Article
Multidisciplinary Sciences
Pauliina M. Munne, Lahja Martikainen, Iiris Raty, Kia Bertula, Nonappa, Janika Ruuska, Hanna Ala-Hongisto, Aino Peura, Babette Hollmann, Lilya Euro, Kerim Yavuz, Linda Patrikainen, Maria Salmela, Juho Pokki, Mikko Kivento, Juho Vaananen, Tomi Suomi, Liina Nevalaita, Minna Mutka, Panu Kovanen, Marjut Leidenius, Tuomo Meretoja, Katja Hukkinen, Outi Monni, Jeroen Pouwels, Biswajyoti Sahu, Johanna Mattson, Heikki Joensuu, Paivi Heikkila, Laura L. Elo, Ciara Metcalfe, Melissa R. Junttila, Olli Ikkala, Juha Klefstrom
Summary: Researchers found that matrix stiffness regulates ERα expression via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation, revealing a crucial mechanobiological component in hormonal signaling in breast tissue.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Sophia Groh, Anna Viktoria Milton, Lisa Marinelli, Cara Sickinger, Angela Russo, Heike Bollig, Gustavo Pereira de Almeida, Andreas Schmidt, Ignasi Forne, Axel Imhof, Gunnar Schotta
Summary: Endogenous retroviruses (ERVs) make up a significant portion of mammalian genomes, and Morc3 has been identified as a key regulator of ERV silencing. Through interactions with the H3.3 chaperone Daxx, Morc3 plays a critical role in incorporating histone H3.3 into ERV regions.
NATURE COMMUNICATIONS
(2021)
Review
Endocrinology & Metabolism
Deborah A. Lannigan
Summary: This review focuses on the coordination between ERK1/2-RSK2 and estrogen signaling through ERα, and their interrelationships at the levels of transcription, translation, and posttranslational modification. Understanding how they cooperate in homeostasis and disease may lead to new therapeutic approaches for estrogen-dependent disorders.
Article
Engineering, Environmental
Qun Wang, Yu Zhang, Ying Yang, Haisong Fu, Youheng Liang, Jun Ma
Summary: This study introduced a new zero valent copper-mediated ferrate(VI) oxidation system for degrading bisphenol AF (BPAF). The effects of various factors on the BPAF degradation process were investigated, including the dosage of ZVC, the concentration of ferrate(VI), the reaction temperature, the initial pH of the solution, inorganic anions, and HA. The results showed that ZVC had a catalytic effect on ferrate(VI), achieving a removal efficiency of 92.4% under standard conditions in just 3 minutes. The use of zero-valent copper and ferrate (VI) provided a viable method for removing refractory organics from wastewater.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Kaiyue Wang, Dongyan Huang, Ping Zhou, Xin Su, Rongfu Yang, Congcong Shao, Aicui Ma, Jianhui Wu
Summary: BPA and BPAF can induce prostatic hyperplasia in rats and modulate the regulation of the NF-kB signaling pathway. In addition, combined exposure to BPA and BPAF can also increase proliferation and reduce apoptosis in human prostate cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Bingli Lei, Lanbing Xu, Qianqian Tang, Su Sun, Mengjie Yu, Yaoyao Huang
Summary: BPAF at low concentrations can significantly induce proliferation of ER alpha-negative SKBR-3 breast cancer cells and promote tumor growth. The study indicates that GPER1 can independently regulate BPAF-induced proliferation of SKBR-3 cells without requiring ER alpha involvement.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Yilong Li, Yongkui Zhang, Xuqian Wang, Yabo Wang
Summary: Iron-based materials, such as biosynthesized schwertmannite, are excellent environmental catalysts. In this study, flake-type graphitic carbon nitride was introduced to regulate the biomineralization process and control the morphology and structure of iron-based minerals. The constructed Light/Peroxymonosulfate/Sch-CN system showed great potential in treating bisphenol wastewater, with excellent degradation ability and wide pH adaptability.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Cell Biology
Alicia Llorente, Maria Teresa Blasco, Irene Espuny, Marc Guiu, Cecilia Ballare, Enrique Blanco, Adria Caballe, Anna Bellmunt, Fernando Salvador, Andrea Morales, Marc Nunez, Guillem Loren, Francesca Imbastari, Marta Fidalgo, Cristina Figueras-Puig, Patrizia Gibler, Mariona Graupera, Freddy Monteiro, Antoni Riera, Ingunn Holen, Alexandra Avgustinova, Luciano Di Croce, Roger R. Gomis
Summary: MAF amplification increases the risk of breast cancer metastasis through various mechanisms. The study found that MAF directly interacts with estrogen receptor alpha, promoting a chromatin landscape that favors metastasis. After exposure to estrogen, certain metastasis-promoting genes are activated in a MAF-dependent manner. The histone demethylase KDM1A plays a crucial role in maintaining this pro-metastatic gene expression program.
NATURE CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sisi Huang, Kaiyue Wang, Dongyan Huang, Xin Su, Rongfu Yang, Congcong Shao, Juan Jiang, Jianhui Wu
Summary: This study found that lower doses of BPAF can promote dorsal prostatic hyperplasia in rats by interfering with multiple biomarkers in the NF-kappa B signaling pathway. These findings further confirm the toxic effect of BPAF on prostate health and provide important clues to the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Yang Liu, Yongli Zhang, Jian Zhang, Wei Li, Peng Zhou, Zhicheng Pan, Bo Lai
Summary: The study demonstrates that the NBO catalytic system shows excellent performance for the degradation of organic pollutants, with singlet oxygen identified as the main reactive oxygen species. The catalytic mechanism involves the extrusion of lattice oxygen to activate oxygen and result in the generation of singlet oxygen through reactions with PMS on the NBO surface.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seng Chuan Tang, Quentin Lion, Olivier Peulen, Philippe Chariot, Arnaud Lavergne, Alice Mayer, Paula Allepuz Fuster, Pierre Close, Sebastian Klein, Alexandra Florin, Reinhard Buettner, Ivan Nemazanyy, Kateryna Shostak, Alain Chariot
Summary: COP1 acts as an oncogenic E3 ligase by promoting ERα signaling but also acts as a tumor suppressor candidate by preventing EMT, reflecting a dual role of COP1 in breast cancer that has sparked widespread interest in the academic community.
Article
Cell Biology
Sven Rosswag, Jonathan P. Sleeman, Sonja Thaler
Summary: RASSF1A suppresses ERα expression by modulating the Hippo pathway and YAP1 activity, inhibiting estrogen-dependent growth of breast cancer cells. Inactivation of RASSF1A leads to changes in Hippo signaling pathway function, aberrant activation of YAP1, and increased ERα expression and function, supporting the initiation of ERα-dependent breast cancer. The tumor-suppressor function of RASSF1A in luminal breast cancers depends on LATS1 and LATS2 in the Hippo pathway.
Article
Environmental Sciences
Eric Gyimah, Xian Zhu, Ziqi Zhang, Mengyuan Guo, Hai Xu, John Kenneth Mensah, Xing Dong, Zhen Zhang, Godfred Nana Wireko Gyimah
Summary: The present study investigated the potential mechanisms in BPAF-induced neurotoxicity in zebrafish embryos. The results showed that BPAF could cause decreased locomotor activity, apoptosis, and oxidative stress response in zebrafish embryos, as well as significant alterations in dopamine-related genes and neurodevelopmental genes expression.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Qing Zhang, Xiao Lei, Fang Wang, Xiaoning He, Lu Liu, Yuxia Hou, Yuan Liu, Fang Jin, Chider Chen, Bei Li
Summary: Immune system disorders, especially T cell disorders, are important therapeutic targets of mesenchymal stem cells (MSCs) in many autoimmune diseases (ADs). ERK1 plays a crucial role in regulating T cells in MSCs, and MSCs treated with LA can improve the efficacy of MSC-based treatments for ADs.
Article
Environmental Sciences
Pengyu Chen, Ruihan Wang, Geng Chen, Baihui An, Ming Liu, Qiang Wang, Yuqiang Tao
Summary: Bisphenol AF (BPAF) showed potential thyroid disruption and hepatotoxicity in zebrafish, decreasing levels of thyroid hormones and deiodinases while increasing expressions of transthyretin. BPAF acted as a thyroid hormone receptor (TR) antagonist and triggered liver impairment and apoptosis. It is suggested that BPAF may not be a safe alternative to BPA.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)