Article
Biochemistry & Molecular Biology
Mourad Azzout, Celine Dietrich, Francois Machavoine, Pauline Gastineau, Alix Bottier, Guillaume Lezmi, Maria Leite-de-Moraes
Summary: IL-33 combined with IL-12 can directly target MAIT cells to induce their activation and cytokine production. This novel mechanism of IL-33 activation provides insight into the mode of action by which human MAIT cells can promote inflammatory responses in a TCR-independent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Angela M. M. Gocher-Demske, Jian Cui, Andrea L. L. Szymczak-Workman, Kate M. M. Vignali, Julianna N. N. Latini, Gwen P. P. Pieklo, Jesse C. C. Kimball, Lyndsay Avery, Ellyse M. M. Cipolla, Brydie R. R. Huckestein, Lee Hedden, Marlies Meisel, John F. F. Alcorn, Lawrence P. P. Kane, Creg J. J. Workman, Dario A. A. Vignali
Summary: Unlike IL12, IFN gamma can induce a T helper 1-like state in regulatory T (T-reg) cells during viral infection in mice that suppresses effector T cell responses and memory formation.
Article
Immunology
Mikel J. Ruterbusch, Brian D. Hondowicz, Kennidy K. Takehara, Kurt B. Pruner, Thomas S. Griffith, Marion Pepper
Summary: CD4(+) lung-resident memory T cells generated in response to influenza infection can be altered by subsequent exposure to allergens, leading to changes in their function and impact on disease outcomes upon reinfection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Gaelen K. Dwyer, Lisa R. Mathews, Jose A. Villegas, Anna Lucas, Anne Gonzalez de Peredo, Bruce R. Blazar, Jean-Philippe Girard, Amanda C. Poholek, Sanjiv A. Luther, Warren Shlomchik, Heth R. Turnquist
Summary: In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular patterns (DAMPs) that generate proinflammatory antigen-presenting cells (APCs) secreting IL-12, which drives the response of donor Th1 cells, leading to graft-versus-host disease (GVHD). However, there are other mechanisms through which alloreactive T cell responses are initiated by directly acting on donor CD4(+) T cells. Among these mechanisms, fibroblastic reticular cell-derived DAMP IL-33 plays a critical role by enhancing T cell expansion and differentiation through the activation of T cell signaling pathways in response to alloantigen, resulting in GVHD.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Surgery
Ravi Dhital, Shashi Anand, Brianna Graber, Qiang Zeng, Victoria M. Velazquez, Srinivasa R. Boddeda, James R. Fitch, Ranjana W. Minz, Mukut Minz, Ashish Sharma, Rachel Cianciolo, Masako Shimamura
Summary: Human cytomegalovirus (HCMV) infection is associated with renal allograft failure. CMV promotes allograft damage via cytokine-mediated Th1/17 cell recruitment. Pharmacologic inhibition of the Th17 cell signature cytokine, IL-17A, ameliorates CMV-associated allograft damage.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Xi Jing, Anna A. Korchagina, Sergey A. Shein, Wayne T. Muraoka, Ekaterina Koroleva, Alexei V. Tumanov
Summary: IL-23 contributes to intestinal inflammation in C. jejuni infected mice by promoting IL-17 and IFN gamma production by innate lymphoid cells. Reduced levels of pro-inflammatory cytokines and immune cell accumulation in the colon were observed in IL-23(-/-) mice, independent from bacterial clearance. Flow cytometry analysis revealed a decrease in IL-17 and IFN gamma production by group 1 and 3 innate lymphoid cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kunal Dhume, Caroline M. Finn, Priyadharshini Devarajan, Ayushi Singh, Joanne D. Tejero, Emily Prokop, Tara M. Strutt, Stewart Sell, Susan L. Swain, Karl Kai McKinstry
Summary: This study reveals the important role of Eomesodermin (Eomes) in maintaining Th1 attributes in T-bet-deficient cells and the concurrent Th17 and Th2 responses in the infected lung in the absence of both T-bet and Eomes. Furthermore, it demonstrates the potent antiviral capacity of unadulterated Th17 responses against influenza A virus (IAV) and the lack of functional plasticity in these Th17 effectors. These findings have important implications for vaccine design.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Chelsea L. Edwards, Susanna S. Ng, Fabian de Labastida Rivera, Dillon Corvino, Jessica A. Engel, Marcela Montes de Oca, Luzia Bukali, Teija C. M. Frame, Patrick T. Bunn, Shashi Bhushan Chauhan, Siddharth Sankar Singh, Yulin Wang, Jinrui Na, Fiona H. Amante, Jessica R. Loughland, Megan S. F. Soon, Nicola Waddell, Pamela Mukhopadhay, Lambros T. Koufariotis, Rebecca L. Johnston, Jason S. Lee, Rachel Kuns, Ping Zhang, Michelle J. Boyle, Geoffrey R. Hill, James S. McCarthy, Rajiv Kumar, Christian R. Engwerda
Summary: Control of malaria requires Th1 cells with IL-10 to mitigate inflammation, but IL-10+Tr1 cells can also promote parasite persistence or impair immunity. Molecular and phenotypic signatures distinguish IL-10-Th1 cells from IL-10+Tr1 cells in malaria-infected individuals and mice, and a conserved Tr1 cell signature is found in patients with malaria, dengue, and graft-versus-host disease.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Yun Hua Lee, Samuel Chuah, Phuong H. D. Nguyen, Chun Jye Lim, Hannah L. H. Lai, Martin Wasser, Camillus Chua, Tony K. H. Lim, Wei Qiang Leow, Tracy Jiezhen Loh, Wei Keat Wan, Yin Huei Pang, Gwyneth Soon, Peng Chung Cheow, Juinn Huar Kam, Shridhar Iyer, Alfred Kow, Glenn K. Bonney, Chung Yip Chan, Alexander Chung, Brian K. P. Goh, Weiwei Zhai, Pierce K. H. Chow, Salvatore Albani, Haiyan Liu, Valerie Chew
Summary: In this study, IL-17-producing CD8 (Tc17) T cells were found to have distinct immunological phenotypes and regulatory circuits in hepatocellular carcinoma (HCC). The IFN gamma(-) Tc17 subset demonstrated pro-tumoral characteristics and higher expression of CCL20, which was associated with increased tumor infiltration of T regulatory cells (Treg) and poorer prognosis in HCC patients.
Article
Biology
Jiro Sakai, Jiyeon Yang, Chao-Kai Chou, Wells W. Wu, Mustafa Akkoyunlu
Summary: Newborns have a lower humoral immune response than adults due to the immunoregulatory role of IL-10. This study found that both B-1 cells and non-B-1 cells in neonatal mice produce IL-10 in response to B cell antigen receptor (BCR) activation. The production of IL-10 is mediated by the activation of STAT5 and IL-6, and further activates STAT3. IL-10 secreted by neonatal non-B-1 cells can inhibit TNF-alpha secretion by macrophages.
Article
Food Science & Technology
Jin Yuan, Xiaoqian Xu, Zhongliang Wang, Ping Tong, Xuanyi Meng, Yong Wu, Xin Li, Jinyan Gao, Hongbing Chen
Summary: This study aimed to characterize the differentiations of naive Th cells stimulated with different doses of Staphylococcus aureus enterotoxin B (SEB). The results showed that the balance of Th1/Th2 could be dominated by the doses of SEB stimulation, with a higher dose inducing more Th1 cells and a lower Th2/Th1 ratio. This finding complements the existing knowledge about SEB as a superantigen and has implications for managing S. aureus colonization and SEB contamination in food.
Article
Immunology
Holly C. Webster, Virginia Gamino, Anna T. Andrusaite, Olivia J. Ridgewell, Jack McCowan, Amy L. Shergold, Graham A. Heieis, Simon W. F. Milling, Rick M. Maizels, Georgia Perona-Wright
Summary: This study finds that IL-10 promotes Th2 differentiation during helminth infection by suppressing Th1 cells. These findings are important for understanding the regulation of Type 2 immunity.
MUCOSAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ting Lu, Rui Ma, Wenjuan Dong, Kun-Yu Teng, Daniel S. Kollath, Zhiyao Li, Jinhee Yi, Christian Bustillos, Shoubao Ma, Lei Tian, Anthony G. Mansour, Zhenlong Li, Erik W. Settles, Jianying Zhang, Paul S. Keim, Bridget M. Barker, Michael A. Caligiuri, Jianhua Yu
Summary: Engineered NK cells expressing soluble interleukin-15 and a chimeric antigen receptor targeting the spike protein of SARS-CoV-2 show promising potential as an off-the-shelf therapy for COVID-19 patients, with enhanced antiviral activity and cytotoxicity against spike protein-expressing cells.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Gabriel Goncalves, Kerry A. Mullan, Divya Duscharla, Rochelle Ayala, Nathan P. Croft, Pouya Faridi, Anthony W. Purcell
Summary: Peptide vaccination is a promising strategy to induce T-cell mediated tumor killing. In this study, the effect of IFN gamma on TNBC cells was analyzed, revealing a significant remodeling of the immunopeptidome with increased diversity and abundance of peptides. The results suggest that cytokine stimulation can unveil a wider range of potential HLA-I and HLA-II vaccine targets, which has important implications for personalized cancer vaccination strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Eni Nano, Maria Petropavlovskaia, Lawrence Rosenberg
Summary: This study demonstrates that both rINGAP and Ingap-p can inhibit cytokine-induced cell apoptosis and related signaling pathways, suggesting that INGAP may act by influencing the crosstalk between cytokine signaling pathways.
CELL DEATH DISCOVERY
(2021)