Article
Biochemistry & Molecular Biology
William G. J. Kerrison, Alexander T. J. Lee, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Immunotherapy in soft tissue sarcoma has become a popular and promising therapeutic strategy, with immune checkpoint inhibitors showing effectiveness in certain subtypes. Combination therapies have also shown enhanced response rates.
Review
Pharmacology & Pharmacy
Tomoki Nakamura, Akihiro Sudo
Summary: Trabectedin is a safe and effective therapeutic option for patients with advanced STS. While it may be effective as first-line treatment in selected patients, doxorubicin remains the preferred choice for locally advanced or metastatic STS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Do Weon Lee, Han-Soo Kim, Ilkyu Han
Summary: The study found that actual 5-year survival in stage III soft tissue sarcoma patients is associated with tumor size, histological grade, and ASA score. Nevertheless, the majority of long-term survivors still exhibit factors of poor prognosis.
Article
Biochemistry & Molecular Biology
Timur I. Fetisov, Sofya A. Khazanova, Polina A. Shtompel, Ekaterina S. Trapeznikova, Victoria Y. Zinovieva, Valeria I. Marshall, Anastasia A. Lovenger, Dmitriy V. Rogozhin, Tararykova A. Anastasia, Beniamin Yu. Bokhyan, Gennady A. Belitsky, Marianna G. Yakubovskaya, Kirill I. Kirsanov
Summary: Treatment of highly malignant soft tissue sarcomas (STSs) involves multicomponent therapy, but personalized selection of chemotherapy is lacking. In this study, in vitro chemosensitivity/resistance assays (CSRAs) were used to predict STS chemoresistance. Results showed that certain cancer histotypes had higher resistance to specific drugs and combinations, and the CSRAs were correlated with clinical responses and survival outcomes. CSRAs can assist physicians in avoiding ineffective treatments and aid researchers in developing new STS drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Teresa Bernardo, Carina Behrends, Diana Klein, Anna Kuntze, Beate Timmermann, Claere von Neubeck
Summary: High-precision radiotherapy with proton beams combined with doxorubicin for aggressive soft tissue sarcoma (STS) has high local recurrence rates. Optimized treatment protocols considering STS heterogeneity are needed. Preclinical STS models showed dose-dependent radiation response with reduced survival, proliferation, viability, and motility. Doxorubicin showed highest efficiency when combined with radiation, especially before or after radiation. Further investigations are needed for alternative drug therapies combined with proton irradiation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, Ruby Yu-Tong Lin, Pushkar Dakle, Kassoum Nacro, Mark Edward Puhaindran, Peter Houghton, Angela Pang, Victor Kwanmin Lee, Ling-Wen Ding, Sigal Gery, Jeffrey Hill, Leilei Chen, Liang Xu, H. Phillip Koeffler
Summary: Depletion of MNK1/2 suppresses growth of soft tissue sarcoma cells, and a novel MNK inhibitor ETC-168 shows significant antiproliferative efficacy. Combination of ETC-168 with MCL1 inhibitor exerts synergistic antiproliferative activity against STS cells. This study highlights the potential clinical translation of MNK inhibitors for the treatment of soft tissue sarcoma.
Article
Biochemistry & Molecular Biology
Mauro Loi, Giulia Salvatore, Michele Aquilano, Daniela Greto, Cinzia Talamonti, Viola Salvestrini, Maria Elena Melica, Marianna Valzano, Giulio Francolini, Mariangela Sottili, Costanza Santini, Carlotta Becherini, Domenico Andrea Campanacci, Monica Mangoni, Lorenzo Livi
Summary: Trabectedin sensitizes STS cells to radiation therapy by reducing cell survival rate, inhibiting invasiveness, altering cell cycle distribution, and increasing γ-H2AX foci formation. However, it does not have a synergistic effect on DNA damage repair, neoangiogenesis, and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Tom Wei-Wu Chen, Ruru Chun-Ju Chiang, Alex Le Cesne, Yu-Chun Hsieh, Antoine Italiano, Ya-Wen Yang, Nicolas Penel, Wen-Chung Lee, Emmanuelle Bompas, Thibaud Valentin, Philippe Anract, Nelly Firmin, Florence Duffaud, Ann-Lii Cheng, Francoise Ducimetiere, K. Arnold Chan, Jean-Yves Blay
Summary: The study found significant differences in the incidence and clinical characteristics of soft tissue sarcoma (STS) among different geographic and ethnic populations, suggesting that geographic and ethnic factors may play a crucial role in the pathogenesis of STS.
Article
Oncology
Jeremy Lewin, Eoghan Malone, Esmail Al-Ezzi, Samir Fasih, Pernille Pedersen, Sarah Accardi, Abha Gupta, Albiruni Abdul Razak
Summary: The study aimed to investigate the safety and efficacy of the combination of Selinexor and doxorubicin in patients with locally advanced/metastatic STS. The results showed potential therapeutic responses in some patients, but also significant drug-related adverse events, including high rates of febrile neutropenia.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Ahmet Bilici, Sinan Koca, Mustafa Karaagac, Sabin Goktas Aydin, Emrah Eraslan, Muhammed Ali Kaplan, Birol Ocak, Sema Sezgin Goksu, Semra Paydas, Fahri Akgul, Sumeyye Derin, Yakup Ergun, Emre Yekeduz, Cihan Erol, Deniz Tataroglu Ozyukseler, Atike Gokcen Demiray, Mustafa Karaca, Zeynep Gulsum Guc, Serkan Menekse, Havva Yesil Cinkir, Ozge Gumusay, Abdullah Sakin, Ozlem Ozkul, Hacer Demir, Dilek Erdem, Mehmet Besiroglu, Olcun Umit Unal, Ramazan Acar, Lokman Koral, Suleyman Sahin, Teoman Sakalar, Aykut Bahceci, Ahmet Ozveren, Ulug Mutlu Gunaydin, Mehmet Metin Seker, Veli Sunar, Pinar Dal, Mehmet Artac, Serdar Turhal
Summary: This study retrospectively analyzed the medical records of patients with non-adipocytic metastatic soft tissue sarcoma treated with pazopanib in 37 oncology clinics in Turkey. The results showed that pazopanib is effective and well-tolerated in the treatment of this disease, with better outcomes observed when used earlier and in patients with good performance status.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Alessandra Buja, Massimo Rugge, Matteo Barillaro, Andrea Miatton, Saveria Tropea, Claudia Cozzolino, Manuel Zorzi, Antonella Vecchiato, Paolo Del Fiore, Antonella Brunello, Vincenzo Baldo, Carlo Riccardo Rossi, Simone Mocellin
Summary: This study aimed to compare the pathological and clinical features of retroperitoneal soft-tissue sarcomas (RPS) and non-RPS, and analyze if the hazard ratio for short-term mortality differs between RPS and non-RPS after adjusting for baseline differences. The analysis found that RPS accounted for 22.8% of cases, with different characteristics compared to non-RPS. The retroperitoneum site was an independent prognostic factor associated with worse overall survival in sarcoma patients.
Article
Immunology
Kayla L. Marritt, Karys M. Hildebrand, Kurt N. Hildebrand, Arvind K. Singla, Franz J. Zemp, Douglas J. Mahoney, Frank R. Jirik, Michael J. Monument
Summary: This study assessed the therapeutic response of intratumoral STING activation in an immunologically cold murine model of undifferentiated pleomorphic sarcoma (UPS). The results showed that a single intratumoral injection of the murine STING agonist resulted in durable cure in up to 60% of UPS-bearing mice. In mice with synchronous lung metastases, STING activation within hindlimb tumors also resulted in 50% cure in both anatomic sites.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Lopez-Alvarez, Cristina Gonzalez-Aguilera, David S. Moura, Paloma Sanchez-Bustos, Jose L. Mondaza-Hernandez, Marta Martin-Ruiz, Marta Renshaw, Rafael Ramos, Carolina Castilla, Elena Blanco-Alcaina, Nadia Hindi, Javier Martin-Broto
Summary: Although the overall survival of advanced soft-tissue sarcoma (STS) patients has increased, there is still an unmet need due to a low median progression-free survival. This study tested the combination of eribulin and gemcitabine in preclinical models of L-sarcoma, finding that the combination showed synergistic effects and delayed tumor growth in vivo. These results suggest that further exploration of eribulin and gemcitabine combination in clinical settings is warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Maria L. Inchaustegui, Kelly Kon-Liao, Kim Ruiz-Arellanos, George Aquilino E. Silva, Marcos R. Gonzalez, Juan Pretell-Mazzini
Summary: This systematic review analyzed the treatment options and outcomes for patients with radiation-induced soft tissue sarcomas (RISs). The most common treatment for RISs was surgery, with chemotherapy and radiotherapy used less frequently. Patients with RISs had a low 5-year survival rate, and high rates of local recurrence and cancer spreading.
Article
Multidisciplinary Sciences
Luiza Ohasi de Figueiredo, Augusto Afonso Guerra Junior, Francisco de Assis Acurcio, Alessandra Maciel Almeida, Mariangela Leal Cherchiglia, Alberto Julius Alves Wainstein, Luiz Claudio Santos Thuler, Angelica Nogueira-Rodrigues
Summary: Brazil lacks comprehensive statistics on soft tissue sarcomas (STS), making it difficult to understand the epidemiological profile and clinical outcomes of patients. This study aimed to bridge this gap by analyzing data from a large cohort of STS patients in the Brazilian public health system. The majority of patients received surgical treatment, and a significant proportion of them resided in the Northeast region of Brazil. The 1-, 5- and 10-year survival rates were 75.4%, 43.4%, and 18.6% respectively.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Kenji Kita, Koji Fukuda, Hiro Takahashi, Azusa Tanimoto, Akihiro Nishiyama, Sachiko Arai, Shinji Takeuchi, Kaname Yamashita, Koshiro Ohtsubo, Sakiko Otani, Naohiro Yanagimura, Chiaki Suzuki, Hiroko Ikeda, Masaya Tamura, Isao Matsumoto, Seiji Yano
Article
Plant Sciences
Lilan Luo, Sayuri Ando, Yuki Sakamoto, Takanori Suzuki, Hiro Takahashi, Nanako Ishibashi, Shoko Kojima, Daisuke Kurihara, Tetsuya Higashiyama, Kotaro T. Yamamoto, Sachihiro Matsunaga, Chiyoko Machida, Michiko Sasabe, Yasunori Machida
Article
Biotechnology & Applied Microbiology
Simon Vial-Pradel, Yoshinori Hasegawa, Ayami Nakagawata, Shido Miyaki, Yasunori Machida, Shoko Kojima, Chiyoko Machida, Hiro Takahashi
PLANT BIOTECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Hiro Takahashi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2020)
Article
Biotechnology & Applied Microbiology
Hiro Takahashi, Noriya Hayashi, Yuta Hiragori, Shun Sasaki, Taichiro Motomura, Yui Yamashita, Satoshi Naito, Anna Takahashi, Kazuyuki Fuse, Kenji Satou, Toshinori Endo, Shoko Kojima, Hitoshi Onouchi
Article
Plant Sciences
Takashi L. Shimada, Katsushi Yamaguchi, Shuji Shigenobu, Hiro Takahashi, Masataka Murase, Shuichi Fukuyoshi, Ikuko Hara-Nishimura
JOURNAL OF PLANT RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Hidekazu Iwakawa, Hiro Takahashi, Yasunori Machida, Chiyoko Machida
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Hiro Takahashi, Shido Miyaki, Hitoshi Onouchi, Taichiro Motomura, Nobuo Idesako, Anna Takahashi, Masataka Murase, Shuichi Fukuyoshi, Toshinori Endo, Kenji Satou, Satoshi Naito, Motoyuki Itoh
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Hiro Takahashi, Takayuki Yoshizaki, Hisashi Kondo, Taichiro Motomura, Masataka Murase, Anna Takahashi, Shuichi Fukuyoshi, Chiyoko Machida, Shin Kanamasa, Hiromi Shimizu, Shin-ichi Iwaguchi
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
Article
Microbiology
Hiro Takahashi, Erika Sakagawa, Ryosuke Toyoda, Taichiro Motomura, Masataka Murase, Anna Takahashi, Shuichi Fukuyoshi, Shin Kanamasa
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
Article
Microbiology
Hiro Takahashi, Tomoyuki Minami, Mitsuyasu Okabe, Enoch Y. Park, Tsukasa Fujimoto, Anna Takahashi, Masataka Murase, Shuichi Fukuyoshi, Kenji Satou, Shin Kanamasa
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
Article
Microbiology
Shin Kanamasa, Tomoyuki Minami, Mitsuyasu Okabe, Enoch Y. Park, Tsukasa Fujimoto, Anna Takahashi, Masataka Murase, Shuichi Fukuyoshi, Akifumi Oda, Kenji Satou, Hiro Takahashi
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Microbiology
Shin Kanamasa, Daiki Yamaguchi, Chiyoko Machida, Tsukasa Fujimoto, Anna Takahashi, Masataka Murase, Shuichi Fukuyoshi, Akifumi Oda, Kenji Satou, Hiro Takahashi
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Microbiology
Hiro Takahashi, Erika Sakagawa, Ikuya Sakakibara, Chiyoko Machida, Shido Miyaki, Anna Takahashi, Shinnosuke Onai, Shuichi Fukuyoshi, Akinori Ohta, Kenji Satou, Shin Kanamasa
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2018)
Article
Microbiology
Hiro Takahashi, Satoshi Tanaka, Shuhei Hayashi, Shido Miyaki, Anna Takahashi, Shinnosuke Onai, Shuichi Fukuyoshi, Hitoshi Miyasaka
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2018)