Article
Biochemistry & Molecular Biology
Anthony Ariza, Yasuhiro Funahashi, Sachi Kozawa, Md Omar Faruk, Taku Nagai, Mutsuki Amano, Kozo Kaibuchi
Summary: This study identified approximately 40 novel candidate proteins in the striatum of the C57BL/6 mouse brain after cocaine administration, with a focus on the protein MKL2. The results demonstrate that dopamine signaling regulates the interaction of MKL2 with CBP in a phosphorylation-dependent manner, thereby controlling SRF-dependent gene expression.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Meriam Nefla, Nicola J. Darling, Manuel van Gijsel Bonnello, Philip Cohen, J. Simon C. Arthur
Summary: Salt Inducible Kinases 2 (SIK2) and 3 (SIK3) play important roles in thymic T cell development, with their loss leading to decreased numbers of peripheral T cells and defects in negative and/or positive selection in the thymus.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Qing Dai, Deqiong Xie, Chenli Zhang, Lei Zhu, Ying Xu, Kui Li, Wen Hao, Hefei Yin
Summary: Renal ischemia-reperfusion (IR) injury is a major cause of kidney injury, and its clinical treatment is challenging. Research has shown that osthole can protect the kidneys by inhibiting inflammatory responses and reducing cell apoptosis. This protective effect has drawn significant attention in recent years.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chengcheng Zhang, Yuan Tian, Shuang Song, Lu Zhang, Yunkun Dang, Qun He
Summary: The deposition of H2A.Z and deacetylation of histone H3 lysine 56 play crucial roles in restricting heterochromatin spreading.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Microbiology
Haijie Ma, Lei Li, Yunpeng Gai, Xiaoyan Zhang, Yanan Chen, Xiaokang Zhuo, Yingzi Cao, Chen Jiao, Fred G. Gmitter, Hongye Li
Summary: This study revealed the essential roles of HATs and HDACs in growth, pathogenicity, and stress response in the phytopathogenic fungus Alternaria alternata, providing genetic evidence for their central role in the biological functions of the fungus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Vitor F. Martins, Samuel A. LaBarge, Alexandra Stanley, Kristoffer Svensson, Chao-Wei Hung, Omer Keinan, Theodore P. Ciaraldi, Dion Banoian, Ji E. Park, Christina Ha, Byron Hetrick, Gretchen A. Meyer, Andrew Philp, Larry L. David, Robert R. Henry, Joseph E. Aslan, Alan R. Saltiel, Carrie. E. McCurdy, Simon Schenk
Summary: This study highlights the fundamental role of acetylation and p300/CBP in the direct regulation of insulin-stimulated glucose transport in skeletal muscle and adipocytes.
Review
Chemistry, Medicinal
Mauricio T. Tavares, Alan P. Kozikowski, Sida Shen
Summary: Histone deacetylase 6 (HDAC6) is a zinc-dependent enzyme that regulates the acetylation of non-histone substrates, impacting various cellular processes. The discovery of mercaptoacetamide (MCA)-based HDAC6 inhibitors has shown promising potential due to their selectivity and lack of mutagenicity. Further research on the structure-activity relationships, selectivity, and pharmacological properties of MCA-based HDAC6 inhibitors could lead to improved drug-like properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Liang Ma, Zeyue Gao, Jiegen Wu, Bijunyao Zhong, Yuchen Xie, Wen Huang, Yihan Lin
Summary: The coactivator p300 can dynamically coordinate its functions by forming clusters with transcription factors, enabling spatially defined activation of its catalytic activity. This co-condensation mechanism modulates the transcriptional initiation rate and burst duration of target genes, contributing to nonlinear gene regulation. The results suggest a mechanism where TF and p300 co-condensation contributes to transcriptional bursting regulation and cooperative gene control.
Article
Neurosciences
Xiaohui Li, Juan Zhang, Dingfeng Li, Cheng He, Keqiang He, Tian Xue, Lili Wan, Chi Zhang, Qiang Liu
Summary: This study demonstrates that astrocytes interact with neurons by delivering microRNAs that modulate neuronal cholesterol biosynthesis genes, affecting neuronal metabolism and epigenetic regulation. The findings reveal a novel mechanism through which astrocytes regulate brain connectivity and function by mediating neuronal epigenetic signals.
Article
Multidisciplinary Sciences
Jorine M. Eeftens, Manya Kapoor, Davide Michieletto, Clifford P. Brangwynne
Summary: Polycomb complex PRC1 forms multicomponent condensates through phase separation, preferentially seeding at H3K27me3 marks and subsequent histone modifications. Inducing Polycomb phase separation can cause chromatin compaction, but the condensates are dispensable for maintaining the compacted state.
NATURE COMMUNICATIONS
(2021)
Review
Microbiology
Yiman Li, Zhihui Song, Ente Wang, Liming Dong, Jie Bai, Dong Wang, Jinyan Zhu, Chao Zhang
Summary: Invasive aspergillosis is a significant cause of death in patients with hematological malignancies and transplant recipients. Antifungal drug resistance has become a concern in managing infections, and understanding histone posttranslational modifications may provide insights for developing new antifungal drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Melanie Heinlein, Luke C. Gandolfo, Kelin Zhao, Charis E. Teh, Nghi Nguyen, Jonathan B. Baell, Yael Goldfarb, Jakub Abramson, Johannes Wichmann, Anne K. Voss, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Daniel H. D. Gray
Summary: The histone acetyltransferase KAT7 plays a critical role in promoting transcription of peripheral tissue genes and regulating immunological tolerance in thymic epithelial cells. Deficiency of KAT7 leads to impaired immunological tolerance and the development of autoimmune diseases.
SCIENCE IMMUNOLOGY
(2022)
Article
Cell Biology
Fang-Fang Zhang, Liang Zhang, Lin Zhao, Yu Lu, Xin Dong, Yan-Qi Liu, Yu Li, Shuang Guo, Si-Yuan Zheng, Ying Xiao, Yu-Zhu Jiang
Summary: This study reveals that circRap1b plays a role in inhibiting neuronal apoptosis in acute ischemic stroke.
NEURAL REGENERATION RESEARCH
(2023)
Article
Cell Biology
Liang Ding, Yalei Wen, Xin Zhang, Fang Zhao, Kenao Lv, Jian-hong Shi, Shigang Shen, Xuefeng Pan
Summary: The study found that CBP and Ku70 positively regulate the expression of Ku70, negatively regulate NOX2, and mitigate intracellular ROS in human melanoma. Knocking down CBP or Ku70 induced necrotic and paraptotic cell death, with chromosomal condensations related to the BAX-associated intrinsic pathway of apoptotic cell death. The results suggest that CBP, Ku70, BAX, and NOX2 form a transcriptional network to prevent cell death in human melanoma.
CELL DEATH DISCOVERY
(2021)
Article
Pharmacology & Pharmacy
Weichen Duan, Miao Yu, Jiajia Chen
Summary: The BET family proteins, including BRD2, BRD3 and BRD4, are epigenetic readers that play multiple roles in the tumorigenesis and growth of various human malignancies. This review focuses on summarizing the roles and mechanisms of BRD4 in the initiation and development of glioblastoma, and evaluates the use of various BRD4 inhibitors and degraders as novel treatment strategies against glioblastoma.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Regina von Rennenberg, Thomas Liman, Christian H. Nolte, Alexander H. Nave, Jan F. Scheitz, Sandra Duezel, Vera Regitz-Zagrosek, Denis Gerstorf, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Matthias Endres
Summary: There is evidence of an association between levels of high-sensitivity cardiac troponin T (hs-cTnT) and cognitive decline in older men, as measured by the Digit Symbol Substitution Test (DSST). This association remained significant even after adjusting for age, sex, education, and cardiovascular risk factors. However, there was no significant association between hs-cTnT and different cognitive domains at baseline.
Article
Clinical Neurology
Luis P. Kuschel, Juergen Hench, Stephan Frank, Ivana Bratic Hench, Elodie Girard, Maud Blanluet, Julien Masliah-Planchon, Martin Misch, Julia Onken, Marcus Czabanka, Dongsheng Yuan, Soeren Lukassen, Philipp Karau, Naveed Ishaque, Elisabeth G. Hain, Frank Heppner, Ahmed Idbaih, Nikolaus Behr, Christoph Harms, David Capper, Philipp Euskirchen
Summary: DNA methylation-based classification is important for the diagnosis of brain tumors. Nanopore sequencing provides a fast and cost-effective method for this classification.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Hematology
Christopher M. Arends, Thomas G. Liman, Paulina M. Strzelecka, Anna Kufner, Pelle Loewe, Shufan Huo, Catarina M. Stein, Sophie K. Piper, Marlon Tilgner, Pia S. Sperber, Savvina Dimitriou, Peter U. Heuschmann, Raphael Hablesreiter, Christoph Harms, Lars Bullinger, Joachim E. Weber, Matthias Endres, Frederik Damm
Summary: Clonal hematopoiesis (CH) is common among older people and is associated with an increased risk of atherosclerosis, inflammation, and shorter overall survival. This study investigated CH in patients with first-ever ischemic stroke and found that CH is associated with an increased risk of recurrent vascular events and death.
Letter
Clinical Neurology
Andreas Meisel, Fulvio Baggi, Anthony Behin, Amelia Evoli, Anna Kostera-Pruszczyk, Renato Mantegazza, Raul Juntas Morales, Anna Rostedt Punga, Sabrina Sacconi, Michael Schroeter, Jan Verschuuren, Louise Crathorne, Kris Holmes, Maria-Isabel Leite
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Christian J. Hoffmann, Melanie T. C. Kuffner, Leif Koschuetzke, Stephanie Lorenz, Janet Lips, Philipp Boehm-Sturm, Susanne Mueller, Stefan P. Koch, Jeehye An, Lucius S. Fekonja, Polina Bugaeva, Andre Rex, Gisela Laettig Tuennemann, Matthias Endres, Christoph Harms
Summary: Paracrine cerebral Interleukin 6 (Il6) plays a role in stroke recovery, but systemic Il6 elevation may worsen outcome. Lithium modulates Il6 responses and improves stroke outcome, but has adverse effects. Zincfinger protein 580 (Zfp580) mediates the effects of lithium on Il6 signaling without adverse effects, improving cognitive and motor function. Inactivation of Zfp580 has positive effects on multiple key mechanisms, making it a potentially more specific and effective treatment target for stroke recovery than lithium. Zfp580 inhibitors must be developed to fully assess its potential.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Andreas Meisel, Djillali Annane, Tuan Vu, Renato Mantegazza, Masahisa Katsuno, Rasha Aguzzi, Glen Frick, Laura F. Gault, James Howard Jr
Summary: This study analyzed the interim results of an ongoing open-label extension study to evaluate the long-term treatment effects of ravulizumab in patients with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis. The findings showed that ravulizumab demonstrated sustained efficacy and safety in improving the disease condition of patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Alexander Nelde, Markus G. Klammer, Christian H. Nolte, Helena Stengl, Michael Kraemer, Regina von Rennenberg, Andreas Meisel, Franziska Scheibe, Matthias Endres, Jan F. Scheitz, Christian Meisel
Summary: This study used data lake-enabled technology to assess post-stroke heart rate and heart rate variability, and found that HR modulation and including HR in machine learning models can improve stroke outcome prediction.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sarah Dewilde, M. F. Janssen, Nafthali H. Tollenaar, Fiammetta Vanoli, Rita Frangiamore, Glenn Phillips, Sandra Paci, Renato Mantegazza, Andreas Meisel, Frauke Stascheit
Summary: This study aims to assess the concordance between self- and physician-reported MG-ADL scores. The results show that patients and neurologists have a concordant assessment of the patient's MG symptoms when using the MG-ADL scale. This evidence supports patient self-administration of the MG-ADL in clinical practice and research.
Article
Clinical Neurology
Frauke Stascheit, Adela Della Marina, Andreas Meisel
Summary: The treatment of myasthenia gravis is focused on the patient's antibody status. Various therapies including steroids, immunosuppressive treatments, and thymectomy are commonly used. New therapeutic approaches have been developed for patients with acetylcholine receptor antibody and muscle-specific receptor tyrosine kinase antibody. The use of modern immunomodulators based on disease activity is recommended.
Article
Clinical Neurology
Antje Mevius, Lars Joeres, Jutta Biskup, Tanja Heidbrede, Milada Mahic, Thomas Wilke, Ulf Maywald, Sophie Lehnerer, Andreas Meisel
Summary: The aim of this retrospective cohort study was to estimate the prevalence and incidence of myasthenia gravis (MG) in Germany and understand the burden of disease and treatment patterns. The study found that the prevalence of MG in Germany was approximately 39.3/10 0,0 0 0, and the incidence in 2019 was 4.6/10 0,0 0 0. A significant proportion of MG patients remained untreated, and many patients experienced exacerbations or myasthenic crises. MG was associated with higher mortality compared to the general non-MG population.
NEUROMUSCULAR DISORDERS
(2023)
Article
Medicine, General & Internal
Sonia Berrih-Aknin, Jacqueline Palace, Andreas Meisel, Kristl G. Claeys, Srikanth Muppidi, Francesco Sacca, Fatemeh Amini, Mark Larkin, Casey Quinn, Jon Beauchamp, Glenn Philips, Femke De Ruyck, Joyce Ramirez, Sandra Paci
Summary: This study aims to explore the impact of myasthenia gravis (MG) in the real world from a patient perspective. The study included MG patients from different countries and found that despite current treatments, patients still experience a significant burden.
Article
Biochemistry & Molecular Biology
Irmina Garcia-Carpio, Vincent Z. Braun, Elias S. Weiler, Marina Leone, Sergio Ninerola, Angel Barco, Luca L. Fava, Andreas Villunger
Summary: Unscheduled increases in ploidy can lead to tissue defects, premature aging, and malignancy. Extra centrosomes in cells, which are associated with tumors, can activate NF-?B signaling and cause inflammation. This activation affects the immune response and can make cancer cells more susceptible to attack by NK cells.
Article
Clinical Neurology
Burcu Ersoy, Marie-Louise Herzog, Wen Pan, Simone Schilling, Matthias Endres, Ria Goettert, Golo D. Kronenberg, Karen Gertz
Summary: This study investigated the regenerative and neuroprotective effects of antidepressants on primary mouse cortical neurons under oxygen-glucose deprivation conditions. The results showed that serotonin, citalopram, and fluoxetine did not provide neuroprotection without supplemental serotonin, whereas tianeptine had significant neuroprotective effects even in the absence of serotonin. Additionally, tianeptine inhibited the transcription of genes related to cell death and hypoxia and attenuated lipid peroxidation.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Kathrin Goedde, Hella Fuegemann, Ute Goerling, Ulrike Grittner, Raphael Kohl, Andreas Meisel, Thomas Reinhold, Susanne J. Schnitzer, P. Markus Deckert, Nikolaj Frost, Stephan Schreiber, Nina Rieckmann, Christine Holmberg
Summary: This feasibility study aims to evaluate a patient-oriented navigation model that integrates data about barriers to care, vulnerable patient populations, and existing support services. The study consists of two randomized controlled trials and observational cohorts, with the intervention group receiving support from personal navigators for 12 months while the control group receives a brochure with regional support offers. The feasibility of the navigation model is evaluated in terms of acceptance, demand, practicality, and efficacy.
Article
Multidisciplinary Sciences
Jeehye An, Leo Wendt, Georg Wiese, Tom Herold, Norman Rzepka, Susanne Mueller, Stefan Paul Koch, Christian J. Hoffmann, Christoph Harms, Philipp Boehm-Sturm
Summary: This paper presents a fully automated method for segmenting ischemic stroke lesions in mice using MRI. The method utilizes an end-to-end deep learning approach, requiring minimal preprocessing and working directly on raw MRI scans. The results show high agreement with manual segmentation, surpassing the consistency between human raters reported in previous studies.
SCIENTIFIC REPORTS
(2023)