Article
Pharmacology & Pharmacy
D. Iezzi, L. Curti, G. Ranieri, E. Gerace, A. Costa, A. Ilari, A. La Rocca, C. Luceri, M. D'Ambrosio, L. Silvestri, M. Scardigli, G. Mannaioni, A. Masi
Summary: This study found that the use of mTOR inhibitors can improve social deficits and revert abnormal excitability in an autism spectrum disorder experimental model. However, it cannot repair synaptic transmission and neuronal morphology issues. Prenatal exposure to valproic acid leads to extensive gene deregulation, which can be partially reversed by postnatal rapamycin treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mohammed A. Alharbi, Dana T. Graves
Summary: Diabetes mellitus is associated with higher risks of fractures and delayed bone healing. FOXO1 plays a key role in diabetes-impaired angiogenesis and chondrocyte apoptosis. This study found that diabetic mice had fewer blood vessels and increased chondrocyte apoptosis, while FOXO1 deletion partially rescued these effects.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Psychology, Developmental
Roza Tabeshian, Maryam Nezakat-Alhosseini, Ahmadreza Movahedi, E. Paul Zehr, Salar Faramarzi
Summary: The study found that Tai Chi Chuan training had a significant impact on stereotypic behavior of children with autism spectrum disorder, with this behavior change being maintained during the follow-up period.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Behavioral Sciences
Maryam Khodaverdi, Mona Rahdar, Shima Davoudi, Razieh Hajisoltani, Zohreh Tavassoli, Zahra Ghasemi, Aeen Ebrahim Amini, Narges Hosseinmardi, Gila Behzadi, Mahyar Janahmadi
Summary: 5-HT7 receptors play a restorative role against prenatal VPA exposure induced behavioral deficits and hippocampal synaptic plasticity impairment in autistic-like mice. Activation of these receptors alleviates behavioral deficits in autistic-like offspring and improves their synaptic plasticity, making them a potential pharmacotherapy target for the treatment of autism.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Genetics & Heredity
Liqin Yang, Zhixiong Xia, Jianhua Feng, Menghuan Zhang, Pu Miao, Yingjie Nie, Xiangyan Zhang, Zijian Hao, Ronggui Hu
Summary: RA signaling is down-regulated in FXS patients and supplementation can partially rescue social novelty behavior. However, it has limited effects on sociability behavior and hyperactivity.
FRONTIERS IN GENETICS
(2022)
Article
Agriculture, Dairy & Animal Science
Thiago Bernardino, Patricia Tatemoto, Jose Evandro de Moraes, Beatrice Morrone, Adroaldo Jose Zanella
Summary: The study found that feeding pregnant gilts with a high fiber diet can reduce stereotypic behavior in sows before feeding, but did not improve performance measures.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2021)
Article
Oncology
Hye-Yeon Park, Jun Go, Young-Kyoung Ryu, Dong-Hee Choi, Jung-Ran Noh, Jin-Pyo An, Won-Keun Oh, Pyung-Lim Han, Chul-Ho Lee, Kyoung-Shim Kim
Summary: The study found that Humulus japonicus may have therapeutic potential for ASD, ameliorating behavioral deficits and neuroinflammation in ASD mouse models.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Neurosciences
Claudia Fuchs, Livia Cosentino, Chiara Urbinati, Maria Cristina Talamo, Giorgio Medici, Maria Cristina Quattrini, Nicola Mottolese, Donatella Pietraforte, Andrea Fuso, Elisabetta Ciani, Bianca De Filippis
Summary: This study investigates the potential therapeutic value of FRAX486 for CDKL5 deficiency disorder (CDD). The results demonstrate that FRAX486 can rescue the abnormal neuronal maturation and metabolic dysfunctions associated with CDD both in vitro and in vivo. The study suggests that PAKs may represent innovative therapeutic targets for CDD.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Behavioral Sciences
Amanda M. M. White, Xianli An, Jacek Debiec
Summary: Disrupted processing of social cues and altered social behaviors are core symptoms of autism spectrum disorders. Prenatal exposure to valproic acid (VPA) may affect infant rats' behavioral responsivity to maternal olfactory cues and maternal buffering of infants' stress responsivity. Although VPA-exposed pups may show impaired responsivity to maternal cues in early infancy, maternal presence is still capable of regulating their stress response.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Anna L. Farmer, Mark H. Lewis
Summary: Restricted repetitive behaviors (RRB) are common in clinical populations, including autism spectrum disorder. Animal studies have shown that these behaviors can be reduced by rearing in enriched environments (EE). This review summarizes the current knowledge of the relationship between EE and RRB, discusses potential mechanisms for EE's attenuation of RRB, and highlights gaps in the literature and future directions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Reproductive Biology
Bruna Lotufo Denucci, Larissa Silva de Lima, Isabela Ferreira Lima Mota, Juliana Rocha Madureira Azevedo, Leticia Germino Veras, Joao Victor Montenegro Luzardo Bicca, Bruna de Miranda Santana, Gabriela Beserra Pinheiro, Gabriela Goncalves Coelho, Marcia Renata Mortari
Summary: Autism Spectrum Disorder (ASD) has been greatly understood over the past 70 years and is characterized as a heterogeneous neuropsychiatric syndrome with difficulties in social communication, restricted and repetitive behavior, interests, or activities. While no treatment can revert ASD, there are various pharmacological and behavioral therapies available. Animal models of ASD, such as valproic acid treatment, provide insights into potential future treatments, including peptides and bioinspired compounds from animal venoms.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Integrative & Complementary Medicine
Fatemeh Amini, Hossein Amini-Khoei, Sara Haratizadeh, Mohammad Setayesh, Mohsen Basiri, Mahboobeh Raeiszadeh, Masoumeh Nozari
Summary: The hydroalcoholic extract of Passiflora incarnata can ameliorate behavioral aberrations induced by prenatal valproic acid (VPA) exposure and reduce oxidative stress markers. The results suggest that Passiflora extract may exert its effects through its antioxidant bioactive compounds.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maria W. A. Teunissen, Elly Lewerissa, Eline J. H. van Hugte, Shan Wang, Charlotte W. Ockeloen, David A. Koolen, Rolph Pfundt, Carlo L. M. Marcelis, Eva Brilstra, Jennifer L. Howe, Stephen W. Scherer, Xavier Le Guillou, Frederic Bilan, Michelle Primiano, Jasmin Roohi, Amelie Piton, Anne de Saint Martin, Sarah Baer, Simone Seiffert, Konrad Platzer, Rami Abou Jamra, Steffen Syrbe, Jan H. Doering, Shenela Lakhani, Srishti Nangia, Christian Gilissen, R. Jeroen Vermeulen, Rob P. W. Rouhl, Han G. Brunner, Marjolein H. Willemsen, Nael Nadif Kasri
Summary: This study aimed to characterize a new neurodevelopmental syndrome caused by loss-of-function variants in ANK2 gene and explore the effects on neuronal network dynamics and homeostatic plasticity in human induced pluripotent stem cell-derived neurons. Clinical and molecular data of 12 individuals with heterozygous de novo loss-of-function variants in ANK2 were collected. HiPSCs with a heterozygous loss-of-function allele of ANK2 were generated using CRISPR/Cas9. Excitatory neurons were differentiated from these hiPSCs and their spontaneous electrophysiological responses were measured using micro-electrode arrays. Results showed a broad neurodevelopmental disorder with intellectual disability, autism spectrum disorders, and early onset epilepsy. HiPSC-derived neurons with ANK2 loss-of-function exhibited a hyperactive and desynchronized neuronal network, increased somatodendritic structures, and altered AIS structure with impaired activity-dependent plasticity.
HUMAN MOLECULAR GENETICS
(2023)
Article
Multidisciplinary Sciences
Araceli Seiffe, Mauro Federico Ramirez, Lucas Sempe, Amaicha Mara Depino
Summary: This article highlights the impact of environmental factors on young animals and their influence on adult brain function and behavior. It focuses on the long-lasting effects of environmental factors during the perinatal period and suggests that handling mice during the juvenile period can rescue the effects of prenatal VPA exposure.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Nasreen Kamalmaz, Abir Ben Bacha, Mona Alonazi, Gadah Albasher, Arwa Ishaq A. Khayyat, Afaf El-Ansary
Summary: This study investigates the role of sex differences in vulnerability to autism spectrum disorder, finding that males are more likely to develop the disorder while females are relatively protected. The study shows that oxidative stress, glutamate excitotoxicity, neuroinflammation, and gut microbiota impairment occur concurrently with altered behavior in the PPA-induced rodent model, with males being more susceptible than females.
Article
Psychology, Developmental
Ji Sun Hong, Young Sik Lee, Minha Hong, Bongseog Kim, Yoo Sook Joung, Hanik K. Yoo, Eui-Jung Kim, Soyoung Irene Lee, Soo Young Bhang, Seung Yup Lee, Geon Ho Bahn, Doug Hyun Han
Summary: The updated conceptualization of whole-lifespan ADHD highlights the probable persistence of impairment into adulthood. A study investigating cognition trajectories in individuals with ADHD from adolescence to mid-adulthood found deficits in complex attention, including divided attention and working memory, rather than simple attention. Patients with ADHD showed varying degrees of cognitive decline across different age intervals.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Environmental Sciences
Geon-Ho Bahn, Sang-Min Lee, Minha Hong, Seung-Yup Lee
Summary: This study aimed to examine abnormalities in iron indices and substantia nigra echogenicity in adults with ADHD using transcranial Doppler sonography (TCS). However, there were no significant differences found between patients with ADHD and controls in these aspects. Additionally, no significant changes were observed in iron indices or TCS findings after treatment with methylphenidate (MPH) medication.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Hyang Yeon Kim, Yong-Jae Lee, Sun Jae Kim, Jung Dae Lee, Suhkmann Kim, Mee Jung Ko, Ji-Woon Kim, Chan Young Shin, Kyu-Bong Kim
Summary: This study investigated the metabolomics and biomarkers related to VPA-induced ASD-like symptoms using 1H-NMR spectral data. The findings demonstrated significant alterations in endogenous metabolites and mitochondrial dysfunction in VPA-treated rats, suggesting potential biomarkers for symptoms resembling ASD as a model of the disorder.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Neurosciences
Ji-Woon Kim, Anita E. Autry, Elisa S. Na, Megumi Adachi, Carl Bjorkholm, Ege T. Kavalali, Lisa M. Monteggia
Summary: This study shows that MeCP2 phosphorylation at a specific site downstream of BDNF is essential for the sustained antidepressant effects of ketamine and scopolamine, and plays a critical role in long-term regulation of synaptic strength. These findings highlight the importance of MeCP2 and associated synaptic plasticity in mediating sustained antidepressant effects of ketamine and scopolamine.
NATURE NEUROSCIENCE
(2021)
Article
Environmental Sciences
Ah-Rah Lee, Geon-Ho Bahn
Summary: This study analyzed trends of first-time patients visiting the pediatric psychiatry clinic in a university hospital, finding a significant decrease in the number of male patients, higher prevalence of neurotic disorders in females, and treatment continuity affected by multiple factors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Cell Biology
Kanzo Suzuki, Ji-Woon Kim, Elena Nosyreva, Ege T. Kavalali, Lisa M. Monteggia
Summary: Acute inhibition of eEF2K activity induces rapid synaptic scaling in the hippocampus, while RA signaling pathway can also elicit similar synaptic scaling independently of eEF2K function. Activation of RAR alpha by retinoic acid leads to rapid antidepressant effects similar to ketamine.
Article
Neurosciences
Geon Ho Bahn, Kyunghoon Seo
Summary: The study examined the efficiency and indications of combined medication with a stimulant and non-stimulant for ADHD in children and adults. The results suggest that combined medication can improve treatment adherence, especially for female patients. Further research in a larger sample is needed to replicate these findings and explore the indications for administering combined medication in individuals with ADHD.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
Minyoung Shin, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Young-Hoon Lee, Won Hyuk Chang, Seyoung Shin, Soo Mi Choi, Seon Kui Lee, Yun-Hee Kim
Summary: This study investigated the impact of post-stroke depression (PSD) on cognitive aging in elderly stroke patients. The results showed that early PSD increased the risk of cognitive decline in older stroke patients, mainly in males. Older male patients with negative thinking were at increased risk of cognitive decline, and older women may also be at risk for cognitive decline.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychiatry
Duk-Soo Moon, Geon Ho Bahn
Summary: This study explores the concept of synchronized individuation between adolescents and parents through the interaction of characters in a movie and a fairy tale. The results confirm the existence of conflicts, mutual impact, ambivalent feelings for separation, selective identification, and role changes in the relationship. Sons and mothers achieve individuation through synchronization.
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Duk-Soo Moon, Geon Ho Bahn
Summary: This study explored the interactions and concept of synchronized individuation during the separation-individuation process between adolescents and their parents. By learning how to navigate conflicts and ambivalent tension, adolescents and parents are able to develop new identities.
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Dong-Hee Choi, In-Ae Choi, Jongmin Lee
Summary: This review discusses the role of DNA methylation in neuroprotection and neuronal recovery after stroke. It summarizes the effects of DNA methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke. Investigating the modulation of DNA methyltransferase, demethylase, and MBD protein expression can aid in the formulation of therapeutic strategies for stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Yea Jin Jo, Dae Hyun Kim, Min Kyun Sohn, Jongmin Lee, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Yun-Hee Kim, Deog Young Kim
Summary: Stroke in young adults has increased and is more likely to be hemorrhagic compared to older adults. Lifestyle-related risk factors such as obesity, smoking, and heavy alcohol consumption are more common in the younger group, while other cardiovascular risk factors are more frequent in the older group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ji-Woon Kim, Kanzo Suzuki, Ege T. Kavalali, Lisa M. Monteggia
Summary: Acute administration of (R,S)-ketamine produces rapid and sustained antidepressant effects by blocking NMDA receptors and inducing a novel form of synaptic plasticity in the hippocampus. This triggers downstream signaling events and transcriptional changes that contribute to the antidepressant effects. This review explores the intracellular signaling pathway triggered by ketamine and its connection to synaptic plasticity and sustained antidepressant effects.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Plant Sciences
Min-Ji Jung, Namkwon Kim, Seung Ho Jeon, Min Sung Gee, Ji-Woon Kim, Jong Kil Lee
Summary: The study investigated the effects of eugenol on Alzheimer's disease (AD) and found that eugenol effectively improved cognitive function and reduced pathological changes in 5xFAD mice. The underlying mechanisms may involve inhibiting neuronal cell death and promoting beta-amyloid clearance.
Article
Psychiatry
Geon Ho Bahn, Joo Seok Park
Summary: This study analyzed the case of Krystal, a fictional character in a novel, who committed suicide after facing adversity in her environment and personal life. Despite some protective factors, she was unable to cope with the loss of loved ones and ultimately took her own life, highlighting the breakdown of the social protection system for youth.
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)