Article
Genetics & Heredity
Reyhaneh Nassiri Mansour, Elham Hasanzadeh, Mozhgan Abasi, Mazaher Gholipourmalekabadi, Amir Mellati, Seyed Ehsan Enderami
Summary: Combining fetal bovine acellular dermal matrix (FADM) with human Wharton's jelly mesenchymal stem cells (hWJ-MSCs) can promote the healing of full-thickness skin wounds. The FADM-WJMSC group showed a higher wound closure rate and fewer inflammatory cells compared to the control and FADM groups. These findings suggest the potential application value of combining FADM with hWJ-MSCs in the treatment of skin wounds.
Article
Dermatology
Yiren Jiao, Yongxia Niu, Xiaolin Chen, Mingxun Luo, Sunxing Huang, Tianqi Cao, Guang Shi, Aisheng Wei, Junjiu Huang
Summary: By embedding Wharton's jelly mesenchymal stem cells (WJMSCs) into three-dimensional gelatin microspheres (GMs) and transplanting them with specific encapsulation materials, the healing rate and dermis regeneration of acute skin wounds can be improved, along with increased collagen deposition, cell proliferation, and neovascularization. This 3D encapsulation technology solves issues related to cell activity and residence time during MSC transplantation.
ADVANCES IN WOUND CARE
(2023)
Article
Dermatology
Mohammad Ali Nilforoushzadeh, Hamideh Afzali, Amir Raoofi, Maryam Nouri, Reza Naser, Omid Gholami, Davood Nasiry, Abdolreza Mohammadnia, Zahra Razzaghi, Alimohammad Alimohammadi, Zahra Safaie Naraghi, Aisan Peyrovan, Faeze Jahangiri, Ebrahim Khodaverdi Darian, Auob Rustamzadeh, Sona Zare
Summary: This study evaluated the effectiveness of using cell spray for the healing of diabetic wounds in rats through clinical, pathological, and biometric parameters. The results showed that the application of cell spray significantly accelerated the healing of diabetic wounds on Days 7, 14, and 21.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Cell & Tissue Engineering
Yiren Jiao, Xiaolin Chen, Yongxia Niu, Sunxing Huang, Jingwen Wang, Mingxun Luo, Guang Shi, Junjiu Huang
Summary: The combination of PF-127 and SAP is beneficial for WJMSCs-mediated diabetic wound healing, promoting cell survival, macrophage transformation, and angiogenesis to improve wound healing in diabetic patients.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Materials Science, Biomaterials
Yiren Jiao, Xiaolin Chen, Baoting Nong, Mingxun Luo, Yongxia Niu, Sunxing Huang, Jue Zhang, Aisheng Wei, Junjiu Huang
Summary: The transplantation of Wharton's jelly mesenchymal stem cells (WJMSCs) encapsulated with Hydroactive (R) Gel can promote diabetic wound healing by promoting macrophage transformation, facilitating cell proliferation and angiogenesis, and prolonging cell retention time.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Cell Biology
Kai-Wen Zhang, Yuan Jia, Yue-Yue Li, Dan-Yang Guo, Xiao-Xiao Li, Kai Hu, Xiao-Xi Qian, Zhong-Hua Chen, Jun-Jie Wu, Zheng-Dong Yuan, Feng-Lai Yuan
Summary: Wound healing is a complex process that can lead to the formation of scars in adults. Leptin and leptin receptors have been found to affect multiple stages of wound healing, but their role in scarless wound healing is paradoxical.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Mei-Qi Mao, Jing Jing, Yu-Jie Miao, Zhong-Fa Lv
Summary: Interactions between epithelial and mesenchymal cells have an impact on hair follicle development and skin wound healing. These interactions involve the exchange of soluble molecules, alteration of key pathways, and extracellular matrix signal transduction. This study summarizes the typical signaling molecules and extracellular components involved in epithelial-mesenchymal interaction, aiming to enhance our understanding of the mechanisms behind hair follicle regeneration and skin wound healing.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
Mohammad Ali Nilforoushzadeh, Amir Raoofi, Hamideh Afzali, Omid Gholami, Sona Zare, Davood Nasiry, Ebrahim Khodaverdi Darian, Auob Rustamzadeh, Shiva Alavi, Rahim Ahmadi, Alimohammad Alimohammadi, Zahra Razzaghi, Zahra Safaie Naraghi, Mona Mahmoudbeyk, Mohammad Amir Amirkhani, Amin Mousavi Khaneghah
Summary: This study investigated the benefits of Wharton's jelly mesenchymal stem cells (WJ-MSCs) derived from the human umbilical cord in wound healing in diabetic rats. The results showed that the WJ-MSCs group had significantly higher wound closure, thickness, and density of new epidermis and dermis, as well as skin elasticity compared to the control group. This suggests that subcutaneous administration of WJ-MSCs can effectively accelerate healing and be used alongside other treatment methods for chronic wounds.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zheng Kou, Balun Li, Aili Aierken, Ning Tan, Chenchen Li, Miao Han, Yuanxiang Jing, Na Li, Shiqiang Zhang, Sha Peng, Xianjun Zhao, Jinlian Hua
Summary: The existing treatment modalities for skin injuries, such as dressings, negative-pressure wound treatment, autologous skin grafting, and high-pressure wound treatment, have limitations such as high time cost and inability to remove inactivated tissue in a timely manner. Mesenchymal stem cells (MSCs) have great potential in cell therapy and regenerative medicine due to their unique self-renewal ability and differentiation potential. The addition of collagen to cell cultures promotes cell proliferation and accelerates the healing of skin wounds in mice and canines by promoting epidermal layer repair, collagen deposition, hair follicle angiogenesis, and an inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Critical Care Medicine
Annika S. Walter, Elias Volkmer, Gerd Gauglitz, Wolfgang Boecker, Maximilian M. Saller
Summary: This systematic review summarizes the current knowledge on molecular pathways activated during burn wound healing and identifies key molecules and new research targets.
Review
Cell & Tissue Engineering
Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang
Summary: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar-free wound repair has been greatly expanded. This paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on scar prevention and strategies for scar-free wound repair.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Camila Francisco Moreira, Puebla Cassini-Vieira, Maria Cecilia Campos Canesso, Mariane Felipetto, Hedden Ranfley, Mauro Martins Teixeira, Jacques Robert Nicoli, Flaviano Santos Martins, Luciola Silva Barcelos
Summary: The study showed that oral treatment with Lactobacillus rhamnosus accelerates skin wound closure, reduces scar formation, alleviates inflammation and fibrogenesis, and improves angiogenesis in wounded skin.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Biochemistry & Molecular Biology
Sangrok Park, Sejong Kim, Kyungmin Lim, Yeokyung Shin, Kwonwoo Song, Geun-Ho Kang, Dae Young Kim, Hang-Cheol Shin, Ssang-Goo Cho
Summary: In this study, we evaluated the utilization of thermostable basic fibroblast growth factor (TS-bFGF) for MSC culture and exosome production. The results showed that MSCs cultured with TS-bFGF had superior proliferation and produced a greater quantity of exosomes. These exosomes displayed anti-inflammatory and wound-healing effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Benjamin J. Main, Nicola Maffulli, Josiah A. Valk, Hugo C. Rodriguez, Manu Gupta, Saadiq F. El-Amin, Ashim Gupta
Summary: Wharton's jelly-derived mesenchymal stem cells (WJSCs) have shown potential therapeutic benefits in orthopedic surgery, but further randomized controlled clinical studies are needed to assess their safety and efficacy.
Article
Veterinary Sciences
Min-Soo Seo, Kyung-Ku Kang, Se-Kyung Oh, Soo-Eun Sung, Kil-Soo Kim, Young-Sam Kwon, Sungho Yun
Summary: Wharton's jelly is a known source of mesenchymal stem cells in various species, but there have been no reports on cats. This study isolated and characterized mesenchymal stem cells from the Wharton's jelly of cats, demonstrating their differentiation potential and therapeutic applications in feline medicine.
VETERINARY SCIENCES
(2021)