Article
Biochemistry & Molecular Biology
Mohammed R. Khalil, Reda S. El-Demerdash, Hazem H. Elminshawy, Eman T. Mehanna, Noha M. Mesbah, Dina M. Abo-Elmatty
Summary: The study demonstrated that bone marrow mesenchymal stem cell therapy was more effective in treating carbon tetrachloride-induced liver fibrosis in rats compared to resveratrol and Silybum marianum. Treatment significantly decreased liver enzyme levels and increased antioxidant enzyme levels, indicating an improvement in liver function.
BIOMEDICAL JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Zhang, Chengwu Huang, Tinghui Yin, Xiaoyan Miao, Huan Deng, Rongqin Zheng, Jie Ren, Shigao Chen
Summary: This study aimed to evaluate the feasibility of ultrasensitive US microvessel imaging in visualizing and quantifying hepatic microvessels in healthy and cirrhotic rats. The findings showed that ultrasensitive US microvessel imaging could detect minute vessels below the liver capsule and quantify the perfusion, tortuosity, and integrity of microvessels. Cirrhotic rats had lower vessel density and fractional moving blood volume, and higher tortuosity compared to control rats, which were strongly correlated with pathologically derived vessel density and hepatic tissue hypoxia.
Article
Cell Biology
Ivana Bertovic, Ana Bura, Antonija Jurak Begonja
Summary: Various lines of evidence indicate differences in megakaryopoiesis during development. In this study, megakaryocytes cultured from adult bone marrow and fetal livers were compared, showing that fetal liver-derived MKs produce more proplatelets in vitro, express higher levels of beta 1-tubulin, and exhibit increased internal GPIb beta staining and fluorescence intensity of GPIb beta and VWF. The data suggest that fetal liver MKs undergo cytoplasmic maturation earlier than bone marrow MKs, leading to more efficient proplatelet formation in vitro.
Article
Cell & Tissue Engineering
Wenting Wang, Weifang Ding, Xuebao Zhang, Shuang Wu, Tianxi Yu, Xin Cui, Yaqi Xie, Diandong Yang, Chunhua Lin
Summary: This study observed the effects of rat-derived bone marrow mesenchymal stem cells (BMSCs) in a rat model of Peyronie's disease (PD) and analyzed the possible mechanism. The results showed that BMSCs treatment in the active phase had better antifibrotic effects compared to the chronic phase, and the mechanism may be related to increased Smad7 expression.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Mariarita Spampinato, Cesarina Giallongo, Alessandra Romano, Lucia Longhitano, Enrico La Spina, Roberto Avola, Grazia Scandura, Ilaria Dulcamare, Vincenzo Bramanti, Michelino Di Rosa, Nunzio Vicario, Rosalba Parenti, Giovanni Li Volti, Daniele Tibullo, Giuseppe A. Palumbo
Summary: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by clonal proliferation of hematopoietic stem cells leading to bone marrow fibrosis. The main consequences of PMF include neoangiogenesis, megakaryocytes hyperplasia, extensive bone marrow fibrosis, osteosclerosis, and bone damage. The involvement of cytokines, growth factors, and resident cells in the bone marrow microenvironment are linked to disease progression in PMF.
Article
Plant Sciences
Nayeli Amalinalli Pulido-Hornedo, Javier Ventura-Juarez, Fidel Guevara-Lara, Herson Antonio Gonzalez-Ponce, Esperanza Sanchez-Aleman, Manon Buist-Homan, Han Moshage, Ma Consolacion Martinez-Saldana
Summary: This study evaluated the protective effect of Opuntia robusta fruit on liver fibrosis and found that it has antioxidant capacity. The results demonstrated that Opuntia robusta fruit can reduce fibrotic liver damage.
Article
Cell & Tissue Engineering
Marwa S. Khattab, Huda O. AbuBakr, Kassem G. El Iraqi, Naglaa A. AbdElKader, Mervat M. Kamel, Khaled Hamed Salem, Julia Steitz, Mamdouh Afify
Summary: Intra-iliac injections cause less distress on animals compared to intra-tibial injections, and by 3 weeks, the animals regained their normal activity.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Yuki Saito, Maki Miyajima, Sena Yamamoto, Norihiro Miura, Tsukasa Sato, Arisa Kita, Shogo Ijima, Mineko Fujimiya, Takako S. Chikenji
Summary: Up to 60% of SLE patients experience autonomic symptoms, and damage to the sympathetic nervous system can result in bone marrow dysfunction and multiple organ damage. This study shows that therapy targeting the nervous system can improve multiple organ damage in SLE, and the administration of BMSCs cultured on a 3D fiber scaffold can improve bone marrow neuropathy, skin lesions, kidney function, and mortality.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Hanyi Liu, Jinglin Wang, Yitao Ding, Xiaolei Shi, Haozhen Ren
Summary: Our study demonstrates that prophylactic antibiotic pretreatment can attenuate liver ischemia-reperfusion injury by reshaping the gut microbiota and altering bile acid composition. This beneficial effect is mediated through the activation of the farnesoid X receptor (FXR) pathway, which suppresses inflammatory responses and cell apoptosis in the liver. These findings suggest that targeting FXR activation may be a potential therapeutic strategy for liver injury.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Chang Lu, Cheng-Jung Ho, Hsuan-Ti Huang, Sung-Yen Lin, Shih-Hsiang Chou, Pei-Hsi Chou, Mei-Ling Ho, Yin-Chun Tien
Summary: Both bone marrow mononuclear cells (BMMNCs) and bone marrow stromal cells (BMSCs) have comparable effects on cell repopulation and interfacial allograft-bone healing after allograft anterior cruciate ligament reconstruction (ACLR). Intra-articular delivery of BM cells has limited benefits on graft cell repopulation and may cause higher inflammation in the early stage, with fibrocartilage formation in the tendon-bone interface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiaoyi Lin, Daoming Zhu, Kaiyang Wang, Pengbo Luo, Gang Rui, Youshui Gao, Fuan Liu, Hongping Yu
Summary: Activated ALDH 2 has been demonstrated to have a protective role in ethanol-induced ONFH by promoting new bone formation, reducing adipogenesis, and stimulating vascularization.
CELL PROLIFERATION
(2022)
Article
Biotechnology & Applied Microbiology
Jun Gu, Biao Gao, Hajra Zafar, Bo Chu, Xiaojun Feng, Yinjie Ni, Lin Xu, Rui Bao
Summary: This study reported a method for treating spinal cord injury in rats by combining thermo-sensitive hydrogel with Sonic Hedgehog (SHH) expressed in rat bone-marrow derived mesenchymal stem cells (RMSCs). The results demonstrated that this treatment method could improve the function of spinal cord injury and promote nerve regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Rafaela Rossetti, Felipe Augusto Ros, Lucas Eduardo Botelho de Souza, Juliana de Matos Maconetto, Pericles Natan Mendes da Costa, Fernanda Ursoli Ferreira, Josiane Serrano Borges, Julianne Vargas de Carvalho, Nayara Patricia Morotti, Simone Kashima, Dimas Tadeu Covas
Summary: The bone marrow microenvironment may contain two distinct populations of mesenchymal stromal cells (MSC), one located perivascularly and the other in the endosteum. Recent research has focused on better understanding these MSC subsets in order to improve their clinical applications. Studies indicate that compact bone is a rich source of MSC and offers lower risk of contamination by hematopoietic cells. Compact bone-derived MSC also show higher osteogenic potential compared to bone marrow-derived MSC. These findings suggest the presence of functionally different MSC populations in bone marrow and compact bone.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Cai Zhang, Qi Shao, Mingchao Liu, Xueying Wang, Juan J. Loor, Qianming Jiang, Shunan Cuan, Xinwei Li, Jianguo Wang, Yuanxiao Li, Lei He, Yong Huang, Guowen Liu, Lin Lei
Summary: Fatty liver is a prevalent metabolic disorder in dairy cows during the transition period. This study aimed to investigate liver fibrosis and its potential causal factors in cows with fatty liver. The results showed that liver fibrosis, induced by excessive accumulation of extracellular matrix, was greater in cows with fatty liver compared to normal ones. Additionally, oxidative stress, hepatocyte apoptosis, and production of inflammatory cytokines were observed in cows with fatty liver.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Oncology
Youshan Zhao, Juan Guo, Sida Zhao, Roujia Wang, Lei Shi, Ying Fang, Zheng Zhang, Luxi Song, Dong Wu, Chunkang Chang
Summary: The presence of bone marrow fibrosis in patients with myelodysplastic syndrome is associated with adverse prognostic characteristics, reduced overall survival, and higher frequency of TP53, U2AF1, and KMT2D mutations. Progression to moderate/severe fibrosis is observed in a subset of patients during follow-up, with similar clinical features, mutation landscape, and prognosis to those with fibrosis at diagnosis. These findings highlight the importance of considering bone marrow fibrosis in the prognosis and treatment selection for MDS patients.
Article
Physics, Multidisciplinary
Peng Xu, Li-E Qiang
Article
Astronomy & Astrophysics
Peng Xu, Zhi Wang, Li-E Qiang
Article
Rheumatology
Tong Chen, Peng-Cheng Xu, Shui-Yi Hu, Shan Gao, Jun-Ya Jia, Tie-Kun Yan
RHEUMATOLOGY INTERNATIONAL
(2019)
Article
Agronomy
Peng Xu, Yajun Liao, Yi Zheng, Chenxu Zhao, Xiangfei Zhang, Zhonghua Zheng, Shengji Luan
AGRICULTURAL AND FOREST METEOROLOGY
(2019)
Article
Green & Sustainable Science & Technology
Bo Luan, Ruixue Yin, Peng Xu, Xin Wang, Xiaomin Yang, Lan Zhang, Xiaoyan Tang
JOURNAL OF CLEANER PRODUCTION
(2019)
Article
Geosciences, Multidisciplinary
Peng Xu, Anping Chen, Benjamin Z. Houlton, Zhenzhong Zeng, Song Wei, Chenxu Zhao, Haiyan Lu, Yajun Liao, Zhonghua Zheng, Shengji Luan, Yi Zheng
GEOPHYSICAL RESEARCH LETTERS
(2020)
Article
Physics, Nuclear
Hong-Bo Jin, Peng Xu
Summary: TAIJI-1 is a micro-gravity experiment spacecraft aimed at verifying key techniques for gravitational wave detection, with data processing pipeline connecting the Science Operations Center and Data Processing Center. The experiment's payload detection devices are fully verified after 3 months, ensuring the spacecraft's techniques and data processing pipeline are reasonable and beneficial for future stages of the TAIJI Program.
INTERNATIONAL JOURNAL OF MODERN PHYSICS A
(2021)
Article
Physics, Multidisciplinary
Yue-Liang Wu, Zi-Ren Luo, Jian-Yu Wang, Meng Bai, Wei Bian, Rong-Gen Cai, Zhi-Ming Cai, Jin Cao, Di-Jun Chen, Ling Chen, Li-Sheng Chen, Ming-Wei Chen, Wei-Biao Chen, Ze-Yi Chen, Lin-Xiao Cong, Jian-Feng Deng, Xiao-Long Dong, Li Duan, Sen-Quan Fan, Shou-Shan Fan, Chao Fang, Yuan Fang, Ke Feng, Pan Feng, Zhun Feng, Rui-Hong Gao, Run-Lian Gao, Zong-Kuan Guo, Jian-Wu He, Ji-Bo He, Xia Hou, Liang Hu, Wen-Rui Hu, Zhi-Qiang Hu, Min-Jie Huang, Jian-Jun Jia, Kai-Li Jiang, Gang Jin, Hong-Bo Jin, Qi Kang, Jun-Gang Lei, Bo-Quan Li, Dong-Jing Li, Fan Li, Hao-Si Li, Hua-Wang Li, Liu-Feng Li, Wei Li, Xiao-Kang Li, Ying-Min Li, Yong-Gui Li, Yun-Peng Li, Yu-Peng Li, Zhe Li, Zhi-Yong Lin, Chang Liu, Dong-Bin Liu, He-Shan Liu, Hong Liu, Peng Liu, Yu-Rong Liu, Zong-Yu Lu, Hong-Wei Luo, Fu-Li Ma, Long-Fei Ma, Xiao-Shan Ma, Xin Ma, Yi-Chuan Man, Jian Min, Yu Niu, Jian-Kang Peng, Xiao-Dong Peng, Ke-Qi Qi, Li-E Qiang, Cong-Feng Qiao, Ye-Xi Qu, Wen-Hong Ruan, Wei Sha, Jia Shen, Xing-Jian Shi, Rong Shu, Ju Su, Yan-Lin Sui, Guang-Wei Sun, Wen-Lin Tang, Hong-Jiang Tao, Wen-Ze Tao, Zheng Tian, Ling-Feng Wan, Chen-Yu Wang, Jia Wang, Juan Wang, Lin-Lin Wang, Shao-Xin Wang, Xiao-Peng Wang, Yu-Kun Wang, Zhi Wang, Zuo-Lei Wang, Yu-Xiao Wei, Di Wu, Li-Ming Wu, Peng-Zhan Wu, Zhi-Hua Wu, Dong-Xue Xi, Yi-Fang Xie, Guo-Feng Xing, Lu-Xiang Xu, Peng Xu, Shu-Yan Xu, Yu Xu, Sen-Wen Xue, Zhang-Bin Xue, Chao Yang, Ran Yang, Shi-Jia Yang, Shuang Yang, Yong Yang, Zhong-Guo Yang, Yong-Li Yin, Jin-Pei Yu, Tao Yu, Ai-Bing Zhang, Chu Zhang, Min Zhang, Xue-Quan Zhang, Yuan-Zhong Zhang, Jian Zhao, Wei-Wei Zhao, Ya Zhao, Jian-Hua Zheng, Cui-Yun Zhou, Zhen-Cai Zhu, Xiao-Bo Zou, Zi-Ming Zou
Summary: The article discusses the potential of using a space borne gravitational wave detector network combining LISA and Taiji to measure the Hubble constant with greater accuracy compared to ground based detectors. Taiji, a Chinese space mission planned for launch in the early 2030s, has already conducted a pilot satellite mission to verify its feasibility. The study also presents the findings of some technology tests conducted on the Taiji-1 satellite mission.
COMMUNICATIONS PHYSICS
(2021)
Article
Physics, Nuclear
Xiaodong Peng, Hongbo Jin, Peng Xu, Zhi Wang, Ziren Luo, Xiaoshan Ma, Li-E Qiang, Wenlin Tang, Xin Ma, Yuzhu Zhang, Zuolei Wang, Pengzhan Wu, Xiaoqin Deng, Haosi Li, Liming Wu, Juan Wang, Yuxiao Wei, Zhiyong Lin, Chen Gao, Mengyuan Zhao
Summary: Taiji-1, the first satellite of the Taiji Program, has completed its nominal science operational phase and successfully accomplished the mission goal. This work reports on the methods employed in Taiji-1 GRS data processing to improve data quality and performance estimations.
INTERNATIONAL JOURNAL OF MODERN PHYSICS A
(2021)
Editorial Material
Physics, Nuclear
Yue-Liang Wu, Zi-Ren Luo, Jian-Yu Wang, Meng Bai, Wei Bian, Hai-Wen Cai, Rong-Gen Cai, Zhi-Ming Cai, Jin Cao, Bin Chen, Di-Jun Chen, Guang-Feng Chen, Kun Chen, Ling Chen, Li-Sheng Chen, Ming-Wei Chen, Wei-Biao Chen, Yan Chen, Ze-Yi Chen, Yi-Xing Chi, Lin-Xiao Cong, Jian-Feng Deng, Xiao-Qin Deng, Xiao-Long Dong, Li Duan, Da Fan, Sen-Quan Fan, Shou-Shan Fan, Chao Fang, Yuan Fang, Ke Feng, Jian-Chao Feng, Pan Feng, Zhun Feng, Chen Gao, Rui-Hong Gao, Run-Lian Gao, Bin Guo, Tong Guo, Xiao-Liang Guo, Xu Guo, Zong-Kuan Guo, Jian-Wu He, Ji-Bo He, Xia Hou, Liang Hu, Wen-Rui Hu, Zhi-Qiang Hu, Min-Jie Huang, Jian-Jun Jia, Kai-Li Jiang, Gang Jin, Hong-Bo Jin, Bao-Peng Kang, Qi Kang, Feng-Lian Kong, Jun-Gang Lei, Bo-Quan Li, Cun-Hui Li, Dong-Jing Li, Fan Li, Hao-Si Li, Hua-Dong Li, Hua-Wang Li, Jiang Li, Liu-Feng Li, Wei Li, Xiao-Kang Li, Ying-Min Li, Yong-Gui Li, Yun-Peng Li, Yu-Peng Li, Zhao Li, Zhe Li, Hong Liang, Huang Lin, Zhi-Yong Lin, Chang Liu, Dong-Bin Liu, He-Shan Liu, Hong Liu, Peng Liu, Yu-Rong Liu, Zong-Yu Lu, Hong-Wei Luo, Jun Luo, Fu-Li Ma, Long-Fei Ma, Xiao-Shan Ma, Xin Ma, Yi-Chuan Man, Jun-Cheng Mao, Jian Min, Yu Niu, Jian-Kang Peng, Xiao-Dong Peng, Ke-Qi Qi, Li-E Qiang, Cong-Feng Qiao, Ye-Xi Qu, Wen-Hong Ruan, Wei Sha, Jia Shen, Xing-Jian Shi, Rong Shu, Ju Su, Peng Su, Yan-Lin Sui, Guang-Wei Sun, He-Ping Tan, Wen-Lin Tang, Hong-Jiang Tao, Wen-Ze Tao, Zheng Tian, Ling-Feng Wan, Chen-Yu Wang, Jia Wang, Juan Wang, Jun-Biao Wang, Lin-Lin Wang, Peng-Cheng Wang, Shao-Xin Wang, Xiao-Peng Wang, Yan-Feng Wang, Yu-Kun Wang, Zhi Wang, Zuo-Lei Wang, Yong-Qiang Wei, Yu-Xiao Wei, Di Wu, Li-Ming Wu, Peng-Zhan Wu, Zhi-Hua Wu, Dong-Xue Xi, Yi-Fang Xie, Guo-Feng Xin, Heng-Tong Xu, Lu-Xiang Xu, Peng Xu, Shu-Yan Xu, Yu Xu, Bing Xue, Da-Tong Xue, Sen-Wen Xue, Zhang-Bin Xue, Chao Yang, Ran Yang, Shi-Jia Yang, Shuang Yang, Yong Yang, Zhong-Guo Yang, Yong-Li Yin, Du-Li Yu, Jin-Pei Yu, Tao Yu, Ai-Bing Zhang, Bing Zhang, Chu Zhang, Min Zhang, Jing Zhang, Rui-Jun Zhang, Xiao-Feng Zhang, Xiao-Qing Zhang, Xue-Quan Zhang, Yong-He Zhang, Yu-Zhu Zhang, Yuan-Zhong Zhang, Meng-Yuan Zhao, Jian Zhao, Wei-Wei Zhao, Ya Zhao, Jian-Hua Zheng, Cui-Yun Zhou, Ying Zhou, Ren Zhu, Xiao-Cheng Zhu, Xiao-Yi Zhu, Zhen-Cai Zhu, Xiao-Bo Zou, Zi-Ming Zou
INTERNATIONAL JOURNAL OF MODERN PHYSICS A
(2021)
Article
Astronomy & Astrophysics
Yuchan Yang, Wen-Biao Han, Qianyun Yun, Peng Xu, Ziren Luo
Summary: This work discusses the improvement that the joint network of LISA and Taiji could provide on exploring two kinds of black hole formation mechanisms. The joint network has the potential to observe growing light seeds in the range 15 < z < 20, shedding light on the light seeding mechanism. For primordial origin, the joint network expands LISA's horizon towards lower mass end, increasing the chance of observing primordial black holes. The joint network also significantly improves the estimation of parameters.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Astronomy & Astrophysics
Gang Wang, Bin Li, Peng Xu, Xilong Fan
Summary: In this study, we characterize the noise components in LISA gravitational wave data by combining TDI channels from Michelson and Relay configurations. Based on the noise characterization, we reconstruct the noise power spectrum and estimate the parameters and spectrum of stochastic gravitational wave signals.
Article
Engineering, Aerospace
Liming Wu, Peng Xu, Shuhong Zhao, Li-E Qiang, Ziren Luo, Yueliang Wu
Summary: Taiji-1 is the first technology demonstration satellite of China's Taiji program for space-borne gravitational wave antenna. It collects data to serve as a gravity recovery mission for China, providing independent measurement of the global static and monthly time-variable gravity field.
MICROGRAVITY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Aerospace
Xiaokang Li, Heshan Liu, Pengzhan Wu, Haosi Li, Peng Xu, Ziren Luo
Summary: The laser frequency fluctuation leads to significant phase noise in the interferometer, which is a major challenge in space-borne gravitational wave detection missions. To address this issue, a post data processing method called time delay interferometer was developed and experimentally validated. The experimental results showed that the time delay interferometer could suppress the laser frequency fluctuation noise by more than 6 orders in the frequency band from 1 mHz to 0.1 Hz.
MICROGRAVITY SCIENCE AND TECHNOLOGY
(2022)
Article
Astronomy & Astrophysics
Gang Wang, Wei-Tou Ni, Wen-Biao Han, Peng Xu, Ziren Luo
Summary: The study investigated three possible configurations of the LISA-TAIJI network, with the LISA-TAIJIm network showing the best performance in sky localization and polarization determination for massive binary systems, while LISA-TAIJIc could achieve optimal sensitivity to observe the stochastic GW background.