Article
Neurosciences
Aaron M. Williams, Christopher F. Angeloni, Maria N. Geffen
Summary: In this study, the researchers investigated how sound and movement interact to modulate V1 visual responses in awake, head-fixed mice. They found that sound modulated the activity of a large percentage of light-responsive neurons, with most neurons increasing their activity in the presence of auditory stimuli. The study also revealed that sound and movement had distinct and complementary effects on neuronal visual responses, improving the decoding of visual stimuli from neuronal activity. These findings enhance our understanding of multimodal processing in the awake brain and clarify the potential confounding role of movement in neuronal audiovisual responses.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Karly M. Turner, Anna Svegborn, Mia Langguth, Colin McKenzie, Trevor W. Robbins
Summary: This study reveals a functional opposition between the dorsomedial and dorsolateral striatum during skill and habit formation. Loss of function in the dorsomedial striatum accelerates sequence acquisition, while loss of function in the dorsolateral striatum impedes it. The mPFC is not involved, but the lateral orbitofrontal cortex plays a critical role.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Thomas Akam, Ines Rodrigues-Vaz, Ivo Marcelo, Xiangyu Zhang, Michael Pereira, Rodrigo Freire Oliveira, Peter Dayan, Rui M. Costa
Summary: Behavioral control consists of parallel systems, model based and model free, and the anterior cingulate cortex plays a critical role in predicting actions and their consequences. ACC represents the complete state space of a task and is necessary for updating model-based strategies.
Article
Multidisciplinary Sciences
Jan Homann, Sue Ann Koay, Kevin S. Chen, David W. Tank, Michael J. Berry
Summary: By recording and observing the activity of neurons in the mouse primary visual cortex, researchers have found that novel images can elicit excessive activity in most neurons, with this novelty response rapidly emerging and having a specific duration. When new image sets are repeatedly presented, the neuronal activity gradually stabilizes. Furthermore, the study reveals that under certain conditions, neural circuits have the capacity to store approximately 15 familiar images.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Xiuxiu Zhuang, Luping Huang, Yixiao Gu, Lu Wang, Rong Zhang, Minyuan Zhang, Fei Li, Yiyi Shi, Yunchang Mo, Qinxue Dai, Chaoyi Wei, Junlu Wang
Summary: The study investigated the role of ACC-DMS in neuropathic pain in mice, suggesting that these areas may be involved in the regulation of pain.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Neurosciences
Julien Corbo, John P. McClure, O. Batuhan Erkat, Pierre-Olivier Polack
Summary: Learning affects neural activity in sensory cortical neurons and alters the representations of cues orientations in the primary visual cortex. This study found that learning an orientation discrimination task improves the accuracy and stability of cue representation in trained mice. It also leads to a distortion of orientation representation space and enhances the generalization of stimuli in the task-relevant computational space.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Wei Wen, Gina G. Turrigiano
Summary: Homeostatic plasticity in neural circuits can be modulated differently at various developmental stages, with excitatory synaptic scaling and intrinsic homeostatic plasticity being induced during critical periods but only excitatory synaptic scaling persisting into adulthood. This suggests that distinct sets of homeostatic plasticity mechanisms are recruited based on the needs of the developing neural circuit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chen-Yun Ding, Yan-Ting Ding, Haifeng Ji, Yao-Yi Wang, Xinwen Zhang, Dong-Min Yin
Summary: This study generated a knockin mouse model using CRISPR/Cas9 techniques to investigate the expression pattern of Nrg1 gene in the mouse brain at the cellular and circuit levels. The results revealed that Nrg1 is broadly expressed in neurons, but has unique expression patterns in different brain regions, with specific cell types and projection patterns.
CELL AND BIOSCIENCE
(2023)
Review
Neurosciences
Vijay Mohan K. Namboodiri, Garret D. Stuber
Summary: This article discusses the role of brain circuits in forming cognitive maps to process and store statistical relationships in the environment, proposing the concepts of prospective and retrospective cognitive maps. Cognitive maps describe environmental states and their relationships, influencing many neural signals and behaviors.
Article
Neurosciences
Yajie Liang, Jiang Lan Fan, Wenzhi Sun, Rongwen Lu, Ming Chen, Na Ji
Summary: Researchers have identified a population of layer 6 excitatory neurons in the primary visual cortex of mice that serve as the main conveyer of transcallosal information. These neurons contribute to a reciprocal network across multiple sensory cortices in two hemispheres, encoding orientation, direction, and receptive field information. The spontaneous activity of these neurons exhibits complex relationships with brain states and stimulus presentation, distinguishing them from other neuron populations.
Article
Multidisciplinary Sciences
Daniel L. Barabasi, Taliesin Beynon, Adam Katona, Nicolas Perez-Nieves
Summary: This paper introduces neurodevelopmental considerations into the framework of machine learning, simulating the evolutionary selection process in brain development by updating the connection rules of neurons to improve task fitness. Experimental results show that this model not only provides high accuracy in machine learning but also compresses the parameter count, and it can select simple circuits from metalearning tasks to provide stable and adaptive performance. By introducing neurodevelopmental considerations, we not only model the emergence of innate behaviors but also define a discovery process for structures that promote complex computations.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Stefano Cataldi, Clay Lacefield, N. Shashaank, Gautam Kumar, Siham Boumhaouad, David Sulzer
Summary: This study investigates the roles of the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) in motor learning using a mouse Treadmill Training Task and photometry. The results show that as mice become more proficient at running, activity in the DMS direct pathway decreases, while direct pathway activity in the DLS remains similar throughout training. Additionally, the study demonstrates the importance of dopamine neurotransmission in efficient motor coordination learning.
Article
Cell Biology
Shovan Naskar, Jia Qi, Francisco Pereira, Charles R. Gerfen, Soohyun Lee
Summary: Extensive hierarchical yet highly reciprocal interactions among cortical areas are crucial for information processing, but the specificity and rules governing corticocortical connections are poorly understood. The study shows that long-range projections from different areas preferentially engage specific sets of GABAergic neurons in the primary somatosensory cortex, leading to distinct feedback mechanisms between neurons.
Article
Biochemistry & Molecular Biology
Ilaria Tonazzini, Chiara Cerri, Ambra Del Grosso, Sara Antonini, Manuela Allegra, Matteo Caleo, Marco Cecchini
Summary: This study provides a comprehensive characterization of morphological and functional alterations in the visual system of Twitcher (TWI) mouse model of Krabbe disease. The findings demonstrate defective basic functional properties in the primary visual cortex, along with specific neuropathological alterations and increasing PSY accumulation over time in the brain and optic nerves.
Article
Biology
Lilya Andrianova, Steliana Yanakieva, Gabriella Margetts-Smith, Shivali Kohli, Erica S. Brady, John P. Aggleton, Michael T. Craig
Summary: The connectivity and interplay between the prefrontal cortex and hippocampus are important for cognitive processes, but the existence of a direct glutamatergic projection from the anterior cingulate cortex to the hippocampus has been questioned. In this study, multiple methods were used to validate a recent finding of this projection, but no evidence of such a projection was found.
Article
Neurosciences
Nicolas X. Tritsch, Adam J. Granger, Bernardo L. Sabatini
NATURE REVIEWS NEUROSCIENCE
(2016)
Editorial Material
Neurosciences
Nicolas X. Tritsch, Adam G. Carter
Article
Neurosciences
Yi-Ya Fang, Takashi Yamaguchi, Soomin C. Song, Nicolas X. Tritsch, Dayu Lin
Article
Neurosciences
Nicolas X. Tritsch, Dwight E. Bergles
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Jennifer S. Goldman, Mohammed A. Ashour, Margaret H. Magdesian, Nicolas X. Tritsch, Stephanie N. Harris, Nicolas Christofi, Raja Chemali, Yaakov E. Stern, Greta Thompson-Steckel, Pavel Gris, Stephen D. Glasgow, Peter Grutter, Jean-Francois Bouchard, Edward S. Ruthazer, David Stellwagen, Timothy E. Kennedy
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Christoph Straub, Nicolas X. Tritsch, Nellwyn A. Hagan, Chenghua Gu, Bernardo L. Sabatini
JOURNAL OF NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Nicolas X. Tritsch, Jun B. Ding, Bernardo L. Sabatini
Article
Neurosciences
Nicolas X. Tritsch, Adrian Rodriguez-Contreras, Tom T. H. Crins, Han Chin Wang, J. Gerard G. Borst, Dwight E. Bergles
NATURE NEUROSCIENCE
(2010)
Review
Neurosciences
Nicolas X. Tritsch, Bernardo L. Sabatini
Article
Biochemistry & Molecular Biology
Nicolas X. Tritsch, Ying-Xin Zhang, Graham Ellis-Davies, Dwight E. Bergles
PURINERGIC SIGNALLING
(2010)
Article
Biology
Nicolas X. Tritsch, Won-Jong Oh, Chenghua Gu, Bernardo L. Sabatini
Article
Multidisciplinary Sciences
Nicolas X. Tritsch, Eunyoung Yi, Jonathan E. Gale, Elisabeth Glowatzki, Dwight E. Bergles
Article
Biochemistry & Molecular Biology
C Flores, C Manitt, D Rodaros, KM Thompson, H Rajabi, KC Luk, NX Tritsch, AF Sadikot, J Stewart, TE Kennedy
MOLECULAR PSYCHIATRY
(2005)
Article
Neurosciences
M Shekarabi, SW Moore, NX Tritsch, SJ Morris, JF Bouchard, TE Kennedy
JOURNAL OF NEUROSCIENCE
(2005)