期刊
PLOS ONE
卷 9, 期 4, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0095600
关键词
-
资金
- Alpha-1 Foundation
- CHEST Foundation Clinical Research Award
- Michael Smith Foundation for Health Research Senior Scholarship award
Oxidative stress is involved in the pathogenesis of airway obstruction in alpha(1)-antitrypsin deficient patients. This may result in a shortening of telomere length, resulting in cellular senescence. To test whether telomere length differs in alpha(1)-antitrypsin deficient patients compared with controls, we measured telomere length in DNA from peripheral blood cells of 217 alpha(1)-antitrypsin deficient patients and 217 control COPD patients. We also tested for differences in telomere length between DNA from blood and DNA from lung tissue in a subset of 51 controls. We found that telomere length in the blood was significantly longer in alpha(1)-antitrypsin deficient COPD patients compared with control COPD patients (p = 1x10(-29)). Telomere length was not related to lung function in alpha(1)-antitrypsin deficient patients (p = 0.3122) or in COPD controls (p = 0.1430). Although mean telomere length was significantly shorter in the blood when compared with the lungs (p = 0.0078), telomere length was correlated between the two tissue types (p = 0.0122). Our results indicate that telomere length is better preserved in alpha(1)-antitrypsin deficient COPD patients than in non-deficient patients. In addition, measurement of telomere length in the blood may be a suitable surrogate for measurement in the lung.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据