Article
Pharmacology & Pharmacy
Alexander Gomez-A, Carol A. Dannenhoffer, Amanda Elton, Sung-Ho Lee, Woomi Ban, Yen-Yu Ian Shih, Charlotte A. Boettiger, Donita L. Robinson
Summary: Adolescent alcohol exposure can have significant impacts on behavioral flexibility and brain functional connectivity in adult animals, leading to impairments in attentional set reversals and decreased connectivity among key brain regions supporting flexible behavior. The study demonstrates a crucial link between reduced brain functional connectivity resulting from alcohol exposure during adolescence and deficits in behavioral flexibility.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Douglas B. Matthews, Samantha Scaletty, Sarah Trapp, Abigail Kastner, Amelia M. Schneider, Areonna Schreiber, Gillian Rossmann
Summary: Chronic intermittent ethanol exposure during adolescence has long-lasting effects on cognitive impairments, particularly on behavioral flexibility, in rats, with different patterns of results observed in female and male rats.
Article
Behavioral Sciences
Silvia Corongiu, Christian Dessi, Elena Espa, Augusta Pisanu, Annalisa Pinna, Daniele Lecca, Sandro Fenu, Cristina Cadoni
Summary: Genetic background and age at first exposure are critical variables in individual vulnerability to drug addiction. The study shows that alcohol consumption, especially binge-drinking, by young people predicts future drinking problems. This study highlights the importance of understanding the influence of age and genetic background on the development of alcohol dependence.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bart de Laat, Yvonne E. Kling, Gwen Schroyen, Maarten Ooms, Jacob M. Hooker, Guy Bormans, Koen Van Laere, Jenny Ceccarini
Summary: This study demonstrates that chronic voluntary alcohol consumption leads to reversible increases in PDE10A enzymatic availability in the striatum, which is related to the amount of alcohol preference. The decrease in striatal PDE10A is associated with alcohol consumption and preference, and PDE10A inhibition may have beneficial effects on reducing alcohol intake.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Elizabeth J. Glover, Fauzan Khan, Kacey Clayton-Stiglbauer, L. Judson Chandler
Summary: Four variables - strain, sex, age, and blood ethanol concentration - have significant impacts on intoxicated behavior in rats exposed to vaporized ethanol. These data provide key factors to consider when studying alcohol use disorder.
Article
Clinical Neurology
Soo Hwan Yim, Kwang Ik Yang, Jee Hyun Kim, Young Hwangbo, Daeyoung Kim, Seung Bong Hong
Summary: Insomnia symptoms are common in Korean high school students, with evening preference being the major factor associated with insomnia symptoms. Various socio-behavioral factors were also found to be associated with insomnia symptoms.
Article
Psychology, Developmental
Lisa J. Pijnenburg, Anais Kaplun, Lieuwe de Haan, Magdalena Janecka, Lauren Smith, Abraham Reichenberg, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Quinlan, Sylvane Desrivieres, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Eva Velthorst
Summary: This study suggests that autistic traits are associated with less frequent and lower quantity of alcohol use during adolescence. Adolescents with higher levels of autistic traits, including social impairment, detail orientation, and anxiety, were found to consume less alcohol and engage in less binge drinking.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Neurosciences
Danil Peregud, Mikhail Stepanichev, Natalia Gulyaeva
Summary: In rats demonstrating gradual escalation of alcohol intake in the IA2BC procedure, PTCH mRNA levels increased in the hippocampus during early abstinence, while SHH, SMO and GLI mRNA levels remained unchanged. Thus, the activated hippocampal SHH signaling cascade is a hallmark of rats with an escalating drinking pattern.
Article
Multidisciplinary Sciences
Mai Kanno, Shun Hiramatsu, Shu Kondo, Hiromu Tanimoto, Toshiharu Ichinose
Summary: The study found that fruit flies showed acute preference for ethanol and methamphetamine but not for cocaine, caffeine, or morphine. Over time, flies developed a long-term preference for ethanol, and dopamine signaling and its plastic changes played a crucial role in controlling voluntary drug intake.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Alina K. Dillahunt, Daniel A. Feldman, Leah R. Thomas, Brian W. Farstead, Summer B. Frandsen, Somi Lee, Myah Pazdera, Jennica Galloway, Katie L. Bessette, Henrietta Roberts, Sheila E. Crowell, Edward R. Watkins, Scott A. Langenecker, Melinda Westlund Schreiner
Summary: Strategies to link impulsivity and self-injurious behaviors show variable results, depending on the measure used. Participants with a history of self-injurious behaviors demonstrated higher self-reported impulsivity, but lower risk-taking on a behavioral measure. There was no relation between rumination and behavioral impulsivity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Substance Abuse
Cassie M. Chandler, Jakob D. Shaykin, Hui Peng, James R. Pauly, Kimberly Nixon, Michael T. Bardo
Summary: Initiating alcohol use in adolescence increases the risk of developing adult alcohol use disorder (AUD), and the combination of social isolation stress and adolescent ethanol exposure may play a key role in this risk.
Article
Nutrition & Dietetics
Jennifer R. Sadler, Gita Thapaliya, Elena Jansen, Anahys H. Aghababian, Kimberly R. Smith, Susan Carnell
Summary: The study found that emotional overeating may exacerbate stress-related intake of high-sugar foods, while cognitive flexibility may mitigate stress-related intake of high-fat foods. Differences in appetitive and cognitive traits may explain changes in and variability of food intake during the COVID-19 pandemic. efforts to decrease emotional overeating and encourage cognitive flexibility could help mitigate the impact of COVID-19-related stress on energy dense food intake.
Article
Nutrition & Dietetics
Zhizhong Zhang, Mengmeng Wang, Shuai Yuan, Xinfeng Liu
Summary: The study suggests that alcohol intake may increase the risk of epilepsy, while milk intake may lower the risk.
Article
Neurosciences
S. G. Quadir, G. M. Arleth, J. Jahad, M. Echeveste Sanchez, D. P. Effinger, M. A. Herman
Summary: This study investigated the relationship between affective states and ethanol intake in male and female Sprague-Dawley rats. It found sex- and test-specific differences in baseline affective behavior, with females showing enhanced anxiety-like behavior and males displaying enhanced anxiety-like behavior. Depressive-like behavior predicted future ethanol intake in female rats only, while post-drinking anxiety-like behavior predicted subsequent ethanol intake in female rats. The research provides insight into the complex interaction between negative affect and ethanol intake in a sex-specific manner.
PSYCHOPHARMACOLOGY
(2022)
Article
Oncology
Julie K. Bassett, Robert J. MacInnis, Yi Yang, Allison M. Hodge, Brigid M. Lynch, Dallas R. English, Graham G. Giles, Roger L. Milne, Harindra Jayasekara
Summary: The study revealed that heavy drinking in early adulthood may increase the risk of alcohol-related cancer later in life for men, while increasing alcohol intake gradually from a young age is associated with an increased risk of alcohol-related cancer for women.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Substance Abuse
Leslie R. Amodeo, Derek N. Wills, Manuel Sanchez-Alavez, William Nguyen, Bruno Conti, Cindy L. Ehlers
Article
Substance Abuse
Manuel Sanchez-Alavez, Derek N. Wills, Leslie Amodeo, Cindy L. Ehlers
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Article
Behavioral Sciences
Shannon M. Thompson, Amber N. Simmons, Matthew S. McMurray
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Amanda C. Welch, Jie Zhang, Jinrui Lyu, Matthew S. McMurray, Jonathan A. Javitch, Christoph Kellendonk, Stephanie C. Dulawa
Summary: D2R-OENAc alters glucose metabolism in both sexes but drives robust weight loss only in females during scheduled fasting, implicating metabolic mechanisms in this sexually dimorphic effect.
MOLECULAR PSYCHIATRY
(2021)
Article
Substance Abuse
Leslie R. Amodeo, Derek N. Wills, Manuel Sanchez-Alavez, Cindy L. Ehlers
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Substance Abuse
Leslie R. Amodeo, Wen Liu, Derek N. Wills, Ryan P. Vetreno, Fulton T. Crews, Cindy L. Ehlers
Article
Psychology, Biological
Danielle N. Tapp, Hannah L. Zerkle, Matthew S. McMurray
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2020)
Article
Behavioral Sciences
Danielle N. Tapp, Mitchell D. Singstock, Meredith S. Gottliebson, Matthew S. McMurray
HORMONES AND BEHAVIOR
(2020)
Article
Substance Abuse
Leslie R. Amodeo, Sarah D. Jennings, Patrick J. Mulholland, Cindy L. Ehlers
Summary: This study investigates the effects of adolescent ethanol exposure on cortical dendritic spine density and morphology in rodents. Results suggest that adolescent intermittent ethanol exposure decreases spine density, particularly in the primary motor cortex. These findings contribute to understanding the vulnerability of certain cortical circuits to alcohol effects during adolescence.
Article
Psychology, Experimental
Max Teaford, William Berg, Vincent A. Billock, Matthew S. McMurray, Robin Thomas, L. James Smart
Summary: The rubber hand illusion is a perceptual illusion where people feel a hand-shaped object is part of their body. This study explores the relationship between muscle activity and experiencing the illusion, and finds that muscle fatigue is positively associated with proprioceptive drift when the stimulation is synchronous or visual movement only.
PSYCHOLOGICAL RESEARCH-PSYCHOLOGISCHE FORSCHUNG
(2023)
Article
Behavioral Sciences
Gabrielle Kelly, Jessica C. Bezenah, Alexandra N. Tejada, Benjamin Johnson, Briana Vazquez, Melissa Espinosa, Leslie R. Amodeo
Summary: This study found that early exposure to methylphenidate in rats can have long-term effects on decision-making in adulthood, and these effects can be influenced by gender.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Behavioral Sciences
Brianna F. Roberts, Alexia L. Zylko, Courtney E. Waters, Jessica D. Crowder, William J. Gibbons Jr, Abhishek K. Sen, J. Andrew Jones, Matthew S. McMurray
Summary: This study investigated the effects of psilocybin on decision-making and motivation in rats. The results showed that psilocybin did not affect decision-making and motivation, but it did cause head twitch responses. Therefore, the study suggests that psilocybin may not impair or improve decision-making and motivation.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Behavioral Sciences
Bryan D. Alvarez, Cheyenne A. Morales, Brandon L. Oliver, Cassandra Cavazos, Leslie R. Amodeo, Dionisio A. Amodeo
Summary: Autism spectrum disorder (ASD) is characterized by impairments in social communication and restricted, repetitive behaviors (RRBs). Traditional tests of behavioral flexibility may not capture the variability of outcomes, prompting the use of an 80%/20% probabilistic reversal learning paradigm. This study aimed to assess the performance of BTBR mice on this task, as well as examine sex-specific differences in reversal learning.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Alexandra M. Adams, Nicholas A. Anas, Abhishek K. Sen, Jordan D. Hinegardner-Hendricks, Philip J. O'Dell, William J. Gibbons, Jessica E. Flower, Matthew S. McMurray, J. Andrew Jones
Summary: Interest in the potential therapeutic efficacy of psilocybin and other psychedelic compounds has increased significantly. In this study, a novel E. coli platform was developed for the production of norbaeocystin, an intermediate compound in the psilocybin pathway. In vivo measurements showed that psilocybin had a dose response, while norbaeocystin did not elicit any pharmacological response, suggesting a weak affinity of norbaeocystin and its metabolites for the serotonin 2A receptor. This research provides a mechanism to source norbaeocystin for future studies and supports the safety of cell broth as a drug delivery vehicle.
METABOLIC ENGINEERING COMMUNICATIONS
(2022)
Review
Psychology, Clinical
Max Teaford, Matthew S. McMurray, Vincent Billock, Madison Filipkowski, L. James Smart
Summary: Individuals with anorexia nervosa show abnormalities in multisensory integration, reduced discrimination ability for complex haptic and tactile stimuli, and decreased sensitivity to nociceptive stimuli, indicating potential avenues for future research.
JOURNAL OF EXPERIMENTAL PSYCHOPATHOLOGY
(2021)