Article
Immunology
Le Nguyen Minh Hoa, Sheena G. Sullivan, Le Quynh Mai, Arseniy Khvorov, Hoang Vu Mai Phuong, Nguyen Le Khanh Hang, Pham Quang Thai, Le Thi Thanh, Louise Carolan, Dang Duc Anh, Tran Nhu Duong, Juliet E. Bryant, H. Rogier van Doorn, Heiman F. L. Wertheim, Peter Horby, Annette Fox
Summary: This study found that infection with H1N1pdm09 induced durable seroprotection, while infection with H3N2Pe09 did not. This could explain the age differences between A(H1N1) and A(H3N2) cases.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Min Dou, Wenjun Song, Yongping Lin, Qigao Chen, Chang Lu, Zhongmin Liu
Summary: The study analyzed clinical characteristics and viral genes in patients with severe pneumonia due to H1N1 influenza virus in Guangzhou in 2019. Risk factors for severe disease were identified as chronic lung disease and cardiovascular disease, with a significant rate of secondary infections in critically ill patients. Furthermore, serum IL-8 levels were significantly higher in critically ill patients compared to nonsevere patients and healthy controls.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Justin R. Ortiz, David Bernstein, Daniel F. Hoft, Christopher W. Woods, Micah T. McClain, Sharon E. Frey, Rebecca C. Brady, Christopher Bryant, Ashley Wegel, Robert W. Frenck Jr, Emmanuel B. Walter, Getahun Abate, Sarah R. Williams, Robert L. Atmar, Wendy A. Keitel, Nadine Rouphael, Mathew J. Memoli, Mamodikoe K. Makhene, Paul C. Roberts, Kathleen M. Neuzil
Summary: This study evaluated the associations between baseline influenza virus-specific HAI and MN titers and subsequent symptomatic influenza virus infection in a controlled human infection study. The results showed that high baseline HAI and MN were associated with protection from illness.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Omid Rashidi, Afagh Moattari, Neda Pirbonyeh, Amir Emami, Mohammad Rahim Kadivar, Nahid Tavakoli Movaghar, Fahimeh Edalat
Summary: The study aimed to determine the genetic mutation of the neuraminidase gene in influenza A (H1N1) viruses in southwest Iran. The emergence of oseltamivir resistance was identified, highlighting the importance of conducting similar evaluations in different geographical regions and planning treatment strategies for influenza.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Takuma Soga, Calvin Duong, David Pattinson, Yuko Sakai-Tagawa, Akifumi Tokita, Naomi Izumida, Tamon Nishino, Haruhisa Hagiwara, Noriyuki Wada, Yumi Miyamoto, Haruo Kuroki, Yuka Hayashi, Masafumi Seki, Natsuko Kasuya, Michiko Koga, Eisuke Adachi, Kiyoko Iwatsuki-Horimoto, Hiroshi Yotsuyanagi, Seiya Yamayoshi, Yoshihiro Kawaoka
Summary: During the 2019-2020 influenza season in Japan, two kinds of antigenically drifted viruses-N156K and D187A/Q189E viruses-co-circulated, leading to changes in the antigenicity of the A(H1N1)pdm09 virus. The D187A and Q189E substitutions in the HA protein emerged and dominated during this season, while the N156K substitution was detected at a higher frequency compared to the previous season.
Article
Immunology
Teena Mohan, Ha T. Nguyen, Krista Kniss, Vasiliy P. Mishin, Angiezel A. Merced-Morales, Jennifer Laplante, Kirsten St George, Patricia Blevins, Anton Chesnokov, Juan A. De la Cruz, Rebecca Kondor, David E. Wentworth, Larisa Gubareva
Summary: Four cases of oseltamivir-resistant influenza A(H1N1) pdm09 virus infection were detected among inhabitants of a border detention center in Texas, USA. The hemagglutinin of these viruses belongs to subclade 6B.1A5A-156K, which may enable viral escape from preexisting immunity, highlighting the importance of monitoring both drug resistance and antigenic drift of circulating viruses.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Chenyi Xie, Wen Su, Sin Fun Sia, Ka-Tim Choy, Steven Morrell, Jie Zhou, Malik Peiris, Jesse D. Bloom, Hui-Ling Yen
Summary: This study identified that A(H1N1)pdm09 influenza viruses are mainly transmitted via airborne particles produced by infected ferrets' upper respiratory epithelial cells. The findings highlight the importance of reducing viral loads in the upper respiratory tract with vaccines and antiviral drugs to prevent influenza transmission.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Gulshan Umbreen, Abdul Rehman, Muhammad Avais, Chanda Jabeen, Shakera Sadiq, Rubab Maqsood, Hamad Bin Rashid, Saira Afzal, Mamoona Chaudhry
Summary: This study aimed to estimate the burden of influenza A (H1N1)pdm09 virus infection among human tuberculosis patients and the general population. The results showed that individuals from the TB cohort had a higher incidence of influenza A (H1N1)pdm09 compared to the general population, suggesting that they should be prioritized for influenza vaccination.
BMC INFECTIOUS DISEASES
(2023)
Letter
Immunology
Jakob N. Nissen, Sophie J. George, Charlotte K. Hjulsager, Jesper S. Krog, Xiaohui C. Nielsen, Tina V. Madsen, Klara M. Andersen, Tyra G. Krause, Lasse S. Vestergaard, Lars E. Larsen, Ramona Trebbien
Summary: In January 2021, a case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine influenza virus was detected in Denmark. The clinical case and testing results of the genetic and antigenic characterizations of the virus were described.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Xiuhua Lu, Zhu Guo, Zhu-Nan Li, Crystal Holiday, Feng Liu, Stacie Jefferson, F. Liaini Gross, Wen-Ping Tzeng, Anand Kumar, Ian A. York, Timothy M. Uyeki, Terrence Tumpey, James Stevens, Min Z. Levine
Summary: This study analyzed the antibody profiles of patients infected with A(H1N1)pdm09 viruses and found that although some adults produced high levels of antibodies, they still suffered from severe illness or death. The study suggests that narrowly-focused, low-quality antibody responses may contribute to severe lower respiratory tract infection.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Luis A. Santos, Filipe Almeida, Marta Giria, Joao Trigueiro-Louro, Helena Rebelo-de-Andrade
Summary: This study aimed to evaluate the impact of I298L, K386R, and V517I mutations in PB1 on viral growth and antigen yield. Mutated viruses showed a decrease in viral growth accompanied by a reduction in hemagglutination titer and neuraminidase activity compared to the wild type. Our findings suggest that adaptive evolution in PB1 improves overall viral fitness and has the potential for optimizing influenza vaccine prototypes.
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Mustapha Abdullahi, Adamu Uzairu, Gideon Adamu Shallangwa, Paul Andrew Mamza, Muhammad Tukur Ibrahim, Anshuman Chandra, Vijay Kumar Goel
Summary: This study utilized molecular modeling strategies to discover new anti-influenza A (H1N1) drug based on camphor imine compounds. 2D-QSAR and 3D-QSAR analyses were performed to predict the activity of the compounds, and ten new compounds were designed based on the most active compound. The stability and pharmacokinetic profiles of the designed compounds were validated through molecular dynamics simulation and ADMET property assessment.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Infectious Diseases
Jeremy C. Jones, Philippe N. Q. Pascua, Walter N. Harrington, Richard J. Webby, Elena A. Govorkova
Summary: Most PA 38 substitutions allow the replication complex to retain some drug resistance, with only a few causing significant reductions in the inhibitory activity of baloxavir acid. This study provides a targeted approach for virus rescue and analysis of baloxavir marboxil reduced-susceptibility markers. The findings support considering a broader range of markers during antiviral surveillance and contribute to understanding baloxavir marboxil resistance profiles.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Tatsufumi Usui, Miya Ueda, Akinori Azumano, Mika Nomura, Toru Arima, Koichi Murata, Toshihiro Ito, Tsuyoshi Yamaguchi
Summary: In January 2019, four cheetahs at a Japanese zoo showed respiratory signs following an incidence of seasonal influenza in animal caregivers. A(H1N1)pdm09 virus was confirmed in the cheetahs through non-invasive collection of respiratory materials and plasma samples. The study demonstrates the possibility of reverse zoonotic transmission from humans to cheetahs in zoo settings.
ZOONOSES AND PUBLIC HEALTH
(2021)
Article
Immunology
Rocio Montejano, Fernando de la Calle-Prieto, Maria Velasco, Carlos Guijarro, Javier Queiruga-Parada, Maria Jimenez-Gonzalez, Patricia Gonzalez-Ruano, Patricia Martinez, Ane Josune Goikoetxea, Marta Ibarrola, Marianela Ciudad, Angela Gutierrez, Miguel Torralba, Ana Diaz-Brasero, Pablo Ryan, Cristina Marcelo, Cristina Diez, Sofia Ibarra, Esperanza Merino, Vicente Estrada, Javier Marcos, Maria Novella, Maria A. Rivera, Manuel Ruiz-Munoz, Marta de Miguel, Llanos Soler, Mikel Del Alamo, Santiago Moreno, Antonio J. Carcas, Alberto M. Borobia, Jose R. Arribas
Summary: This study aimed to evaluate the effectiveness of tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) treatment in high-risk patients with severe COVID-19. The results showed that TDF/FTC did not provide significant benefits, while the beneficial effect of baricitinib, as established by prior clinical trials, was confirmed.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Jane Agergaard, Benjamin Yamin Ali Khan, Thomas Engell-Sorensen, Berit Schiottz-Christensen, Lars ostergaard, Eva K. Hejbol, Henrik D. Schroder, Henning Andersen, Jakob Udby Blicher, Thomas Holm Pedersen, Thomas Harbo, Hatice Tankisi, M. U. L. T. I. C. O. V. Consortium MULTICOV Consortium
Summary: This study examined 84 patients with long COVID using qEMG and sfEMG, and performed muscle biopsies in a subset of patients. The results showed that the mean MUP duration was decreased in >= 1 muscles in 52% of the patients, and the mean jitter was increased in 17% of the patients in the tibialis anterior and 25% in the extensor digitorum communis. Muscle biopsies revealed damage of terminal nerves and motor endplate with abundant basal lamina material. These findings suggest a muscle pathophysiology behind fatigue in long COVID.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Respiratory System
Rebekka Faber Thudium, Andreas Ronit, Shoaib Afzal, Yunus Colak, Julie Lyng Forman, Fernando Mendo, Fabian Chen, Vicente Estrada, Nagalingeswaran Kumarasamy, Borge G. Nordestgaard, Jens Lundgren, Jorgen Vestbo, Ken M. Kunisaki, Susanne Dam Nielsen
Summary: This study compared the decline in lung function between people living with HIV who receive antiretroviral therapy and matched controls, and found that well-treated PLWH have faster lung function decline than controls. Smoking seems to modify this association, suggesting that smoking may lead to more rapid lung function decline in PLWH than in controls.
Review
Chemistry, Medicinal
Vicente Soriano, Victor Moreno-Torres, Ana Trevino, Octavio Corral, Carmen de Mendoza
Summary: It has been ten years since the identification of NTCP as the cell surface receptor for HBV and HDV entry into hepatocytes. Bulevirtide (BLV) has been developed as a potential inhibitor of NTCP-HBV/HDV binding and has shown promising results in preclinical and clinical studies. Combination therapies with BLV and other anti-HBV/HDV agents are expected to lead to a cure for hepatitis delta in the near future.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Infectious Diseases
Rodrigo Alonso-Navarro, Margarita Ramirez, Mar Masia, Roger Paredes, Rocio Montejano, Marina Povar-Echeverria, Jordi Carratala, Miguel Salavert, Enrique Bernal, Carlos Duenas, Juan Flores, Francisco Fanjul, Isabel Gutierrez, Veronica Rico, Lourdes Mateu, Julen Cadinanos, Juan Berenguer, Alex Soriano
Summary: This study evaluated the variables associated with the need for ICU admission in COVID-19 patients receiving remdesivir, including the duration from symptom onset to remdesivir use. The results showed that a shorter duration from symptom onset to remdesivir use (within 5 days) decreased the risk of ICU admission. Other factors associated with ICU admission included clinical signs of severe disease and the use of corticosteroids and anti-inflammatory drugs.
BMC INFECTIOUS DISEASES
(2023)
Letter
Medicine, General & Internal
V Moreno-Torres, V Soriano
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Immunology
Wendy P. Bannister, Dorthe Raben, Palle Valentiner-Branth, Martin Tolstrup, Lykke Larsen, Britta Tarp, Mette Brouw Iversen, Ole Schmeltz Sogaard, Sisse Rye Ostrowski, Nina Breinholt Staerke, Marie Louise Jakobsen, Susan Olaf Lindvig, Maria Ruwald Juhl, Isik Somuncu Johansen, Ahmed B. Mustafa, Lars Ostergaard, Fredrikke Dam Larsen, Lene Surland Knudsen, Vibeke Klastrup, Lothar Wiese, Thomas Benfield, Kristine Toft Petersen, Kasper K. Iversen, Henrik Nielsen, Joanne Reekie, Jens Lundgren
Summary: Concerns about side effects may contribute to vaccine hesitancy, but knowing that SARS-CoV-2 vaccines can lead to a stronger immune response may encourage more individuals to get vaccinated. Severe adverse reactions were associated with a stronger antibody response after the second vaccine dose, but not after the first. Regardless of side effects, most people experienced an effective immune response following vaccination.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Rocio Montejano, Alfredo Soler-Carracedo, Alberto M. Borobia, Alejandro Martin-Quiros, David Grandioso, Carlos Canada, Alicia Roman, Jose R. Arribas
Summary: An evaluation of 100 hospitalized COVID-19 patients in Madrid revealed a mismatch between current clinical trial designs and the characteristics of the patients, indicating a need to reconsider trial criteria.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Kristoffer Skaalum Hansen, Sofie Eg Jorgensen, Morten Kelder Skouboe, Jane Agergaard, Berit Schiottz-Christensen, Line Khalidan Vibholm, Martin Tolstrup, Lars Ostergaard, Steffen Leth, Trine H. Mogensen
Summary: Long COVID is an emerging global health concern, and its underlying mechanism and pathophysiology are still unclear. This study found that autoantibodies against type 1 interferons in patients with Long COVID do not contribute to the symptoms.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jesper D. Gunst, Jesper F. Hojen, Marie H. Pahus, Miriam Rosas-Umbert, Birgitte Stiksrud, James H. Mcmahon, Paul W. Denton, Henrik Nielsen, Isik S. Johansen, Thomas Benfield, Steffen Leth, Jan Gerstoft, Lars Ostergaard, Mariane H. Schleimann, Rikke Olesen, Henrik Stovring, Line Vibholm, Nina Weis, Anne M. Dyrhol-Riise, Karen B. H. Pedersen, Jillian S. Y. Lau, Dennis C. Copertino, Noemi Linden, Tan T. Huynh, Victor Ramos, R. Brad Jones, Sharon R. Lewin, Martin Tolstrup, Thomas A. Rasmussen, Michel C. Nussenzweig, Marina Caskey, Dag Henrik Reikvam, Ole S. Sogaard
Summary: In people with HIV-1 undergoing antiretroviral treatment interruption, combining lefitolimod with broadly neutralizing antibodies (bNAbs) did not delay viral rebound beyond that achieved with bNAbs alone, raising the question of how to optimize combination immunotherapy to control HIV-1.
Article
Biochemistry & Molecular Biology
Kirstine K. Rasmussen, Quenia dos Santos, Cameron Ross Macpherson, Adrian G. Zucco, Lars Klingen Gjaerde, Emma E. Ilett, Isabelle Lodding, Marie Helleberg, Jens D. Lundgren, Susanne D. Nielsen, Susanne Brix, Henrik Sengelov, Daniel D. Murray
Summary: This study investigated the associations between metabolic profiles and cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (aHSCT). The results showed that lower levels of trimethylamine N-oxide were associated with subsequent CMV infection. Exploratory analysis also revealed other metabolic clusters associated with CMV infection.
Correction
Medicine, Research & Experimental
Rebecka Svanberg, Cameron MacPherson, Adrian Zucco, Rudi Agius, Tereza Faitova, Michael Asger Andersen, Caspar da Cunha-Bang, Lars Klingen Gjaerde, Maria Elizabeth Engel Moller, Patrick Terrence Brooks, Birgitte Lindegaard, Adin Sejdic, Zitta Barrella Harboe, Anne Ortved Gang, Ditte Stampe Hersby, Christian Brieghel, Susanne Dam Nielsen, Daria Podlekareva, Annemette Hald, Jakob Thaning Bay, Hanne Marquart, Jens Lundgren, Anne-Mette Lebech, Marie Helleberg, Carsten Utoft Niemann, Sisse Rye Ostrowski
COMMUNICATIONS MEDICINE
(2023)
Article
Immunology
Oskar Ayerdi, Rafael Benito, Diego Ortega, Antonio Aguilera, Natalia Montiel, Ilduara Pintos, Alberto Diaz de Santiago, Begona Baza, Vicente Soriano, Carmen de Mendoza
Summary: The prevalence of HTLV infection among individuals with STIs in Spain is 0.5%, higher than in the general population. These results suggest the need for universal HTLV screening in individuals attending clinics for STIs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Dina Leth Moller, Soren Schwartz Sorensen, Michael Perch, Finn Gustafsson, Annemette Hald, Andreas Delhbaek Knudsen, Ranya Abdulovski, Nicoline Stender Arentoft, Jens Lundgren, Allan Rasmussen, Sisse Rye Ostrowski, Susanne Dam Nielsen
Summary: This study investigated the change in induced cytokine concentrations after solid organ transplantation (SOT) and found that all stimuli except IL-10 showed decreased concentrations post-SOT. The study also found no difference in induced cytokine concentrations pre-SOT between recipients with or without acute rejection. This standardized assay may provide important information on immune function post-SOT.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Sara Morup, Lusine Nazaryan-Petersen, Migle Gabrielaite, Joanne Reekie, Hanne V. Marquart, Hans Jakob Hartling, Rasmus Marvig, Terese L. Katzenstein, Tania N. Masmas, Jens D. Lundgren, Daniel D. Murray, Marie Helleberg, Line Borgwardt
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)