Review
Urology & Nephrology
Michael C. Haffner, Wilbert Zwart, Martine P. Roudier, Lawrence D. True, William G. Nelson, Jonathan Epstein, Angelo M. De Marzo, Peter S. Nelson, Srinivasan Yegnasubramanian
Summary: Prostate cancer is heterogeneous, with primary tumors being multifocal and metastatic tumors potentially originating from a single clone but exhibiting subclonal heterogeneity at the genomic, epigenetic, and phenotypic levels. The complex heterogeneous constellation of molecular alterations poses challenges for diagnosis and treatment of prostate cancer.
NATURE REVIEWS UROLOGY
(2021)
Review
Cell Biology
Tala Tayoun, Marianne Oulhen, Agathe Aberlenc, Francoise Farace, Patrycja Pawlikowska
Summary: CTCs provide a tool for studying tumor heterogeneity and metastatic potential, with recent progress in single-cell analysis shedding light on genomic instability and its impact on tumor evolution and resistant clones emergence. Evaluating CIN and CNA in CTCs reveals their role in metastatic progression and resistance, despite technical obstacles in single CTC analysis, but showing potential predictive value for genotoxic treatment response.
Article
Genetics & Heredity
Junji Kitamura, Satoru Taguchi, Takatsugu Okegawa, Kazuki Honda, Toshihiko Kii, Yoshihiro Tomida, Ryuki Matsumoto, Naoki Ninomiya, Kazuki Masuda, Yu Nakamura, Tsuyoshi Yamaguchi, Manami Kinjo, Mitsuhiro Tambo, Aya Isomura, Akimasa Hayashi, Hiroshi Kamma, Eiji Higashihara, Junji Shibahara, Hiroshi Fukuhara
Summary: This case report presents the clinical presentation, treatment course, pathological diagnosis, and genomic assessment of CTCs in a patient with ASCP. Despite the poor prognosis of ASCP, genomic analysis of CTCs may offer effective treatment options and improved survival for patients.
BMC MEDICAL GENOMICS
(2021)
Article
Ecology
Jean P. Gibert, Ze-Yi Han, Daniel J. Wieczynski, Samantha Votzke, Andrea Yammine
Summary: This study reveals the link between body size and population density, and their impacts on ecological dynamics through experiments and mathematical models. It shows that changes in body size more strongly influence changes in density, and rapid changes in body size may have a larger effect on population dynamics.
FUNCTIONAL ECOLOGY
(2022)
Article
Urology & Nephrology
Liancheng Fan, Xiaochen Fei, Yinjie Zhu, Jiahua Pan, Jianjun Sha, Chenfei Chi, Yiming Gong, Xinxing Du, Lixin Zhou, Baijun Dong, Wei Xue
Summary: This study investigated the genomic profiles of Chinese patients with different stages of prostate cancer using germline and circulating tumor DNA sequencing. The results showed a similar frequency of deleterious germline alterations between patients with castration sensitive prostate cancer and metastatic castration resistant prostate cancer. Circulating tumor DNA sequencing may guide clinical treatment for metastatic prostate cancer.
JOURNAL OF UROLOGY
(2021)
Article
Health Care Sciences & Services
Ingrid Jenny Guldvik, Lina Ekseth, Amar U. Kishan, Andreas Stensvold, Else Marit Inderberg, Wolfgang Lilleby
Summary: In this study, the impact of circulating tumor cells (CTCs) in prostate cancer patients eligible for peptide vaccine therapy was evaluated. The study found a correlation between CTC counts and immune responses, serum protein profiles, and clinical outcomes in patients receiving vaccine therapy. Additionally, in recurrent patients, CTCs were found to express PSMA, PAP, and PD-L1.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Kathryn A. McGurk, Bernard D. Keavney, Anna Nicolaou
Summary: There is a need for new biomarkers of atherosclerotic cardiovascular disease, with recent studies highlighting circulating ceramides as potential indicators of coronary artery disease, type-2 diabetes and insulin resistance. Ceramides are highly regulated by enzymatic reactions throughout the body in terms of their activity and metabolism, including production, degradation and transport. Genetic studies have shown that DNA variants in genes involved in ceramide biosynthesis play a key role in influencing heritable, circulating ceramide levels.
Review
Microbiology
Amber Grace, Rajnish Sahu, Donald R. R. Owen, Vida A. A. Dennis
Summary: Pseudomonas aeruginosa is a common pathogen that has been identified as a multi-drug resistant strain. PAO1 and PA14, two laboratory strains, have contributed significantly to our understanding of the bacterium. However, there are discrepancies between their behaviors and therapeutic susceptibilities observed in human infections. This review aims to compare the two strains and propose methods to improve their clinical relevance.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dezhi Zhang, Huishang She, Frank E. Rheindt, Lei Wu, Huan Wang, Kai Zhang, Yalin Cheng, Gang Song, Chenxi Jia, Yanhua Qu, Urban Olsson, Per Alstrom, Fumin Lei
Summary: This study investigated the population structure and genomic and phenotypic differences associated with differences in migratory behavior in the songbird species, Yellow-throated Bunting. The findings revealed extensive gene flow between the resident and migratory populations of this species, with the resident populations showing reduced flight efficiency. The study also suggested that genes related to energy metabolism, nervous system, and circadian rhythm may play significant roles in regulating migration change.
Review
Oncology
Helena J. Janse van Rensburg, Pavlina Spiliopoulou, Lillian L. Siu
Summary: Circulating biomarkers play a valuable role in evaluating disease states in solid malignancies, and their use in monitoring treatment response is diverse, including disease burden markers, tumor markers, circulating tumor cells, nucleic acids, exosomes, and metabolomic arrays. This review summarizes the discovery and application of these circulating biomarkers in influencing treatment decisions, as well as the barriers to their application.
Article
Urology & Nephrology
Ethan S. Barnett, Nikolaus Schultz, Konrad H. Stopsack, Ernest T. Lam, Andrea Arfe, Jerry Lee, Jimmy L. Zhao, Joseph D. Schonhoft, Emily A. Carbone, Niamh M. Keegan, Andreas Wibmer, Yipeng Wang, David B. Solit, Wassim Abida, Richard Wenstrup, Howard I. Scher
Summary: Single-cell, shallow whole-genome sequencing (CTC sWGS) is a more effective method for detecting BRCA2 loss in patients with metastatic castration-resistant prostate cancer (mCRPC) compared to tissue biopsies.
Article
Biology
C. -E. Schaum, A. Buckling, N. Smirnoff, G. Yvon-Durocher
Summary: This study examines the evolution of trait and tolerance curves in marine ecosystem foundation organisms using a globally distributed phytoplankton species. The results demonstrate that fluctuations in temperature rapidly lead to enhanced trait plasticity and elevated thermal tolerance in the populations. Furthermore, long-term temperature fluctuations result in the formation of two distinct populations, one evolving high trait plasticity and enhanced thermal tolerance, and the other resembling samples evolved under constant warming conditions.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Enrico Lunghi, Fabio Cianferoni, Simone Giachello, Yahui Zhao, Raoul Manenti, Claudia Corti, Gentile Francesco Ficetola
Summary: European plethodontid salamanders are a group of eight strictly protected amphibian species which are sensitive to human-induced environmental changes. Long-term monitoring using low-impact methodologies allowed for the collection of a large dataset on two mainland Speleomantes species, providing the opportunity for analyzing phenotypic traits and stomach contents of eight populations belonging to two species. This dataset also allows for potential analyses over a wide temporal scale, supporting long-term studies.
Article
Biochemistry & Molecular Biology
Denise Martini, Nicolas Dussex, Bruce C. Robertson, Neil J. Gemmell, Michael Knapp
Summary: Climate warming poses a serious threat to alpine species, particularly in limited dispersal environments like islands. Research on the New Zealand kea, the only alpine parrot in the world, suggests that it may not be a true alpine specialist and lacks major genomic differences with its forest adapted sister species, the kaka. Despite this, divergent demographic responses to past climate warming between the species highlight potential future threats to kea survival in a warming world.
Article
Biotechnology & Applied Microbiology
Zheng Chen, Jue Wang, Yangbai Lu, Caiyong Lai, Lijun Qu, Yumin Zhuo
Summary: This study found that Ezrin expression is significantly upregulated in PCa tissues and cells, and promotes the migration and invasion abilities of PCa cells. Clinical data revealed that Ezrin expression in CTCs is associated with the metastatic degree of PCa. Therefore, Ezrin expression in CTCs may have potential roles in the prognosis and management of PCa.
Article
Biochemistry & Molecular Biology
Vijay Kumar, Julie Rosenbaum, Zihua Wang, Talitha Forcier, Michael Ronemus, Michael Wigler, Dan Levy
NUCLEIC ACIDS RESEARCH
(2018)
Article
Medical Laboratory Technology
Mariam Rodriguez-Lee, Anand Kolatkar, Madelyn McCormick, Angel D. Dago, Jude Kendall, Nils Anders Carlsson, Kelly Bethel, Emily J. Greenspan, Shelley E. Hwang, Kathryn R. Waitman, Jorge J. Nieva, James Hicks, Peter Kuhn
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2018)
Article
Multidisciplinary Sciences
Andreas Buja, Natalia Volfovsky, Abba M. Krieger, Catherine Lord, Alex E. Lash, Michael Wigler, Ivan Iossifov
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Endocrinology & Metabolism
Shikha Gaur, Mitchell E. Gross, Chun-Peng Liao, Bin Qian, Jean C. Shih
Article
Biochemistry & Molecular Biology
Siran Li, Jude Kendall, Sarah Park, Zihua Wang, Joan Alexander, Andrea Moffitt, Nissim Ranade, Cassidy Danyko, Bruno Gegenhuber, Stephan Fischer, Brian D. Robinson, Herbert Lepor, Jessica Tollkuhn, Jesse Gillis, Eric Brouzes, Alex Krasnitz, Dan Levy, Michael Wigler
Article
Cell Biology
Anand Vasudevan, Prasamit S. Baruah, Joan C. Smith, Zihua Wang, Nicole M. Sayles, Peter Andrews, Jude Kendall, Justin Leu, Narendra Kumar Chunduri, Dan Levy, Michael Wigler, Zuzana Storchova, Jason M. Sheltzer
DEVELOPMENTAL CELL
(2020)
Article
Biochemistry & Molecular Biology
Andrea B. Moffitt, Mona S. Spector, Peter Andrews, Jude Kendall, Joan Alexander, Asya Stepansky, BeiCong Ma, Jonathan Kolitz, Nicholas Chiorazzi, Steven L. Allen, Alex Krasnitz, Michael Wigler, Dan Levy, Zihua Wang
NUCLEIC ACIDS RESEARCH
(2020)
Article
Oncology
Mitchell E. Gross, David B. Agus, Tanya B. Dorff, Jacek K. Pinski, David Quinn, Olga Castellanos, Patrick Gilmore, Jean C. Shih
Summary: Phenelzine showed efficacy in patients with biochemical recurrent castrate-sensitive prostate cancer, with mild treatment-related toxicities observed in most patients and rare significant and reversible cardiovascular toxicities. Treatment reduced anxiety symptoms significantly, but did not change depressive symptoms. Therapies targeting MAOA may provide a new avenue for treating recurrent prostate cancer patients.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Biology
Timour Baslan, Jude Kendall, Konstantin Volyanskyy, Katherine McNamara, Hilary Cox, Sean D'Italia, Frank Ambrosio, Michael Riggs, Linda Rodgers, Anthony Leotta, Junyan Song, Yong Mao, Jie Wu, Ronak Shah, Rodrigo Gularte-Merida, Kalyani Chadalavada, Gouri Nanjangud, Vinay Varadan, Assaf Gordon, Christina Curtis, Alex Krasnitz, Nevenka Dimitrova, Lyndsay Harris, Michael Wigler, James Hicks
Article
Biology
Seungtai Yoon, Adriana Munoz, Boris Yamrom, Yoon-ha Lee, Peter Andrews, Steven Marks, Zihua Wang, Catherine Reeves, Lara Winterkorn, Abba M. Krieger, Andreas Buja, Kith Pradhan, Michael Ronemus, Kristin K. Baldwin, Dan Levy, Michael Wigler, Ivan Iossifov
Summary: The study found that de novo mutations play a significant role in the incidence of autism, with a larger contribution in low-risk families. Additionally, previous studies using low resolution microarrays and whole exome sequencing have underestimated the rate of de novo mutations.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siran Li, Sarah Park, Catherine Ye, Cassidy Danyko, Matthew Wroten, Peter Andrews, Michael Wigler, Dan Levy
Summary: In this study, a novel method for haplotype-phased sequence assembly using short-read sequencers is described. With the introduction of mutation patterns and correction strategies, it achieves accurate assembly and phasing of long genomic regions with low error rates.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zihua Wang, Andrea B. Moffitt, Peter Andrews, Michael Wigler, Dan Levy
Summary: In this study, we accurately measured microsatellite lengths by using bisulfite mutagenesis to disrupt repeat structures of initial templates, thus reducing the error rate during amplification. This method proved successful and revealed new information on the distribution of microsatellite lengths.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Computer Science, Information Systems
Yongkui Tang, Leng-Ying Chen, Ailin Zhang, Chun-Peng Liao, Mitchell Eric Gross, Eun Sok Kim
Summary: The study evaluated the therapeutic effects of a new pulsed high-frequency medium-intensity focused ultrasound in selective cancer treatment with promising results, demonstrating reduced tumor size without thermal damage for potentially safer cancer treatment.
Article
Oncology
Lubomir Chorbadjiev, Jude Kendall, Joan Alexander, Viacheslav Zhygulin, Junyan Song, Michael Wigler, Alexander Krasnitz
JCO CLINICAL CANCER INFORMATICS
(2020)
Article
Oncology
Joan Alexander, Jude Kendall, Jean McIndoo, Linda Rodgers, Robert Aboukhalil, Dan Levy, Asya Stepansky, Guoli Sun, Lubomir Chobardjiev, Michael Riggs, Hilary Cox, Inessa Hakker, Dawid G. Nowak, Juliana Laze, Elton Llukani, Abhishek Srivastava, Siobhan Gruschow, Shalini S. Yadav, Brian Robinson, Gurinder Atwal, Lloyd C. Trotman, Herbert Lepor, James Hicks, Michael Wigler, Alexander Krasnitz