Article
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Evangelia Gkougkoudi, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Georgia Valsami
Summary: Dabigatran etexilate and exercise training have complementary effects on the development and stability of atherosclerotic lesions in diabetic mice, mediated by anti-inflammatory modulation.
Article
Endocrinology & Metabolism
Julia Leipner, Tsai-Sang Dederichs, Alexander von Ehr, Simon Rauterberg, Carolin Ehlert, Julian Merz, Bianca Dufner, Natalie Hoppe, Katja Krebs, Timo Heidt, Constantin von zur Muehlen, Peter Stachon, Klaus Ley, Dennis Wolf, Andreas Zirlik, Christoph Bode, Ingo Hilgendorf, Carmen Haerdtner
Summary: The study provides genetic evidence that selectively altering macrophage polarization induces a stable plaque phenotype in mice. Specific deletion of IRF5 in myeloid cells showed protective effects against atherosclerosis by altering plaque composition and reducing inflammatory gene expression. Though the plaque size was not reduced, the study suggests a potential therapeutic target in modulating macrophage function to stabilize atherosclerotic plaques.
MOLECULAR METABOLISM
(2021)
Article
Immunology
Yifan Cai, Qiutang Zeng, Yuzhou Liu, Ruirui Zhu, Kunwu Yu, Wenbin Xu, Yue Wang, Yan Ding, Jian Yu, Chengliang Pan, Yudong Peng, Yi Mao, Peng Cheng, Lun Huang, Xiaobo Mao, Yucheng Zhong
Summary: The study demonstrated that GARP overexpression enhances Treg cell activity, suppresses Th1 and Th17 function, and reduces INF-gamma and IL-17A secretion, leading to a protective effect on atherosclerosis. In vitro experiments showed that GARP-tDCs have a tolerance-inducing phenotype and can induce tolerance when co-cultured with CD4(+) T cells. Furthermore, adoptive transmission of GARP-tDCs results in reduced atherosclerotic plaque size.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Tieying Yin, Yanhong Li, Yuzhen Ren, Atik Rohmana Maftuhatul Fuad, Fangfang Hu, Ruolin Du, Yang Wang, Guixue Wang, Yazhou Wang
Summary: The study investigated the effects of PLGA NPs on the development of aortic atherosclerotic plaques in ApoE(-/-) mice, showing that the accumulation of PLGA NPs significantly increased plaque extension, expression of inflammatory factors, and accelerated macrophage conversion to foam cells. These results highlight the importance of understanding the interaction between PLGA NPs and atherosclerotic plaques for future nanomaterial design and use in cardiovascular disease treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Qing Li, Xu Zhang, Yushi Du, Xiuping Liu, Guanyu Chen, Panying Xiang, Hao Wu, Chaoqun Liu, Dongliang Wang
Summary: Brussels chicory may help stabilize atherosclerotic plaques by reducing intestinal permeability and gut microbial LPS production.
JOURNAL OF NUTRITION
(2022)
Article
Cell Biology
Gary Ro-Lin Chang, Wei-Yuan Cheng, Hueng-Chuen Fan, Hsiao-Ling Chen, Ying-Wei Lan, Ming-Shan Chen, Chih-Ching Yen, Chuan-Mu Chen
Summary: This study found that kefir peptides (KPs) have preventive effects on vascular calcification (VC) and osteoporosis in ApoE(-/-) mice fed a high-cholesterol atherogenic diet (AD). KPs alleviate the development of these diseases by reducing oxidative stress and inflammatory responses. These findings contribute to the application of KPs as preventive medicines for the treatment of hyperlipidemia-induced vascular and bone degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Junpei Sanada, Atsushi Obata, Yoshiyuki Obata, Yoshiro Fushimi, Masashi Shimoda, Kenji Kohara, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Summary: The study analyzed the anti-atherosclerotic effects of Dula in early and late phases of diabetes, finding that Dula demonstrated more beneficial effects in the early phase of diabetes compared to the late phase.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Pauline Puylaert, Melissa Van Praet, Frederik Vaes, Cedric H. G. Neutel, Lynn Roth, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Summary: GSDMD plays a critical role in atherosclerotic plaque destabilization, with its deficiency leading to increased plaque stability and apoptosis. Targeting GSDMD may be an effective approach to limit the transition to an inflammatory, vulnerable plaque phenotype.
Article
Biology
Chen-Chung Liao, Jin-Wei Xu, Wen-Ching Huang, Hung-Chang Chang, Yu-Tang Tung
Summary: Exercise can mitigate atherosclerosis by improving complement system activation and reducing inflammation in the aorta. This study found that exercise intervention had systematic effects on an ApoE knockout atherosclerotic model and high-fat-diet intervention, modulating multiple pathways and proteins associated with cardiovascular disease.
Article
Biochemistry & Molecular Biology
So-Yeon Choi, Eun-Bi Lee, Jee-Hae Kim, Jong Ran Lee
Summary: Over-expression of p190RhoGEF promotes atherosclerotic plaque formation, increases secretion of inflammatory cytokines, and enhances inflammatory responses. These results highlight the crucial role of enhanced p190RhoGEF expression in the progression of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Jiyun Liu, Mohammed E. Hefni, Cornelia M. Witthoft, Maria Bergstrom, Stephen Burleigh, Margareta Nyman, Frida Hallenius
Summary: This study found that the flavonoids and dietary fiber in lingonberries have different effects on atherosclerotic plaques, gut microbiota, and metabolites.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Laeticia Scherler, Sofia N. Verouti, Daniel Ackermann, Bruno Vogt, Genevieve Escher
Summary: In this study, adenine was used to induce nephropathy in mice, showing the loss of protective effects of renal cholesterol and vitamin D-3 metabolism under this condition. It was found that adenine enhanced cholesterol efflux and eliminated lipids in feces, which had a protective effect against atherosclerosis but also affected bone growth.
Article
Biochemistry & Molecular Biology
Aneta Stachowicz, Anna Wisniewska, Katarzyna Kus, Magdalena Bialas, Magdalena Lomnicka, Justyna Toton-Zuranska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Beata Bujak-Gizycka, Jacek Jawien, Rafal Olszanecki
Summary: DIZE stabilized atherosclerotic lesions and attenuated hepatic steatosis in apoE(-/-) mice fed a high-fat diet, likely through regulating macrophages, increasing alpha-smooth muscle actin levels, and changing macrophage polarization. Furthermore, DIZE showed anti-steatotic effects in the liver by increasing HDL levels, decreasing triglycerides levels, and promoting taurine biosynthesis and concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Wanzhong Yuan, Jianlin Zhang, Ran Huo, Chaofan Hou, Jun Yang, Tao Wang
Summary: Intraperitoneal injection of FT-H in APOE-knockout mice resulted in lower glucose and lipid levels, reduced iron deposition and collagen content in the arteries, improved arterial structure, and inhibited the progression of aortic atherosclerosis in mice.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Eirini Christodoulou, Georgia Valsami, Nikolaos Kostomitsopoulos
Summary: This study evaluated the effects of exercise training on the progression of atherosclerotic lesions in hypercholesterolemic mice. It was found that exercise training reduced aortic stenosis, increased fibrous cap thickness and collagen/elastin content within plaques. Furthermore, exercise training decreased the concentrations of VE-cadherin, MMP-8 and MMP-9, while increasing the concentrations of TIMP-1 and TIMP-2 within the plaques.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Ignatios Ikonomidis, George Pavlidis, Nikolaos Kadoglou, George Makavos, Konstantinos Katogiannis, Aikaterini Kountouri, John Thymis, Gavriella Kostelli, Irini Kapniari, Konstantinos Theodoropoulos, John Parissis, Pelagia Katsimbri, Evangelia Papadavid, Vaia Lambadiari
Summary: The phosphodiesterase 4 inhibitor apremilast has significant effects on endothelial glycocalyx, vascular, and myocardial function in the treatment of psoriasis. It restores glycocalyx integrity and confers greater improvement in vascular and myocardial function compared to anti-tumor necrosis factor-alpha or cyclosporine.
Article
Pharmacology & Pharmacy
Adam Paclawski, Stavros Politis, Evangelos Balafas, Ekaterini Mina, Paraskevi Papakyriakopoulou, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Dimitrios M. Rekkas, Georgia Valsami, Stefano Giovagnoli
Summary: This study developed a novel highly performing inhalable acetylsalicylic acid dry powder using nano spray-drying technique and leucine as an excipient. Compared with oral administration, the dry powder showed faster absorption in blood and higher retention in the lungs. The results suggest that this dry powder formulation has promising features for the treatment of inflammatory and infectious lung diseases.
Article
Biochemistry & Molecular Biology
Paraskevi B. Vasilakopoulou, Aimilia-Tatiana Gousgouni, Amalia E. Yanni, Nikolaos Kostomitsopoulos, Vaios T. Karathanos, Antonia Chiou
Summary: The present study evaluated different extraction methods for polar phenolic moieties from plasma and serum, and assessed the presence of these substances in the serum of rats following a long-term diet supplemented with Corinthian Currant. Most polar phenolics were found as phase II metabolites in the bloodstream.
Review
Biology
Elina Khattab, Nikolaos Velidakis, Evaggelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Exercise-induced pulmonary hypertension (EIPH) is characterized by an increase in pulmonary arterial pressure during exercise in otherwise healthy individuals. It may precede the development of manifest pulmonary hypertension and is associated with decreased life expectancy in patients with heart failure or left ventricle valvular diseases. The gold standard for EIPH assessment is right heart catheterization, but non-invasive methods like exercise stress echocardiography and cardiopulmonary exercise testing are also used. However, further research is needed to determine the role of EIPH diagnosis in clinical practice.
Review
Biochemistry & Molecular Biology
Konstantinos Parperis, Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Pulmonary hypertension is commonly seen in patients with systemic lupus erythematosus, presenting with non-specific symptoms and negatively affecting survival. It can result from immune system dysregulation, as well as various other conditions. Early diagnosis and identification of underlying pathogenetic mechanisms are crucial for introducing targeted therapy and preventing irreversible pulmonary vascular damage. The management of pulmonary hypertension in SLE patients is similar to that of idiopathic PAH, but specific diagnostic tools for early diagnosis seem to be unavailable yet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ekaterina-Michaela Tomou, Paraskevi Papakyriakopoulou, Helen Skaltsa, Georgia Valsami, Nikolaos P. E. Kadoglou
Summary: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, making it a top priority for scientific research to find interventions that modify risk factors. Herbal supplements, such as apigenin, quercetin, and silibinin, have shown potential as beneficial supplements for preventing CVDs. This comprehensive review focuses on the cardioprotective effects and mechanisms of these compounds, as well as their extraction and identification methods. However, uncertainties remain due to limited clinical studies, inconsistent doses, diverse constituents, and the lack of pharmacodynamic/pharmacokinetic analyses.
Article
Biochemistry & Molecular Biology
Antonios D. Tsiailanis, Constantinos C. Tellis, Paraskevi Papakyriakopoulou, Androniki D. Kostagianni, Vasileios Gkalpinos, Christos M. Chatzigiannis, Nikolaos Kostomitsopoulos, Georgia Valsami, Alexandros D. Tselepis, Andreas G. Tzakos
Summary: The simultaneous administration of three antiplatelet agents is an efficient strategy for preventing atherothrombotic events, but it increases the risk of bleeding. Finding new antiplatelet agents with improved efficacy and fewer side effects is important. In this study, the flavonoid apigenin was found to target different platelet activation pathways and hybridization with docosahexaenoic acid (DHA) enhanced its inhibitory activity against platelet aggregation. The new hybrid molecule, 4'-DHA-apigenin, showed significantly enhanced inhibitory activity in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Vasiliki Kompoura, Ioanna Prapa, Paraskevi B. B. Vasilakopoulou, Gregoria Mitropoulou, Grigorios Nelios, Evangelos Balafas, Nikolaos Kostomitsopoulos, Antonia Chiou, Vaios T. T. Karathanos, Eugenia Bezirtzoglou, Yiannis Kourkoutas, Amalia E. E. Yanni
Summary: The study aimed to investigate the benefits of a dietary intervention with Corinthian currants, which are rich in phenolic compounds, on type 1 diabetes. The results showed that the currant diet restored serum phenolic compounds, decreased IL-1b levels, and improved the balance of gut microbiota.
Article
Biology
Alkistis Kapelouzou, Styliani Geronikolou, Irene Lidoriki, Christos Kontogiannis, Loukas Kaklamanis, Loukas Tsourelis, Dennis V. V. Cokkinos
Summary: Higher levels of six biomarkers associated with cardiovascular pathology were found in the serum and tissue of patients with Degenerative Aortic Stenosis (DAS). These biomarkers were also present in the aortic valve cusps of DAS patients but not in transplantation valves. The study aims to investigate novel biomarkers to understand the biological processes involved in DAS.
Article
Biochemistry & Molecular Biology
Stelios Zerikiotis, Panagiotis Efentakis, Danai Dapola, Anna Agapaki, Georgios Seiradakis, Nikolaos Kostomitsopoulos, Alexios-Leandros Skaltsounis, Ioulia Tseti, Filippos Triposkiadis, Ioanna Andreadou
Summary: This study evaluates and compares the potential pulmonary protective effects of natural prolyl oligopeptidase (POP) inhibitors against lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS). The combination of rosmarinic acid (RA) and gallic acid (GA) shows synergistic effects in improving respiratory parameters, reducing inflammation, and decreasing cell damage, suggesting their potential prophylactic/therapeutic intervention against ARDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Grigorios Nelios, Ioanna Prapa, Anastasios Nikolaou, Gregoria Mitropoulou, Amalia E. Yanni, Nikolaos Kostomitsopoulos, Yiannis Kourkoutas
Summary: The viability of Lacticaseibacillus rhamnosus OLXAL-1 cells immobilized on cereals and fruits was investigated in comparison to free cells through both in vitro and in vivo experiments. The results showed higher survival rates of immobilized cells during in vitro digestion, with the highest survival rate observed in oat flakes (84.76%). In the subsequent in vivo experiment, mice receiving immobilized cells exhibited significantly higher lactobacilli counts in feces compared to those fed with free cells (8.02 log CFU/g and 7.64 log CFU/g, respectively). Multiplex PCR analysis confirmed the presence of L. rhamnosus cells at levels > 6 log CFU/g in the feces of both groups.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Evangelia Gkougkoudi, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Georgia Valsami
Summary: Dabigatran etexilate and exercise training have complementary effects on the development and stability of atherosclerotic lesions in diabetic mice, mediated by anti-inflammatory modulation.
Review
Chemistry, Medicinal
Kyriakos Goulas, Dimitrios Farmakis, Anastasia Constantinidou, Nikolaos P. E. Kadoglou
Summary: This systematic review and meta-analysis found that the use of beta-blockers, angiotensin receptor blockers, or angiotensin converting enzyme inhibitors did not significantly reduce the occurrence of cardiotoxicity in breast cancer patients receiving trastuzumab therapy.
Review
Biology
Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Left ventricular valvular diseases are common causes of pulmonary hypertension. The pathophysiology involves increased left ventricular filling pressure and left atrial pressure, leading to elevated pulmonary artery pressure and increased pulmonary vascular resistance. Early intervention in patients with severe LV valvular diseases can improve prognosis, but post-operative cardiac and all-cause mortality rates remain relatively high.
