Article
Cell Biology
Wenhua Su, Liwen Liang, Liang Zhou, Yu Cao, Xiuli Zhou, Shiqi Liu, Qian Wang, Hong Zhang
Summary: This study identified a crucial gene, LILRB2, associated with the progression of peripheral atherosclerotic disease (PAD) through bioinformatics analysis. The role of this gene in PAD was validated using a mouse model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Clara Matei, Simona Roxana Georgescu, Ilinca Nicolae, Corina Daniela Ene, Cristina Iulia Mitran, Madalina Irina Mitran, Mircea Tampa
Summary: Investigating 30 patients with chronic spontaneous urticaria, the study revealed altered levels of TDHPs which normalized after treatment with H1-antihistamines, leading to symptom relief. These findings suggest the potential role of TDHPs in the defense against oxidative stress and in monitoring H1-antihistamine therapy in patients with chronic spontaneous urticaria.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yuki Shimba, Rena Senda, Keigo Katayama, Akihito Morita, Masahiko Ikeda, Yasutomi Kamei, Shinji Miura
Summary: The research demonstrates that inducing the expression of FOXO-1 in skeletal muscle can suppress the progression of atherosclerosis in ApoE-KO mice, reducing vascular cell adhesion molecule-1 and macrophage infiltration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Juan Ma, Hui-Min Ma, Meng-Qi Shen, Yuan Yuan Wang, Yu-Xin Bao, Yong Liu, Ya Ke, Zhong-Ming Qian
Summary: The role of iron in atherosclerosis remains controversial, but this study suggests that an increase in iron content in aortic tissues may contribute to ApoE deficiency-induced atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Shouming Luo, Xiaogen Ma, Weiqiang Wu, Shu Lin, Mindian Li, Zhihui Zhang, Ping Zhu, Zhiyuan Song
Summary: Continuous hypobaric hypoxia (CHH) may accelerate the progression of atherosclerosis by promoting angiogenesis and inflammation.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuwen Shi, Mengcheng Jiang, Yuhang Zhang, Yuanyuan Diao, Na Li, Weipeng Liu, Zhidong Qiu, Ye Qiu, Ailing Jia
Summary: This study prepared hybrid nanomicelles containing hyperoside and evaluated their effects on atherosclerosis. The results showed that these nanomicelles reduced the aortic plaque area, lowered lipid levels, decreased inflammatory factors, and improved gut bacteria. The nanomicelles also regulated gut flora and lipid metabolism, and inhibited inflammatory responses. These beneficial effects may be mediated by inhibiting NF-κB signal activation and improving gut microflora and dyslipidemia.
Article
Immunology
Lei Wang, Xiaoqi Zhao, Jiawen Ding, Yutong Liu, Han Liu, Lei Zheng, Hongting Zhao, Zichen Sun, Kuanyu Li, Jing Cai, Tong Qiao
Summary: In this study, the effect of amino oxygen ions on thermal runaway of lithium-ion batteries was measured using the double filter paper method. It was found that the pseudo-current significantly decreased when filter paper soaked with aminoxalate disodium was used, confirming the inhibitory effect of amino oxygen ions on the thermal runaway of lithium-ion batteries.
INFLAMMOPHARMACOLOGY
(2023)
Review
Peripheral Vascular Disease
A. D. Marais
Summary: This review discusses the functions, genetic variations, and clinical significance of apolipoprotein E in lipid metabolism, including its impact on dyslipidaemia, atherogenic disorders, and glomerulopathy. It also highlights the potential therapeutic approaches using mimetic peptides. Overall, apolipoprotein E plays a crucial role in determining lipid profiles and cardiovascular health, with implications for medical care improvement.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Pharmacology & Pharmacy
Chunping Liu, Guiling Chen, Yanfen Chen, Yue Dang, Guangning Nie, Dinghong Wu, Jinhua Li, Zide Chen, Hailong Yang, Dongyue He, Xiong Li, Jingbo Sun, Jiahong Lu, Lei Wang
Summary: Atherosclerosis is a chronic vascular disease characterized by lipid deposition and plaque formation. Danlou tablets showed potential in reducing aortic atherosclerotic plaques and promoting macrophage autophagy, possibly through inhibiting the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yoshinori Ohmura, Naoki Ishimori, Akimichi Saito, Takashi Yokota, Shunpei Horii, Satoshi Tokuhara, Kazuya Iwabuchi, Hiroyuki Tsutsui
Summary: Our study demonstrated that iNKT cells are involved in exacerbating plaque instability by activating inflammatory cells and upregulating MMP-2 in vascular tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Qianqian Zheng, Liangwei Duan, Yunwei Lou, Tianzhu Chao, Guo Guo, Liaoxun Lu, Hongxia Zhang, Yucong Zhao, Yinming Liang, Hui Wang
Summary: The study shows that Slfn4 plays a significant role in the pathogenesis of atherosclerosis, regulating inflammatory cell numbers and arterial plaque development. Slfn4 deficiency results in reduced inflammatory cell numbers, decreased expression of proinflammatory cytokines, and cell apoptosis.
Article
Biochemistry & Molecular Biology
Juan Ma, Christopher Qian, Yong Bao, Meng-Yue Liu, Hui-Min Ma, Meng-Qi Shen, Wei Li, Jiao-Jiao Wang, Yu-Xin Bao, Yong Liu, Ya Ke, Zhong-Ming Qian
Summary: The study found that ApoE knockout leads to the accumulation of iron in the liver and spleen of mice, which is due to the up-regulation of transferrin receptor 1 and down-regulation of ferroportin 1. Replenishment of ApoE can partially reverse the iron-related phenotype.
Article
Cell Biology
Wenwang Rao, Yunshu Zhang, Keqing Li, Xiang Yang Zhang
Summary: The ApoE gene polymorphism may impact changes in blood lipid levels and cognitive impairment in the general population, but its effects in schizophrenia have not been extensively studied. This research investigated the association of ApoE rs429358 with schizophrenia using the RBANS test and SNPStats analysis. The study found that levels of ApoA1 and ApoB were predictors for various cognitive domains in schizophrenia, with the association being regulated by the ApoE rs429358 genotype.
Article
Nutrition & Dietetics
Cheng-Hsin Lin, Hung-Yuan Li, Shu-Huei Wang, Yue-Hwa Chen, Yang-Ching Chen, Hung-Tsung Wu
Summary: The study revealed that non-nutritive sweetener AceK may exacerbate dyslipidemia and atherosclerotic lesion induced by high cholesterol diet, increasing the risk of atherosclerosis.
Article
Pharmacology & Pharmacy
Wenbing Ma, Liting Zhang, Lei Luo, Suya Zhang, Shuang Yang, Hongping Yao, Lei Zhang, Xiaoyun Lu, Weiyi Feng
Summary: This study investigates the relationship between apolipoprotein E (ApoE) gene polymorphism and carotid atherosclerosis (CAS) in the ShaanXi Han populations. The results show that the ??4 allele of ApoE, hypertension, ApoA-I, LDL-C, and TG levels are independent risk factors for CAS. Furthermore, the association between ApoE polymorphism and CAS is partially mediated through blood lipids. These findings have important implications for individual preventative and therapeutic strategies.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2022)
Article
Anesthesiology
Stephen Bruehl, Ginger Milne, Jonathan Schildcrout, Yaping Shi, Sara Anderson, Andrew Shinar, Gregory Polkowski, Puneet Mishra, Frederic T. Billings
Summary: This study examined the relationship between the dysfunctional chronic pain (Dysfunctional CP) phenotype and elevated oxidative stress (OS). The results showed that higher levels of OS were associated with more severe pain, widespread pain, greater depressive symptoms and pain catastrophizing, higher pain interference, and lower function.
Article
Nutrition & Dietetics
Yu Jiang, Yingya Zhao, Ginger Milne, Qi Dai, Qingxia Chen, Xianglan Zhang, Qing Lan, Nathaniel Rothman, Yu-Tang Gao, Qiuyin Cai, Xiao-Ou Shu, Wei Zheng, Gong Yang
Summary: This study provides evidence that the quality of dietary carbohydrate may be more important than the quantity of the intake with regard to systemic lipid peroxidation.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Allergy
Katherine N. Cahill, Pingsheng Wu, Ginger L. Milne, Taneem Amin, Joseph Singer, Katherine Murphy, Erin Lewis, Deborah Gapko, Joshua A. Boyce, Katherine M. Buchheit, Tanya M. Laidlaw
Summary: There is a discrepancy between nasal and systemic levels of mast cell products in patients with aspirin-exacerbated respiratory disease, with systemically detected levels likely derived from mast cells outside of the sinonasal cavity. Increased body mass index decreases systemic mast cell mediator production and reaction severity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Anesthesiology
David Amar, Hao Zhang, Mina K. Chung, Kay See Tan, Dawn Desiderio, Bernard J. Park, Alessia Pedoto, Nancy Roistacher, James M. Isbell, Daniela Molena, Ginger L. Milne, Bryan F. Meyers, Gregory W. Fischer, Valerie W. Rusch, David R. Jones
Summary: The study found that dual therapy comprising N-acetylcysteine plus amiodarone did not reduce the incidence of postoperative atrial fibrillation or markers of inflammation and oxidative stress early after major thoracic surgery, compared with amiodarone alone.
Article
Endocrinology & Metabolism
Caitlin Resendes, Daniel J. Horan, Alexander G. Robling, Benlian Gao, Ginger L. Milne, Matthew L. Warman
Summary: Serotonin has been found to have effects on bone, but the correlation between blood serotonin levels and bone mass is still unclear. Recent study shows that administering serotonin to mice with low serotonin levels can restore intestinal motility and bone mass, but whether it directly affects bone metabolism or indirectly affects metabolism by improving intestinal function needs further research.
Article
Environmental Sciences
Jarrod L. Eaton, Amber L. Cathey, Jennifer A. Fernandez, Deborah J. Watkins, Monica K. Silver, Ginger L. Milne, Carmen Velez-Vega, Zaira Rosario, Jose Cordero, Akram Alshawabkeh, John D. Meeker
Summary: This study aims to investigate the impact of glyphosate and its primary environmental degradate, AMPA, on oxidative stress in pregnant women. It found that an increase in urinary AMPA concentration was associated with higher levels of certain oxidative stress biomarkers, while the association with glyphosate was weaker.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Public, Environmental & Occupational Health
Jordan R. Kuiper, Katie M. O'Brien, Barrett M. Welch, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Ginger L. Milne, Shanna H. Swan, Kelly K. Ferguson, Jessie P. Buckley
Summary: The study shows that different dilution-adjustment methods can be used when combining urinary biomarker data with different measures of urinary dilution, and these methods yield comparable and comparable results.
Article
Nutrition & Dietetics
Yong-Moon Mark Park, Jenna Lilyquist, Thomas J. Van't Erve, Katie M. O'Brien, Hazel B. Nichols, Ginger L. Milne, Clarice R. Weinberg, Dale P. Sandler
Summary: Plasma carotenoids, as well as supplemental beta-carotene, were found to be associated with lower concentrations of 8-iso-PGF(2 alpha) metabolite. These associations may reflect antioxidant effects.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Anesthesiology
Stephen Bruehl, Ginger Milne, Jonathan Schildcrout, Yaping Shi, Sara Anderson, Andrew Shinar, Gregory Polkowski, Puneet Mishra, Frederic T. Billings
Summary: Total knee arthroplasty (TKA) is effective for pain reduction in most patients, but 15% or more report unsatisfactory long-term pain outcomes. Elevated perioperative oxidative stress (OS) seems to exert small but significant adverse effects on long-term post-TKA pain outcomes, although this OS seems unrelated to ischemic reperfusion (IR) injury associated with extended tourniquet use.
Article
Environmental Sciences
Kaitlin R. Taibl, Susan Schantz, Max T. Aung, Amy Padula, Sarah Geiger, Sabrina Smith, June-Soo Park, Ginger L. Milne, Joshua F. Robinson, Tracey J. Woodruff, Rachel Morello-Frosch, Stephanie M. Eick
Summary: This study is the first to investigate the relationship between PFAS exposure and biomarkers of oxidative stress during human pregnancy. The researchers found that PFOS was associated with elevated levels of oxidative stress, which is consistent with prior work in animal models and cell lines. Further research is needed to understand how prenatal PFAS exposure and maternal oxidative stress may affect fetal development.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Angel D. Davalos, Lidia Minguez-Alarcon, Thomas J. van T' Erve, Alexander P. Keil, Paige L. Williams, John D. Meeker, Ginger L. Milne, Shanshan Zhao, Russ Hauser, Kelly K. Ferguson
Summary: Phthalate exposure is associated with oxidative stress, but co-exposure confounding and joint effects need to be considered. This study examined the associations between phthalate metabolites and oxidative stress, finding positive associations in single-exposure models but clear co-exposure confounding. Several phthalate metabolites remained associated with oxidative stress in co-exposure models.
ENVIRONMENTAL RESEARCH
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Ginger Milne, Xiao-Ou Shu, Yu-Tang Gao, Qingxia Chen, Qiuyin Cai, Wan-Qing Wen, Qing Lan, Nathaniel Rothman, Wei Zheng, Gong Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Marina Nogueira, Yingya Zhao, Xingyi Guo, Hui Cai, Qing Lan, Nathaniel Rothman, Qiuyin Cai, Yu-Tang Gao, Qingxia Chen, Xiao-Ou Shu, Ginger Milne, Gong Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yingya Zhao, Marina S. Nogueira, Ginger L. Milne, Xingyi Guo, Hui Cai, Qing Lan, Nathaniel Rothman, Qiuyin Cai, Yu-Tang Gao, Qingxia Chen, Xiao-Ou Shu, Gong Yang
Summary: The study found that miRNAs associated with F2-IsoP-M are enriched for various lipid peroxidation-related processes, and some miRNAs exhibited functional interactions with mRNAs involved in the regulation of beta-oxidation.
Review
Medicine, General & Internal
Reem Saud Alhejailan, Gloria Garoffolo, Vineesh Vimala Raveendran, Maurizio Pesce
Summary: After more than 20 years of research in regenerative medicine, the best cell types and materials to effectively translate into clinical practice for cardiac diseases are still uncertain. It is now clear that the heart lacks a consistent reservoir of stem cells for generating new myocytes, and other cells may only contribute with their pro-angiogenic or immunomodulatory potential. New developments in somatic cells' reprogramming, material science, and cell biophysics may be helpful in protecting the heart and enhancing its lost regenerative potential.
JOURNAL OF CLINICAL MEDICINE
(2023)