Article
Cell Biology
Yong Liao, Zhiping Liu, Weile Ye, Zunnan Huang, Jiaojiao Wang
Summary: Monkeypox, a member of the Poxviridae family, poses a great threat to humans. This study comprehensively analyzed monkeypox-related genes (MRGs) in tumor samples from 33 types of cancer using genomic and transcriptomic approaches. The results showed that MRGs are highly correlated with immune infiltration and can predict survival in cancer patients. Genomic alterations of MRGs were associated with tumorigenesis and patient survival. Pathway analysis revealed the involvement of MRGs in various cellular processes. The study also identified potential drugs targeting MRGs.
Article
Immunology
Yi Liu, Jiandong Wang, Mengxi Jiang
Summary: The relationship between copper homeostasis and breast cancer development is complex. Copper elimination and overload both have therapeutic potential in cancer treatment. This study analyzed the impact of copper-related genes on breast cancer prognosis, immune infiltration, drug sensitivity, and metabolic profile. Immunohistochemistry staining showed high expression of copper-related genes in breast cancer samples, and copper distribution was observed in breast cancer tissue.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Tingting Huang, Yankuo Liu, Jiwei Li, Bingbing Shi, Zhengda Shan, Zhiyuan Shi, Zhangru Yang
Summary: Breast cancer ranks first in incidence and is the leading cause of death among female cancers worldwide. Regulated cell death plays a significant role in tumor formation and treatment. The role of cuproptosis-related genes in breast cancer remains unclear.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Cheng Wang, Liyong Zhang, Lin Ren, Guozhi Zhang, Andi Wan, Siyi Xiong, Hao Tian, Zaihui Peng, Tingting Zhao, Pingping Gao, Na Sun, Yi Zhang, Xiaowei Qi
Summary: Cell pyroptosis is closely associated with breast cancer, and a prognostic model based on cell-pyroptosis-related genes provides innovative insights into the prognosis and treatment of breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang, Qiu Li
Summary: This study analyzed EMT-related genes in CRC using bioinformatics methods, identified nine EMT-related genes that impact CRC prognosis, metastasis, drug efficacy, and immunity, and constructed a risk prognosis model.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Qun Zheng, Shuai Shi, Ning Zhang, Haohao Chen
Summary: This study aimed to explore the applications of cuproptosis-related genes (CRGs) in predicting the prognosis of breast cancer (BRCA) through bioinformatics analysis. The results showed significant differences in immune-related pathways and drug sensitivity between the high-risk and low-risk groups, indicating the potential of the CRGs model in predicting BRCA patients' prognosis and guiding treatment.
Article
Immunology
Jinhui Liu, Guoliang Cui, Shuning Shen, Feng Gao, Hongjun Zhu, Yinghua Xu
Summary: This study aimed to establish a prognostic signature for endometrial cancer (EC) related to epithelial-mesenchymal transition (EMT). Through analyzing the expression of relevant genes and clinical data, 10 genes associated with the survival rate of EC patients were identified, and a predictive model for survival rate was constructed. Additionally, the study discovered differences in immune infiltrating, tumorigenesis pathways, and drug response between high and low-risk groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Mei-Huan Wang, Xiao Liu, Qian Wang, Hua-Wei Zhang
Summary: This study found that circadian rhythm-related genes are associated with breast cancer and developed a model to accurately predict patient survival time. The model can also assess immune cell infiltration and treatment response.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Dandan Xu, Zhipeng Ji, Ling Qiang
Summary: Pyroptosis-related genes play crucial roles in cancer immunity in breast cancer, and a gene signature can predict patient survival. These genes are closely related to immune factors and can serve as a prognostic factor for breast cancer patients.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Yingrong Shi, Si Chen, Huijuan Xing, Guanglie Jiang, Nan Wu, Qiannan Liu, Norihiro Sakamoto, Takayoshi Kuno, Reiko Sugiura, Qinghuan Xiao, Feng Jin, Yue Fang, Fan Yao
Summary: Recent studies have shown that the tumor microenvironment plays a crucial role in breast cancer development, progression, and therapeutic response. The immune/stromal/ESTIMATE scores calculated by the ESTIMATE algorithm can reflect the tumor microenvironment. This study analyzed the correlation between immune/stromal/ESTIMATE scores and invasive breast cancer prognosis, and identified high-frequency differential expression genes (HF-DEGs) associated with the tumor microenvironment that have prognostic value. The results suggest that these HF-DEGs may serve as potential biomarkers and therapeutic targets for invasive breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jianguo Lai, Bo Chen, Yingzi Li, Xiaoyi Lin, Min Li, Jing Liu, Ning Liao
Summary: This study identified five key cell cycle-related genes (CDK4, CCND1, CDKN1A, CDKN1C, and CHEK2) as independent prognostic variables in HR+/HER2- BC patients. A risk score based on these five genes effectively classified patients into low-risk and high-risk groups. The potential functional pathways of these genes include cell cycle regulation and G1/S transition.
Article
Oncology
Wanpeng Wang, Sha Wang
Summary: This study found that immune genetic characteristics are closely associated with the prognosis of uveal melanoma (UM). By analyzing gene expression and constructing a risk scoring model, UM patients can be categorized into different subgroups. Certain immune-related genes can serve as prognostic markers and predictors. This research provides new possibilities for early detection, recurrence, and treatment of UM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lin Chen, Yuxiang Dong, Yitong Pan, Yuhan Zhang, Ping Liu, Junyi Wang, Chen Chen, Jianing Lu, Yun Yu, Rong Deng
Summary: By analyzing the expression of immune genes in breast cancer patients, a risk score model containing 15 immune genes was established, which has potential value for prognostic prediction of breast cancer patients. Additionally, the immune risk signature was proven to be an independent prognostic factor for breast cancer patients.
Article
Cell Biology
Yingan Zhao, Yingjue Zhang, Chen Dai, Kai Hong, Yangyang Guo
Summary: This study established a 13-gene signature and robust nomogram to predict the prognosis of breast cancer patients. The research showed that patients with high-risk breast cancer had poorer survival and the signature was an independent prognostic factor. This can be beneficial for the diagnosis and treatment of breast cancer.
Article
Genetics & Heredity
Zhenlan Xie, Jialin Li, Chen Liu, Tie Zhao, Yixiang Xing
Summary: A 5-mRNA immune ferroptosis signature (IFRSig) was constructed and demonstrated good predictive ability in both training and validation cohorts. A correlation analysis revealed that clinical characteristics were closely related to risk characteristics. Our diagnostic model, combining risk characteristics and clinical parameters, was proven to accurately predict prognosis in BRCA. Additionally, patients were divided into low-risk and high-risk groups based on the expression of model-related genes, with the high-risk group showing lower levels of immune cell infiltration, immune-related functions, and immune checkpoint molecules, which may be associated with poor prognosis.
FRONTIERS IN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Doo-Ho Lee, Woongchang Yoon, Areum Lee, Youngmin Han, Yoonhyeong Byun, Jae Seung Kang, Hongbeom Kim, Wooil Kwon, Young-Ah Suh, Yonghwan Choi, Junghyun Namkung, Sangjo Han, Sung Gon Yi, Jin Seok Heo, In Woong Han, Joon Oh Park, Joo Kyung Park, Song Cheol Kim, Eunsung Jun, Chang Moo Kang, Woo Jin Lee, Hyeon Kook Lee, Huisong Lee, Seungyeoun Lee, Seung-Yong Jeong, Kyu Eun Lee, Wonshik Han, Taesung Park, Jin-Young Jang
Summary: This study developed a prediction model using a multi-marker panel as a diagnostic screening tool for pancreatic ductal adenocarcinoma and demonstrated its significant diagnostic performance in distinguishing pancreatic ductal adenocarcinoma from normal and benign pancreatic disease states, as well as patients with other cancers.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nan Song, Jin-Ah Sim, Qian Dong, Yinan Zheng, Lifang Hou, Zhenghong Li, Chia-Wei Hsu, Haitao Pan, Heather Mulder, John Easton, Emily Walker, Geoffrey Neale, Carmen L. Wilson, Kirsten K. Ness, Kevin R. Krull, Deo Kumar Srivastava, Yutaka Yasui, Jinghui Zhang, Melissa M. Hudson, Leslie L. Robison, I-Chan Huang, Zhaoming Wang
Summary: Social epigenomics is a field that investigates the biological effects of social determinants of health (SDOH) through DNA methylation analysis. In this study, researchers found significant associations between DNA methylation, SDOH factors (such as education, income, and deprivation), and genes related to smoking. These findings suggest that social factors can influence health outcomes through epigenetic mechanisms.
Article
Public, Environmental & Occupational Health
Ga Bin Lee, Sun Jae Jung, Yang Yiyi, Jea Won Yang, Hoang Manh Thang, Hyeon Chang Kim
Summary: This study examined socioeconomic inequalities in compliance with precautions and health behavior changes during the COVID-19 outbreak in Korea. The results showed that individuals with lower education or income levels were more likely to not comply with safety precautions and had increased smoking and changes in sleep duration. Conversely, higher education and income levels were associated with decreased physical activity and increased delivery food consumption. Additionally, lower education and income levels were associated with increased alcohol drinking in younger men but with higher levels in younger women. These findings suggest the importance of developing customized strategies to address the unique characteristics of different population groups and mitigate the impact of the COVID-19 outbreak.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Youngrong Lee, Ye Jin Jeon, Sunghyuk Kang, Jae Il Shin, Young-Chul Jung, Sun Jae Jung
Summary: The study aimed to summarize the association between the time spent on social media platforms during the COVID-19 quarantine and mental health outcomes, specifically anxiety and depression. The analysis demonstrated that excessive time spent on social media platforms was significantly associated with higher likelihood of experiencing symptoms of anxiety and depression.
Meeting Abstract
Cardiac & Cardiovascular Systems
Ga Bin Lee, Sun Jae Jung, Eun Lee, Song Vogue Ahn, Kyoung Min Kim, Hyeon Chang Kim
Article
Public, Environmental & Occupational Health
Youngrong Lee, Ye Jin Jeon, Jee-Seon Shim, Sun Jae Jung
Summary: This study examined the relationship between dietary behaviors and suicidal behaviors in Korean adolescents, with a focus on the differences in this relationship among children of immigrant parents. The findings suggest that unfavorable dietary behaviors, such as skipping meals and consuming unhealthy foods, are associated with a higher likelihood of suicidal behaviors. This association appears to be more prominent in adolescents with immigrant parents.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Psychiatry
Doo Woong Lee, San Lee, Sarah Soyeon Oh, Hin Moi Youn, Dong-Woo Choi, Sun Jae Jung, Sung-In Jang, Eun-Cheol Park
Summary: In this nested case-control study, poor continuity of care and higher area deprivation were found to be associated with an increased risk of suicide in psychiatric patients. The combination of poor continuity of care and the highest area deprivation showed a negative synergistic effect on suicide risk. Age acted as an effect modifier in the relationship between suicide risk and poor continuity of care as well as suicide risk and higher area deprivation.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Sunghyuk Kang, Eosu Kim, Hanna Cho, Dae Jung Kim, Hyeon Chang Kim, Sun Jae Jung
Summary: This study found an association between non-alcoholic fatty liver disease (NAFLD) and cognitive impairment, with this association being stronger in women with higher inflammatory status.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Kwanghyun Kim, Alexander C. Tsai, Sarah Lowe, Robert Stewart, Sun Jae Jung
Summary: This study analyzed the association between urbanicity and the onset of posttraumatic stress disorder (PTSD) and found that urban residence was associated with an increased risk of PTSD diagnosis. The association was more prominent among younger individuals and at both extremes of socioeconomic position (SEP), but only among younger participants.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Public, Environmental & Occupational Health
D. W. Lee, H. S. Lee, S. G. Kim, K. J. Kim, S. J. Jung
Summary: This study examines the relationship between the defection process of North Korean refugees and metabolic syndrome (MetS) in South Korea. The findings suggest that the number of countries transited during the defection process and the duration of residence in South Korea are associated with the prevalence of MetS among the refugees.
Review
Medicine, General & Internal
Ji Hyun Baek, Sun Jae Jung, Amy Peters, Alpdogan Kantarci, Andrew A. Nierenberg
Summary: Periodontal diseases are more common in patients with bipolar disorder. The association may be attributed to poor oral hygiene, the effects of inflammatory mediators, direct invasion of oral microbiota, modulation of the neurotransmitter system, and impact on the vagus nerve and hypothalamic-pituitary-adrenal axis. Further clinical studies are needed to explore the relationship between periodontal diseases and bipolar disorder.
PRECISION AND FUTURE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Hyo Choon Lee, Eun Hye Yang, Soonsu Shin, Seoung Ho Moon, Nan Song, Jae-Hong Ryoo
Summary: There is insufficient research on the link between commute time and mental health among Koreans. Using the 6th Korean Working Conditions Survey (KWCS), this study aimed to identify the relationship between commute time and subjective mental health. The results showed that long commute times were associated with increased risk of depression, anxiety, and fatigue.
ANNALS OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Sun Young Shim, Sun Jae Jung, Seung Up Kim, Hyeon Chang Kim
Summary: This study examined the association between cardiovascular health metrics and NAFLD in middle-aged Koreans. The findings showed that individuals with ideal cardiovascular health had a lower risk of NAFLD, while those with poor cardiovascular health had a higher risk.
CLINICAL HYPERTENSION
(2023)
Correction
Cardiac & Cardiovascular Systems
Eunsun Seo, Sun Jae Jung, Hokyou Lee, Hyeon Chang Kim
KOREAN CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Eunsun Seo, Sunjae Jung, Hokyou Lee, Hyeon Chang Kim
Summary: The prevalence of hypertension is higher in men than in women in Korea, but among older adults, women have a higher prevalence and number of people with hypertension. Undiagnosed hypertension and diagnosed-but-untreated hypertension are more common in men, while treated-but-uncontrolled hypertension is more common in women.
KOREAN CIRCULATION JOURNAL
(2022)
