Article
Biochemistry & Molecular Biology
Xiaomei Zhu, Qunshu Su, Haiyuan Xie, Lizhi Song, Fan Yang, Dandan Zhang, Binghong Wang, Shixian Lin, Jun Huang, Mengjie Wu, Ting Liu
Summary: The cell-cycle checkpoint kinase WEE1 is a potential therapeutic target for cancer treatment, but the regulation of its catalytic activity and the identification of reliable biomarkers for predicting response to WEE1 inhibitor remain unclear. This study identifies a conserved segment surrounding its Lys177 residue that inhibits WEE1 activity through an interaction with the catalytic kinase domain. Phosphorylation and acetylation modifications of WEE1 regulate its activation status, and the expression level of SIRT1 and WEE1 Lys177 acetylation in tumor cells could serve as useful biomarkers for predicting WEE1 inhibitor sensitivity or resistance.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Oncology
Gro Elise Rodland, Sissel Hauge, Grete Hasvold, Lilli T. E. Bay, Tine T. H. Raabe, Mrinal Joel, Randi G. Syljuasen
Summary: Inhibitors of ATR and WEE1 kinases are considered promising for cancer treatment, but the effects may vary between different cancer cell lines. More studies are needed to understand the potential of simultaneous inhibition of ATR and WEE1 in cancer therapy.
Article
Cell Biology
Rindert Missiaen, Nicole M. Anderson, Laura C. Kim, Bailey Nance, Michelle Burrows, Nicolas Skuli, Madeleine Carens, Romain Riscal, An Steensels, Fuming Li, M. Celeste Simon
Summary: Hepatocellular carcinoma (HCC) depends on exogenous arginine due to repression of urea cycle gene expression and unique dependence on cationic amino acid transporter SLC7A1. Arginine deprivation induces an integrated stress response, leading to HCC cell-cycle arrest and quiescence. Inhibiting GCN2 in arginine-deprived HCC cells promotes a senescent phenotype, making these cells vulnerable to senolytic compounds. Combined dietary arginine deprivation, GCN2 inhibition, and senotherapy show potential for HCC treatment.
Article
Oncology
Gregory Naylor, Linda Julian, Steven Watson-Bryce, Margaret Mullin, Robert J. Nibbs, Michael F. Olson
Summary: This article discusses the therapeutic effects of ROCK inhibitors on tumors and finds that using ROCK inhibitors to induce immunogenic cell death (ICD) may not increase therapeutic efficacy compared to standard care therapies.
Article
Biochemistry & Molecular Biology
Fangnan Wu, Chaoyong Tu, Kun Zhang, Hanyang Che, Qiaomei Lin, Zhuokai Li, Qingyun Zhou, Bufu Tang, Yang Yang, Minjiang Chen, Chuxiao Shao
Summary: This study found that PKMYT1 is overexpressed in HCC patients and is associated with poor prognosis. Knockdown of PKMYT1 inhibited proliferation and migration of HCC cell lines, inhibited autophagy, and induced apoptosis. These findings suggest that PKMYT1 may function as an oncogene and could be a new target for HCC treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Kim
Summary: The study found that kahweol induces apoptosis in hepatocellular carcinoma cells by inhibiting the phosphorylation of specific signaling pathways, suggesting it as a potential inhibitor of HCC cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Reem J. Abdualmjid, Consolato M. Sergi
Summary: This study investigated the anti-tumor effects of thymoquinone (TQ), derived from Nigella sativa, on hepatocellular carcinoma and cholangiocarcinoma. The results showed that TQ suppressed cell proliferation and induced apoptosis, suggesting its potential as a therapeutic agent for these types of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Manuela Mancini, Cecilia Monaldi, Sara De Santis, Michela Rondoni, Cristina Papayannidis, Chiara Sartor, Antonio Curti, Samantha Bruno, Michele Cavo, Simona Soverini
Summary: This study aimed to identify new therapeutic targets in the pathogenesis of systemic mastocytosis (SM). The results identified Aurora kinase A and Polo-like kinase 1 as potential targets for SM treatment. Inhibiting these kinases can induce apoptotic cell death in SM cell lines, suggesting it as an attractive therapeutic strategy. Further clinical development of inhibitors for these kinases could improve the outcome of patients with advanced SM.
Article
Pharmacology & Pharmacy
Guan-Rong Chen, Mei-Ling Chang, Shang-Tzen Chang, Yu-Tung Ho, Hui-Ting Chang
Summary: This study evaluated the cytotoxicity of Taiwania cryptomerioides essential oil and its phytochemical on human hepatocellular carcinoma cells. The results demonstrated that 6,7-dehydroroyleanone from the essential oil exhibited significant cytotoxicity and had better efficacy than the commonly used anticancer drug.
Article
Pharmacology & Pharmacy
Jiunn-Chang Lin, Tsang-Pai Liu, Yan-Bin Chen, Tun-Sung Huang, Tung-Ying Chen, Pei-Ming Yang
Summary: The expression of CDK9 protein in adjacent non-tumor tissues predicts the overall and progression-free survivals of hepatocellular carcinoma (HCC) patients. The CDK9-selective inhibitor LDC000067 exhibits anticancer activity in HCC cells by inhibiting the expression of RRM1 and RRM2. The downregulation of RRM1 and RRM2 by LDC000067 is achieved through post-transcriptional pathways, and RRM2 is degraded via proteasome-, lysosome-, and calcium-dependent pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyungjin Kim, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Su-Yeon Park, Eungyeong Jang, Bonglee Kim, Sung-Hoon Kim
Summary: The study found that CB-PIC exerts an apoptotic effect by inhibiting the Warburg effect mediated by STAT3, thereby showing anticancer activity against hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Federica Ragusa, Nadia Panera, Silvia Cardarelli, Marco Scarsella, Marzia Bianchi, Stefano Biagioni, Mauro Giorgi, Anna Alisi, Mara Massimi
Summary: The study found that PDE4D gene/protein were over-expressed in HCC samples compared to normal livers, and silencing or pharmacological inhibition of PDE4D activity showed anti-tumorigenic effects by reducing cell proliferation and increasing apoptosis. Over-expression of PDE4D in human HCCs correlated with up-regulated pro-oncogenic genes, suggesting a new potential molecular network for further investigation. PDE4D depletion/inhibition may serve as a novel biomarker for diagnosis and a potential adjuvant target for HCC therapy.
Article
Chemistry, Medicinal
Nari Shin, Hyo-Jung Lee, Deok Yong Sim, Eunji Im, Ji Eon Park, Woon Yi Park, Ah Reum Cho, Bum Sang Shim, Sung-Hoon Kim
Summary: This study investigated the mechanism of action of Compound K, an active ginseng saponin metabolite, in human hepatocellular carcinoma cells, revealing that it induces apoptosis through inhibition of glycolysis and AKT/mTOR/c-Myc signaling. These findings suggest that Compound K could be a promising candidate for liver cancer therapy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Han Ki Lee, Subin Bae, Jongsung Lee, Hyo Sun Cha, Myeong Jin Nam, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, Kwang-Hyeon Liu, See-Hyoung Park
Summary: The aim of this study was to investigate the apoptotic effects and anticancer mechanism of the biflavonoid bilobetin against human hepatocellular carcinoma (HCC) cells. The results showed that bilobetin inhibited cell proliferation, induced apoptosis and DNA fragmentation, elevated ROS levels, and caused DNA damage in HCC cells. It also regulated the expression of apoptotic signaling pathway proteins.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yuze Wei, Weiwei Ke, Zaiming Lu, Ying Ren
Summary: PI-3065 specifically inhibits survivin expression and exerts anti-HCC activity in vivo and in vitro, suggesting it may serve as an effective antitumor drug for HCC treatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
