Article
Immunology
Miao Zhou, Chao Xue, Zhongdao Wu, Xiaoying Wu, Miaoxin Li
Summary: This study conducted a genome-wide association study on a Chinese population to investigate the genetic factors influencing schistosomiasis complications. Several novel significant single-nucleotide polymorphisms (SNPs) and genes were identified that were associated with liver damage indicators, serum levels, and clinical signs of schistosomiasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Mo Li, Yi Hu, Baihui Zhao, Luan Chen, Hailiang Huang, Cong Huai, Xiaoqing Zhang, Jinghong Zhang, Wei Zhou, Lu Shen, Qi Zhen, Bao Li, Wenjun Wang, Lin He, Shengying Qin
Summary: A two-stage study identified genetic markers associated with TB susceptibility in 616 TB patients and 709 healthy controls. The study confirmed 6 nominally significant SNPs and a HLA-II allele as predisposing factors for TB. The research provides insight into the genetic variants linked to TB susceptibility and sheds light on tuberculosis pathogenesis.
Article
Plant Sciences
Changwei Ge, Li Wang, Yongfei Yang, Ruihua Liu, Shaodong Liu, Jing Chen, Qian Shen, Huijuan Ma, Li Yang, Siping Zhang, Chaoyou Pang
Summary: GhSAD1 regulates cold stress responses in cotton by modulating the activity of C-repeat binding factors, regulating COLD-REGULATED genes and ABA signaling. Overexpression of GhSAD1 increases cold tolerance and ABA content, while silencing of GhSAD1 decreases ABA content. GhSAD1 also induces the expression of COLD-REGULATED genes and increases metabolites associated with cold stress tolerance. These findings contribute to our understanding of the molecular mechanisms underlying cold stress responses in cotton mediated by GhSAD1.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Clinical Neurology
Longfei Jia, Fangyu Li, Cuibai Wei, Min Zhu, Qiumin Qu, Wei Qin, Yi Tang, Luxi Shen, Yanjiang Wang, Lu Shen, Honglei Li, Dantao Peng, Lan Tan, Benyan Luo, Qihao Guo, Muni Tang, Yifeng Du, Jiewen Zhang, Junjian Zhang, Jihui Lyu, Ying Li, Aihong Zhou, Fen Wang, Changbiao Chu, Haiqing Song, Liyong Wu, Xiumei Zuo, Yue Han, Junhua Liang, Qi Wang, Hongmei Jin, Wei Wang, Yang Lu, Fang Li, Yuying Zhou, Wei Zhang, Zhengluan Liao, Qiongqiong Qiu, Yan Li, Chaojun Kong, Haishan Jiao, Jie Lu, Jianping Jia
Summary: This study validated predictive models based on genome-wide association studies for assessing the risk of Alzheimer's disease onset in a large Chinese population. These models effectively predicted Alzheimer's disease onset in individuals carrying risk variants, confirming the contribution of these identified variants to disease pathogenesis.
Article
Oncology
Daisuke Nishizawa, Ryozo Morino, Rie Inoue, Seii Ohka, Shinya Kasai, Junko Hasegawa, Yuko Ebata, Kyoko Nakayama, Hiroyuki Sumikura, Masakazu Hayashida, Miyuki Yokota, Kazutaka Ikeda
Summary: This study identified several genetic variations associated with the vulnerability to PONV through a genome-wide association study (GWAS), providing valuable information for predicting the vulnerability to PONV.
Review
Biochemistry & Molecular Biology
Yin Huang, Dan Li, Lu Qiao, Yu Liu, Qianqian Peng, Sijie Wu, Manfei Zhang, Yajun Yang, Jingze Tan, Shuhua Xu, Li Jin, Sijia Wang, Kun Tang, Stefan Grunewald
Summary: This study conducted a genome-wide association study on the genetic basis of facial morphology in the Han Chinese population, identifying significant associations between multiple facial features and different genomic regions. These findings contribute to a more comprehensive understanding of the genetic factors underlying variation in human facial morphology.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Cell Biology
Yuguang Niu, Chengyong Xie, Zhenhua Du, Jifeng Zeng, Hongxia Chen, Liang Jin, Qing Zhang, Huiying Yu, Yahui Wang, Jie Ping, Chenning Yang, Xinyi Liu, Yuanfeng Li, Gangqiao Zhou
Summary: This study conducted a genome-wide association study on noise-induced hearing loss in Chinese populations, and identified two novel loci at 7q11.22 and 7q36.3 that are associated with susceptibility to NIHL.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Shan Lin, Cuncun Ke, Lin Liu, Yahui Gao, Lingna Xu, Bo Han, Yaofeng Zhao, Shengli Zhang, Dongxiao Sun
Summary: In this study, 14 candidate genes related to immunoglobulin concentrations in colostrum and serum in dairy cattle were identified through genome-wide association studies (GWASs). These findings provide a basis for further investigation into key genes and mutations affecting immunoglobulin concentrations, as well as important information for genetic improvement of immune traits in dairy cattle.
Article
Medicine, General & Internal
Hyun-Ju An, Jae-Hwa Kim, Siyeong Yoon, Junwon Choi, Jeongmo Koo, Soonchul Lee
Summary: This study aimed to identify specific genes or genetic variants associated with rotator cuff tears through a genome-wide association study. More than 20 significantly associated SNPs were found. However, the study was limited by the small sample size and requires further validation. Nevertheless, the identification of potential genetic variants related to rotator cuff injury would aid in the early detection of individuals at risk and provide insight into future gene therapies.
Article
Agriculture, Dairy & Animal Science
Zexi Cai, Xiaoping Wu, Bo Thomsen, Mogens Sandra Lund, Goutam Sahana
Summary: This study identified QTL regions and genes associated with calf survival traits using GWAS. Different effects and additional QTL regions were found for different stages of calf growth and stillbirth traits. Candidate genes and potential causal variants were also identified, providing insights for reducing calf mortality.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Duojian Guo, Yu Zhou, Xingwei Wei, Shanshan Zhang, Tianbo Jin, Yutian Zhang, Mei Lin, Xiaoli Zhou, Yufei Xie, Chanyi He, Qi Lin, Ping He, Yipeng Ding
Summary: Through genetic association studies, we identified multiple genetic loci associated with serum levels of copper, zinc, calcium, magnesium, iron, and lead elements. These findings provide new insights into the potential mechanisms regulating serum mineral elements levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Multidisciplinary Sciences
Fangli Zhou, Xiaoli He, Dan Liu, Yan Ye, Haoming Tian, Li Tian
Summary: Serum ferritin and uric acid levels are closely associated with the risk of NAFLD. The AUC value of serum ferritin and uric acid in the NAFLD group was 0.771.
Article
Immunology
Shou-En Wu, Wei Liang Chen
Summary: The study investigated sarcopenia-related SNPs in Asian older adults and created a genotype score to test the combined effect of these SNPs on sarcopenia risk. Results revealed significant associations between SNPs and sarcopenic indices, with higher genotype scores linked to increased sarcopenia risk.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Haijie Song, Wenting Li, Yuanfang Li, Bin Zhai, Yujie Guo, Yi Chen, Ruili Han, Guirong Sun, Ruirui Jiang, Zhuanjian Li, Fengbin Yan, Guoxi Li, Xiaojun Liu, Yanhua Zhang, Yadong Tian, Xiangtao Kang
Summary: In this study, a genome-wide association study (GWAS) was conducted to identify genetic variations associated with serum biochemical indicators in chickens. A total of 236 single-nucleotide polymorphisms (SNPs) on 9 chicken chromosomes were found to be significantly associated with eight serum biochemical indicators. Additionally, ten novel quantitative trait loci (QTLs) were identified for these serum biochemical indicators. Literature mining also revealed potential candidate genes for these traits.
Article
Multidisciplinary Sciences
Ruidong Xiang, Iona M. MacLeod, Hans D. Daetwyler, Gerben de Jong, Erin O'Connor, Chris Schrooten, Amanda J. Chamberlain, Michael E. Goddard
Summary: This study presents a method for fine-mapping potentially causal mutations by integrating functional, evolutionary, and pleiotropic information and developing a custom genotyping array. The custom array, containing variants with biological functions, outperformed the standard array in predicting genetic values for multiple traits in dairy cattle populations across different countries. This highlights the potential improvement in genomic prediction by utilizing mutations with functional, evolutionary, and pleiotropic consequences.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xiuming Feng, Longman Li, Lulu Huang, Haiying Zhang, Zengnan Mo, Xiaobo Yang
Summary: The study found that tin and zinc levels in men in southern China are independently and interactively associated with metabolic syndrome. High tin and zinc may be risk factors for metabolic syndrome.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Urology & Nephrology
Yulan Bai, Zefeng Chen, Zheng Wen, Xinyang Long, Zengnan Mo, Jianfeng Xu
Summary: This study found that adiponectin has a causal effect on estimated glomerular filtration rate (eGFR), but eGFR has no causal effect on adiponectin. This suggests that adiponectin may be a potential clinical target for improving kidney function and treating chronic kidney disease.
Article
Oncology
Zhenyuan Yu, Wenhao Lu, Cheng Su, Yufang Lv, Yu Ye, Bingqian Guo, Deyun Liu, Haibiao Yan, Hua Mi, Tianyu Li, Qingyun Zhang, Jiwen Cheng, Zengnan Mo
Summary: The study on bilateral RCC using single-cell RNA sequencing revealed the gene expression characteristics of bilateral RCC cells and significant differences in gene expression among different site tumour cells. This work provides insights for the diagnosis and treatment of bilateral RCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Andrology
Juanjuan Xie, Xin Li, Yufan Lu, Caishen Huang, Xinyan Long, Yong Liu, Huaxiang Lu, Jianhua Long, Bo Chen, Zhigang Luo, Zengnan Mo
Summary: Female chronic posterior urethritis is often misdiagnosed as other conditions, but its diagnosis and treatment are crucial for alleviating urethral symptoms. Transurethral electroresection is an effective and safe approach in treating female chronic posterior urethritis, with a high success rate and minimal complications.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Andrology
Shaohua Chen, Chengbang Wang, Xiaotao Su, Xiaodi Dai, Songheng Li, Zengnan Mo
Summary: The study revealed a negative correlation between ImmuneScore and patient prognosis, indicating the importance of immune cells in the tumor microenvironment. Through intersection analysis, 118 immune-related genes were identified, with 6 critical genes used to build a prognostic model for KIRC. KCNN4 was identified as the most critical gene affecting KIRC prognosis, with further analysis showing its impact on the TME immune status and potential as a prognostic marker.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinwei Cai, Cuiting Lin, Shuiqing Lai, Yingshan Liu, Min Liang, Yingfen Qin, Xinghuan Liang, Aihua Tan, Yong Gao, Zheng Lu, Chunlei Wu, Shengzhu Huang, Xiaobo Yang, Haiying Zhang, Jian Kuang, Zengnan Mo
Summary: All anthropometric indicators were significantly associated with MAFLD, with LAP having the highest AUC. WHtR was identified as the strongest predictor of MAFLD in young Chinese males, followed by LAP and AVI. The strongest association was found between LAP and sex hormones.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Microbiology
Xianwu Pang, Pu Li, Lifeng Zhang, Lusheng Que, Min Dong, Bo Xie, Qihui Wang, Yinfeng Wei, Xing Xie, Lanxiang Li, Chunyue Yin, Liuchun Wei, Kexin Huang, Yiming Hua, Qingniao Zhou, Yingfang Li, Lei Yu, Weidong Li, Zengnan Mo, Maosheng Zhang, Jing Leng, Yanling Hu
Summary: Mutations in the SARS-CoV-2 genome are directly associated with clinical outcomes and pandemic, with mutations more likely to occur in mild and severe cases. Mutations associated with asymptomatic cases are mainly found in open reading frame 1ab (ORF1ab) and N genes, while mutations in mild and severe cases are more prevalent.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Cheng Su, Rongzhi Huang, Zhenyuan Yu, Jie Zheng, Fengling Liu, Haiqi Liang, Zengnan Mo
Summary: Nephroblastoma, also known as Wilms' tumor, is the most common renal tumor in children. Despite improvements in treatment efficacy, some patients still have poor prognosis. The study suggests that MAL may serve as a potential prognostic factor for nephroblastoma and is closely related to the tumor microenvironment.
Article
Oncology
Chao Feng, Xi Wang, Yuting Tao, Yuanliang Xie, Zhiyong Lai, Zhijian Li, Jiaxin Hu, Shaomei Tang, Lixin Pan, Liangyu He, Qiuyan Wang, Tianyu Li, Zengnan Mo
Summary: Muscle invasive bladder cancer (MIBC) is a malignancy with significant heterogeneity. The MIBC tumor microenvironment (TME) is highly complex, comprising diverse phenotypes and spatial architectures. This study used a combination of mass cytometry and imaging mass cytometry to analyze the complexity of the MIBC TME at the single-cell level. The identification of abnormal cell clusters and spatial characteristics provides valuable insights for potential targeted therapies in MIBC patients.
Article
Oncology
Cheng Su, Yufang Lv, Wenhao Lu, Zhenyuan Yu, Yu Ye, Bingqian Guo, Deyun Liu, Haibiao Yan, Tianyu Li, Qingyun Zhang, Jiwen Cheng, Zengnan Mo
Summary: This study identified new tumor-specific markers for different pathological types of RCC using single-cell transcriptome sequencing, as well as characterized different types of endothelial cells and their association with fibroblasts in ccRCC and type 2 pRCC. Furthermore, drug target pathway activation and drug response sensitivity were predicted in different pathological types of RCC based on scRNA-seq results.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Longman Li, Wenjun Yang, Lulu Huang, Xiuming Feng, Hong Cheng, Xiaoting Ge, Gaohui Zan, Yanli Tan, Lili Xiao, Chaoqun Liu, Xing Chen, Zengnan Mo, Xiaobo Yamg
Summary: Magnesium plays a crucial role in physiological processes, and variations in serum magnesium levels can have significant implications for health. The study found causal relationships between serum magnesium levels and multiple disease outcomes, as well as gender-specific effects on disease outcomes. Additionally, the study identified potential new disease outcomes related to serum magnesium levels.
Article
Environmental Sciences
Chaoqun Liu, Lulu Huang, Shengzhu Huang, Luyun Wei, Dehao Cao, Gaohui Zan, Yanli Tan, Sida Wang, Minjing Yang, Long Tian, Weijun Tang, Caitong He, Chunhua Shen, Bangzhu Luo, Maoling Zhu, Tao Liang, Baohong Pang, Mujun Li, Zengnan Mo, Xiaobo Yang
Summary: This study systematically assessed the associations between metals exposure during pregnancy and childhood and neurodevelopment in children aged 2-3 years. The results showed that prenatal aluminum and cadmium exposure were negatively associated with neurodevelopmental outcomes. The study also revealed that infants of different sexes had different sensitivities to metal exposure, and metal exposure during the first and second trimester had a more significant impact on neurobehavioral development.
ENVIRONMENTAL RESEARCH
(2022)
Article
Oncology
Chunmeng Wei, Xi Chen, Jin Ji, Yalong Xu, Xing He, Huiyong Zhang, Zengnan Mo, Fubo Wang
Summary: The study evaluated the performance of urinary exosomal prostate-specific antigen (UE-PSA) in predicting the results of initial prostate biopsies and distinguishing clinically significant prostate cancer. The results showed that UE-PSA had high accuracy and clinical value in predicting and distinguishing prostate cancer, making it a promising noninvasive biomarker to improve prostate cancer detection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Xi Chen, Chunyan Liao, Xiong Zou, Bei Zhang, Zengnan Mo
Summary: This study aimed to develop a signature of cancer-associated fibroblasts (CAFs)-related genes (CRGs) to predict the survival outcomes and treatment response of bladder cancer (BLCA). Weighted gene co-expression network analysis was utilized to uncover CAFs-associated hub genes, and a risk model for survival prognosis was constructed using LASSO-Cox regression. The findings suggest that the CRG signature offers new avenues for the prognosis evaluation and development of personalized treatment strategies for BLCA.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Qingyun Zhang, Qinqiao Lai, Shan Wang, Qinggui Meng, Zengnan Mo
Summary: The dynamic change of postoperative NLR is a potential marker for the early detection of bladder cancer recurrence. Patients with increased NLR after surgery tend to have higher risk of recurrence.
CANCER MANAGEMENT AND RESEARCH
(2021)
