Review
Endocrinology & Metabolism
Yue Han, Jun Wang, Xiaoying Wang, Ling Ouyang, Yan Li
Summary: This study conducted a systematic review and meta-analysis to evaluate the relationship between subclinical hypothyroidism in pregnancy and hypertensive disorders of pregnancy (HDP). The results indicated that pregnant women with subclinical hypothyroidism had an increased risk of developing HDP, regardless of the gestational period. However, the available evidence does not support the benefit of thyroxine intervention for these patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Nawsherwan, Zhiyi Liu, Zhang Le, Sumaira Mubarik, Yanmei Sun, Shafaq Naeem, Hui Li
Summary: Gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) are associated with adverse maternal-perinatal outcomes in singleton and twin pregnancies. GDM is linked to increased risks of cesarean section and macrosomia in singletons, and preterm birth in twins. HDP is associated with higher risks of cesarean section, preterm birth, perinatal mortality, and low birth weight in both singleton and twin pregnancies. Twin pregnancies complicated with GDM and HDP have higher odds of adverse maternal-neonatal outcomes compared to singleton pregnancies with these complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Maeliss Peigne, Jacques de Mouzon, Amelie Khiel, Alice Fraissinet, Victoria Maget, Jacqueline Saias-Magnan, Emmanuelle Mathieu-D'Argent, Olivia Gervereau, Helene Letur
Summary: This study compared the risk of complications between pregnancies with donated embryos and autologous frozen-thawed embryo transfer (FET). The results showed that pregnancies with donated embryos had a significantly higher incidence of hypertensive disorders of pregnancy (HDP), particularly the severe forms. Additionally, the rate of C-sections was higher in donated-embryo pregnancies, while there were no significant differences in newborn outcomes between the two groups.
FERTILITY AND STERILITY
(2023)
Article
Psychiatry
Jordana L. Sommer, Amanda Shamblaw, Natalie Mota, Kristin Reynolds, Renee El-Gabalawy
Summary: This study found that postpartum females with perinatal complications are more likely to have mental disorders, while those without complications do not have increased odds. Pregnant females without complications, on the other hand, have reduced odds of mental disorders. All perinatal groups had reduced odds of any substance use disorder compared to non-pregnant females.
GENERAL HOSPITAL PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Amira M. Aker, Simone N. Vigod, Cindy-Lee Dennis, Hilary K. Brown
Summary: The study found that there was no clinically meaningful mediating effect of perinatal complications in the association between chronic disease and postpartum mental illness. Perinatal complications explained only 1.5% of the association between chronic disease and postpartum mental illness.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Obstetrics & Gynecology
Ronghua Che, Jindan Pei, Huiyan Chen, Lingling Dong, Yuelin Wu, Xiaolin Hua
Summary: The study found that HDP has an impact on the perinatal outcomes of twin pregnancies, especially more significantly on dichorionic twins, with increasing risk of adverse outcomes with higher HDP grades. However, HDP has little relevance to the perinatal outcomes of monochorionic twins.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Mar Bennasar, Julia Ponce, Ximena Torres, Olga Gomez, Joan Sabria, Eduard Gratacos, Antoni Borrell, Josep M. Martinez
Summary: The study evaluated the perinatal outcomes of selective termination in dichorionic twin pregnancies with discordant anomalies, with higher survival rates associated with early or late procedures compared to intermediate procedures. Selective termination before 18 weeks was found to have lower pregnancy loss and preterm delivery rates.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Health Care Sciences & Services
Simona-Alina Abu-Awwad, Marius Craina, Lioara Boscu, Elena Bernad, Paula Diana Ciordas, Catalin Marian, Mircea Iurciuc, Ahmed Abu-Awwad, Stela Iurciuc, Brenda Bernad, Diana Maria Anastasiu Popov, Anca Laura Maghiari
Summary: This research investigates the association between altered lipid profiles and hypertensive disorders of pregnancy (HDP). The study finds significant elevations in Apolipoprotein B (ApoB) and Lipoprotein(a) (Lp(a)) levels in pregnant women with HDP, emphasizing the importance of early detection and specialized handling of cardiovascular risks in expectant mothers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Ellen O. Carlsen, Quaker Harmon, Maria C. Magnus, Helle M. Meltzer, Iris Erlund, Lars C. Stene, Siri E. Haberg, Allen J. Wilcox
Summary: This study found that among women without a history of diabetes, higher HbA1c levels at 18 weeks of pregnancy were associated with important perinatal outcomes, including birth weight, large-for-gestational age, preterm delivery, and preeclampsia.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Blessing Akombi-Inyang, Pramesh Raj Ghimire, Elizabeth Archibong, Emma Woolley, Husna Razee
Summary: This study found that women exposed to physical violence were more likely to report not using institutional delivery (adjusted Odds Ratio = 1.30) and not having skilled delivery assistants (adjusted Odds Ratio = 1.43). Women with partners who used alcohol and experienced emotional or physical violence were also more likely to not attend 4 or more skilled antenatal care visits.
Article
Multidisciplinary Sciences
Hui Li, Yuanmei Shi, Zahoor Ahmed, Abbas Khan, Kang Xu, Xiaoping Yin, Nawsherwan, Hong Zhang
Summary: The incidence rates of adverse perinatal outcomes have significantly decreased in Hubei province over the past 9 years. However, both extremes of maternal age groups and young and old cohorts are associated with a higher risk of preterm birth, perinatal mortality, and congenital defect.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Alexa X. D. Zhang, Holan Liang, Fiona S. McEwen, Charlotte Tye, Emma Woodhouse, Lisa Underwood, Elizabeth Shephard, Fintan Sheerin, Patrick F. Bolton
Summary: The study found that maternal tuberous sclerosis complex (TSC) is a significant marker of increased perinatal risk. However, after controlling for confounders, there was no significant association between perinatal adversities and neurodevelopmental outcomes.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Wei Zhao, Jiangli Di, Aiqun Huang, Qi Yang, Huanqing Hu
Summary: This study demonstrates that the incidence of hypertensive disorders of pregnancy increases gradually with the age, body mass index, and blood pressure of pregnant women in the first trimester. To reduce the incidence of hypertensive disorders effectively, more attention should be paid to older women planning to become pregnant, and measures should be taken to control blood pressure and weight before pregnancy.
Article
Cardiac & Cardiovascular Systems
Veronica Giorgione, Asma Khalil, Jamie O'Driscoll, Basky Thilaganathan
Summary: This study assessed the effectiveness of peripartum screening in predicting CHT after HDP and found that a prediction model combining clinical and echocardiographic features showed excellent accuracy in identifying women at risk of persistent hypertension after HDP.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Qin-Yu Cai, Yin Yang, Yong-Heng Wang, Han-Lin Cui, Xue-Peng Wu, Kai-Mai Liao, Xin Luo, Tai-Hang Liu
Summary: The COVID-19 quarantine may lead to poor pregnancy outcomes in hypertensive disorders of pregnancy (HDP) patients, with those who have a history of home quarantine being more prone to complications such as increased gestational weight gain, obesity rates, blood pressure, and uric acid levels, as well as lower newborn weight, shorter body length, lower Apgar scores, and an increased risk of fetal growth restriction.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Editorial Material
Neurosciences
Daniel R. Crabtree, David Muggeridge, Stephen J. Leslie, Ian L. Megson, James N. Cobley
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Psychiatry
Ryan Thomas McLean, Lorna Halley, David St Clair, Jun Wei
PSYCHIATRY RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Chan Li, Ruth Whelan, Hua Yang, Yaling Jiang, Chaosen Qiu, Qingyong Meng, Jun Wei
Article
Physiology
David J. Muggeridge, Katarzyna Goszcz, Andrew Treweeke, Janet Adamson, Kirsty Hickson, Daniel Crabtree, Ian L. Megson
FRONTIERS IN PHYSIOLOGY
(2019)
Review
Toxicology
Lekaashree Rambabu, Ian L. Megson, Michael Eddleston
CLINICAL TOXICOLOGY
(2020)
Article
Health Care Sciences & Services
David Joseph Muggeridge, Kirsty Hickson, Aimie Victoria Davies, Oonagh M. Giggins, Ian L. Megson, Trish Gorely, Daniel R. Crabtree
Summary: This study assessed the validity of heart rate measurements during various exercises using Polar OH1 and Fitbit Charge 3 devices. The Polar OH1 showed good accuracy across different activities, while Fitbit Charge 3 performed poorly, especially during cycling exercises.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Pharmacology & Pharmacy
Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston
Summary: Contrast-induced nephropathy (CIN) is a major complication in patients with chronic kidney disease (CKD) undergoing imaging. Previous studies suggested that oral N-acetylcysteine (NAC) could reduce CIN, but subsequent research showed no benefit. This study evaluated the mechanisms of action of NAC in healthy and diseased kidneys.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
David J. Muggeridge, Daniel R. Crabtree, Ahmet Tuncay, Ian L. Megson, Gareth Davison, James N. Cobley
Summary: New readily accessible systemic redox biomarkers are needed to understand the biological roles reactive oxygen species (ROS) play in humans. The study used a maximal exercise bout to disrupt redox homeostasis and determine a candidate systemic redox biomarker in human erythrocytes. The results showed that the oxidation level of a specific phosphatase decreased during exercise, and the activity of the phosphatase was greater at rest compared to exercise.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Maria Luisa Fiorello, Andrew T. Treweeke, David P. Macfarlane, Ian L. Megson
Summary: Research shows that even low levels of fructose intake can significantly decrease nitric oxide production in endothelial cells and increase metabolic activity, while glucose alone does not have a metabolic impact. Endothelial cells are highly sensitive to circulating fructose, which could have significant implications for the development of atherosclerotic disease associated with high fructose consumption.
Article
Immunology
Ryan Thomas Mclean, Elizabeth Buist, David St Clair, Jun Wei
Summary: Autoantibodies targeting the central nervous system can induce psychiatric symptoms resembling schizophrenia, and genetic studies have identified risk variants associated with schizophrenia. The functional implications of these risk variants are not well understood, but they may potentially be replicated by autoantibodies against the corresponding proteins. This study found that increased levels of antiCACNA1I IgG were associated with schizophrenia, but not with symptom domains related to the reduction of sleep spindles. Anti-Cav3.3 autoantibodies may function independently of pro-inflammatory processes, as they were not associated with depressive symptoms.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Materials Science, Multidisciplinary
Morven J. Duncan, Paul S. Wheatley, Emma M. Coghill, Simon M. Vornholt, Stewart J. Warrender, Ian L. Megson, Russell E. Morris
MATERIALS ADVANCES
(2020)
Article
Multidisciplinary Sciences
Maria Luisa Fiorello, Andrew T. Treweeke, David P. Macfarlane, Ian L. Megson
SCIENTIFIC REPORTS
(2020)
Review
Cardiac & Cardiovascular Systems
Emma M. Coghill, Timothy Johnson, Russell E. Morris, Ian L. Megson, Stephen J. Leslie
WORLD JOURNAL OF CARDIOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Denise Burtenshaw, Michael Kitching, Eileen M. Redmond, Ian L. Megson, Paul A. Cahill
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Matteo Scipioni, Graeme Kay, Ian L. Megson, Paul Kong Thoo Lin