Article
Pediatrics
Joshua Garfein, Kerry S. J. Flannagan, Mercedes Mora-Plazas, Henry Oliveros, Constanza Marin, Eduardo Villamor
Summary: This study found that longer LTL among girls in middle childhood is associated with smaller increases in waist circumference, an indicator of abdominal adiposity.
Article
Clinical Neurology
Nurul Hanis Ramzi, Juha Auvinen, Juha Veijola, Jouko Miettunen, Leena Ala-Mursula, Sylvain Sebert, Sirkka Keinanen-Kiukaanniemi, Rauli Svento, Jari Jokelainen, Fotios Drenos, Terence M. Dovey, Marjo-Riitta Jarvelin, Alexandra I. F. Blakemore
Summary: This study examined the relationship between depressive symptoms and body mass index (BMI) in adults, and found a significant correlation between them. Depressive symptoms were found to partially and completely mediate the effects of BMI over a 15-year period. These findings have important implications for future clinical obesity research.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Tiina Lankila, Soile Puhakka, Mikko Karmeniemi, Maarit Kangas, Jarmo Rusanen, Raija Korpelainen
Summary: This study examined the association between residential environmental history and changes in perceived health in the middle-age population. The study found that living in areas with a higher economic dependency ratio or distance from local services increased the risk of deteriorating perceived health, while living farther from green areas reduced the risk of deteriorating perceived health. The urban/rural context of the residential environment may contribute to these findings.
Article
Medicine, General & Internal
Kaisa Lampainen, Rahman Shiri, Juha Auvinen, Jaro Karppinen, Jorma Ryhanen, Sina Hulkkonen
Summary: This study found an association between body mass index (BMI) and carpal tunnel syndrome (CTS), but no association between waist circumference or waist-to-hip ratio (WHR) and CTS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Petteri Oura, Leena Ala-Mursula, Andrew Chamberlain, Juho-Antti Junno, Ina Rissanen
Summary: Family's socioeconomic profile constructed prenatally has predictive value for midlife mortality among male offspring. Different socioeconomic profiles are associated with offspring mortality rates, demonstrating that premature mortality of men and women seem to be two distinct phenomena.
PREVENTIVE MEDICINE
(2022)
Article
Clinical Neurology
Brian J. Miller, Karl-Heinz Herzig, Jari Jokelainen, Toni Karhu, Sirkka Keinanen-Kiukaanniemi, Marjo-Riitta Jarvelin, Juha Veijola, Heimo Viinamaki, Paivikki Tanskanen, Erika Jaaskelainen, Matti Isohanni, Markku Timonen
Summary: Elevated blood interleukin-6 (IL-6) levels in midlife schizophrenia patients are associated with smaller hippocampal volumes. The study suggests a potential role of IL-6 in the pathophysiology of schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Yifan Fan, Yulin Guo, Jiuchang Zhong, Hongjie Chi, Xiaotao Zhao, Pixiong Su, Jie Gao, Mulei Chen
Summary: This study found an independent association between Visceral Adiposity Index (VAI) and Leukocyte Telomere Length (LTL). Higher VAI is associated with shorter LTL. The results suggest that VAI may be used for predicting LTL and accelerating biological aging.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Oncology
Anniina Tastula, Arja Jukkola, Anni-Emilia Alakokkare, Tanja Nordstrom, Sanna Etelainen, Peeter Karihtala, Jouko Miettunen
Summary: This study suggests that early-life residence and socioeconomic conditions may play a role in the development of breast cancer in women in adult life, with factors such as urban maternal residence during pregnancy, low education, and a personal history of breast cancer increasing the risk. Lower BMI at age 14 was also found to potentially impact breast cancer risk, but no association was found with birth size. This study is one of the few prospective birth cohort studies examining early-life socioeconomic factors and breast cancer risk in adult life, but is limited by the small number of cases.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Clinical Neurology
Ina Rissanen, Mirjam Geerlings, Seppo Juvela, Jouko Miettunen, Markus Paananen, Sami Tetri
Summary: The study suggests that the general health condition of mothers during pregnancy may impact the risk of cerebrovascular disease in offspring. Factors such as hospitalization, having multiple ill health conditions, and not using vitamin or iron supplements were associated with an increased risk of cerebrovascular disease in the offspring.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Nutrition & Dietetics
Christina Raftopoulou, George Paltoglou, Evangelia Charmandari
Summary: This review summarizes the impact of childhood obesity on telomere length, revealing a negative association. Lifestyle interventions in children may lead to increased telomere length peripherally, suggesting a potential mechanistic relation worth further investigation.
Article
Psychiatry
Tuomas Majuri, Anni-Emilia Alakokkare, Marianne Haapea, Tanja Nordstrom, Jouko Miettunen, Erika Jaaskelainen, Leena Ala-Mursula
Summary: This study compared employment trajectories among individuals with schizophrenia, other psychoses, and without psychosis. The findings showed that most individuals with mental illnesses had unstable employment trajectories, indicating a higher risk of unemployment and part-time work. The study highlights the importance of improving labor market attachment during the early stages of mental illness.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ina Rissanen, Iiro Nerg, Leena Ala-Mursula, Marko Korhonen
Summary: This study examined the impact of stroke, heart attack, and cancer on individual income, finding that stroke and heart attack can lead to economic losses while cancer does not. The decrease in income among control group men suggests that severe health events do not account for all income decreases.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Orthopedics
Teija Mertimo, Jaro Karppinen, Jaakko Niinimaki, Roberto Blanco, Juhani Maatta, Markku Kankaanpaa, Petteri Oura
Summary: LDD is significantly associated with both mild-to-moderate and bothersome-and-frequent LBP, but the presence of mental distress weakens this association.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Endocrinology & Metabolism
Chenxue Bai, Zixiong Shen, Binxu Qiu, Songling Zhang
Summary: The study found that a genetically predicted longer LTL increases the risk of endometriosis, but endometriosis has no causal impact on LTL. The results strengthen the causal link between LTL and endometriosis, suggesting that LTL may serve as a potential biomarker for endometriosis, offering new possibilities for prevention and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Heli Kiema-Junes, Aino Saarinen, Raija Korpelainen, Maarit Kangas, Leena Ala-Mursula, Riitta Pyky, Mirka Hintsanen
Summary: Physical activity and sedentary behavior have an impact on work engagement, which can be measured through self-report and accelerometer data.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Surgery
Stefan Wallen, Gustaf Bruze, Johan Ottosson, Claude Marcus, Johan Sundstrom, Eva Szabo, Torsten Olbers, Maria Palmetun-Ekback, Ingmar Naslund, Martin Neovius
Summary: This study aimed to compare the use of opioids in patients with obesity who underwent bariatric surgery versus those who underwent intensive lifestyle modification. The results showed that patients who underwent bariatric surgery had a higher proportion of opioid users and a larger total opioid dose, especially in those who received additional surgery during follow-up.
Article
Genetics & Heredity
K. Alaine Broadaway, Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P. Wilson, Anne H. Moxley, Swarooparani Vadlamudi, Arushi Varshney, Anne U. Jackson, Vasudha Ahuja, Stefan R. Bornstein, Laura J. Corbin, Graciela E. Delgado, Om P. Dwivedi, Lilian Fernandes Silva, Timothy M. Frayling, Harald Grallert, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Christian Herder, Sandra Herrmann, Kurt Hojlund, David A. Hughes, Marcus E. Kleber, Cecilia M. Lindgren, Ching-Ti Liu, Jian'an Luan, Anni Malmberg, Angela P. Moissl, Andrew P. Morris, Nikolaos Perakakis, Annette Peters, John R. Petrie, Michael Roden, Peter E. H. Schwarz, Sapna Sharma, Angela Silveira, Rona J. Strawbridge, Tiinamaija Tuomi, Andrew R. Wood, Peitao Wu, Bjorn Zethelius, Damiano Baldassarre, Johan G. Eriksson, Tove Fall, Jose C. Florez, Andreas Fritsche, Bruna Gigante, Anders Hamsten, Eero Kajantie, Markku Laakso, Jari Lahti, Deborah A. Lawlor, Lars Lind, Winfried Maerz, James B. Meigs, Johan Sundstrom, Nicholas J. Timpson, Robert Wagner, Mark Walker, Nicholas J. Wareham, Hugh Watkins, Ines Barroso, Stephen O'Rahilly, Niels Grarup, Stephen CJ. Parker, Michael Boehnke, Claudia Langenberg, Eleanor Wheeler, Karen L. Mohlke
Summary: Insufficient insulin secretion and increased proinsulin levels indicate beta-cell stress and insulin resistance. A meta-analysis of European-ancestry individuals identified 36 independent signals at 30 loci associated with fasting proinsulin. These loci are involved in various mechanisms that affect insulin processing and beta-cell function. Colocalization analysis provided potential candidate genes and regulatory mechanisms for proinsulin production and glucose regulation. This study highlights the importance of genetic studies for understanding disease predisposition.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Tracey G. Simon, Bjorn Roelstraete, Naim Alkhouri, Hannes Hagstrom, Johan Sundstrom, Jonas F. Ludvigsson
Summary: This study found that children and young adults with biopsy-proven NAFLD had significantly higher rates of incident MACE, including ischaemic heart disease and congestive heart failure, compared to matched population controls.
Article
Endocrinology & Metabolism
Alina Rodriguez, Katarzyna Korzeniowska, Kamila Szarejko, Hubert Borowski, Malgorzata Mysliwiec, Michal Brzezinski, Leszek Czupryniak, Per-Olof Berggren, Marcin Radziwill, Piotr Soszynski
Summary: Using data from a large-scale screening program, this study aimed to predict factors influencing the willingness and engagement of adolescents in an obesity management intervention. Results showed that approximately one third of adolescents with high obesity risk declined the initial invitation. Poor diet, sedentary behavior, and parental education were predictive of willingness and continued participation, while body mass index did not matter. Perceived family support rather than initial motivation facilitated engagement. The study also emphasized the importance of regional socio-geographical factors, such as trust in local authorities.
OBESITY RESEARCH & CLINICAL PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Sara Higueras-Fresnillo, Angel Herraiz-Adillo, Viktor H. Ahlqvist, Daniel Berglind, Cecilia Lenander, Bledar Daka, Maria Braennholm Syrjala, Johan Sundstrom, Carl Johan Ostgren, Karin Radholm, Pontus Henriksson
Summary: The aim of this study was to examine the prevalence of ideal cardiovascular health (iCVH) in the middle-aged population of Sweden. Data from a large population-based study were analyzed and a total iCVH score was calculated based on seven components. Results showed that only 18.2% of the population reached ideal status, while 51.9% were classified as intermediate status and 29.9% as poor status of iCVH. Women had a higher prevalence of iCVH status and a lower prevalence of poor iCVH status. These findings can be used as benchmarks for future comparisons and efforts to promote cardiovascular health.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Lind, Tove Fall, Johan Arnlov, Solve Elmstahl, Johan Sundstrom
Summary: This study explored the relationship between a wide range of circulating metabolites and future cardiovascular disease (CVD) as well as subclinical markers of CVD in the general population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson, Jocelyne Benatar, Lisa Brandin, David Erlinge, Urban Haaga, Claes Held, Pelle Johansson, Patric Karlstrom, Thomas Kellerth, Toomas Marandi, Katarina Mars, Annica Ravn-Fischer, Johan Sundstrom, Ollie Ostlund, Robin Hofmann, Tomas Jernberg
Summary: This article introduces a trial called REDUCE-AMI, which aims to evaluate the effect of long-term beta-blocker treatment on death and recurrent myocardial infarction in patients with acute MI. The study will involve 5000 patients and observe both primary and secondary endpoints. The results will have important implications for guidelines and clinical practice.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jared G. Maina, Vincent Pascat, Liudmila Zudina, Anna Ulrich, Igor Pupko, Amelie Bonnefond, Zhanna Balkhiyarova, Marika Kaakinen, Philippe Froguel, Inga Prokopenko
Summary: This study assessed the association between obesity, type 2 diabetes (T2D), and pancreatic cancer using polygenic scores (PGS) and Mendelian randomisation (MR) analyses. The results showed that abdominal adiposity measured by waist-to-hip ratio adjusted BMI (WHRadjBMI) may be a more significant risk factor for pancreatic cancer compared to total adiposity, with T2D potentially driving this relationship.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Norhammar, Johan Bodegard, Marc Vanderheyden, Navdeep Tangri, Avraham Karasik, Aldo Pietro Maggioni, Kari Anne Sveen, Tiago Taveira-Gomes, Manuel Botana, Lukas Hunziker, Marcus Thuresson, Amitava Banerjee, Johan Sundstrom, Andreas Bollmann
Summary: The CaReMe HF study collected individual level data from digital healthcare systems in 11 countries to estimate the prevalence, clinical outcomes, and costs of HF. The study found that 1-2% of the contemporary adult population has HF, and these individuals are at significant risk of adverse outcomes and associated costs.
Article
Clinical Neurology
Nurul Hanis Ramzi, Juha Auvinen, Juha Veijola, Jouko Miettunen, Leena Ala-Mursula, Sylvain Sebert, Sirkka Keinanen-Kiukaanniemi, Rauli Svento, Jari Jokelainen, Fotios Drenos, Terence M. Dovey, Marjo-Riitta Jarvelin, Alexandra I. F. Blakemore
Summary: This study examined the relationship between depressive symptoms and body mass index (BMI) in adults, and found a significant correlation between them. Depressive symptoms were found to partially and completely mediate the effects of BMI over a 15-year period. These findings have important implications for future clinical obesity research.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Genetics & Heredity
Shing Wan Choi, Judit Garcia-Gonzalez, Yunfeng Ruan, Hei Man Wu, Christian Porras, Jessica Johnson, Clive Hoggart, Paul O'Reilly
Summary: Polygenic risk scores (PRSs) are widely used in biomedicine and have become a leading advance in recent years. However, current methods for computing PRSs often lose key information about an individual's genetic profile. In this study, we introduce a pathway-based PRS method that calculates polygenic scores across genomic pathways for each individual, providing individual-level estimates of genetic liability for each pathway. We find that pathway-based PRSs have similar capabilities for evaluating pathway enrichment and disease stratification compared to leading methods, with the advantage of offering pathway-level insights.
Article
Cardiac & Cardiovascular Systems
Joel Ohm, Ralf Kuja-Halkola, Anna Warnqvist, Henrike Haebel, Per H. Skoglund, Johan Sundstroem, Kristina Hambraeus, Tomas Jernberg, Per Svensson
Summary: Low socioeconomic status is associated with worse prognosis after myocardial infarction. This study identified nonparticipation in cardiac rehabilitation, cardiometabolic risk profile, and persistent smoking as mediating factors in the relationship between low income and post-MI recurrent atherosclerotic cardiovascular disease events.
Article
Psychiatry
Eric Clapham, Johan Reutfors, Marie Linder, Lena Brandt, Johan Sundstrom, Robert Boden
Summary: The risk of cardiac adverse events following the use of clozapine is debated; however, its risk for chemically related antipsychotics olanzapine and quetiapine is unknown. A Swedish study used registers to analyze the risk of perimyocarditis and heart failure in patients receiving these antipsychotics. The study found that clozapine use was associated with a significantly increased short-term risk of perimyocarditis and an increased long-term risk of heart failure. Olanzapine and quetiapine use did not show an increased risk compared to no antipsychotic treatment.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
Article
Biology
Shing Wan Choi, Timothy Shin Heng Mak, Clive J. Hoggart, Paul F. O'Reilly
Summary: Polygenic risk score (PRS) analyses are widely used in biomedical research. This study highlights the potential impact of sample overlap between GWAS and target samples on PRS results and provides a solution for controlling the inflation effect caused by this overlap. The EraSOR method and software can effectively eliminate the inflation effect and be useful in PRS studies to adjust for sample overlap or as a sensitivity tool to detect and account for this overlap.
