Review
Biochemistry & Molecular Biology
Holly Ingram, Murat Dogan, James D. Eason, Cem Kuscu, Canan Kuscu
Summary: Hepatic ischemia-reperfusion injury (IRI) is a major factor in early allograft dysfunction in liver transplantation. miRNAs have been shown to play a crucial role in regulating gene expression and can be manipulated to attenuate liver damage and improve patient outcomes.
Review
Medicine, General & Internal
Xin-li Mao, Yue Cai, Ya-hong Chen, Yi Wang, Xiu-xiu Jiang, Li-ping Ye, Shao-wei Li
Summary: Hepatic ischemia reperfusion injury (IRI) is a major complication caused by various clinical situations, and the exact mechanisms and therapeutic targets are yet to be clarified. Activation of PPAR gamma, FAM3A, and non-coding RNAs may have a protective effect against hepatic IRI, but further research is needed.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jing Mu, Chunxiao Li, Shi Yu, Guoyong Liu, Jianhua Zou, Dong-Yang Zhang, Chao Jiang, Xiuli Wang, Liangcan He, Peng Huang, Yuxin Yin, Xiaoyuan Chen
Summary: This study presents a novel strategy for protecting the liver against ischemia-reperfusion injury using nanotherapeutics. By combining reactive oxygen species scavenging and nitric oxide modulation, the researchers demonstrated that the nanotherapeutics effectively reduced oxidative stress and inflammation in the liver.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Zexin Li, Ying Wang, Yu Zhang, Xiao Wang, Baoqin Gao, Yan Li, Rong Li, Jianguo Wang
Summary: Fisetin was found to alleviate liver damage, cell apoptosis, and oxidative stress induced by liver IRI, at least through the Nrf2/HO-1 signaling pathway, suggesting its potential as a targeted drug for liver IRI treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Fengwei Li, Lei Zhang, Hui Xue, Jianbing Xuan, Shu Rong, Kui Wang
Summary: The activation of SIRT1 inhibits the XBP1/NLRP3 inflammatory pathway by regulating miR-182, thus alleviating hepatic IR injury in mice.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Jiarui Feng, Lilong Zhang, Enfu Xue, Zhendong Qiu, Ning Hu, Kunpeng Wang, Yingru Su, Weixing Wang
Summary: In this study, the role of the celiac ganglion (CG) in hepatic ischemia-reperfusion injury (HIRI) was investigated. The results showed that silencing Bmal1 expression in the CG can reduce liver fat reserve, hepatocyte apoptosis, and liver fibrosis, and increase liver glycogen accumulation. Furthermore, the downregulation of Bmal1 can suppress the levels of hepatic neurotransmitters norepinephrine and neuropeptide Y, as well as sympathetic nerve activity in HIRI. Additionally, decreased Bmal1 expression in the CG can reduce inflammation, oxidative stress, and increase glutathione levels in the liver. These findings suggest that reducing Bmal1 expression in the CG can improve hepatocyte injury in HIRI.
Article
Medicine, Research & Experimental
Jing-yi Hou, Guang-zhao Cao, Liang-liang Tian, Rui Zhou, Yi Zhang, He Xu, Hong-wei Wu, Li -fang Wang, Hong-jun Yang, Jing-jing Zhang
Summary: The study found that Duzhi Wan (DZW) significantly reduced infarction size and improved neurological deficits after middle cerebral artery occlusion (MCAO)-induced brain injury. Transcriptomics and metabolomics analysis revealed that C3 and C5ar1 were core targets of DZW and regulated downstream metabolic pathways via inflammatory cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Multidisciplinary
Yu Guan, Weifeng Yao, Ke Yi, Chunxiong Zheng, Shixian Lv, Yu Tao, Ziqing Hei, Mingqiang Li
Summary: Nanomaterials offer targeted delivery and controllable release of contrast agents and therapeutic drugs in hepatic IRI regions, improving imaging sensitivity and therapeutic effects, making them a novel alternative for hepatic IRI diagnosis and therapy.
Article
Biotechnology & Applied Microbiology
Xiaobing Zhang, Jiajia Hu, Kaelyn V. Becker, Jonathan W. Engle, Dalong Ni, Weibo Cai, Dong Wu, Shuping Qu
Summary: The study developed a nanomaterial with high liver uptake rate to scavenge ROS and block C5a, effectively alleviating clinical symptoms of hepatic IRI, reducing the release of pro-inflammatory cytokines, and inhibiting inflammatory reactions. This synthesized Ceria@Apt has great potential for medical application in hepatic IRI repair and other ischemic-related diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Omar Abdulhameed Almazroo, Imam H. Shaik, Christopher B. Hughes, Abhinav Humar, Raman Venkataramanan
Summary: Treprostinil treatment reduces ischemia-reperfusion injury and alters the expression of drug transporters in the liver. This is of great significance for improving the outcomes of deceased donor liver transplantation.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Wen An, Ju-Seop Kang
Summary: Metformin can alleviate hepatic and myocardial injury induced by hepatic ischemia-reperfusion by inhibiting oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yongjun Zhang, Hua Wei, Mengmei Wang, Yang Yu, Mengyue Gu, Hui Zhong, Shuhua Dong
Summary: Dexmedetomidine ameliorates ferroptosis in hepatic ischemia-reperfusion injury (HIRI) by positively regulating the Nrf2/GPx4 axis, potentially presenting a therapeutic avenue for addressing HIRI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Tong Wu, Cheng Zhang, Tianfeng Shao, Jianzhong Chen, Diyu Chen
Summary: Ischemia-reperfusion injury (IRI) is a crucial factor in liver transplantation, and the activation of hepatic macrophages, especially NLRP3 inflammasome, plays a significant role in the progression of IRI. The NLRP3 inflammasome pathway in hepatic macrophages is highly expressed and may lead to liver IRI, making it a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lina Lai, Aimee Zhang, Boris Yang, Eric J. Charles, Irving L. Kron, Zequan Yang
Summary: This study suggests that cell-free DNA and HMGB1 released by ischemically injured cardiomyocytes stimulate pDCs to secrete IFN-I, which exacerbates myocardial ischemia-reperfusion injury. Inhibiting pDCs can reduce infarct size and interferon levels, presenting new potential therapeutic targets for mitigating this type of injury.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Anne Barden, Tomas B. Corcoran, James Preuss, Michael Phillips, Emilie Mas, Trevor A. Mori
Summary: This controlled trial found that higher levels of inspired oxygen during surgery can reduce oxidative stress and increase resolution of inflammation in procedures involving reperfusion after tourniquet application. Increased oxygen levels were associated with lower levels of IsoFs and higher levels of SPM, highlighting the potential benefits of oxygen therapy in surgical settings.
FREE RADICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Nicole Lafontaine, Purdey J. Campbell, Juan E. Castillo-Fernandez, Shelby Mullin, Ee Mun Lim, Phillip Kendrew, Michelle Lewer, Suzanne J. Brown, Rae-Chi Huang, Phillip E. Melton, Trevor A. Mori, Lawrence J. Beilin, Frank Dudbridge, Tim D. Spector, Margaret J. Wright, Nicholas G. Martin, Allan F. McRae, Vijay Panicker, Gu Zhu, John P. Walsh, Jordana T. Bell, Scott G. Wilson
Summary: This study identified associations between blood-based DNAm and both fT3 and TSH, shedding light on the mechanisms underlying thyroid hormone action and/or pituitary-thyroid axis function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Sharon Ong, Nicola P. Bondonno, Luke A. Downey, Andrew Scholey, Michael A. Smith, Con Stough, Lauren C. Blekkenhorst, Richard Woodman, Kevin D. Croft, Jonathan M. Hodgson, Catherine P. Bondonno
Summary: This study aimed to explore the effects of chewing gum after a nitrate-rich meal on nitrate metabolism, endothelial function, blood pressure, neurocognitive performance, mood, and anxiety. The study found that chewing gum after a nitrate-rich meal resulted in an acute improvement in endothelial function and a small increase in blood pressure, but had no significant effects on neurocognitive function, mood, or anxiety.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Benjamin H. Parmenter, Kevin D. Croft, Lachlan Cribb, Matthew B. Cooke, Catherine P. Bondonno, Ana Lea, Grace M. McPhee, Mrudhula Komanduri, Karen Nolidin, Karen Savage, Matthew P. Pase, Jonathan M. Hodgson, Con Stough, Nicola P. Bondonno
Summary: The study found that increasing intake of anthocyanins and flavanones is associated with lower central diastolic blood pressure, mean arterial pressure, and augmentation index. These associations remained significant even after adjusting for dietary quality and other major nutrients, indicating potential benefits of dietary anthocyanin and flavanone intake on central hemodynamics and arterial stiffness.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Marc Sim, Kevin D. Croft, Gunnar Gislason, Christian Torp-Pedersen, Anne Tjonneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno
Summary: This study found that high dietary intake of vitamin K-1 or K-2 was inversely associated with the risk of ASCVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Respiratory System
Nicola P. Bondonno, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Daniel Bech Rasmussen, Cecilie Kyro, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Gunnar Gislason, Augustin Scalbert, Anne Tjonneland, Kim Overvad, Anja Olsen, Jonathan M. Hodgson
Summary: This study found that higher flavonoid intakes were associated with a lower risk of COPD. Additionally, higher flavonoid intakes appeared to mitigate the increased risk of COPD associated with smoking. However, smoking cessation remains the highest priority in preventing COPD.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Food Science & Technology
Liezhou Zhong, Alex H. Liu, Lauren C. Blekkenhorst, Nicola P. Bondonno, Marc Sim, Richard J. Woodman, Kevin D. Croft, Joshua R. Lewis, Jonathan M. Hodgson, Catherine P. Bondonno
Summary: A systematic review was conducted to investigate the nitrate and nitrite content in animal-based foods, revealing the main sources and distribution of these compounds. The study found that some industrial processed meat products and canned fish products have higher levels of nitrate and nitrite, while meat products from high-income regions tend to have lower content.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Karen Savage, Lee Gogarty, Ana Lea, Saurenne Deleuil, Karen Nolidin, Kevin Croft, Con Stough
Summary: The increasing proportion of older citizens in society calls for a better understanding of the biological basis of mood as people age. This study examines the relationship between oxidative stress biomarkers and mood symptoms in healthy older adults. The findings suggest that elevated oxidative stress markers contribute to depressed mood and reduced general health in this population.
Article
Hematology
Benjamin H. Parmenter, Catherine P. Bondonno, Kevin Murray, John T. Schousboe, Kevin Croft, Richard L. Prince, Jonathan M. Hodgson, Nicola P. Bondonno, Joshua R. Lewis
Summary: This study found that higher habitual dietary flavonoid intake is associated with less extensive abdominal aortic calcification in older women.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Pediatrics
Kwi Moon, Elizabeth Mckinnon, Kevin Croft, Delia Hendrie, Sanjay Patole, Karen Simmer, Shripada Rao
Summary: This study aims to evaluate the benefits and risks of early versus late parenteral nutrition in term and late preterm infants. The optimal time to commence PN in these infants is currently uncertain due to different guidelines and variations in clinical practice.
Article
Nutrition & Dietetics
Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Guillaume Marquis-Gravel, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyro, Gunnar Gislason, Augustin Scalbert, Anne Tjonneland, Kim Overvad, Jonathan M. Hodgson, Nicola P. Bondonno
Summary: This study found no overall association between habitual dietary flavonoid intake and the risk of ischemic heart disease (IHD). However, stratified analysis by sex and smoking status showed that higher intakes of specific subclasses of flavonoids were associated with a lower risk of IHD among ever-smokers, but not among never-smokers or either sex specifically.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Chemistry, Applied
Liezhou Zhong, Lauren C. Blekkenhorst, Nicola P. Bondonno, Marc Sim, Richard J. Woodman, Kevin D. Croft, Joshua R. Lewis, Jonathan M. Hodgson, Catherine P. Bondonno
Summary: An up-to-date nitrate food composition database of plant-based foods is imperative for assessing dietary nitrate intakes and their health implications. A recent study updated and expanded the vegetable nitrate database, including data from 1980 to 2021 on fruits, cereals, herbs, spices, pulses, and nuts. The study found substantial variations in nitrate contents among 264 plant-based foods from 64 countries, with leaf vegetables having the highest nitrate levels. This updated database, along with the animal-based food nitrate & nitrite database, can now be used to evaluate dietary nitrate intake in clinical and epidemiological studies.
Article
Nutrition & Dietetics
Yang Liu, Kevin D. Croft, Trevor A. Mori, Tracey A. Gaspari, Barbara K. Kemp-Harper, Natalie C. Ward
Summary: This study aimed to investigate the effects of long-term dietary nitrate supplementation on the progression of established atherosclerosis and the underlying mechanisms of its cardiovascular protective effects. The results showed that long-term high dose nitrate supplementation significantly attenuated the plaque lesion area, increased collagen expression and smooth muscle accumulation, and reduced lipid deposition and macrophage accumulation within atherosclerotic plaques.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Food Science & Technology
Catherine P. Bondonno, Liezhou Zhong, Nicola P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Alex Liu, Anjana Rajendra, Pratik Pokharel, Dorit W. Erichsen, Oliver Neubauer, Kevin D. Croft, Jonathan M. Hodgson
Summary: Vegetables, meat, and water are the main sources of dietary nitrate, which has been regulated and monitored due to concerns over cancer risk. However, evidence suggests that nitrate from vegetables can actually protect against cardiovascular disease and other chronic illnesses. The potential formation of carcinogenic N-nitrosamines from nitrate is still a concern.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kyle Raubenheimer, Alex H. Liu, Henrietta Koch, Erika Bosio, Nicola P. Bondonno, Vance Matthews, Marc Sim, Lauren Blekkenhorst, Richard J. Woodman, Kevin Murray, Kevin Croft, Oliver Neubauer, Jonathan M. Hodgson, Catherine P. Bondonno
Summary: We investigated the effects of daily consumption of beetroot juice for one week on circulating inflammatory markers in individuals with treated hypertension. The results showed that increasing dietary nitrate intake did not significantly reduce soluble inflammatory mediators, but led to changes in nitrate metabolism.