Article
Pharmacology & Pharmacy
Yuan-Yao Fan, Chi-Hsien Liu, An-Lun Wu, Hung-Chi Chen, Yi-Jen Hsueh, Kuan-Jen Chen, Chi-Chun Lai, Chung-Ying Huang, Wei-Chi Wu
Summary: The study investigated the potential role of a specific microRNA, miR-126, in regulating VEGFA expression and retinal neovascularization, with results showing that intravitreal injection of miR-126 plasmid effectively suppressed VEGFA expression and significantly inhibited retinal neovascularization in a rat OIR model, suggesting a potential therapeutic effect for ROP.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Minyoung Noh, Yeomyeong Kim, Haiying Zhang, Hyejeong Kim, Cho-Rong Bae, Sunghye Lee, Young-Guen Kwon
Summary: Retinal vascular diseases are a major cause of blindness worldwide, with common mechanisms including VEGF signaling, hypoxia, and inflammation. Current treatments improve outcomes but have limitations and side effects. A new therapeutic approach, such as oral administration of CU06-1004, could potentially address the underlying cause and provide better treatment for retinal vascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Tianying Hong, Xianmei Pan, Han Xu, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia
Summary: Vascular inflammation is a common pathological basis for many cardiovascular diseases. Jatrorrhizine, a component of Rhizoma Coptidis, has been found to reduce carotid intimal hyperplasia and vascular inflammation in mice, and inhibit endothelial cell inflammation induced by H2O2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Medicinal
Abraham Hang, Samuel Feldman, Aana Amin, Jorge A. Rivas Ochoa, Susanna Park
Summary: Vascular endothelial growth factors (VEGFs) are important in mediating complications associated with common retinal disorders and drugs that inhibit VEGF have been developed to minimize vision loss. These drugs are injected into the vitreous cavity in a clinic setting.
Article
Ophthalmology
Ruonan Wang, Yi Xu, Chen Niu, Xihui Gao, Xun Xu
Summary: H-KI20 exhibited inhibitory effects on angiogenesis both in vitro and in vivo, targeting JNK2 directly. The crucial role of ATF2 in VEGF-induced retinal neovascularization was elucidated for the first time. Therefore, H-KI20 shows potential as a sustained and low-toxic peptide for pathological retinal angiogenesis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jiang-Hui Wang, Yu-Fan Chuang, Jinying Chen, Vikrant Singh, Fan-Li Lin, Richard Wilson, Leilei Tu, Chenkai Ma, Raymond C. B. Wong, Peng-Yuan Wang, Jingxiang Zhong, Alex W. Hewitt, Peter van Wijngaarden, Gregory J. Dusting, Guei-Sheung Liu
Summary: In this study, we found that miR-143-3p was significantly downregulated in a rat model of oxygen-induced retinopathy. Injection of synthetic miR-143 mimics could effectively improve retinal neovascularization. miR-143 negatively impacted endothelial cell activity through regulating cell-matrix adhesion and mediating hypoxia-inducible factor-1 signaling.
NUCLEIC ACID THERAPEUTICS
(2022)
Article
Hematology
Raj Kumar, Gadiparthi N. Rao
Summary: The study reveals that PLC beta 3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Akiyoshi Uemura, Yoko Fukushima
Summary: Rho GTPases, especially RhoJ, play essential roles in regulating cell migration and junctions in vascular endothelial cells, affecting vascular formation and permeability. RhoJ, enriched in angiogenic ECs, induces actin depolymerization by competing with Cdc42 for common effector proteins, thus influencing cytoskeletal rearrangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Xueli Liu, Bin Zhu, Yujie Li, Xinyue Liu, Sheng Guo, Chenglong Wang, Sen Li, Dingxuan Wang
Summary: Angiogenesis and VEGF play crucial roles in tendon healing, but the effects of exogenous VEGF application are controversial and require further research.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chang Lu, Qiuyang Zhang, Huiying Zhang, Xiumiao Li, Qin Jiang, Jin Yao
Summary: Anlotinib has shown promise in inhibiting ocular neovascularization by reducing avascular areas and pathological neovascular tufts in animal models, suggesting its potential as a therapeutic candidate for eye diseases in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Qiu-Ping Liu, Yu-Ying Chen, Yuan-Yuan Yu, Pei An, Yi-Zhuo Xing, Hong-Xuan Yang, Yin-Jian Zhang, Khalid Rahman, Lei Zhang, Xin Luan, Hong Zhang
Summary: Proliferative diabetic retinopathy (PDR) is one of the main complications of diabetes, mainly caused by the aberrant proliferation of retinal vascular endothelial cells and the formation of new blood vessels. Traditional Chinese medicine formula Bie-Jia-Ruan-Mai-Tang (BJ) has potential in preventing and treating PDR. BJ inhibits cell proliferation, induces apoptosis, and regulates cell signaling pathways to impede the development of PDR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Neurosciences
Jeremie Canonica, Richard Foxton, Marina Garcia Garrido, Cheng-Mao Lin, Sabine Uhles, Sumathi Shanmugam, David A. Antonetti, Steven F. Abcouwer, Peter D. Westenskow
Summary: Clinical trials have shown that faricimab, a medication targeting angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF-A), provides effective and long-lasting treatment for neovascular age-related macular degeneration and diabetic macular edema. However, the mechanism behind these results and the role of Ang-2 inhibition require further investigation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Maria Hytti, Johanna Ruuth, Iiris Kanerva, Niina Bhattarai, Maria L. Pedersen, Carsten U. Nielsen, Anu Kauppinen
Summary: Age-related macular degeneration (AMD) is caused by chronic inflammation, possibly fueled by high glucose levels. Phloretin, found in apples, has anti-inflammatory effects and inhibits glucose uptake. In this study, ARPE-19 cells were exposed to lipopolysaccharide (LPS) and then treated with phloretin. Phloretin reduced the release of pro-inflammatory cytokines and increased intracellular reactive oxygen species levels. The Nrf2 pathway was found to be the main mechanism of phloretin's anti-inflammatory effects.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Lele Li, Xin Cao, Lili Huang, Xiaobo Huang, Jiayi Gu, Xiaoli Yu, Yan Zhu, Yue Zhou, Yu Song, Manhui Zhu
Summary: Choroidal neovascularization (CNV) is a leading cause of blindness, and LYC has been found to inhibit the process of EndMT in choroidal vascular endothelial cells (CVECs). This inhibition occurs through the modulation of the AR/MITF/PEDF/LR/AKT/beta-catenin pathway. Additionally, LYC has shown promising therapeutic effects in a mouse model of CNV.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Ophthalmology
Yue Wang, Xue Wang, Yue-Xia Wang, Yuan Ma, Yu Di
Summary: This study investigated the relationship between TUG1, VEGF, and miR-299-3p in retinopathy of prematurity (ROP) using an oxygen-induced retinal neovascularization mouse model and human retinal endothelial cells under hypoxia. The findings suggest that TUG1 reduces the expression of VEGFA by competitively adsorbing miR-299-3p, facilitating the regulation of retinal neovascularization.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)