on the growth of Streptococcus mutans and saliva biofilm, but its effect on the core microbiome of caries needs further research.
Article
Dentistry, Oral Surgery & Medicine
Q. Wu, Z. Li, Y. Zhang, K. Luo, X. Xu, J. Li, X. Peng, X. Zhou
Summary: There is a relationship between periodontitis and atherosclerotic cardiovascular diseases, and the periodontal pathogen Porphyromonas gingivalis (Pg) contributes to the progression of atherosclerosis. Cyclic diadenylate monophosphate (c-di-AMP) has been studied as an immune adjuvant and has shown potential in regulating trained immunity. This study aimed to investigate the role of c-di-AMP in Pg-associated atherosclerosis.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y. Huang, Q. Han, X. Peng, B. Ren, J. Li, X. Zhou, M. Li, L. Cheng
Summary: This investigation aimed to specify the inhibitory effects of disaggregated nano-hydroxyapatite (DnHAP) on regrown biofilms and demineralization. The results showed that DnHAP can inhibit the metabolism, lactic acid production, biofilm structure, and biomass of regrown single/dual-species biofilms. In addition, DnHAP treatment can reduce the metabolic activity and lactic acid production of saliva-derived biofilms. Therefore, DnHAP could be a promising solution for managing regrown biofilms and preventing dental caries.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Wen Zhou, Hong Chen, Michael D. Weir, Thomas W. Oates, Xuedong Zhou, Suping Wang, Lei Cheng, Hockin H. K. Xu
Summary: This review provides an overview of cutting-edge research on the development of new bioactive restorations to inhibit secondary caries in enamel and dentin under biofilms. Novel bioactive materials are categorized based on their remineralization and antibacterial biofunctions. However, there is still a need for new intelligent and pH-responsive materials, and the evaluation should be performed using more clinically relevant biofilm-based secondary caries models.
JOURNAL OF DENTISTRY
(2023)
Article
Business, Finance
Wen Shi, Xiaogang Bi
Summary: This research examines the impact of Buddhism on mergers & acquisitions (M&As) performance using data from 4622 M&A transactions of Chinese public firms between 2004 and 2018. The findings provide ample evidence that acquirers located in regions with a higher intensity of Buddhism achieve better short-term and long-term performance after the merger. Furthermore, the study reveals that state ownership plays a crucial role in mitigating this effect, and the value creation is driven by higher deal completion rates and fewer violation cases for acquiring firms. Finally, the study addresses the issue of endogeneity, and the results remain unchanged.
ACCOUNTING AND FINANCE
(2023)
Review
Biotechnology & Applied Microbiology
Xu Dong, Xin Xu
Summary: Bioceramics, particularly mineral trioxide aggregate (MTA), have been widely used in endodontics for their excellent bioactivity and biocompatibility. Recently, new bioceramics have shown promising clinical outcomes in various endodontic treatments. However, more clinical trials are needed to provide high-level evidence for their application in endodontics.
BIOENGINEERING-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jinchi Liu, Bei Tang, Xin Xu
Summary: This study found a concurrent relationship between the presence of additional canals in mandibular incisors and the second mesiobuccal canal in maxillary first molars among the Chinese population. The prevalence of the second mesiobuccal canal increased with the number of mandibular incisors with additional canals. Furthermore, when at least one mandibular incisor had additional canals, the presence of the second mesiobuccal canal in maxillary first molars could be highly expected.
AUSTRALIAN ENDODONTIC JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Xi Chen, Tiantian Shan, Biao Ren, Lin Zhang, Hockin H. K. Xu, Nanxi Wang, Xuedong Zhou, Hong Li, Lei Cheng
Summary: This study investigated the antibacterial effects of dimethylaminododecyl methacrylate (DMADDM) against H. pylori. The results showed that DMADDM possessed excellent antibacterial and antibiofilm effects on H. pylori, inhibiting its growth and colonization effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Yiling Li, Bolei Li, Xiao Guo, Haohao Wang, Lei Cheng
Summary: This review comprehensively summarizes the current developments of quaternary ammonium compounds (QACs) in the prevention and treatment of oral diseases. The applications of QACs mainly focus on dental material modification and direct pharmacological interventions. Potential risks to normal tissues, drug resistance, and microbial persistence pose challenges to their application. The latest studies explore smart materials and nanoparticle formulations for QACs to overcome these challenges.
JOURNAL OF DENTISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Bingqing Song, Wenpan Xian, Yan Sun, Lichen Gou, Qiang Guo, Xuedong Zhou, Biao Ren, Lei Cheng
Summary: Periodontitis, caused by plaque biofilm, is the leading cause of tooth loss in adults and is associated with systemic diseases. Fusobacterium nucleatum plays a role in periodontitis through its virulence factors and coaggregating effects with other periodontal pathogens. Traditional periodontal treatment is time-consuming and expensive, while antibiotic use may lead to oral microbial resistance. Akkermansia muciniphila, a probiotic, can regulate microbial balance and is inversely correlated with various diseases. Co-culture experiments showed that A. muciniphila inhibited the expression of F. nucleatum's virulence gene. Inflammatory effects of F. nucleatum on gingival epithelial cells were inhibited by A. muciniphila through modulation of the TLR/MyD88/NF-kappaB pathway and secretion of inflammatory factors. Animal experiments demonstrated the inhibition of F. nucleatum-induced periodontitis by A. muciniphila in mice.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Biochemistry & Molecular Biology
Yuke Shou, Lanzhi Deng, Xiaoyu Huang, Xinyu Peng, Xinxuan Zhou, Zheng Wang, Yannan Huang, Bina Yang, Haohao Wang, Min Zhang, Lei Cheng
Summary: This study investigated the effects of saliva biofilm-induced bio-aging on resin composites with different filler types. The results showed that the mechanical properties and microbial behavior of the composites remained relatively stable after 30 days of bio-aging. This suggests that different filler types can be flexibly selected for clinical use.