Review
Immunology
Gabriela M. Wiedemann
Summary: This review focuses on the epigenetic regulation of NK cell functionality and plasticity in different tissue and tumor microenvironments, which is crucial for the development of NK cell-based cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Robyn Broad, Stacey J. Jones, Melina C. Teske, Laura M. Wastall, Andrew M. Hanby, James L. Thorne, Thomas A. Hughes
Summary: CAFs induce activation of IFN signaling in claudin-low TNBCs, leading to chemoresistance. High expression of IFN beta 1 (CAFs) or MX1 (tumour cells) correlates with reduced survival after chemotherapy, especially in claudin-low subtype tumors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biophysics
Milos Nikolic, Giuliano Scarcelli, Kandice Tanner
Summary: By measuring cell mechanical phenotypes using different modalities, it was found that cells exhibit different mechanical characteristics in different environments; meanwhile, the heterogeneity in cell shape is closely linked to the cells' mechanical state; in multicellular spheroids, there is mechanical cooperativity between cells.
BIOPHYSICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Barbara T. Grunwald, Antoine Devisme, Geoffroy Andrieux, Foram Vyas, Kazeera Aliar, Curtis W. McCloskey, Andrew Macklin, Gun Ho Jang, Robert Denroche, Joan Miguel Romero, Prashant Bavi, Peter Bronsert, Faiyaz Notta, Grainne O'Kane, Julie Wilson, Jennifer Knox, Laura Tamblyn, Molly Udaskin, Nikolina Radulovich, Sandra E. Fischer, Melanie Boerries, Steven Gallinger, Thomas Kislinger, Rama Khokha
Summary: Through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models, we identified distinct subTMEs in the human pancreatic tumor microenvironment (TME) that are linked to tumor immunity, subtypes, differentiation, and treatment response. Reactive subTMEs rich in coordinated fibroblast communities were immune hot, while matrix-rich deserted subTMEs harbored fewer activated fibroblasts but showed chemoprotective features. These subTMEs originated in fibroblast differentiation trajectories and produced patient-specific heterogeneity tightly linked to malignant biology.
Article
Biochemistry & Molecular Biology
Jing Zheng, Yan Xie, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: This study investigated different microenvironmental conditions for the controlled proliferation and chondrogenic differentiation of human bone-marrow-derived mesenchymal stem cells (hMSCs). The results showed that collagen sponges promoted cell proliferation and chondrogenic differentiation. Combining collagen sponges with collagen hydrogels and induction factors had the highest promotive effect on chondrogenic differentiation. These findings provide useful information for stem cell chondrogenic differentiation and cartilage tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
L. Michael Carastro, Ethan J. Vallebuona, Ricardo Cordova, Ashely N. Gannon, Seung Joon Kim, Corrine M. Costello, Ricardo A. Declet-Bauzo, Nagi Kumar, Jong Y. Park
Summary: Poly E, a green tea extract, has chemopreventive activity against PCa. It induces gene expression changes in PCa cells, with significant increases in MXD1 and RGS4 expression, suggesting that Poly E may exert its chemopreventive activity through the regulation of these genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Alina M. Hamilton, Amber N. Hurson, Linnea T. Olsson, Andrea Walens, Joseph Nsonwu-Farley, Erin L. Kirk, Yara Abdou, Stephanie M. Downs-Canner, Jonathan S. Serody, Charles M. Perou, Benjamin C. Calhoun, Melissa A. Troester, Katherine A. Hoadley
Summary: The immune microenvironment in breast cancer is closely related to race, age, tumor subtype, and grade. Black and young women have higher immune response, which may be associated with higher recurrence risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Food Science & Technology
Xiuxiu Wang, Xiaoyu Liu, Zhenzhen Jia, Yilun Zhang, Shuo Wang, Hongyan Zhang
Summary: The study found that high-salt, high-sugar, and high-fat diets significantly promoted the increase in CTC numbers, while ketogenic, low-fat, low-protein, diet restriction, and Mediterranean diets delayed the increase. Through in-depth study of the effects of different dietary patterns on tumor growth and metastasis, a new horizon in future cancer treatments may be expanded.
Article
Genetics & Heredity
Gaurav Bhatt, Akshita Gupta, Latha Rangan, Anil Mukund Limaye
Summary: Karanjin, a furanoflavonoid compound, has diverse biological effects in vivo and in vitro. This study explored the transcriptomic footprint of Karanjin in MCF-7 breast cancer cells, revealing its potential estrogen-like activity and cautioning its anticancer potential. Further investigations are needed to understand the mechanism of action.
Article
Oncology
Dylan L. Schaff, Shambhavi Singh, Kee-Beom Kim, Matthew D. Sutcliffe, Kwon-Sik Park, Kevin A. Janes
Summary: This study reveals that the single-cell regulatory heterogeneity of small-cell lung cancer becomes increasingly complex in the liver, a common metastatic site. Heterotypic interactions in the liver and lung may accelerate intratumor heterogeneity in small-cell lung cancer. These findings provide insights into the progression and complexity of small-cell lung cancer metastasis.
Article
Oncology
Joel S. Parker, Michael Mullins, Maggie C. U. Cheang, Samuel Leung, David Voduc, Tammi Vickery, Sherri Davies, Christiane Fauron, Xiaping He, Zhiyuan Hu, John F. Quackenbush, Inge J. Stijleman, Juan Palazzo, J. S. Marron, Andrew B. Nobel, Elaine Mardis, Torsten O. Nielsen, Matthew J. Ellis, Charles M. Perou, Philip S. Bernard
Summary: This study developed a risk model that incorporates gene expression-based intrinsic subtypes for breast cancer prognosis and prediction of chemotherapy benefit. The intrinsic subtypes showed significant prognostic significance and remained significant even when standard parameters were incorporated. The model can be used to predict prognosis for node-negative breast cancer and assess the likelihood of efficacy from neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christina D. Camell
Summary: Adipose tissue plays a crucial role in nutrient sensing, energy storage, and metabolic health. Impairment of adipose tissue homeostasis during aging leads to metabolic disease. Aging is associated with dysfunction in the immune, nervous, and lymphatic systems, resulting in reduced ability to stimulate lipolysis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Multidisciplinary Sciences
Ramesh Chaudhari, Simran Nasra, Nikita Meghani, Ashutosh Kumar
Summary: MicroRNAs play important roles in various diseases, including cancer. They can act as tumor suppressors or oncogenes, and their expression levels vary depending on cancer subtypes and mutations. Modified metallic nanoparticles can be used for effective miRNA delivery.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Olga Sularz, Aneta Koronowicz, Cayla Boycott, Sylwester Smolen, Barbara Stefanska
Summary: The study evaluated the effect of iodine-biofortified lettuce on anti-tumor properties in human gastrointestinal cancer cell lines. The results showed that extracts from iodine-biofortified lettuce reduced the viability and proliferation of gastric and colon cancer cells. The extracts also affected cell cycle and protein expression, mediating the anti-tumor effects.
Article
Multidisciplinary Sciences
Jian Liao, Qing-hong Qin, Fa-you Lv, Zhen Huang, Bin Lian, Chang-yuan Wei, Qin-guo Mo, Qi-xing Tan
Summary: In this study, the researchers found that the expression of IKK alpha in TNBC is associated with changes before and after chemotherapy, and high expression is correlated with a lower pathological response. In addition, the overexpression of IKK alpha promotes the formation of drug resistance, and inhibiting the expression of IKK alpha can enhance the cytotoxic effect of chemotherapy on tumor cells. These findings suggest that combining IKK alpha inhibitors with chemotherapy may be an effective strategy to improve treatment outcomes in TNBC patients with chemoresistance.
SCIENTIFIC REPORTS
(2023)