Article
Materials Science, Multidisciplinary
Tian Tian, Bo Dang, Fengkun Li, Kai Yang, Dongbo Wei, Pingze Zhang
Summary: In this study, silver was implanted on the surface of TiNb-based alloy using metal vapor vacuum arc (MEVVA) ion implantation technology, resulting in the formation of nanocrystalline structures that improved the surface comprehensive mechanical properties, including hardness and elastic modulus. The suitable Ag-implanted specimen exhibited excellent antibacterial ability.
Review
Chemistry, Multidisciplinary
Gattu Sampath, Yih-Yuan Chen, Neelamegam Rameshkumar, Muthukalingan Krishnan, Kayalvizhi Nagarajan, Douglas J. H. Shyu
Summary: Nanotechnology is a rapidly developing field in material science, and silver nanoparticles (AgNPs) are of great interest due to their small size, large surface area, and multiple applications. The use of plant sources as reducing agents for synthesizing AgNPs is attractive because it is cheaper and less time-consuming. AgNPs have received significant attention in scientific fields for their antibacterial, anticancer, and anti-inflammatory activities, as well as their potential for clean environment applications.
Article
Materials Science, Multidisciplinary
Ningning Yang, Siyuan Wang, Peng Ding, Shaolan Sun, Qianqian Wei, Hafez Jafari, Ling Wang, Yanting Han, Oseweuba Valentine Okoro, Tianwen Wang, Guicai Li, Amin Shavandi, Lei Nie
Summary: This study successfully synthesized magnesium-doped biphasic calcium phosphate nanoparticles containing silver and confirmed their excellent cytocompatibility and antibacterial activity.
Article
Chemistry, Multidisciplinary
Nadezhda Samoilova, Maria Krayukhina, Alexander Naumkin, Nelya Anuchina, Dmitry Popov
Summary: The study proposed composites containing silver nanoparticles and silver cations, which were found to be active against a wide range of opportunistic microorganisms. The introduction of silver cations into the system reduced the charge of the polymer matrix and potentiated the activity of the silver nanoparticles.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Roberta Grazia Toro, Abeer Mohamed Adel, Tilde de Caro, Fulvio Federici, Luciana Cerri, Eleonora Bolli, Alessio Mezzi, Marianna Barbalinardo, Denis Gentili, Massimiliano Cavallini, Mona Tawfik Al-Shemy, Roberta Montanari, Daniela Caschera
Summary: The study demonstrates the excellent long-lasting antibacterial behavior of silver nanocomposites supported on oxidized nanocellulose, while also showing significant cytotoxicity in mouse embryonic fibroblasts.
Article
Chemistry, Multidisciplinary
Jayashree Shanmugam, Manikandan Dhayalan, Mohammed Riyaz Savaas Umar, Mayakkannan Gopal, Moonis Ali Khan, Jesus Simal-Gandara, Antonio Cid-Samamed
Summary: The synthesis of silver nanoparticles using Allium cepa var. Aggregatum extract as a stabilizer and reducer is analyzed in this study. The results confirm the successful synthesis of metallic AgNPs and demonstrate their antibacterial, antioxidant, and cytotoxic properties.
Article
Chemistry, Physical
Tetiana Dyrda-Terniuk, Oleksandra Pryshchepa, Katarzyna Rafinska, Mateusz Kolankowski, Adrian Golebiowski, Michal Gloc, Renata Dobrucka, Krzysztof Kurzydlowski, Pawel Pomastowski
Summary: The physicochemical and biological properties of silver-casein complexes were investigated using various techniques. The study focused on the modification of casein using a novel method, which resulted in high colloidal stability and minimized metal secondary reduction risk. The sorption mechanism and the influence of protein ions on the silver binding process were studied. The results showed that the silver sorption had a complex character, and phosphoserine residues played a significant role in the interaction. The silver-casein complex exhibited effective inhibition of bacterial growth but showed toxicity towards fibroblast cells, possibly due to the release of Ag+ ions.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Chemistry, Multidisciplinary
Alvaro Teran-Alcocer, Francisco Bravo-Plascencia, Carlos Cevallos-Morillo, Alex Palma-Cando
Summary: Electrochemical sensors based on conducting polymers are low-cost, rapid, and versatile for detecting analytes in liquid solutions. The focus is on the synthetic processes, morphological characterization, and nanostructure formation to enhance sensitivity for detecting molecules in the human body and water pollutants. Polypyrroles, polyanilines, and polythiophenes are commonly used conducting polymers for building electrochemical sensors.
Article
Chemistry, Physical
Alireza Allafchian, Farideh Balali, Mohammad Reza Vahabi, Seyed Amir Hossein Jalali
Summary: This study presents a simple method for synthesizing spherical silver nanoparticles and investigates their antibacterial and cytotoxic properties. The results demonstrate that the silver nanoparticles can effectively control Gram-negative bacteria and their cytotoxicity on L-929 cell line is dependent on time and dosage.
CHEMICAL PHYSICS LETTERS
(2022)
Article
Biotechnology & Applied Microbiology
Irum Shahzadi, Syed Munawar Aziz Shah, Mohammad Maroof Shah, Tariq Ismail, Nighat Fatima, Maria Siddique, Ummara Waheed, Ayesha Baig, Aisha Ayaz
Summary: The study examines the antioxidant, anticancer, antibacterial, and antifungal potential of biosynthesized silver nanoparticles (TpAgNPs) using plant extract. The findings reveal the critical role of phenolics, flavonoids, and anthocyanins in the production of TpAgNPs. TpAgNP6 exhibits low cytotoxicity and high antibacterial and antifungal activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hui Li, Qixiu You, Xiaoyan Feng, Conglong Zheng, Xianxiang Zeng, Hengyi Xu
Summary: Wound healing from bacterial infections is a challenge, especially with the emergence of antibiotic-resistant bacteria. This study explored the antibacterial effects of silver nanoparticles and Ag+ on Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. The results showed that both silver nanoparticles and Ag+ had excellent antibacterial effects in vitro, but in vivo, silver nanoparticles showed better antibacterial effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Congling Yang, Rui Jian, Ke Huang, Qilin Wang, Bo Feng
Summary: A method was developed for speciation analysis and accurate detection of silver ions and silver nanoparticles at trace levels. The results indicate that silver nanoparticles anchored on polydopamine/titania nanotubes play a crucial role in bactericidal action, while released silver ions synergistically enhance the antibacterial activity.
MICROCHEMICAL JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Anna Diez-Escudero, Elin Carlsson, Brittmarie Andersson, Josef D. Jarhult, Nils P. Hailer
Summary: Research has shown that silver-coated porous titanium scaffolds can inhibit the growth and biofilm formation of common PJI pathogens, while promoting normal metabolic activity and bone cell function in human osteoblasts. This technology has the potential to enhance osseointegration and reduce the risk of bacterial infections.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
A. Wasilewska, U. Klekotka, M. Zambrzycka, G. Zambrowski, I. Swiecicka, B. Kalska-Szostko
Summary: Understanding the properties of silver nanoparticles is crucial for developing new antimicrobial agents. In this study, silver nanoparticles were synthesized using natural reducing agents from plant extracts, and their antimicrobial properties were evaluated against various microorganisms. The results showed that the nanoparticles obtained from different extracts exhibited specific characteristics and varied antimicrobial activities.
Article
Chemistry, Multidisciplinary
Clarissa Marcelle Naidoo, Yougasphree Naidoo, Yaser Hassan Dewir, Moganavelli Singh, Aliscia Nicole Daniels, Johnson Lin, Ali Alsughayyir
Summary: This study successfully synthesized silver nanoparticles using latex extracts and evaluated their biological activities. The silver nanoparticles showed strong antibacterial and cytotoxic activities. Latex extracts can be used as effective capping agents for nanoparticles.
APPLIED SCIENCES-BASEL
(2023)
Review
Critical Care Medicine
A. Davies, F. Spickett-Jones, A. T. A. Jenkins, A. E. Young
Article
Chemistry, Multidisciplinary
Lauren Gwynne, George T. Williams, Kai-Cheng Yan, Jordan E. Gardiner, Kira L. F. Hilton, Bethany L. Patenall, Jennifer R. Hiscock, Jean-Yves Maillard, Xiao-Peng He, Tony D. James, Adam C. Sedgwick, A. Toby A. Jenkins
Summary: Two TCF-based fluorescent probes, TCF-OAc and TCF-OBu, were synthesized and showed different selectivity and fluorescence responses in the detection of gram-positive and gram-negative bacteria.
ISRAEL JOURNAL OF CHEMISTRY
(2021)
Article
Physics, Fluids & Plasmas
Bhagirath Ghimire, Endre J. Szili, Bethany L. Patenall, Pradeep Lamichhane, Nishtha Gaur, Alexander J. Robson, Dhruv Trivedi, Naing T. Thet, A. Toby A. Jenkins, Eun Ha Choi, Robert D. Short
Summary: This study investigates how to increase the production rate of hydrogen peroxide (H2O2) in deionised water (DIW) using an argon atmospheric-pressure plasma jet and explores the influence of operational parameters on H2O2 generation. Additionally, it demonstrates the synergistic action between H2O2 and other plasma generated molecules in DIW for effective decontamination of common wound pathogens.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Scarlet Milo, Rachel A. Heylen, John Glancy, George T. Williams, Bethany L. Patenall, Hollie J. Hathaway, Naing T. Thet, Sarah L. Allinson, Maisem Laabei, A. Toby A. Jenkins
Summary: This study presents a potential therapeutic candidate, 2-mercaptoacetamide (2-MA), as an inhibitor to prevent encrustation and blockage of urinary catheters caused by bacterial infections. By targeting urease as a therapeutic candidate, researchers have found a way to disarm bacterial virulence and limit the development of resistance.
SCIENTIFIC REPORTS
(2021)
Review
Critical Care Medicine
Keng Siang Lee, Amber Young, Hayley King, A. Toby A. Jenkins, Anna Davies
Summary: This study investigated the variation in burn wound infection (BWI) definitions in systematic reviews (SRs) of burn care interventions and its impact on the identification of effective treatments. The findings revealed heterogeneity in BWI definitions, which affected the drawing of conclusions and limited the validation of effective treatments.
Article
Physics, Applied
Endre J. Szili, Bhagirath Ghimire, Bethany Lee Patenall, Mohammed Rohaim, Dharmit Mistry, Adrian Fellows, Muhammad Munir, A. Toby A. Jenkins, Robert D. Short
Summary: This study presents a strategy utilizing cold plasma for the on-demand activation of acetyl donor molecules, generating an effective non-antibiotic antimicrobial formulation capable of eradicating common pathogens and inactivating viruses.
APPLIED PHYSICS LETTERS
(2021)
Article
Genetics & Heredity
Bethany L. Patenall, Hollie J. Hathaway, Maisem Laabei, Amber E. Young, Naing T. Thet, A. Toby A. Jenkins, Robert D. Short, Sarah L. Allinson
Summary: The main bactericidal components of cold atmospheric plasma are believed to be reactive oxygen and nitrogen species (RONS) along with UV-radiation, capable of causing DNA damage and mutations. CAP treatment may generate mutagenic effects on Escherichia coli, leading to resistance to the antibiotic ciprofloxacin.
Article
Biophysics
Rachel A. Heylen, Max Branson, Lauren Gwynne, Bethany L. Patenall, Nina Hauschildt, James Urie, June Mercer-Chalmers, Naing T. Thet, Maisem Laabei, A. Toby A. Jenkins
Summary: An optimised biosensor lozenge that can detect impending catheter blockage has been developed, providing early warning and allowing for quicker clinical intervention to reduce morbidity and mortality associated with blockage.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Physics, Applied
Bhagirath Ghimire, Bethany L. Patenall, Endre J. Szili, Nishtha Gaur, Pradeep Lamichhane, Naing T. Thet, Dhruv Trivedi, Andrew Toby A. Jenkins, Robert D. Short
Summary: This study investigates the influence of adding a 2nd ground electrode on the production of hydrogen peroxide (H2O2) in deionised water (DIW) in an argon plasma jet. It is found that the addition of a 2nd ground electrode leads to higher charge accumulation and increased discharge current and dissipated power, resulting in a higher electron temperature and more than twice the production of H2O2. The double ground electrode plasma jet is effective in reducing the growth of common wound pathogens and has low cytotoxicity in skin-like cells. These findings are valuable for optimizing plasma sources for clinical applications.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Nanoscience & Nanotechnology
Nishtha Gaur, Bethany L. Patenall, Bhagirath Ghimire, Naing T. Thet, Jordan E. Gardiner, Krystal E. Le Doare, Gordon Ramage, Bryn Short, Rachel A. Heylen, Craig Williams, Robert D. Short, Toby A. Jenkins
Summary: We introduce a versatile drug-loaded composite hydrogel that can simultaneously deliver a drug and CAP-generated molecules in a tissue target when activated by an argon-based cold atmospheric plasma jet. We demonstrated this concept by encapsulating gentamicin in sodium polyacrylate particles dispersed within a poly(vinyl alcohol) hydrogel matrix. The resulting gentamicin-PAA-PVA composite hydrogel can release gentamicin and effectively eradicate bacteria, including those in planktonic state and biofilm, when activated by CAP. The concept of the composite hydrogel can also be applied to other antimicrobial agents like cetrimide and silver, and activated by any dielectric barrier discharge CAP device.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Emily J. Owen, Rachel A. Heylen, Kyle Stewart, Paul G. Winyard, A. Toby A. Jenkins
Summary: This review discusses the current understanding of the prevention and treatment of Incontinence Associated Dermatitis (IAD). It emphasizes the need for specific preventative measures targeting faecal/urinary irritants, including the use of urease inhibitors. The lack of internationally accepted diagnostic methods for IAD severity is identified, with current diagnosis relying on visual inspection. Non-invasive techniques, such as impedance spectroscopy, could potentially provide objective assessments of skin barrier function and aid in early detection and intervention.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2023)
Review
Dermatology
Bethany L. Patenall, Joanne D. Ridgley, A. Toby A. Jenkins, Amber E. Young
Summary: The prevalence and role of biofilm formation in acute wounds has been rarely investigated. Understanding the presence of biofilm in acute wounds could lead to earlier targeted management, reducing the morbidity and mortality associated with wound infection, improving patient experience and potentially reducing healthcare costs. This study aimed to summarize the evidence for biofilm formation within acute wounds.
JOURNAL OF WOUND CARE
(2023)
Article
Chemistry, Multidisciplinary
Kai-Cheng Yan, Jordan E. E. Gardiner, Adam C. C. Sedgwick, Naing Thet, Rachel A. A. Heylen, Tony D. D. James, A. Toby A. Jenkins, Xiao-Peng He
Summary: A new fluorescent probe was developed to determine the NTR activity of different bacterial species under various growth conditions, which can be applied in complex clinical environments with high sensitivity and detection accuracy for both planktonic cultures and biofilms.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Kai-Cheng Yan, Bethany L. L. Patenall, Jordan E. E. Gardiner, Rachel A. A. Heylen, Naing Thet, Xiao-Peng He, Adam C. C. Sedgwick, Tony D. D. James, A. Toby A. Jenkins
Summary: TCF-OTf is a fluorescent probe that can monitor the production of superoxide anions in bacteria. It is responsive to chloramphenicol and heat shock treatment, and can detect the presence of superoxide anions in Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Lauren Gwynne, George T. Williams, Kai-Cheng Yan, Bethany L. Patenall, Jordan E. Gardiner, Xiao-Peng He, Jean-Yves Maillard, Tony D. James, Adam. C. Sedgwick, A. Toby. A. Jenkins
Summary: Alkaline phosphatase (ALP) is an important enzyme biomarker with potential in detecting pathogenic bacteria. Research has shown that ALP has colorimetric and fluorescent responses towards Staphylococcus aureus and demonstrates selectivity over other bacteria. Encapsulation of ALP in hydrogels can be used as smart wound dressings for monitoring and treating wound infections.
BIOMATERIALS SCIENCE
(2021)