Article
Immunology
Christopher M. Skopnik, Khlowd Al-Qaisi, Rosaleen A. Calvert, Philipp Enghard, Andreas Radbruch, Brian J. Sutton, Hiromi Kubagawa
Summary: This study identified critical amino acid residues of human Fc mu R for binding to IgM Fc, as well as the effects of certain residues on receptor expression and IgM binding. Results suggest specific sites and stretches within the Fc mu R structure that are essential for its proper function and interaction with IgM.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ronit Rosenfeld, Tal Noy-Porat, Adva Mechaly, Efi Makdasi, Yinon Levy, Ron Alcalay, Reut Falach, Moshe Aftalion, Eyal Epstein, David Gur, Theodor Chitlaru, Einat B. Vitner, Sharon Melamed, Boaz Politi, Ayelet Zauberman, Shirley Lazar, Adi Beth-Din, Yentl Evgy, Shmuel Yitzhaki, Shmuel C. Shapira, Tomer Israely, Ohad Mazor
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has severe consequences on human life and economy. Using human monoclonal antibodies like MD65 can effectively prevent and treat infections, showing promising results in saving lives of infected animals.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Fabian Bohlaender, Sabrina Weissmueller, Dennis Riehl, Marcus Gutscher, Joerg Schuettrumpf, Stefanie Faust
Summary: The study aims to investigate the functional aspects of the IgA component in trimodulin, a new plasma-derived polyvalent immunoglobulin preparation, and demonstrates its potent immunomodulatory and anti-pathogenic effects, especially on neutrophil function.
Article
Fisheries
Jing Wu, Yifan Nie, Yanping Ma, Le Hao, Zhenxing Liu, Yugu Li
Summary: The phagocytic activity of B cells in fish has been confirmed. This study produced five monoclonal antibodies (MAbs) against largemouth bass IgM and demonstrated their ability to specifically recognize the membrane-bound IgM molecule. Flow cytometry analysis revealed the distribution of largemouth bass mIgM+ lymphocytes in different tissues. qPCR analysis showed the upregulation of various cytokines and genes related to the phagocytic signaling pathway in mIgM+ lymphocytes. These findings are important for understanding the role of mIgM+ lymphocytes in largemouth bass and the involvement of Fc gamma R in phagocytosis.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Nicolas Rochereau, Eva Michaud, Louis Waeckel, Martin Killian, Remi Gayet, Roman Goguyer-Deschaumes, Xavier Roblin, Gilles Biolley, Blaise Corthesy, Stephane Paul
Summary: Recent studies have shown that SIgM can also undergo retrotranscytosis through M cells, indicating a potential role in regulating mucosal immunity.
Article
Chemistry, Physical
Elijah Thimsen
Summary: Metal pentazolate compounds are unique materials that only exist at extremely high pressures. The synthesis of these compounds is challenging, but their potential energy release is comparable to combustion reactions. Developing new synthesis routes, such as using non-equilibrium plasma, could unlock the properties of these exotic materials beyond their typical applications in explosives and propellants.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Oncology
Hulin Jin, Vittorio D'Urso, Berend Neuteboom, Sean D. McKenna, Rene Schweickhardt, Alec W. Gross, Yves Fomekong Nanfack, Andrea Paoletti, Carina Carter, Lars Toleikis, Markus Fluck, Juergen Scheuenpflug, Ti Cai
Summary: Avelumab, an IgG1 anti-PD-L1 monoclonal antibody, has been approved for certain cancers but its rapid clearance and shorter half-life compared to other antibodies is not fully understood. Our study suggests that the unique internalization mechanism of avelumab, involving both Fc gamma R and PD-L1 binding, may explain its fast clearance and provides insights for future therapeutic development.
Article
Pediatrics
Ling-Sai Chang, Mindy Ming-Huey Guo, Mao-Hung Lo, Ho-Chang Kuo
Summary: This study indicates that IgA, IgE, IgG, and IgM receptors are associated with KD, highlighting potential biomarkers related to Fc receptors and their regulation.
PEDIATRIC RESEARCH
(2021)
Article
Oncology
Rens Braster, Marijn Bogels, Hreinn Benonisson, Manfred Wuhrer, Rosina Plomp, Arthur E. H. Bentlage, Rianne Korthouwer, Remco Visser, J. Sjef Verbeek, Marjolein van Egmond, Gestur Vidarsson
Summary: Research has shown that afucosylated human IgG1 exhibits enhanced effector functions against peritoneal metastasis of melanoma cells in mice through the mouse Fc gamma RIV, indicating functional conservation across species. The study further confirms the potential of using afucosylated therapeutic IgG to increase efficacy, as seen in reduced metastasis outgrowth in mice treated with afucosylated human IgG1-TA99 compared to wildtype antibodies.
Article
Cell Biology
Jacqueline M. Brady, Meredith Phelps, Scott W. MacDonald, Evan C. Lam, Adam Nitido, Dylan Parsons, Christine L. Boutros, Cailin E. Deal, Wilfredo F. Garcia-Beltran, Serah Tanno, Harini Natarajan, Margaret E. Ackerman, Vladimir D. Vrbanac, Alejandro B. Balazs
Summary: This study investigates the efficacy and relative contribution of HIV antibodies using a humanized mouse model. The findings suggest that antibodies lacking Fc-mediated functionality have reduced protection against HIV transmission, while highly functional antibodies can provide significant protection against infection.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Charles A. Specht, E. Jane Homan, Chrono K. Lee, Zhongming Mou, Christina L. Gomez, Maureen M. Hester, Ambily Abraham, Florentina Rus, Gary R. Ostroff, Stuart M. Levitz
Summary: This study reveals the potential of protein peptides in the development of cryptococcosis vaccines, and demonstrates that peptide vaccines can effectively protect mice from cryptococcosis.
Article
Materials Science, Ceramics
M. S. I. Sarker, Marufa Yeasmin, Md Abdullah Al-Mamun, S. Manjura Hoque, M. K. R. Khan
Summary: The structural and magnetic properties of Gd doped CoFe2O4 nanoparticles synthesized by sol-gel method have been studied, showing their potential applications in various fields.
CERAMICS INTERNATIONAL
(2022)
Article
Immunology
Edward B. Irvine, Anthony O'Neil, Patricia A. Darrah, Sally Shin, Alok Choudhary, Wenjun Li, William Honnen, Smriti Mehra, Deepak Kaushal, Hannah Priyadarshini Gideon, JoAnne L. Flynn, Mario Roederer, Robert A. Seder, Abraham Pinter, Sarah Fortune, Galit Alter
Summary: Alter and colleagues demonstrate that IgM titers in plasma and bronchoalveolar lavage fluid are markers of reduced Mtb burden in rhesus macaques vaccinated intravenously with Bacille Calmette-Guerin. This study suggests the potential importance of IgM responses as a marker and mediator of protection against TB, highlighting the superior antibody responses induced by intravenous BCG compared to traditional intradermal administration.
Article
Multidisciplinary Sciences
Tryssia S. M. Moi, Bruno W. Minto, Ana P. Macedo, Dayvid V. F. Lucena, Caio A. S. Malta, Luis G. G. G. Dias
Summary: The aim of this study was to describe and evaluate a novel plate designed specifically for the canine ilium using finite element methods. The results showed that this novel implant has evenly distributed stress and has potential applicability in iliac fractures in dogs.
Article
Multidisciplinary Sciences
Amir Hossein Saeedi Dehaghani, Reza Gharibshahi, Mohammad Mohammadi
Summary: This study investigated the effect of silane-based silica (SiO2) Janus nanoparticles (JNPs) on stabilizing the foam generated by different types of gases. The results showed that the synthesized SiO2 JNPs exhibited similar ability to reduce surface tension as bare SiO2 nanoparticles. However, the synthesis of SiO2 JNPs significantly enhanced their foamability and foam stability compared to bare SiO2 nanoparticles. The type of gas atmosphere played a crucial role in the efficiency of the synthesized JNPs, with CH4 medium showing superior foamability. HMDS-SiO2 JNPs exhibited better foamability and foam stability compared to APTS-SiO2 JNPs, especially in oil reservoirs.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Tomoko Takano, Eric Bareke, Naoki Takeda, Lamine Aoudjit, Cindy Baldwin, Philip Pisano, Jun Matsuda, Jasmine El Andalousi, Lina Muhtadie, Chantal Bernard, Jacek Majewski, Toru Miyazaki, Ken-ichi Yamamura, Indra R. Gupta
KIDNEY INTERNATIONAL
(2019)
Article
Urology & Nephrology
Akiko Takahata, Satoko Arai, Emiri Hiramoto, Kento Kitada, Rina Kato, Yuko Makita, Hitoshi Suzuki, Junichiro Nakata, Kimi Araki, Toru Miyazaki, Yusuke Suzuki
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Multidisciplinary Sciences
Hideaki Hasegawa, Izuru Mizoguchi, Naoko Orii, Shinya Inoue, Yasuhiro Katahira, Toshihiko Yoneto, Mingli Xu, Toru Miyazaki, Takayuki Yoshimoto
Summary: IL-23, composed of p19 and p40 subunits, plays a critical role in the expansion of Th17 cells. The composite cytokine p19/CD5L activates STAT5 and enhances differentiation into GM-CSF-producing CD4(+) T cells. Deficiency of p19 or CD5L alleviates EAE with reduced frequency of GM-CSF(+)CD4(+) T cells. Serum level of p19/CD5L correlates with clinical symptoms during EAE, suggesting its role as a novel cytokine contributing to EAE development.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ji Yun Lee, Shabitha Arumugarajah, Dameng Lian, Natsumi Maehara, Aaron R. Haig, Rita S. Suri, Toru Miyazaki, Lakshman Gunaratnam
Summary: Reperfusion injury is unavoidable during kidney transplantation and may lead to delayed graft function and early loss of the organ. Kidney Injury Molecule-1 (KIM-1) has a protective effect during renal injury, while recombinant AIM (rAIM) may help mitigate reperfusion injury, reducing inflammation and tissue damage.
Article
Cell Biology
Natsumi Maehara, Kaori Taniguchi, Ami Okuno, Hideaki Ando, Aika Hirota, Zhiheng Li, Ching-Ting Wang, Satoko Arai, Toru Miyazaki
Summary: Sterile inflammation caused by DAMPs aggravates the prognosis of primary injury such as ischemic stroke. The AIM protein can reduce sterile inflammation by attenuating DAMPs and administration of AIM can ameliorate the deleterious effects of ischemic stroke. AIM binds to DAMPs through charge-based interactions and disulfide bond formation, promoting their phagocytic removal and neutralizing their inflammatory effects.AIM-deficient mice in experimental stroke show severe damage and higher mortality, while administration of recombinant AIM reduces sterile inflammation in the infarcted region, leading to a significant reduction in animal mortality. Targeting DAMPs may improve therapies for ischemic stroke.
Article
Multidisciplinary Sciences
Ching-Ting Wang, Tetsushi Tezuka, Naoki Takeda, Kimi Araki, Satoko Arai, Toru Miyazaki
Summary: Excessive salt intake can worsen AKI by inhibiting the dissociation of AIM from IgM, and AIM shows potential as a therapeutic tool for severe AKI by interacting with the KIM-1 axis.
Article
Gastroenterology & Hepatology
Tomo Shimizu, Takashi Sawada, Tomohide Asai, Yuka Kanetsuki, Jiro Hirota, Michihisa Moriguchi, Tomoaki Nakajima, Toru Miyazaki, Takeshi Okanoue
Summary: This study established a fully automatic and high-throughput electrochemiluminescence immunoassay to measure IgM-free apoptosis inhibitor of macrophage (AIM) and found its effective diagnostic efficacy in NASH-HCC and viral HCC.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Takeshi Okanoue, Kanji Yamaguchi, Toshihide Shima, Yasuhide Mitsumoto, Masayuki Mizuno, Takayuki Katayama, Yuya Seko, Michihisa Moriguchi, Atsushi Umemura, Yoshito Itoh, Toru Miyazaki
Summary: This study suggests that serum IgM-free AIM levels could be a sensitive biomarker for detecting latent NASH-HCC, as AIM activation in blood appears to start before HCC is diagnostically detectable.
HEPATOLOGY RESEARCH
(2022)
Article
Biology
Kyohei Matsuura, Natsumi Maehara, Aika Hirota, Ayaka Eguchi, Keisuke Yasuda, Kaori Taniguchi, Akemi Nishijima, Nobuyuki Matsuhashi, Yoshiyuki Shiga, Rumi Ishii, Yasuhiro Iguchi, Kazunari Tanabe, Satoko Arai, Toru Miyazaki
Summary: The prevalence and recurrence rate of kidney stones are high, and there is currently no effective treatment to prevent their occurrence. However, this study reveals that AIM can suppress stone development and improve stone-induced physical damages. AIM interacts with calcium oxalate crystals to inhibit stone formation, and also removes inflammatory molecules to reduce stone development. Furthermore, AIM improves kidney function and alleviates physical symptoms such as weight loss. These findings provide a basis for the development of comprehensive therapy for kidney stone disease.
COMMUNICATIONS BIOLOGY
(2022)
Article
Veterinary Sciences
Ginga Komatsu, Toru Nonomura, Mai Sasaki, Yuki Ishida, Satoko Arai, Toru Miyazaki
EXPERIMENTAL ANIMALS
(2019)