Review
Cell Biology
Kai-Wen Zhang, Yuan Jia, Yue-Yue Li, Dan-Yang Guo, Xiao-Xiao Li, Kai Hu, Xiao-Xi Qian, Zhong-Hua Chen, Jun-Jie Wu, Zheng-Dong Yuan, Feng-Lai Yuan
Summary: Wound healing is a complex process that can lead to the formation of scars in adults. Leptin and leptin receptors have been found to affect multiple stages of wound healing, but their role in scarless wound healing is paradoxical.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Environmental Sciences
Ewelina Maculewicz, Agata Leonska-Duniec, Andrzej Mastalerz, Ewa Szarska, Aleksandra Garbacz, Tomasz Lepionka, Roman Lakomy, Anna Anyzewska, Jerzy Bertrandt
Summary: This study analyzed the associations between FTO, FABP2, LEP, LEPR, and MC4R gene polymorphisms and obesity-related parameters. The FTO A/T polymorphism was found to be significantly associated with fat mass index (FMI). In addition, gene-gene interaction analysis showed that all investigated genes had additional influence on body mass index (BMI) and FMI.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Julia Wilhelm, Anna Birkenstock, Vanessa Buchholz, Astrid Mueller, Sherif Adel Aly, Kerstin Gruner-Labitzke, Hinrich Koehler, Ralf Lichtinghagen, Kirsten Jahn, Adrian Groh, Kai G. Kahl, Martina De Zwaan, Thomas Hillemacher, Stefan Bleich, Helge Frieling
Summary: The study revealed significant differences in promoter methylation levels of LEP and LEPR genes between pre- and postbariatric surgery patients, with leptin serum levels showing a significant change before and after the surgery.
Article
Biochemistry & Molecular Biology
Hanna Holysz, Anna Paszel-Jaworska, Aleksandra Romaniuk-Drapala, Sylwia Grodecka-Gazdecka, Blazej Rubis
Summary: Breast cancer is the most common type of cancer in women worldwide, with obesity identified as a significant risk factor for breast cancer development in Polish women. However, the studied gene polymorphisms did not show a significant association with breast cancer risk or disease severity. Certain gene polymorphisms may affect receptor expression and disease severity, revealing a potentially important contribution to understanding the molecular mechanisms of carcinogenesis.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Endocrinology & Metabolism
Jelte Wieting, Kirsten Jahn, Vanessa Buchholz, Ralf Lichtinghagen, Stephanie Deest-Gaubatz, Stefan Bleich, Christian K. Eberlein, Maximilian Deest, Helge Frieling
Summary: Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder characterized by insatiable appetite and obesity. This study found elevated serum leptin levels and altered DNA methylation of the leptin and leptin receptor gene in adult PWS patients.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Asta Raskiliene, Alina Smalinskiene, Vilma Kriaucioniene, Vaiva Lesauskaite, Janina Petkeviciene
Summary: The study found that the associations of MC4R and LEP gene polymorphisms with obesity-related parameters strengthened with age.
Article
Genetics & Heredity
Ivana Kolic, Ljiljana Stojkovic, Aleksandra Stankovic, Milan Stefanovic, Evica Dincic, Maja Zivkovic
Summary: The study findings suggest that investigated genetic variants have an impact on the pathogenesis of multiple sclerosis. For example, the PGC1A rs8192678 minor allele increases the risk for disease occurrence, and there is an interaction effect between LEPR variant and gender on the severity score of multiple sclerosis.
Article
Genetics & Heredity
Mao Li, Hejiang Wei, Shuyi Zhong, Yanhui Cheng, Simin Wen, Dayan Wang, Yuelong Shu
Summary: This study investigated the association of leptin gene, leptin receptor gene, and peroxisome proliferator activated receptor gamma gene polymorphisms with humoral immune response to influenza vaccine. The results showed that PPARG rs17793951 variants were significantly associated with immune response to influenza vaccine. Gender differences were found in the association of LEPR and PPARG variants with immune response to influenza vaccine.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Mahmoud A. Alfaqih, Lina Elsalem, Mohamad Nusier, Khawla Mhedat, Yousef Khader, Ebaa Ababneh
Summary: This study found a correlation between obesity and increased risk of bladder cancer. The levels of leptin and its receptor are often deregulated in obese individuals and these changes are associated with the development of bladder cancer. Additionally, certain genetic variants are also associated with bladder cancer.
Article
Oncology
Makoto Matsushita, Kazutoshi Fujita, Takuji Hayashi, Hisako Kayama, Daisuke Motooka, Hiroaki Hase, Kentaro Jingushi, Gaku Yamamichi, Satoru Yumiba, Eisuke Tomiyama, Yoko Koh, Yujiro Hayashi, Kosuke Nakano, Cong Wang, Yu Ishizuya, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Maria D. C. Rodriguez Pena, Jennifer B. Gordetsky, George J. Netto, Kazutake Tsujikawa, Shota Nakamura, Kiyoshi Takeda, Norio Nonomura
Summary: This study found that excessive intake of animal fat can change the composition of gut microbiota, leading to prostate cancer. By administering antibiotics, prostate cancer cell proliferation and IGFI levels can be inhibited, thus disrupting the growth of prostate cancer.
Article
Endocrinology & Metabolism
Manon Duquenne, Cintia Folgueira, Cyril Bourouh, Marion Millet, Anisia Silva, Jerome Clasadonte, Monica Imbernon, Daniela Fernandois, Ines Martinez-Corral, Soumya Kusumakshi, Emilie Caron, S. Rasika, Eleonora Deliglia, Nathalie Jouy, Asturo Oishi, Massimiliano Mazzone, Eric Trinquet, Jan Tavernier, Young-Bum Kim, Stephane Ory, Ralf Jockers, Markus Schwaninger, Ulrich Boehm, Ruben Nogueiras, Jean-Sebastien Annicotte, Stephane Gasman, Julie Dam, Vincent Prevot
Summary: The expression of leptin receptors in tanycytes is crucial for leptin to enter the brain and regulate peripheral lipogenesis and pancreatic beta-cell function. Tanycytic transport of leptin through LepRb-EGFR may also be important in the pathophysiology of diabetes.
Article
Multidisciplinary Sciences
Hui-Mei Chen, Yu-Chu Ella Chung, Hsi-Chung Chen, Yen-Wenn Liu, I-Ming Chen, Mong-Liang Lu, Felix Shih-Hsiang Hsiao, Chun-Hsin Chen, Ming-Chyi Huang, Wei-Liang Shih, Po-Hsiu Kuo
Summary: The microbiota-gut-brain axis signaling plays a crucial role in mood disorders. This study reveals the correlation between specific bacterial genera and miRNAs in fecal samples of MDD patients and predicts the miRNA pathways associated with MDD. These findings provide insights into the interaction between gut microbiota and miRNAs in depression.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Audrey Jalabert, Laura Reininger, Emmanuelle Berger, Yohann Coute, Emmanuelle Meugnier, Alexis Forterre, Elizabeth Errazuriz-Cerda, Alain Geloen, Myriam Aouadi, Karim Bouzakri, Jennifer Rieusset, Sophie Rome
Summary: The study revealed differences in the lipid, protein, and miRNA composition of skeletal muscle-released extracellular vesicles between atrophic insulin-resistant mice and wild-type mice, indicating a role of the ELVs in lipid metabolism and fatty acid oxidation.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Liang Li, Xingchen Meng, Liyuan Liu, Yujuan Xiang, Fei Wang, Lixiang Yu, Fei Zhou, Chao Zheng, Wenzhong Zhou, Shude Cui, Fuguo Tian, Zhimin Fan, Cuizhi Geng, Xuchen Cao, Zhenlin Yang, Xiang Wang, Hong Liang, Shu Wang, Hongchuan Jiang, Xuening Duan, Haibo Wang, Guolou Li, Qitang Wang, Jianguo Zhang, Feng Jin, Jinhai Tang, Liang Li, Shiguang Zhu, Wenshu Zuo, Chunmiao Ye, Gengshen Yin, Zhongbing Ma, Shuya Huang, Zhigang Yu
Summary: The study showed that polymorphisms rs1137101 and rs4655555 in the LEPR gene can decrease the risk of breast cancer in Chinese females, potentially serving as a research-worthy bio-diagnostic marker for early prediction and risk assessment of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Alessandro Lima Machado, Ariana Nascimento Meira, Adrian de Farias Juca, Hymerson Costa Azevedo, Evandro Neves Muniz, Luiz Lehmann Coutinho, Gerson Barreto Mourao, Victor Breno Pedrosa, Luis Fernando Batista Pinto
Summary: This study aimed to investigate the association between growth hormone, insulin-like growth factor 1, and leptin genes with body traits in Santa Ines sheep. The single-locus and haplotype association analysis revealed significant relationships between variants in IGF1 and LEP genes with traits such as ADG, body height, and body width in the sheep.
Article
Gastroenterology & Hepatology
Sandro da Costa Ferreira, Ibrahim Abiodoun Sadissou, Rogerio Serafim Parra, Marley Ribeiro Feitosa, Fermino Sanches Lizarte Neto, Daniela Pretti da Cunha Tirapelli, Leandra Naira Zambelli Ramalho, Omar Feres, Jose Joaquim Ribeiro da Rocha, Eduardo Antonio Donadi, Luiz Ernesto de Almeida Troncon
Summary: This study evaluated intestinal HLA-G expression and sHLA-G levels in CD/UC patients, finding increased HLA-G expression in infiltrating plasma cells/lymphocytes in CD/UC biopsies and higher levels of sHLA-G in lesion areas of surgical specimens from CD/UC patients compared to margins.Higher levels of sHLA-G were observed in UC/CD patients compared to controls, with no difference between the two diseases.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Medicine, General & Internal
Ricardo Brianezi Tiraboschi, Fermino Sanches Lizarte Neto, Daniela Pretti da Cunha Tirapelli, Jose de Bessa Jr, Eduardo Paula Miranda, Mucio Luiz de Assis Cirino, Luis Fernando Tirapelli, Silvio Tucci Jr, Carlos Augusto Fernandes Molina
Summary: miRNAs were downregulated in both corpus cavernosum and blood in diabetic animals with alcohol consumption, showing potential as biomarkers for endothelial dysfunction. Serum miRNAs demonstrated high diagnostic accuracy in predicting endothelial dysfunction, suggesting their role as potential diagnostic biomarkers for endothelial injury.
Article
Clinical Neurology
Hallie Coltin, Lakshmikirupa Sundaresan, Kyle S. Smith, Patryk Skowron, Luca Massimi, Charles G. Eberhart, Karisa C. Schreck, Nalin Gupta, William A. Weiss, Daniela Tirapelli, Carlos Carlotti, Kay K. W. Li, Marina Ryzhova, Andrey Golanov, Olga Zheludkova, Oksana Absalyamova, Konstantin Okonechnikov, Damian Stichel, Andreas von Deimling, Caterina Giannini, Scott Raskin, Erwin G. Van Meir, Jennifer A. Chan, Daniel Fults, Lola B. Chambless, Seung-Ki Kim, Alexandre Vasiljevic, Cecile Faure-Conter, Rajeev Vibhakar, Shin Jung, Sarah Leary, Jaume Mora, Roger E. McLendon, Ian F. Pollack, Peter Hauser, Wieslawa A. Grajkowska, Joshua B. Rubin, Marie-Lise C. van Veelen, Pim J. French, Johan M. Kros, Linda M. Liau, Stefan M. Pfister, Marcel Kool, Noriyuki Kijima, Michael D. Taylor, Roger J. Packer, Paul A. Northcott, Andrey Korshunov, Vijay Ramaswamy
Summary: Medulloblastoma in adults can be classified into WNT, SHH, Group 3, and Group 4 subgroups, with SHH tumors being diagnosed at an older age. The 5-year progression-free survival varies among different subtypes, but clinical variables do not show a significant association with subtype-specific PFS.
ACTA NEUROPATHOLOGICA
(2021)
Article
Cell Biology
Joel del Bel Padua, Carolline Fontes Alves Mariano, Alexandre Todorovic Fabro, Daniela Pretti da Cunha Tirapelli, Ajith Kumar Sankarankutty, Jose Sebastiao dos Santos, Mariangela Ottoboni Brunaldi
Summary: This study found that RAD51 and BRCA2 are valuable immunohistochemical prognostic markers in gastric adenocarcinoma, which are associated with clinical prognosis.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Maria Julia Nunes, Rafael Z. Figueiredo, Vitor C. Tirapelli, Ana Laura R. e Silva Stevanato, Sebastiao de Campos Reis Filho, Mucio Luiz d. A. Cirino, Daniela P. da Cunha Tirapelli, Luis Fernando Tirapelli
Meeting Abstract
Biochemistry & Molecular Biology
Gabriel P. N. de Souza, Lucas B. Porsani, Victor C. Tirapelli, Ana Laura R. Stevanato, Paulo C. Novais, Mucio L. de Assis Cirino, Daniela Tirapelli, Luis F. Tirapelli
Meeting Abstract
Biochemistry & Molecular Biology
Paulo C. Novais, Matheus B. Moscatel, Marcella S. Rosa, Daniela Tirapelli, Mucio L. Cirino, Rafael Kemp, Jose S. Santos
Article
Clinical Neurology
D. Gattas, F. S. L. Neto, P. Freitas-Lima, R. Bonfim-Silva, S. Malaquias de Almeida, M. L. de Assis Cirino, D. Guimaraes Tiezzi, L. F. Tirapelli, T. R. Velasco, A. C. Sakamoto, C. M. Matias, C. G. Carlotti Jr, D. P. C. Tirapelli
Summary: This study evaluated the applicability of three specific miRNAs as biomarkers for diagnosis and surgical outcomes in adult patients with MTLE-HS. The miRNAs miR-629-3p, miR-1202, and miR-1225-5p were found to be hyper-expressed in the blood of MTLE-HS patients.
Article
Oncology
Leticia Passi Turra, Andressa Romualdo Rodrigues, Fermino Sanches Lizarte Neto, Paulo Cezar Novais, Maria Julia Nunes, Victor Cunha Tirapelli, Fernanda Maris Peria, Vinicius Marques Carneiro, Mucio Luiz de Assis Cirino, Carlos Gilberto Carlotti, Daniela Pretti da Cunha Tirapelli
Summary: This study aimed to identify a tumor malignancy signature associated with the regulation of HIF-1 alpha by microRNAs miR-21 and miR-326 in glioblastoma stem cells. The results showed that miR-21 had a high level of expression in the irradiated neurosphere group, suggesting its role in radioresistant neurospheres. miR-326 was associated with tumor recurrence in both groups, indicating that its positive regulation is independent of ionizing radiation treatment.
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY
(2022)
Article
Medicine, General & Internal
Thiago L. Da Costa Almeida, Andressa R. Rodrigues, Mucio Cirino, Felipe A. Trevisan, Fernanda Peria, Daniela Tirapelli, Carlos Gilberto Carlotti Jr
Summary: This study evaluated the expression of genes and miRNAs in glioblastoma cell lines after treatment with temozolomide and ionizing radiation. The results showed changes in gene expression and miRNA profiles, with ionizing radiation being an independent and determining factor for radioresistance in neurospheres.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Anatomy & Morphology
Rafael Zimak Figueiredo, Mucio Luiz de Assis Cirino, Lucas Barhosa Porsani, Fermino Sanches Lizarte Neto, Paulo Cezar Novais, Maria Julia Nunes, Janaina Regina Lellis, Jairo Pinheiro da Silva, Maria de Fatima Galli Sorita Tazima, Marina de Toledo Durand, Valeria Paula Sassoli Fazan, Benedicto Oscar Colli, Daniela Pretti da Cunha Tirapelli, Luis Fernando Tirapelli
Summary: Stroke is a major cause of death and disability worldwide. Physical exercise is considered an important approach for preventing non-communicable chronic diseases. miRNAs and other biomarkers respond to physical exercise and are associated with various epigenetic mechanisms. Studying the molecular mechanisms of physical exercise can improve the understanding of stimuli and optimal dosages, leading to better control of treatment and recovery processes for various diseases.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2022)
Article
Oncology
Alvaro Fabricio Lopes Rios, Daniela Pretti da Cunha Tirapelli, Mucio Luiz de Assis Cirino, Andressa Romualdo Rodrigues, Ester S. Ramos, Carlos Gilberto Carlotti
Summary: This study investigated the expression of four pluripotency-associated genes in the most malignant primary human brain tumor, glioblastoma (GBM). The results showed a signature of OCT4/SOX2/CARM1 genes and a significant increase in CARM1 expression in GBM cases.
NEURO-ONCOLOGY ADVANCES
(2022)
Article
Anatomy & Morphology
Brenno Marco De Russi, Lucas Barbosa Porsani, Mucio Luiz de Assis Cirino, Jairo Pinheiro da Silva, Leticia Passi Turra, Paulo Cezar Novais, Fermino Sanches Lizarte Neto, Valeria de Paula Sassoli Fazan, Jose Antonio Thomazini, Benedicto Oscar Colli, Daniela Pretti da Cunha Tirapelli, Luis Fernando Tirapelli, Camila Albuquerque Melo de Carvalho
Summary: Cerebral ischemia is a major cause of death and disability worldwide, with microRNAs playing a role in its pathophysiology. Recent studies suggest that physical exercise may have a protective role in cerebral ischemia.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2021)
Meeting Abstract
Biotechnology & Applied Microbiology
Lilian L. S. Figueiredo, Claudia E. V. Wiezel, Daniela P. C. Tirapelli, Vania D'Almeida, Velia Siciliano, Ron Weiss, Kuruvilla J. Abraham, Stanton L. Gerson, Aparecida M. Fontes
Meeting Abstract
Urology & Nephrology
R. Tiraboschi, J. Bessa Junior, C. A. Fernandes Molina, F. S. Lizarte, E. Miranda, D. Pretti da Cunha Tirapelli, L. F. Tirapelli, S. Tucci Junior
JOURNAL OF SEXUAL MEDICINE
(2021)
