Tumor-Derived Interleukin-1 Promotes Lymphangiogenesis and Lymph Node Metastasis through M2-Type Macrophages

Unique versus redundant functions of IL-1α and IL-1β in the tumor microenvironment

(2014) Elena Voronov   Frontiers in Immunology

N-myc Downstream-regulated Gene 1 Promotes Tumor Inflammatory Angiogenesis through JNK Activation and Autocrine Loop of Interleukin-1α by Human Gastric Cancer Cells

(2013) Yuichi Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

(2012) Jianhua Ling et al.   CANCER CELL

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

(2012) Tanja Holopainen et al.   JNCI-Journal of the National Cancer Institute

Macrophage Infiltration Predicts a Poor Prognosis for Human Ewing Sarcoma

(2011) Toshifumi Fujiwara et al.   AMERICAN JOURNAL OF PATHOLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-κB activation

(2008) Kosuke Watari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Tyrosine Kinase Inhibitor Cediranib Blocks Ligand-Induced Vascular Endothelial Growth Factor Receptor-3 Activity and Lymphangiogenesis

(2008) C. A. Heckman et al.   CANCER RESEARCH

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

(2008) Koji Hiraoka et al.   CANCER SCIENCE

Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy

(2008) Mayumi Ono   CANCER SCIENCE

Is interleukin-1 a good or bad ‘guy’ in tumor immunobiology and immunotherapy?

(2008) Ron N. Apte et al.   IMMUNOLOGICAL REVIEWS

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE