Proteinase-Activated Receptor 1 (PAR1) Regulates Leukemic Stem Cell Functions

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Matrix metalloproteases and PAR1 activation

(2012) K. M. Austin et al.   BLOOD

Thrombin Receptor Regulates Hematopoiesis and Endothelial-to-Hematopoietic Transition

(2012) Rui Yue et al.   DEVELOPMENTAL CELL

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

(2012) C. Simon et al.   GENES & DEVELOPMENT

FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia

(2012) A Y H Leung et al.   LEUKEMIA

Leukemia Gene Atlas – A Public Platform for Integrative Exploration of Genome-Wide Molecular Data

(2012) Katja Hebestreit et al.   PLoS One

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

Inhibitor of Cyclin-dependent Kinase (CDK) Interacting with Cyclin A1 (INCA1) Regulates Proliferation and Is Repressed by Oncogenic Signaling

(2011) Nicole Bäumer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leukemic spleen cells are more potent than bone marrow-derived cells in a transgenic mouse model of CML

(2011) M Schemionek et al.   LEUKEMIA

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

Polarization and Migration of Hematopoietic Stem and Progenitor Cells Rely on the RhoA/ROCK I Pathway and an Active Reorganization of the Microtubule Network

(2010) Ana-Violeta Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

(2009) Vishal Trivedi et al.   CELL

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

PAR1 is selectively over expressed in high grade breast cancer patients: a cohort study

(2009) Norma A Hernández et al.   Journal of Translational Medicine

AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2

(2009) B Jiao et al.   LEUKEMIA

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

(2009) Ann-Marie Bröske et al.   NATURE GENETICS

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity

(2008) V. Shpacovitch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

(2008) N Misaghian et al.   LEUKEMIA

Roles of the EZH2 histone methyltransferase in cancer epigenetics

(2008) Jeffrey A. Simon et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion

(2008) P Arora et al.   ONCOGENE