Article
Biochemistry & Molecular Biology
Sang Shin Lee, Jong Ho Choi, Seung Mook Lim, Gi Jin Kim, Suk Keun Lee, Yoon Kyung Jeon
Summary: The study found that by regulating the expression of PTTG1, newly identified microRNA-186 and -655 can impact the invasion activity of oral squamous cell carcinoma cells, providing further insights into the role of PTTG1 in oral SCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa
Summary: The miRNAs miR-31-5p and miR-31-3p play important roles in regulating the oncogenic properties of HNSCC cells, affecting patient prognosis by controlling a series of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yingchao Ma, Xishen Zhang, Xiao Han, Zhizhong Hao, Rong Ji, Jianhui Li, Wenna Guo, Yanting Zhang, Fangxia Guan, Shanshan Ma
Summary: Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with late-stage diagnosis and poor prognosis. In this study, PDK1 was found to play a role in ESCC by regulating metabolic reprogramming, and its inhibition using DCA showed promising antitumor effects. Additionally, the combination of DCA and cisplatin synergistically inhibited glycolysis and progression of ESCC cells through the Keap1/Nrf2 signaling pathway.
MOLECULAR CARCINOGENESIS
(2023)
Review
Nutrition & Dietetics
Helen B. Everts, Eleonore-Nausica Akuailou
Summary: Animal studies in the 1920s showed that vitamin A deficiency could lead to cancer in epithelial tissues, but typically results in death in humans. Recent research indicates that a high dietary intake of vitamin A can reduce the risk of skin cancer, specifically caused by excess exposure to UVB. This highlights the potential importance of vitamin A in preventing certain types of cancer.
Article
Biochemistry & Molecular Biology
Jia Chen, Shu-Fen Hou, Feng-Jie Tang, Dai-Song Liu, Zi-Zi Chen, Hong-Lian Zhang, Shao-Hua Wang
Summary: HOTAIR, through up-regulating Sp1 and targeting miR-199a, promotes stemness and progression of CSCC. Targeting HOTAIR, Sp1 or the underlying mechanisms may benefit CSCC treatment, as shown by functional assays and in vivo models.
Review
Oncology
Marten C. G. Winge, Laura N. Kellman, Konnie Guo, Jean Y. Tang, Susan M. Swetter, Sumaira Z. Aasi, Kavita Y. Sarin, Anne Lynn S. Chang, Paul A. Khavari
Summary: This Review provides an overview of risk factors and prevention strategies for cSCC, and highlights recent advances in understanding the impact of molecular and cellular intra-tumour heterogeneity in new therapeutic strategies. Despite clinical benefits associated with prevention and therapeutic management, the prognosis for advanced cSCC remains poor. Understanding the interaction between genetic mechanisms driving cSCC and the tumour microenvironment is a current focus in cSCC research.
NATURE REVIEWS CANCER
(2023)
Article
Biotechnology & Applied Microbiology
Lin Fu, Quanxiu Jin, Qianze Dong, Qingchang Li
Summary: The study identified that AATF is overexpressed in human HNSCC, correlating with poor patient survival and resistance to cisplatin, possibly through regulation of the STAT3/survivin signaling pathway. AATF could serve as a potential therapeutic target in HNSCC by promoting cisplatin resistance and reducing apoptosis.
ONCOTARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Matthew L. Hedberg, Corbett T. Berry, Ata S. Moshiri, Yan Xiang, Christopher J. Yeh, Cem Attilasoy, Brian C. Capell, John T. Seykora
Summary: Non-melanoma skin cancers, primarily basal cell carcinomas and squamous cell carcinomas, are the most common form of cancer in the US. The increasing incidence of squamous cell carcinomas leads to significant morbidity and rising treatment costs, exceeding one billion dollars annually. Research on the molecular basis and development of squamous cell carcinomas aims to provide new insights into pathogenesis and drive the development of cost-effective and low morbidity therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Che-Yuan Hsu, Teruki Yanagi, Hideyuki Ujiie
Summary: TRIM proteins, including TRIM29, are essential in a variety of cell processes and have been linked to functions such as DNA binding, carcinogenesis, DNA damage signaling, and radioresistance. In particular, TRIM29 plays a significant role in regulating keratin distribution and is involved in cutaneous squamous cell carcinoma.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du
Summary: The study reveals that miR-106b-5p enhances proliferation, colony formation, adhesion, migration, and invasion, and induces cell cycle progression, while repressing apoptosis in esophageal squamous cell carcinoma (ESCC) by targeting HPGD. This finding suggests that the miR-106b-5p/HPGD axis may serve as a promising target for the diagnosis and treatment of ESCC.
Article
Biochemistry & Molecular Biology
Chie Nakashima, Rina Fujiwara-Tani, Shiori Mori, Shingo Kishi, Hitoshi Ohmori, Kiyomu Fujii, Takuya Mori, Yoshihiro Miyagawa, Kazuhiko Yamamoto, Tadaaki Kirita, Yi Luo, Hiroki Kuniyasu
Summary: In this study, the researchers identified the role and mechanism of action of HOXA11-AS in human oral squamous cell carcinoma (OSCC). They found that HOXA11-AS promotes NQO1 expression by sponging microRNA-494, while suppressing NQO2 expression via recruitment of EZH2 to the NQO2 promoter. These changes in enzyme activities affect cellular metabolism, glycolysis, and metastatic potential. Targeting HOXA11-AS may be a potential therapeutic strategy for high-grade OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Xiangzhi Li, Yawen Yuan, Yimeng Wang, Kaisheng Xie, Sheng Lu, Fuqiang Chen, Meijuan Zhou, Peilin Zhen
Summary: miR-486-3p functions as an oncogene in cSCC by suppressing FLOT2 expression, promoting tumor development and proliferation.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Oncology
Timothy Budden, Caroline Gaudy-Marqueste, Sarah Craig, Yuan Hu, Charles H. Earnshaw, Shilpa Gurung, Amelle Ra, Victoria Akhras, Patrick Shenjere, Ruth Green, Lynne Jamieson, John Lear, Luisa Motta, Carlos Caulin, Deemesh Oudit, Simon J. Furney, Amaya Viros
Summary: This study demonstrates that cSCC is more aggressive in men, while immunocompetent women develop mild cSCC later in life. The research also shows that female immunity offers greater protection than male immunity against cSCC.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Carrick Burns, Shelby Kubicki, Quoc-Bao Nguyen, Nader Aboul-Fettouh, Kelly M. Wilmas, Olivia M. Chen, Hung Quoc Doan, Sirunya Silapunt, Michael R. Migden
Summary: Cutaneous squamous cell carcinoma (cSCC) is a prevalent and morbid cancer, and recent developments in risk stratification and treatment options, such as immune checkpoint inhibitors, have improved outcomes for patients with locally advanced and metastatic disease. Ongoing clinical trials continue to advance the field and offer hope for better management of cSCC in the future.
Review
Dermatology
C. Dessinioti, M. Pitoulias, A. J. Stratigos
Summary: The lack of epidemiological data on locally advanced cSCC highlights the need for standardization in defining and reporting both locally advanced and metastatic cSCC. Metastatic cSCCs, though a small portion, have aggressive characteristics contributing to higher morbidity and mortality, requiring systemic treatments.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Dongqing Li, Hongmei Peng, Le Qu, Pehr Sommar, Aoxue Wang, Tongbin Chu, Xi Li, Xinling Bi, Queping Liu, Irene Gallais Serezal, Ola Rollman, Warangkana Lohcharoenkal, Xiaowei Zheng, Sofie Eliasson Angelstig, Jacob Grunler, Andor Pivarcsi, Eniko Sonkoly, Sergiu-Bogdan Catrina, Changchun Xiao, Mona Stahle, Qing-Sheng Mi, Li Zhou, Ning Xu Landen
Summary: The study reveals that miR-19a/b and miR-20a are crucial regulators of wound inflammation, and their lack may contribute to sustained inflammation and impaired healing in chronic wounds. Combinatory treatment with miR-19b and miR-20a improved wound healing in a mouse model of type 2 diabetes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Warangkana Lohcharoenkal, Chen Li, Kunal Das Mahapatra, Jan Lapins, Bernhard Homey, Eniko Sonkoly, Andor Pivarcsi
Summary: The study found that miR-130a is downregulated in cSCC and regulated by the HRAS and MAPK signaling pathways. Overexpression of miR-130a suppressed the growth, motility, and invasion ability of cSCC cells, as well as inhibited the growth of cSCC xenografts in mice. Mechanistically, miR-130a targets ACVR1, leading to decreased BMP/SMAD pathway activity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Dongqing Li, Shangli Cheng, Yu Pei, Pehr Sommar, Jaanika Karner, Eva K. Herter, Maria A. Toma, Letian Zhang, Kim Pham, Yuen Ting Cheung, Zhuang Liu, Xingqi Chen, Liv Eidsmo, Qiaolin Deng, Ning Xu Landen
Summary: This study compared the single-cell transcriptomic profiles of epidermal cells from pressure ulcer (PU) wounds with those from acute wounds and uninjured skin. The researchers identified significant shifts in cell composition and gene expression patterns in PU. They also found that patients with worse healing outcomes had an enrichment of major histocompatibility complex class II-expressing keratinocytes. Furthermore, the study showed that IFN-gamma in PU-derived wound fluid could induce major histocompatibility complex II expression in keratinocytes, which inhibited autologous T-cell activation. T cells from PUs with major histocompatibility complex II+ keratinocytes produced fewer inflammatory cytokines. The study provides insights into PU pathology and the future development of tailored wound therapy.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Chemistry, Analytical
Warangkana Lohcharoenkal, Zareen Abbas, Yon Rojanasakul
Summary: Cytokines are small proteins secreted by immune and non-immune cells in response to external stimuli, with applications in early disease diagnosis and therapeutic response assessment. Various methods are available for cytokine detection, but using wearable biosensors for multiplexed or continuous measurements is highly desirable.
Article
Dermatology
Maria A. Toma, Zhuang Liu, Qizhang Wang, Letian Zhang, Dongqing Li, Pehr Sommar, Ning Xu Landen
Summary: By analyzing clinical samples, we revealed the changed expression pattern of circRNAs during human skin repair and their abnormal expression in venous ulcers. We also identified regulatory networks specific to the inflammatory and proliferative phases of wound repair and venous ulcers and the potential biological processes regulated by circRNAs. Furthermore, we found that two upregulated circRNAs in venous ulcers hindered cell migration while promoting proliferation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Cell Biology
Dongqing Li, Guanglin Niu, Ning Xu Landen
Summary: Noncoding RNAs play important roles in skin wound healing by regulating gene expression and protein functions. They have crucial functions in every stage of wound healing and are also associated with common wound complications. With their unique expression and functional properties, noncoding RNAs have promising applications in wound care therapeutics and diagnostics.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Article
Biology
Zhuang Liu, Letian Zhang, Maria A. Toma, Dongqing Li, Xiaowei Bian, Irena Pastar, Marjana Tomic-Canic, Pehr Sommar, Ning Xu Landen
Summary: This study identified 17 pathologically relevant miRNAs that are involved in chronic wound pathology and showed their high cooperativity. By targeting these miRNAs, innovative wound treatments with higher efficacy and specificity could be developed.
Article
Dermatology
Longlong Luo, Lorenzo Pasquali, Ankit Srivastava, Jan C. Freisenhausen, Andor Pivarcsi, Eniko Sonkoly
Summary: This study identified LINC00958 as an overexpressed long noncoding RNA in keratinocytes from psoriasis skin lesions. IL-17A induced LINC00958 expression in keratinocytes through C/EBP-b and the p38 pathway. Inhibiting LINC00958 led to decreased cell proliferation and altered expression of cell cycle-related genes in keratinocytes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Letian Zhang, Minna Piipponen, Zhuang Liu, Dongqing Li, Xiaowei Bian, Guanglin Niu, Jennifer Geara, Maria A. Toma, Pehr Sommar, Ning Xu Landen
Summary: HOXC13-AS, a long noncoding RNA, is a crucial regulator of human epidermal differentiation. It promotes keratinocyte differentiation by interfering with Golgi-to-endoplasmic reticulum molecular transport, leading to ER stress.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Public, Environmental & Occupational Health
Xi Li, Sakthi Ponandai-Srinivasan, Kutty Selva Nandakumar, Susanne Fabre, Ning Xu Landen, Alain Mavon, Ia Khmaladze
Summary: miRNAs play important regulatory roles in human skin, influencing cell proliferation, differentiation, immune regulation, and wound healing. Regulating miRNA expression shows promise as a novel therapy for skin diseases and cosmeceutical interventions to boost skin health.
HEALTH SCIENCE REPORTS
(2021)
Meeting Abstract
Dermatology
M. A. Toma, Q. Wang, M. Vij, Z. Liu, M. M. Piipponen, X. Bian, D. Li, A. Wang, P. Sommar, N. X. Landen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Meeting Abstract
Dermatology
L. Zhang, M. M. Piipponen, N. X. Landen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Meeting Abstract
Cell Biology
Ning Xu Landen, Dongqing Li, Shangli Cheng, Qiaolin Deng, Pehr Sommar, Yu Pei, Jaanika Karner, Eva Herter, Maria Toma, Letian Zhang, Kim Pham, Xingqi Chen, Liv Eidsmo
WOUND REPAIR AND REGENERATION
(2021)
Meeting Abstract
Dermatology
D. Li, S. Cheng, Q. Deng, N. Xu Landen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
