Article
Oncology
Junqiang Liu, Zhiyuan Chou, Chun Li, Kai Huang, Xuejian Wang, Xiunan Li, Chuanchun Han, Abdullah Al-Danakh, Xiaodong Li, Xishuang Song
Summary: This study reveals the function and molecular mechanism of ZBTB7A in bladder cancer. The results indicate that ZBTB7A promotes tumorigenesis of bladder cancer through downregulating HIC1 expression.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Lan-Ting Zhou, Juan Zhang, Lu Tan, He-Zhou Huang, Yang Zhou, Zhi-Qiang Liu, Youming Lu, Ling-Qiang Zhu, Chengye Yao, Dan Liu
Summary: The study revealed that elevated levels of miR-144-3p in AD model mice target tPA mRNA, resulting in abnormal NGF maturation, cholinergic degeneration, and synaptic/memory deficits. Injection of miR-144-3p replicated the pathological features in the mice, while injection of an antagomir partially rescued these symptoms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yong Xi, Yaxing Shen, Donglei Wu, Jingtao Zhang, Chengbin Lin, Lijie Wang, Chaoqun Yu, Bentong Yu, Weiyu Shen
Summary: This study found that circBCAR3 is highly expressed in esophageal cancer and it can promote the tumorigenesis of esophageal cancer by interacting with miR-27a-3p to upregulate TNPO1. The splicing factor QKI was identified as a positive regulator of circBCAR3 and hypoxia upregulates E2F7 to transcriptionally activate QKI.
Article
Biotechnology & Applied Microbiology
Zhaoping Che, Jie Xueqin, Zongyu Zhang
Summary: The research showed that OIP5-AS1 influences the evolution of intervertebral disc degeneration by targeting miR-25-3p. Silencing OIP5-AS1 promotes nucleus pulposus cell proliferation, inhibits apoptosis and extracellular matrix degradation, and suppresses inflammation response.
Article
Cell Biology
Yen-You Lin, Chih-Yuan Ko, Shan-Chi Liu, Yu-Han Wang, Chin-Jung Hsu, Chun-Hao Tsai, Tsung-Ju Wu, Chih-Hsin Tang
Summary: The study showed a negative correlation between miR-144-3p and IL-1 beta expression in OA, with transfection of miR-144-3p mimic downregulating IL-1 beta levels and blocking related signaling pathways. Administration of miR-144-3p mimic effectively ameliorated OA progression in a rat model, indicating miR-144-3p as a potential therapeutic target for OA.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Congjing An, Zhigang Hu, Yuehong Li, Pengxin Zhao, Runtian Liu, Qing Zhang, Peiling Zhu, Yanting Li, Ying Wang
Summary: The study identified that LINC00662 is overexpressed in breast cancer and promotes cancer cell progression by competitively binding to miR-144-3p to upregulate SOX2 expression. This suggests that LINC00662 could be a potential therapeutic target for breast cancer treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Yu-Xiang Yan, Huan-Bo Xiao, Ya-Ke Lu, Yue Sun, Shuo Wang, Jing Dong, Li-Juan Wu
Summary: This study identified the association between hsa_circ_0111707 and stress-related T2D. Decreased hsa_circ_0111707 expression was associated with increased risk of T2D development, and it functions as a sponge for miR-144-3p. hsa_circ_0111707 in PBMCs can be considered a potential biomarker of stress-related T2D.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Elisa Zago, Alessandra Dal Molin, Giovanna Maria Dimitri, Luciano Xumerle, Chiara Pirazzini, Maria Giulia Bacalini, Maria Giovanna Maturo, Tiago Azevedo, Simeon Spasov, Pilar Gomez-Garre, Maria Teresa Perinan, Silvia Jesus, Luca Baldelli, Luisa Sambati, Giovanna Calandra-Buonaura, Paolo Garagnani, Federica Provini, Pietro Cortelli, Pablo Mir, Claudia Trenkwalder, Brit Mollenhauer, Claudio Franceschi, Pietro Lio, Christine Nardini
Summary: This study aims to investigate the relevance of microRNAs as biomarkers of Parkinson's Disease within the ageing framework. The down-regulation of hsa-miR-144-3p in early Parkinson's Disease patients and its involvement in the regulation of coagulation were consistently observed.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Donglin Zhang, Aiqin Pan, Jianke Gu, Renfeng Liao, Xueyu Chen, Zhaozhu Xu
Summary: This study revealed that miR-144-3p regulates the occurrence and development of heart failure by targeting SOCS2. Upregulation of miR-144-3p alleviates Dox-induced cardiac dysfunction and cardiomyocyte apoptosis.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Gastroenterology & Hepatology
Noriaki Murayama, Koichi Okamoto, Tadahiko Nakagawa, Jinsei Miyoshi, Kensei Nishida, Tomoyuki Kawaguchi, Kaizo Kagemoto, Shinji Kitamura, Beibei Ma, Hiroshi Miyamoto, Naoki Muguruma, Mitsuyasu Yano, Koichi Tsuneyama, Takahiro Fujimori, Yasushi Sato, Tetsuji Takayama
Summary: The overexpression of miR-144/miR-451 cluster promotes lymphovascular invasion in rectal NET-G1 cells by repressing PTEN and p19. The miR-144/451 cluster may be a novel biomarker for predicting invasion/metastasis in rectal NET-G1.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Wei Liu, Dunwei Wang, Lidi Liu, Lin Wang, Ming Yan
Summary: The study revealed the important role of miR-140 in osteosarcoma development, inhibiting tumor cell proliferation, migration, and invasion, as well as promoting cell apoptosis by targeting USP22.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Dongyun Li, Mingzhi Shen, Xinxin Deng, Yongyi Bai
Summary: The upregulation of miR-27a-3p plays a significant role in the progression of cardiac hypertrophy, promoting hypertrophy by targeting NOVA1.
Article
Biotechnology & Applied Microbiology
Xingqin Zhou, Yazhou Chang, Lirong Zhu, Chaoyan Shen, Jing Qian, Renan Chang
Summary: This study found that LINC00839 is upregulated in HCC and its oncogenic function in HCC cells is mediated by the miR-144-3p/WTAP axis. The results suggest that LINC00839 may serve as a therapeutic target and prognostic marker for HCC.
Article
Immunology
Ye Huang, Liang Wang, Di Liu
Summary: Colorectal cancer is a common malignancy with limited therapeutic options, leading to delayed treatment and increased risk of tumor recurrence. Long noncoding RNAs play important roles in the development and progression of colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Yanhua Jiang, Fan Xiao, Lin Wang, Ting Wang, Linlin Chen
Summary: Elevated expression of circular RNA circ_0000034 in retinoblastoma tissues and cells was found to interact with miR-361-3p and ADAM19, leading to induction of apoptosis in RB cells and accelerated progression of RB.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)