Review
Cardiac & Cardiovascular Systems
Hui Jiang, Yongwen Zhou, Seyed M. Nabavi, Amirhossein Sahebkar, Peter J. Little, Suowen Xu, Jianping Weng, Jianjun Ge
Summary: Atherosclerosis is an immuno-metabolic disease involving chronic inflammation, oxidative stress, epigenetics, and metabolic dysfunction. Oxidation of low-density lipoprotein (LDL) is a primary modification in atherosclerosis, leading to pathophysiological changes and plaque formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Yi Zhong, Li Deng, Jiafu Li, Xiaoqiu Tan, Jian Feng
Summary: Diabetes eventually leads to chronic vascular complications, with TGR5 potentially serving as a novel therapeutic target for diabetes-associated endothelial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Lei Zhao, Cheng-Lin Zhang, Lei He, Qinghua Chen, Limei Liu, Lijing Kang, Jian Liu, Jiang-Yun Luo, Lingshan Gou, Dan Qu, Wencong Song, Chi Wai Lau, Ho Ko, Vincent C. T. Mok, Xiao Yu Tian, Li Wang, Yu Huang
Summary: Monomerization and uncoupling of eNOS play crucial roles in mediating vascular dysfunction in diabetes. This study reveals that impaired autophagic flux leads to eNOS monomerization and reduced nitric oxide bioavailability in diabetic mice. Restoring autophagic flux improves endothelial cell oxidative stress, promotes eNOS dimerization, and enhances endothelium-dependent relaxations in diabetic mice.
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Raul Lopez-Fernandez-Sobrino, Jorge R. Soliz-Rueda, Javier Avila-Roman, Anna Arola-Arnal, Manuel Suarez, Begona Muguerza, Francisca Isabel Bravo
Summary: The study found that wine lees powder has antihypertensive effects related to flavanols, anthocyanins, and endothelial factors, reducing blood pressure by affecting NO and prostacyclin production. Additionally, the antihypertensive effect of wine lees powder is mediated by SIRT1, leading to increased expression of eNos and Sirt1 genes.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Environmental Sciences
Anouar Feriani, Meriam Tir, Rafik Hachani, Mohamed Salah Allagui, Nizar Tlili, Saber Nahdi, Saleh Alwasel, Abdel Halim Harrath
Summary: This study is the first to examine the potential mechanism by which long-term exposure to permethrin promotes arterial retention of proatherogenic lipids and lipoproteins, leading to vascular dysfunction in rats. Permethrin exposure induces arterial oxidative damage, exacerbates inflammatory responses, and disrupts the aortic extracellular matrix content.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cardiac & Cardiovascular Systems
Xiangwen Liang, Ping Li, Wenchao Xie, Zhihai Lin, Zhengdong Wang, Shuyi Zeng, Ming Liu
Summary: This study demonstrates that febuxostat has a protective effect on endothelial dysfunction by reducing oxidative stress, inflammation, and monocyte attachment induced by ox-LDL stimulation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Sarah M. McCann Haworth, Zhengbing Zhuge, Carina Nihlen, Matilda Fornell Von Rosen, Eddie Weitzberg, Jon O. Lundberg, Rafael T. Krmar, Josefine Nasiell, Mattias Carlstrom
Summary: This study reveals that in patients with pre-eclampsia, red blood cells exhibit increased arginase activity and expression, which are correlated with disease severity. Red blood cells can mediate endothelial dysfunction in pre-eclampsia through arginase-dependent and oxidative stress-dependent mechanisms. Targeting red blood cell arginase may offer a novel treatment approach for pre-eclampsia.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, Research & Experimental
Bradley Miller, Oleg Palygin, Ashraf El-Meanawy, David L. Mattson, Aron M. Geurts, Alexander Staruschenko, Andrey Sorokin
Summary: The adaptor protein p66Shc plays a crucial role in oxidative stress-related diseases and abnormal signaling of p66Shc may affect nephrons development and renal function negatively. Furthermore, irregular H2O2 renal production could also have a negative impact on kidney diseases and hypertension-induced nephropathy.
Article
Nutrition & Dietetics
Jia-Ning Syu, Hung-Yu Lin, Tun Yu Huang, Der-Yen Lee, En-Pei Isabel Chiang, Feng-Yao Tang
Summary: In this study, it was found that trimethylamine-N-oxide (TMAO) has detrimental effects on the neovascularization of human endothelial progenitor cells (hEPCs), while docosahexaenoic acid (DHA) could alleviate these effects. The mechanism involves upregulation of miR-221 level, inactivation of Akt/eNOS and MAPK/ERK signaling cascades, suppression of ?-GCS protein, and decreased levels of glutathione (GSH) and GSH/GSSG ratio. DHA reverses these effects by suppressing miR-221 level, activating Akt/eNOS and MAPK/ERK signaling cascades, increasing expression of ?-GCS protein, and increasing cellular GSH level and GSH/GSSG ratio in hEPCs.
Article
Biochemistry & Molecular Biology
Layal El-Hajjar, Judy Hindieh, Rana Andraos, Marwan El-Sabban, Jalil Daher
Summary: Cardiovascular disease caused by atherosclerosis is a major cause of death worldwide. This study explores the role of oxidized LDL and the LOX-1 scavenger receptor in endothelial dysfunction and inflammation, providing insight into the pathways involved in atherosclerosis progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Polyxeni Papadea, Electra Kalaitzopoulou, Marianna Skipitari, Athina Varemmenou, Marios Papasotiriou, Evangelos Papachristou, Dimitrios Goumenos, Tilman Grune, Christos D. Georgiou
Summary: Maintenance peritoneal dialysis (PD) is associated with cardiovascular diseases (CVDs), assessed via LDL-C. This study measures six novel oxLDL markers in atherosclerosis-prone PD patients, chronic kidney disease patients under hemodialysis (HD) and healthy controls. The levels of all oxLDL lipid-OOH markers were significantly elevated in PD patients versus control, while the levels of cholesteryl ester-/triglyceride-/free cholesterol-OOH were significantly elevated in PD versus HD patients. The study suggests the potential prognostic value of oxLDL regarding CVD risk assessment.
Review
Cardiac & Cardiovascular Systems
Mariann Gyongyosi, Pilar Alcaide, Folkert W. Asselbergs, Bianca J. J. M. Brundel, Giovanni G. Camici, Paula da Costa Martins, Peter Ferdinandy, Marianna Fontana, Henrique Girao, Massimiliano Gnecchi, Can Gollmann-Tepekoylu, Petra Kleinbongard, Thomas Krieg, Rosalinda Madonna, Melanie Paillard, Antonis Pantazis, Cinzia Perrino, Maurizio Pesce, Gabriele G. Schiattarella, Joost P. G. Sluijter, Sabine Steffens, Carsten Tschope, Sophie Van Linthout, Sean M. Davidson
Summary: Long COVID is a global non-communicable epidemic characterized by long-lasting multiorgan symptoms after SARS-CoV-2 infection has subsided. This scientific document aims to provide insight into the cardiovascular manifestations of long COVID and the possible causes and therapeutic options available. Imaging has shown evidence of chronic perimyocarditis, arterial wall inflammation, and microthrombosis in certain patient populations. Understanding the underlying cellular and molecular mechanisms is crucial for the development of effective treatment strategies. However, current biomarkers are not highly predictive for the presence or outcome of long COVID.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Liberale, Simon Kraler, Yustina M. Puspitasari, Nicole R. Bonetti, Alexander Akhmedov, Stefano Ministrini, Fabrizio Montecucco, Nikolaus Marx, Michael Lehrke, Niels Ulrik K. Hartmann, Jurg H. Beer, Florian A. Wenzl, Francesco Paneni, Thomas F. Luscher, Giovanni G. Camici
Summary: The study showed that SGLT-2 inhibition by empagliflozin does not impact experimental arterial thrombus formation, neither under baseline conditions nor during sustained low-grade inflammation. The results suggest that the beneficial effects of empagliflozin are likely independent of pathways mediating arterial thrombosis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Federico Carbone, Edoardo Elia, Matteo Casula, Aldo Bonaventura, Maria Bertolotto, Silvia Minetti, Nathan Artom, Giovanni G. Camici, Paola Contini, Roberto Pontremoli, Francesca Viazzi, Stefano Bertolini, Aldo Pende, Livia Pisciotta, Fabrizio Montecucco, Luca Liberale
Summary: This study investigated the potential influence of neutrophils and their degranulation markers on the improvement of metabolic syndrome. The findings showed a negative correlation between baseline MMP8 levels and MetS improvement, suggesting the pivotal role of inflammation in metabolic alteration.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Liberale, Yustina M. Puspitasari, Stefano Ministrini, Alexander Akhmedov, Simon Kraler, Nicole R. Bonetti, Georgia Beer, Ana Vukolic, Dario Bongiovanni, Jiaying Han, Kilian Kirmes, Isabell Bernlochner, Jaroslav Pelisek, Jurg H. Beer, Zheng-Gen Jin, Daniela Pedicino, Giovanna Liuzzo, Konstantinos Stellos, Fabrizio Montecucco, Filippo Crea, Thomas F. Luscher, Giovanni G. Camici
Summary: JCAD promotes arterial thrombosis by modulating coagulation and fibrinolysis. Knockout of JCAD reduces thrombogenicity in mice, and silencing of JCAD inhibits the expression of coagulation factors and fibrinolysis factors. These findings suggest JCAD as a potential therapeutic target for atherothrombosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Luciani, Daniel Mueller, Chiara Vanetta, Thamonwan Diteepeng, Arnold von Eckardstein, Stefanie Aeschbacher, Nicolas Rodondi, Giorgio Moschovitis, Tobias Reichlin, Tim Sinnecker, Jens Wuerfel, Leo H. Bonati, Seyed Soheil Saeedi Saravi, Patricia Chocano-Bedoya, Michael Coslovsky, Giovanni G. Camici, Thomas F. Luescher, Michael Kuehne, Stefan Osswald, David Conen, Juerg Hans Beer
Summary: This study investigated the role of trimethylamine-N-oxide (TMAO) in predicting adverse events in patients with atrial fibrillation. The results showed that high levels of TMAO are associated with increased risk of cardiovascular mortality and cerebral infarction.
Article
Cardiac & Cardiovascular Systems
Daniel S. Gaul, Natacha Calatayud, Jurgen Pahla, Nicole R. Bonetti, Yu-Jen Wang, Julien Weber, Samuele Ambrosini, Luca Liberale, Sarah Costantino, Shafeeq A. Mohammed, Simon Kraler, Lambertus J. Van Tits, Lisa Pasterk, Daria Vdovenko, Alexander Akhmedov, Frank Ruschitzka, Francesco Paneni, Thomas F. Luscher, Giovanni G. Camici, Christian M. Matter
Summary: Deletion of endothelial SIRT6 gene accelerates arterial thrombosis in mice, and silencing of SIRT6 enhances TF expression and activates inflammatory pathways in cultured human aortic endothelial cells.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Florian A. Wenzl, Alessandro Mengozzi, Shafeeq A. Mohammed, Nicola Riccardo Pugliese, Alessia Mongelli, Era Gorica, Samuele Ambrosini, Peter Riederer, Peter Fischer, Margareta Hinterberger, Yustina Puspitasari, Thomas F. Luscher, Giovanni G. Camici, Christian M. Matter, Gian Paolo Fadini, Agostino Virdis, Stefano Masi, Frank Ruschitzka, Edna Grunblatt, Francesco Paneni, Sarah Costantino
Summary: This study investigated the association between circulating long noncoding RNAs (lncRNAs) and incident type 2 diabetes in older adults. The researchers found that four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with the development of type 2 diabetes and were linked to hemoglobin A(1c) levels throughout the 7.5-year follow-up period.
Article
Immunology
Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi, Hao Fang
Summary: This study aimed to investigate the involvement of regulatory T cells (Tregs) in the development of postoperative cognitive dysfunction (POCD). The findings from animal experiments demonstrated that POCD in aged mice was accompanied by elevated levels of inflammatory factors and increased circulating Tregs. Transfusion of Tregs from young mice partially restored the blood-brain barrier structure and alleviated POCD in aged mice, indicating a crucial role of aged Tregs in the occurrence of POCD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Seyed Soheil Saeedi Saravi, Nicole R. Bonetti, Ana Vukolic, Daria Vdovenko, Pratintip Lee, Luca Liberale, Cristina Basso, Stefania Rizzo, Alexander Akhmedov, Thomas F. Luscher, Giovanni G. Camici, Jurg H. Beer
Summary: This study investigated the preventive effects of long-term dietary alpha linolenic acid (ALA) on left ventricular diastolic dysfunction and vascular aging in aged mice. The results showed that long-term dietary ALA supplementation could alleviate age-related left ventricular diastolic dysfunction, impaired vasorelaxation, cardiac fibrosis, inflammation, and arterial stiffening, accompanied by reductions in fibrosis biomarkers expression. This study provides evidence for the efficacy of ALA in preventing age-related heart failure and vascular dysfunction.
VASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Philipp F. Baumgartner, Martin Reiner, Andrea Wiencierz, Michael R. Coslovsky, Nicole G. Bonetti, Mark Filipovic, Stefanie Aeschbacher, Michael S. Kuhne, Christine Zuern, Nicolas Rodondi, Jolanda Oberle, Giorgio F. Moschovitis, Thomas G. Luscher, Giovanni Camici, Stefan Osswald, David Conen, Jurg H. Beer
Summary: This study found no strong evidence for an association between n-3 FA blood levels and AF type, but higher total n-3 FA levels and docosahexaenoic acid may be correlated with lower heart rate, and docosapentaenoic acid with lower heart rate variability triangular index.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Kraler, Florian A. Wenzl, Jody Vykoukal, Johannes F. Fahrmann, Ming-Yi Shen, Der-Yuan Chen, Kuan-Cheng Chang, Ching-Kun Chang, Arnold von Eckardstein, Lorenz Raber, Francois Mach, David Nanchen, Christian M. Matter, Luca Liberale, Giovanni G. Camici, Alexander Akhmedov, Chu-Huang Chen, Thomas F. Luscher
Summary: Changes in LDL electronegativity are associated with adverse outcomes in patients with ACS, including increased all-cause and cardiovascular mortality. The LDL lipidome is also affected by these alterations, and specific lipid species are independently associated with fatal events.
Article
Cardiac & Cardiovascular Systems
Kangmin Yang, Srividya Velagapudi, Alexander Akhmedov, Simon Kraler, Tetiana Lapikova-Bryhinska, Martin O. Schmiady, Xiaoping Wu, Leiluo Geng, Giovanni G. Camici, Aimin Xu, Thomas F. Luscher
Summary: This study aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice. The results showed that arterial SIRT1 levels were significantly reduced in diabetic conditions, while rmSIRT1 supplementation restored SIRT1 levels and improved endothelial function and vascular compliance. The study suggests that SIRT1 supplementation may represent a novel therapeutic strategy to prevent and treat diabetic vascular disease by enhancing eNOS activity and suppressing NOX-related oxidative stress.
CARDIOVASCULAR RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alessandro Scuricini, Francesco Andreozzi, Cosimo Sgura, Stefano Ministrini, Maria Bertolotto, Davide Ramoni, Luca Liberale, Giovanni G. Camici, Gaia C. Mannino, Elena Succurro, Giuseppe Armentaro, Teresa V. Fiorentino, Velia Cassano, Sofia Miceli, Maria Perticone, Mariangela Rubino, Giorgio Sesti, Fabrizio Montecucco, Angela Sciacqua, Federico Carbone
Summary: Diabetic cardiomyopathy is characterized by restrictive pattern and the risk of heart failure. The osteopontin (OPN) was independently associated with left ventricular diastolic dysfunction and increased with the severity of DbCM.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Florian A. Wenzl, Francesco Bruno, Simon Kraler, Roland Klingenberg, Alexander Akhmedov, Stefano Ministrini, Karine Santos, Konstantin Godly, Julia Godly, David Niederseer, Robert Manka, Andreas Bergmann, Giovanni G. Camici, Arnold von Eckardstein, Barbara Staehli, Olivier Muller, Marco Roffi, Lorenz Raeber, Thomas F. Luescher, SPUM ACS Investigators
Summary: This study identifies circulating DPP3 as a novel marker of cardiogenic shock (CS) and increased mortality in patients with acute coronary syndromes (ACS). Persistently elevated cDPP3 levels at 12-24 h were associated with significantly higher 30-day and 1-year mortality risk. These findings are consistent across various patient subgroups.
EUROPEAN HEART JOURNAL
(2023)
Article
Hematology
Nicole R. Bonetti, Annukka S. Jouppila, Seyed Soheil Saeedi Saravi, Brian C. Cooley, Lisa Pasterk, Luca L. Liberale, Sara Gobbato, Thomas F. Luscher, Giovanni G. Camici, Riitta P. Lassila, Jurg H. Beer
Summary: This study investigated the effects of a semi-synthetic dual antiplatelet and anticoagulant (APAC) on arterial thrombosis. The results showed that APAC can target vascular injury sites after administration, exerting local dual antiplatelet and anticoagulant actions, and reducing thrombosis caused by carotid injuries in mice. This study suggests that APAC may be a novel antithrombotic that can help reduce the risk of cardiovascular complications.
THROMBOSIS RESEARCH
(2023)