Review
Immunology
Ming Cui, Jing Huang, Shenghua Zhang, Qiaofei Liu, Quan Liao, Xiaoyan Qiu
Summary: Traditionally, immunoglobulin was believed to be produced only by B cells, but increasing evidence shows cancer cells also express high levels of immunoglobulin, known as cancer-derived Ig. While sharing similar basic structures with B cell-derived Ig, cancer-derived Ig has distinct features and can promote tumor growth through various mechanisms, offering potential as a diagnostic and therapeutic target for cancer patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jian-Ting Chen, Yuan-Ling Hsu, Yi-Chiung Hsu, Yi-Hsin Tseng, Ming-Han Liu, Chia-Wei Weng, Ching-Hao Lin, Szu-Hua Pan, Jeremy J. W. Chen, Chi-Chung Wang
Summary: Our study suggests that the Id2 gene may act as a metastasis suppressor in lung adenocarcinoma, providing new insights into LADC progression and therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Nitao Cheng, Junliang Liu, Chen Chen, Tang Zheng, Changsheng Li, Jingyu Huang
Summary: Tumor metastasis is the leading cause of death in cancer patients, and early prediction is crucial for intervention. This study focused on gene expression data from 226 patients to identify key transcripts for predicting lung cancer metastasis. The deep neural network (DNN) method achieved the highest precision compared to other methods, and the inclusion of 7 vital genes further improved the performance of the model.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Oncology
Raghav Chandra, John D. Karalis, Charles Liu, Gilbert Z. Murimwa, Josiah Voth Park, Christopher A. Heid, Scott I. Reznik, Emina Huang, John D. Minna, Rolf A. Brekken
Summary: Colorectal cancer (CRC) ranks as the third most common malignancy globally and the second leading cause of cancer-related deaths. The cellular components of the tumor microenvironment (TME) play crucial roles in tumor engraftment and metastasis to distant organs such as the liver and lungs.
Article
Medicine, Research & Experimental
Muhammad Tariq, Nadia Hussain, Kanwal Rehman, Muhammad Sajid Hamid Akash, Amal H. I. Al Haddad, Amira S. A. Said, Adel Al Fateasej, Ali Alamri, Awaji Y. Safhi, Fahad Y. Sabei, Ahmed Abdullah Al Awad, Musaddique Hussain
Summary: In this study, it was found that lapatinib effectively suppressed the expression of IL_13-induced M2 polarized macrophages surface markers and downregulated M2 genes related to tumor progression. Lapatinib also inhibited the invasion and migration of cancer cells mediated by M2 polarized macrophages. Mechanistically, lapatinib inhibited IL-13 triggered STAT6 phosphorylation. In the mouse model, lapatinib significantly reduced tumorigenesis and downregulated M2 markers in the tumor.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Kellie A. Mouchemore, Robin L. Anderson
Summary: G-CSF has been reported to play a pro-tumour role in cancer by mainly affecting neutrophils and MDSCs, suppressing T cells in the presence of G-CSF. Recent studies have also highlighted other tumour-promoting effects of G-CSF on myeloid cells, raising concerns about its impact on anti-cancer treatments like immune checkpoint blockade.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Rong Wang, Piaopiao Wen, Ganglong Yang, Yanyan Feng, Yuanyuan Mi, Xiaoying Wang, Shenglong Zhu, Yong Q. Chen
Summary: This study reveals a novel regulatory mechanism of prostate cancer AR inhibitor resistance, showing that GDF15 plays a role in this resistance and its N70 glycosylation is involved in relieving the inhibitory effect on the EGFR pathway. Interfering with GDF15 or the EGFR pathway can reduce the survival of resistant cells and tumor growth.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Rui Zhou, Young Hyun Yu, Hangun Kim, Hyung-Ho Ha
Summary: This study synthesized new coumarin derivatives and evaluated their biological activities. Several of the tested compounds showed inhibitory effects on lung cancer cell motility, without causing cytotoxic effects. The 4-hydroxycoumarin derivatives 4h and 4i significantly inhibited lung cancer cell motility by suppressing expression of the epithelial-mesenchymal transition markers N-cadherin, Snail, and Twist.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Weixian Liu, Xinxian Huang, Weizhao Luo, Xinguang Liu, Weichun Chen
Summary: Paxillin is a multi-domain adaptor protein that plays an important role in physiological processes such as nervous system development, embryonic development, and vascular development. Abnormal expression of paxillin has been found in many cancers and is associated with prognosis, metastases, invasion, survival, angiogenesis, and other aspects of malignant tumors. Understanding the mechanism of how aberrant paxillin expression affects tumorigenesis and metastasis can help in the development of more effective cancer therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Lihui Si, Lina Zhang, Shaoliang Xing, Panke Fang, Xiu Tian, Xiaoyan Liu, Xiaohong Xv
Summary: Curcumin, a natural polyphenol compound, has been identified as an effective therapeutic agent against cancer. It exerts its anti-tumor activities through modulating various cellular processes and the alterations of noncoding RNAs. Curcumin has been shown to modulate several circRNAs, targeting the expression of mRNAs and modifying various signaling pathways and hallmarks of cancer.
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
Anika Mijakovac, Julija Juric, Wendy M. Kohrt, Jasminka Kristic, Domagoj Kifer, Kathleen M. Gavin, Karlo Miskec, Azra Frkatovic, Frano Vuckovic, Marija Pezer, Aleksandar Vojta, Peter A. Nigrovic, Vlatka Zoldos, Gordan Lauc
Summary: The composition of IgG glycome changes significantly with age, with women experiencing the most notable changes during the perimenopausal period. Hormonal changes affect the glycan composition of IgG, with estradiol supplementation sufficient to prevent these changes. Notably, estrogen depletion primarily affects B cell glycosylation while liver glycosylation remains mostly unchanged.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Zhe Liu, Liang Ma, Yiming Sun, Wenying Yu, Xue Wang
Summary: The study demonstrated that the STAT3/ZEB1 axis is critical in gefitinib resistance in lung cancer, and a new potential therapeutic strategy targeting STAT3 has been identified with the inhibitor LL1. LL1 was shown to sensitize resistant cells to gefitinib by depleting STAT3 activity and blocking its signaling pathways, with little observed toxicity in animal models, indicating it could be a chemotherapeutic adjuvant for gefitinib resistance in NSCLC.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Chen Ni, Xiaohan Lou, Xiaohan Yao, Linlin Wang, Jiajia Wan, Xixi Duan, Jialu Liang, Kaili Zhang, Yuanyuan Yang, Li Zhang, Chanjun Sun, Zhenzhen Li, Ming Wang, Linyu Zhu, Dekang Lv, Zhihai Qin
Summary: This study reveals a mechanism by which a subset of zinc-transporter positive cancer-associated fibroblasts directly interacts with lung cancer cells through gap junctions, promoting chemoresistance in tumors. This finding provides insights into the role of fibroblast-tumor cell interactions in lung cancer chemo-resistance.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Heng Zhang, Shao-Qiang Wang, Jie-Bo Zhu, Li-Na Wang, Hang Lin, Lin-Feng Li, Yuan-Da Cheng, Chao-Jun Duan, Chun-Fang Zhang
Summary: CALML3-AS1 is upregulated while BTNL9 is downregulated in NSCLC. Depletion of CALML3-AS1 inhibits malignant phenotypes, tumor growth, and liver metastasis in NSCLC. Mechanistically, ALKBH5 enhances the stability of CALML3-AS1 through m6A demethylation, while YTHDC2 destabilizes CALML3-AS1. Additionally, CALML3-AS1 represses BTNL9 transcription and expression through the recruitment of EZH2. Downregulation of BTNL9 counteracts the antitumor effects mediated by CALML3-AS1 in NSCLC.
CANCER GENE THERAPY
(2023)
Article
Multidisciplinary Sciences
Zao-Hui Li, Dan Yu, Nan-Nan Huang, Jun-Kai Wu, Xiao-Wei Du, Xi-Jun Wang
Summary: Ginseng leaves, as a traditional medicinal herb, inhibit lung cancer cell proliferation by regulating multiple signaling proteins and may achieve an immune response against lung cancer through multiple signaling pathways.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yu Lei, Qiaoling Hu, Jiang Gu
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Oncology
Hui Wang, Qian Xu, Chanyuan Zhao, Ziqi Zhu, Xiaoqing Zhu, Junjie Zhou, Shuming Zhang, Tiqun Yang, Biying Zhang, Jun Li, Meiling Yan, Renming Liu, Changchun Ma, Yan Quan, Yongqu Zhang, Weifeng Zhang, Yiqun Geng, Chuangzhen Chen, Shaobin Chen, Ditian Liu, Yuping Chen, Dongping Tian, Min Su, Xueling Chen, Jiang Gu
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Qian Xu, Xiaodong Deng, Biying Zhang, Chanyuan Zhao, Tao Huang, Yimin Zhang, Zhiming Chen, Jiang Gu
Summary: The study showed that Fab-glycosylated IgG does not inhibit tumor growth and metastasis in the model, but may help tumor cells evade immune surveillance by affecting antigen-antibody binding and macrophage polarization. This suggests a new mechanism of immune evasion with Fab-glycosylated IgG playing a significant role.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Immunology
Hui Wang, Junjie Zhou, Jun Li, Yiqun Geng, Pei Meng, Changchun Ma, Ziqi Zhu, Weifeng Zhang, Liangli Hong, Yan Quan, Jiacong Wei, Qiongyi Huang, You Zhou, Zuoqing Su, Xiaoqing Zhu, Chuangzhen Chen, Shaobin Chen, Jiang Gu
Summary: The study revealed the presence of MGCs in esophageal cancer and their correlation with pathological characteristics and clinical behavior, showing a molecular profile of M1 macrophages. This suggests that MGCs could serve as a prognostic marker for patient survival.
CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yao Tang, Qian Xu, Meiling Yan, Yimin Zhang, Ping Zhu, Xianghong Li, Limin Sang, Ming Zhang, Wenhe Huang, Lianxing Lin, Jundong Wu, Yue Xin, Junhui Fu, Li Zhang, Shuming Zhang, Jiang Gu
SCIENTIFIC REPORTS
(2020)
Article
Andrology
Ting-Ting Han, Ji-Hua Huang, Jiang Gu, Qing-Dong Xie, Ying Zhong, Tian-Hua Huang
Summary: Exposure to HBs can activate the Bax/Bcl2 signaling cascade leading to AIF/Endo G-mediated apoptosis, resulting in sperm DNA fragmentation, sperm injury, and death, ultimately decreasing sperm fertilizing capacity.
Article
Biochemistry & Molecular Biology
Guo-Wei Huang, Qian-Qian Chen, Chang-Chun Ma, Ling-Hui Xie, Jiang Gu
Summary: The research discovers a novel mechanism where cytoplasmic linc01305 stabilizes HTR3A mRNA through interaction with IGF2BP2 and IGF2BP3, thereby promoting metastasis and proliferation of esophageal squamous cell carcinoma (ESCC).
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Mazhar Ali Raja, Martin Maldonado, Jianying Chen, Ying Zhong, Jiang Gu
Summary: The study successfully developed curcumin encapsulated arginine and N-acetyl histidine modified chitosan nanoparticles, which showed promising therapeutic potential in reversing PCOS symptoms in rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Cell & Tissue Engineering
Shuling Zhou, Yu Lei, Ping Wang, Jianying Chen, Liting Zeng, Ting Qu, Martin Maldonado, Jihua Huang, Tingting Han, Zina Wen, Erpo Tian, Xiangqian Meng, Ying Zhong, Jiang Gu
Summary: The study focused on the role of PF-127 encapsulation of hUC-MSCs in regenerating thin endometrium, leading to increased endometrial thickness and gland number. IL-1 beta-stimulated hUC-MSCs enhanced angiogenesis factors release, promoting thin endometrium regeneration.
STEM CELLS INTERNATIONAL
(2022)
Article
Virology
Yan-Na Xiao, Fei-Yuan Yu, Qian Xu, Jiang Gu
Summary: This study investigated the expression of influenza virus receptors in the human placenta and found that it is susceptible to 2009 influenza A virus (H1N1/09) infection. The study highlights the importance of protecting pregnant women from infection during influenza season.
Article
Immunology
Hongxia Ye, Lan Li, Yajun Dong, Qu Zheng, Yulin Sha, Li Li, Panyu Yang, Yan Jia, Jiang Gu
Summary: This study aimed to investigate the characteristics and possible contribution of low-density granulocytes (LDGs) and their subpopulations in early pregnancy, especially in early spontaneous abortion (SA). The results showed that LDG participates in the maintenance of early pregnancy, while dysregulated LDG is responsible for early SA, providing novel potential targets for further exploration of SA pathogenesis and therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hui Wang, Chanjuan Su, Ziteng Li, Changchun Ma, Liangli Hong, Zhe Li, Xiaonan Ma, Yien Xu, Xiaolong Wei, Yiqun Geng, Weifeng Zhang, Penghao Li, Jiang Gu
Summary: Recent reports suggest that immune cells in solid cancers play a significant role in predicting and treating the disease. IgG4, a subclass of IgG, has been found to inhibit tumor immunity. This study aimed to assess the importance of IgG4 and T cell subtypes in tumor prognosis. Through immunostaining and analysis of clinical data, the density and distribution of immune markers CD4, CD8, Foxp3, IL-10, and IgG4 were investigated in esophageal squamous cell carcinoma (ESCC). The results showed that higher levels of CD4(+) and CD8(+) T cells predicted better prognosis, and the density of IgG4(+) B lymphocytes was correlated with CD4(+) and IL-10(+) cell densities. Increased serum concentration of IgG4 indicated a poorer prognosis. These findings highlight the potential of T cells and serum IgG4 as predictors of prognosis in ESCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weifeng Zhang, Yan Quan, Xiaonan Ma, Liting Zeng, Jirui Li, Shuqi Chen, Meng Su, Liangli Hong, Penghao Li, Hui Wang, Qian Xu, Chanyuan Zhao, Xiaoqing Zhu, Yiqun Geng, Xiaomiao Yan, Zheng Fang, Muwang Chen, Dongping Tian, Min Su, Xueling Chen, Jiang Gu
Summary: The study reveals that GSH and IgG4 in the tumor microenvironment can synergistically inhibit immune responses and promote tumor growth. This effect is achieved through the Fc-Fc reaction between IgG4 and other tissue-bound IgG subtypes, which is facilitated by GSH disrupting the disulfide bonds of IgG4. This finding provides a new understanding of the interaction between the redox system and the immune system in the tumor microenvironment and has implications for cancer immunotherapy.
Article
Obstetrics & Gynecology
Yan Jia, Ting Qu, Aixiang Tan, Shenggong Hu, Martin Maldonado, Ying Zhong, Jiang Gu
Summary: Embryo morphological stage at transfer and endometrial thickness (or endometrial volume) on the day before transfer are more important variables in affecting pregnancy outcome in in vitro fertilization, with blastocyst stage embryos combined with specific endometrial thickness or volume predicting successful IVF pregnancy outcome.
JOURNAL OF REPRODUCTIVE MEDICINE
(2021)
Article
Cell Biology
Martin Maldonado, Jianying Chen, Yang Lujun, Huiqin Duan, Mazhar Ali Raja, Ting Qu, Tianhua Huang, Jiang Gu, Ying Zhong
Summary: The interaction between a high-calorie diet (HCD) and calorie restriction (CR) influences metabolic and physiological characteristics of skeletal muscles in mice. Dietary interventions alter genetic activation patterns and boost the expression of regulatory factors, impacting mitochondrial biogenesis and metabolic fiber transition. This suggests that a balance between HCD and CR may bring potential benefits for skeletal muscle function and energy metabolism by triggering key anti-aging mechanisms.