Article
Cell Biology
Amritha Varshini Hanasoge Somasundara, Matthew A. Moss, Mary J. Feigman, Chen Chen, Samantha L. Cyrill, Michael F. Ciccone, Marygrace C. Trousdell, Macy Vollbrecht, Siran Li, Jude Kendall, Semir Beyaz, John E. Wilkinson, Camila O. dos Santos
Summary: Pregnancy induces expansion of NKT-like immune cells and upregulation of immune signaling molecules in mammary epithelial cells. Lack of CD1d expression or activated NKT cells may lead to mammary oncogenesis.
Article
Agriculture, Dairy & Animal Science
Muhammad Umair Ul Hassan Malik, Nighat Hashmi, Marium Khan, Zain ul Aabdin, Rokayya Sami, Amani H. Aljahani, Rasha A. Al-Eisa, Mamdoh S. Moawadh, Naseh A. Algehainy
Summary: The aim of this study was to evaluate the defensive role of resveratrol against oxidative stress and inflammation caused by LPS in mammary tissue of female mice. Results showed that LPS significantly increased oxidative stress and inflammatory cytokine secretion, while resveratrol administration alleviated these negative effects. Therefore, resveratrol plays a crucial role in protecting mammary glands from negative alterations.
Article
Reproductive Biology
F. A. C. C. Silva, L. E. Camacho, C. O. Lemley, D. M. Hallford, K. C. Swanson, K. A. Vonnahme
Summary: The study suggests that nutrient restriction does not affect mammary hemodynamics and endocrine profile in pregnant cows.
Article
Cell Biology
Giovanni Risato, Rudy Celeghin, Raquel Branas Casas, Alberto Dinarello, Alessandro Zuppardo, Andrea Vettori, Kalliopi Pilichou, Gaetano Thiene, Cristina Basso, Francesco Argenton, Silvia Visentin, Erich Cosmi, Natascia Tiso, Giorgia Beffagna
Summary: This study identified the Wnt/β-catenin and Jak/Stat3 pathways as key players in the development of Fetal Growth Restriction (FGR). By using drugs targeting these pathways, the researchers were able to rescue FGR phenotypes in zebrafish models. This data suggests the potential of targeting the Wnt/β-catenin pathway for pharmacological intervention in FGR.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Juliane Winkler, Pengyuan Liu, Kiet Phong, Johanna H. Hinrichs, Nassim Ataii, Katherine Williams, Elin Hadler-Olsen, Susan Samson, Zev J. Gartner, Susan Fisher, Zena Werb
Summary: The study showed that replacement bisphenols have protumorigenic effects on the mammary gland, leading to disruption of normal model structure and producing proteomic changes. This finding highlights the importance of evaluating the potential harmful effects of structurally related environmental chemicals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Sharon A. McCracken, Sean K. M. Seeho, Tamara Carrodus, Jenny H. Park, Narelle Woodland, Eileen D. M. Gallery, Jonathan M. Morris, Anthony W. Ashton
Summary: Preeclampsia and intrauterine growth restriction are major causes of maternal and fetal morbidity/mortality. This study reveals abnormal expression of hypoxia-inducible factors and identifies a significant mechanism driving maladaptive responses to hypoxia in pathological placentae from severe Preeclampsia and intrauterine growth restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Dorottya Nagy, Clare M. C. Gillis, Katie Davies, Abigail L. Fowden, Paul Rees, John W. Wills, Katherine Hughes
Summary: The research focuses on the growth of sheep TDLUs as a model for breast development, revealing differences in epithelial nuclear Ki67 positivity between younger and older lambs. The study also highlights a dynamic immune microenvironment in the sheep mammary gland, indicating its value as a model system for understanding postnatal breast development.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
Fabia de Oliveira Andrade, Lu Jin, Robert Clarke, Imani Wood, MaryAnn Dutton, Chezaray Anjorin, Grace Rubin, Audrey Gao, Surojeet Sengupta, Kevin FitzGerald, Leena Hilakivi-Clarke
Summary: Social isolation increases breast cancer mortality by increasing inflammatory cytokines and impairing mitochondrial metabolism. It impairs the response to tamoxifen therapy and increases the risk of tumor recurrence, and affects multiple signaling pathways in the mammary glands. An anti-inflammatory herbal mixture can block the effects of social isolation.
Article
Cell Biology
Anna Kosenko, Tomer Meir Salame, Gilgi Friedlander, Itamar Barash
Summary: Studies have identified macrophages and secreted CSF1 as the energy sensor and paracrine transmitter in the self-renewal of mammary stem cells. Through experiments with conditioned medium and analyses using RNA-Seq, immunohistochemistry, and immunofluorescence, this mechanism was confirmed.
Article
Agriculture, Dairy & Animal Science
Xudong Sun, Yan Tang, Chunhui Jiang, Shengbin Luo, Hongdou Jia, Qiushi Xu, Chenxu Zhao, Yusheng Liang, Zhijun Cao, Guang Shao, Juan J. Loor, Chuang Xu
Summary: This study evaluated the changes in oxidative stress, inflammation, and apoptotic pathways in the mammary gland of dairy cows with ketosis. The results indicate that the mammary gland of cows with subclinical or clinical ketosis undergoes severe oxidative stress, inflammation, and cell death.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Junqiang Lin, Shihui Ye, Hao Ke, Liang Lin, Xia Wu, Mengfei Guo, Baowei Jiao, Ceshi Chen, Limin Zhao
Summary: The functional capacity of organisms declines with aging. Abnormal mammary gland development can lead to dysfunction in milk secretion and the onset of diseases such as breast cancer. Aging is characterized by gradual degeneration of the terminal duct lobular units (TDLUs) in the breast, increased proportion of adipose tissue, and changes in hormonal levels. This review summarizes the changes in morphology, internal structure, and cellular composition that occur in the mammary gland during aging, and explores the mechanisms and relationship between breast aging and breast-related diseases, as well as potential interventions.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Lorena de Souza Almeida, Caio Jordao Teixeira, Carolina Vieira Campos, Lais Guadalupe Casaloti, Frhancielly Shirley Sodre, Vinicius Cooper Capetini, Andressa Godoy Amaral, Tanyara Baliani Payolla, Lucas Carminatti Pantaleao, Gabriel Forato Anhe, Silvana Bordin
Summary: Exposure to excess glucocorticoid during fetal development leads to intrauterine growth restriction (IUGR) and metabolic inflexibility in adulthood. When combined with fructose treatment, IUGR rats also develop hepatic steatosis and exhibit molecular changes associated with non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). These changes include increased myeloperoxidase activity, AKT phosphorylation, and aspartate transaminase levels, as well as altered expression of TRIB3, GADD45a, Cyclin D, PCNA, Hgf, Hspa4/Hsp70, and IGF-1.
Article
Oncology
Patrice M. Witschen, Alexis K. Elfstrum, Andrew C. Nelson, Kathryn L. Schwertfeger
Summary: The extracellular matrix (ECM) plays a vital role in the structure and function of the mammary gland, and understanding the regulation of hyaluronan (HA) in the mammary gland is important for studying mammary tumors. The researchers found that HA-rich septa exist in the mammary gland stroma during different developmental stages and heterogeneous HA deposition occurs in breast cancer models. They also identified elevated levels of Hyal1 and Hyal2 in tumor-associated macrophages (TAMs), suggesting their involvement in HA degradation within the tumor microenvironment.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2023)
Article
Endocrinology & Metabolism
Ali Abbara, Maya Al-Memar, Maria Phylactou, Elisabeth Daniels, Bijal Patel, Pei C. Eng, Rans Nadir, Chioma Izzi-Engbeaya, Sophie A. Clarke, Edouard G. Mills, Tia Hunjan, Ewa Pacuszka, Lisa Yang, Paul Bech, Tricia Tan, Alexander N. Comninos, Tom W. Kelsey, Christopher Kyriacou, Hanine Fourie, Tom Bourne, Waljit S. Dhillo
Summary: Our study aimed to evaluate the changes in circulating kisspeptin levels in women with antenatal complications. The results showed that third-trimester kisspeptin levels were higher in women with hypertensive disorders of pregnancy (HDP) but lower in those with fetal growth restriction (FGR). We found that the odds of HDP increased by 30% and the odds of FGR decreased by 28% for every 1 nmol/L increase in plasma kisspeptin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Estelle Guillot, Anna Lemay, Manon Allouche, Sara Vitorino Silva, Hanna Coppola, Florence Sabatier, Francoise Dignat-George, Alexandre Sarre, Anne-Christine Peyter, Stephanie Simoncini, Catherine Yzydorczyk
Summary: Individuals born with intrauterine growth restriction (IUGR) have an increased risk of cardiovascular diseases (CVDs). This study found that endothelial colony-forming cells (ECFCs) in male rats with IUGR exhibited dysfunction, related to oxidative stress and stress-induced premature senescence (SIPS). Treatment with resveratrol (R), a polyphenol compound, improved the functionality of ECFCs in the IUGR group by increasing proliferation, capillary-like sprout formation, nitric oxide production, and endothelial nitric oxide synthase expression, while reducing oxidative stress and reversing SIPS. However, no effects of R were observed in the control group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
R. Erber, A. Hartmann, P. Fasching, R. Stoehr, M. W. Beckmann, M. Zentgraf, M. Ruebner, H. Huebner, J. Fischer, E. Guerini Rocco, G. Viale, A. Cayre, F. Penault-Llorca, T. Caniego Casa, J. Palacios Calvo, P. Jank, C. Denkert, L. Khoury, T. Mairinger, F. Ferrazzi
ANNALS OF ONCOLOGY
(2020)
Article
Genetics & Heredity
Haoyu Zhan, Thomas U. Ahearn, Julie Lecarpentier, Daniel Barnes, Jonathan Beesley, Guanghao Qi, Xia Jiang, Tracy A. O'Mara, Ni Zhao, Manjeet K. Bolla, Alison M. Dunning, Joe Dennis, Qin Wang, Zumuruda Abu Ful, Kristiina Aittomaki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Paul L. Auer, Jacopo Azzollini, Daniel Barrowdale, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Katarzyna Bialkowska, Ana Blanco, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Davide Bondavalli, Ake Borg, Hiltrud Brauch, Hermann Brenner, Ignacio Briceno, Annegien Broeks, Sara Y. Brucker, Thomas Bruening, Barbara Burwinkel, Saundra S. Buys, Helen Byers, Trinidad Caldes, Maria A. Caligo, Mariarosaria Calvello, Daniele Campa, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Melissa Christiaens, Hans Christiansen, Wendy K. Chung, Kathleen B. M. Claes, Christine L. Clarke, Sten Cornelissen, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Orland Diez, Susan M. Domchek, Thilo Doerk, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Lenka Foretova, Florentia Fostira, Eitan Friedman, Debra Frost, Manuela Gago-Dominguez, Susan M. Gapstur, Judy Garber, Jose A. Garcia-Saenz, Mia M. Gaudet, Simon A. Gayther, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna Gonzalez-Neira, Mark H. Greene, Jacek Gronwald, Pascal Guenel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Christopher R. Hake, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk-Gerritsen, Peter Hillemanns, Frans B. L. Hogervorst, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Hanna Huebner, Peter J. Hulick, Evgeny N. Imyanitov, Claudine Isaacs, Louise Izatt, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Paul James, Ramunas Janavicius, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Pooja Middha Kapoor, Beth Y. Karlan, Renske Keeman, Sofia Khan, Elza Khusnutdinova, Cari M. Kitahara, Yon-Dschun Ko, Irene Konstantopoulou, Linetta B. Koppert, Stella Koutros, Vessela N. Kristensen, Anne-Vibeke Laenkholm, Diether Lambrechts, Susanna C. Larsson, Pierre Laurent-Puig, Conxi Lazaro, Emilija Lazarova, Flavio Lejbkowicz, Goska Leslie, Fabienne Lesueur, Annika Lindblom, Jolanta Lissowska, Wing-Yee Lo, Jennifer T. Loud, Jan Lubinski, Alicja Lukomska, Robert J. MacInnis, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Laura Matricardi, Lesley McGuffog, Catriona McLean, Noura Mebirouk, Alfons Meindl, Usha Menon, Austin Miller, Elvira Mingazheva, Marco Montagna, Anna Marie Mulligan, Claire Mulot, Taru A. Muranen, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, William G. Newman, Finn C. Nielsens, Liene Nikitina-Zake, Jesse Nodora, Kenneth Offit, Edith Olah, Olufunmilayo Olopade, Hakan Olsson, Nick Orr, Laura Papi, Janos Papp, Tjoung-Won Park-Simon, Michael T. Parsons, Bernard Peissel, Ana Peixoto, Beth Peshkin, Paolo Peterlongo, Julian Peto, Kelly-Anne Phillips, Marion Piedmonte, Dijana Plaseska-Karanfilska, Karolina Prajzendanc, Ross Prentice, Darya Prokofyeva, Brigitte Rack, Paolo Radice, Susan J. Ramus, Johanna Rantala, Muhammad U. Rashid, Gad Rennert, Hedy S. Rennert, Harvey A. Risch, Atocha Romero, Matti A. Rookus, Matthias Ruebner, Thomas Ruediger, Emmanouil Saloustros, Sarah Sampson, Dale P. Sandler, Elinor J. Sawyer, Maren T. Scheuner, Rita K. Schmutzler, Andreas Schneeweiss, Minouk J. Schoemaker, Ben Schoettker, Peter Schuermann, Leigha Senter, Priyanka Sharma, Mark E. Sherman, Xiao-Ou Shu, Christian F. Singer, Snezhana Smichkoska, Penny Soucy, Melissa C. Southey, John J. Spinelli, Jennifer Stone, Dominique Stoppa-Lyonnet, Anthony J. Swerdlow, Csilla Szabo, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Manuel R. Teixeira, MaryBeth Terry, Mads Thomassen, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Rob A. E. M. Tollenaar, Ian Tomlinson, Diana Torres, Melissa A. Troester, Therese Truong, Nadine Tung, Michael Untch, Celine M. Vachon, Ans M. W. van den Ouweland, Lizet E. van der Kolk, Elke M. van Veen, Elizabeth J. vanRensburg, Ana Vega, Barbara Wappenschmidt, Clarice R. Weinberg, Jeffrey N. Weitzel, Hans Wildiers, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Drakoulis Yannoukakos, Wei Zheng, Kristin K. Zorn, Roger L. Milne, Peter Kraft, Jacques Simard, Paul D. P. Pharoah, Kyriaki Michailidou, Antonis C. Antoniou, Marjanka K. Schmidt, Georgia Chenevix-Trench, Douglas F. Easton, Nilanjan Chatterjee, Montserrat Garcia-Closas
Article
Obstetrics & Gynecology
Hanna Huebner, Kirsten Heussner, Matthias Ruebner, Matthias Schmid, Jennifer Nadal, Joachim Woelfle, Andrea Hartner, Carlos Menendez-Castro, Manfred Rauh, Matthias W. Beckmann, Sven Kehl, Fabian B. Fahlbusch
Summary: This study compared the direct and indirect enzymatic activity of 11 β-HSD2 in placentas of women who had spontaneous births and cesarean sections. The ratio of cortisol to cortisone correlated with the direct microsomal enzymatic turnover, while mode of delivery had a strong influence on tissue steroids. HSD11B2 expression correlated with indirect and direct cortisol turnover rates in C-section placentas only, with significantly increased levels of CRH, cortisol, and cortisone following spontaneous birth.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Jutta Pretscher, Matthias Ruebner, Arif B. Ekici, Melanie Roedl, Hanna Huebner, Judith Schwitulla, Adriana Titzmann, Charlotte Hartwig, Matthias W. Beckmann, Peter A. Fasching, Michael O. Schneider, Eva Schwenke
Summary: This study identified a significant association between one SNP in the progesterone receptor and preeclampsia, suggesting a potential genetic link to the onset of preeclampsia. Further research is needed to explore the role and causal relationship of genetic variations in the development of preeclampsia.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Hematology
Shrey Kohli, Kunal Kumar Singh, Anubhuti Gupta, Paulina Markmeyer, Franziska Lochmann, Dheerendra Gupta, Rajiv Rana, Ahmed Elwakiel, Hanna Huebner, Matthias Ruebner, Berend Isermann
Summary: The study revealed a unidirectional interaction between placental inflammasome activation and reduced placental TM expression, and demonstrated that soluble TM treatment or placental TM restoration can alleviate PE-like symptoms.
Article
Multidisciplinary Sciences
Franziska M. Wuerfel, Hanna Huebner, Lothar Haeberle, Paul Gass, Alexander Hein, Sebastian M. Jud, Carolin C. Hack, Marius Wunderle, Ruediger Schulz-Wendtland, Ramona Erber, Arndt Hartmann, Arif B. Ekici, Matthias W. Beckmann, Peter A. Fasching, Matthias Ruebner
SCIENTIFIC REPORTS
(2020)
Article
Reproductive Biology
Barbara Denkl, Nada Cordasic, Hanna Huebner, Carlos Menendez-Castro, Marius Schmidt, Alexander Mocker, Joachim Woelfle, Andrea Hartner, Fabian B. Fahlbusch
Summary: The study investigates the roles of placental UPR and oxidative stress in IUGR and PE, finding that placental ER stress is not induced in rat and mouse models, while oxidative stress is significantly increased in female IUGR rat placentas.
BIOLOGY OF REPRODUCTION
(2021)
Article
Oncology
Peter A. Fasching, Siddhartha Yadav, Chunling Hu, Marius Wunderle, Lothar Haeberle, Steven N. Hart, Matthias Ruebner, Eric C. Polley, Kun Y. Lee, Rohan D. Gnanaolivu, Peyman Hadji, Hanna Huebner, Hans Tesch, Johannes Ettl, Friedrich Overkamp, Michael P. Lux, Arif B. Ekici, Bernhard Volz, Sabrina Uhrig, Diana Lueftner, Markus Wallwiener, Volkmar Mueller, Erik Belleville, Michael Untch, Hans-Christian Kolberg, Matthias W. Beckmann, Andre Reis, Arndt Hartmann, Wolfgang Janni, Pauline Wimberger, Florin-Andrei Taran, Tanja N. Fehm, Diethelm Wallwiener, Sara Y. Brucker, Andreas Schneeweiss, Andreas D. Hartkopf, Fergus J. Couch
Summary: Among patients with metastatic breast cancer, around 10.4% carry germline mutations in established breast cancer predisposition genes such as BRCA1 and BRCA2. While these mutations may impact tumor characteristics, they do not significantly affect progression-free survival or overall survival in patients with metastatic breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paulina Markmeyer, Franziska Lochmann, Kunal Kumar Singh, Anubhuti Gupta, Ruaa Younis, Khurrum Shahzad, Ronald Biemann, Hanna Huebner, Matthias Ruebner, Berend Isermann, Shrey Kohli
Summary: Research indicates that procoagulant extracellular vesicles (EV) can affect trophoblast morphology and differentiation by inducing a thrombo-inflammatory pathway, leading to an increase in giant trophoblast and spongiotrophoblast cells. These effects are related to platelet activation and NLRP3 inflammasome, with inflammasome activation in humans showing negative correlation with trophoblast differentiation marker GCM1 and positive correlation with blood pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Hanna Huebner, Hannah Lubrich, Simon Blum, Sophia Antoniadis, Johannes Lermann, Arif Ekici, Peter A. Fasching, Matthias W. Beckmann, Matthias Ruebner, Stefanie Burghaus
Summary: The study compared two extraction methods for isolating and quantifying ccfDNA from endometriosis patients, with the Maxwell method showing significantly higher yield and the QIAamp method showing higher ccfDNA integrity. Both methods are suitable for downstream applications in non-invasive detection and analysis of somatic mutations within endometriosis tissue.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Oncology
Ramona Erber, Arndt Hartmann, Peter Andreas Fasching, Matthias Ruebner, Robert Stohr, Matthias Wilhelm Beckmann, Miriam Zentgraf, Verena Popp, Jodi Weidler, Iris Simon, Steffi Becker, Hanna Huebner, Josephine Fischer, Elena Guerini Rocco, Giuseppe Viale, Anne Cayre, Frederique Penault-Llorca, Tamara Caniego Casas, Belen Perez-Mies, Jose Palacios, Paul Jank, Carsten Denkert, Lina Khoury, Thomas Mairinger, Fulvia Ferrazzi
Summary: This study compared the performance of the mRNA-based STRAT4 method with the gold standard of immunohistochemistry, finding that ESR1 and ERBB2 mRNA results were entirely consistent, while PGR and MKI67 results showed some inconsistencies.
Article
Oncology
Ramona Erber, Sareetha Kailayangiri, Hanna Huebner, Matthias Ruebner, Arndt Hartmann, Lothar Haeberle, Julia Meyer, Simon Voelkl, Andreas Mackensen, Laura Landgraf, Carol Geppert, Ruediger Schulz-Wendtland, Matthias W. Beckmann, Peter A. Fasching, Nicole Farwick, Claudia Rossig, Paul Gass
Summary: The study found that GD2 is expressed in more than 50% of breast cancer cases, with the highest frequency in hormone receptor-positive tumors. However, GD2 expression was not significantly associated with patient outcome.
Article
Oncology
Hanna Huebner, Lothar Haeberle, Volkmar Mueller, Iris Schrader, Ralf Lorenz, Helmut Forstbauer, Visnja Fink, Fabienne Schochter, Inga Bekes, Sven Mahner, Julia Jueckstock, Naiba Nabieva, Andreas Schneeweiss, Hans Tesch, Sara Y. Brucker, Jens-Uwe Blohmer, Tanja N. Fehm, Georg Heinrich, Mahdi Rezai, Matthias W. Beckmann, Peter A. Fasching, Wolfgang Janni, Brigitte Rack
Summary: CA27.29 (MUC1) is a well-known biomarker for predicting prognosis and treatment efficacy in breast cancer, mainly evaluated in the preoperative setting. This study suggests that both pre- and post-chemotherapy CA27.29 values do not provide additional prognostic information, but pre-chemotherapy CA27.29 may help identify a group with unfavorable prognosis among node-positive patients.
Article
Chemistry, Analytical
Johanna Gleichauf, Lukas Hennemann, Fabian B. B. Fahlbusch, Oliver Hofmann, Christine Niebler, Alexander Koelpin
Summary: The monitoring of vital signs and improving patient comfort in neonatal intensive care is important. Non-contact methods are being researched to resolve the discomfort caused by skin contact in preterm neonates. We propose a novel approach using fusion data of thermal and RGB cameras for neonatal face detection. Our results show high precision and increased data efficiency, contributing to the development of non-contact monitoring for preterm neonates.
Article
Obstetrics & Gynecology
Carla E. Schulmeyer, Simon Bader, Hanna Huebner, Matthias Ruebner, Peter A. Fasching
Summary: Next generation sequencing (NGS) technology has revolutionized genomic research by allowing rapid sequencing of the entire human genome within a day. It is widely used in genetic, microbiological, and oncological research, but has not yet been fully integrated into clinical routine. In obstetrics and gynecology, NGS is particularly valuable for noninvasive prenatal testing (NIPT), reproductive medicine, and oncology.