Article
Pharmacology & Pharmacy
Francisco Chagas Filho, Janyerson Dannys Pereira Silva, Caio Petri, Joao Santos Lima Almendra, Icaro Araujo de Sousa, Suzana Maria Galvao Cavalcanti, Bagnolia A. Silva, Margareth Fatima Formiga Melo, Paulo Marques da Silva Cavalcanti
Summary: This study found that activation of GABA(A) receptors induces nonadrenergic, noncholinergic (NANC) neuronal relaxations in the rat duodenum. These relaxations depend on the activity of Na+ K+ Cl- cotransporters and the activation of calcium channels. It is suggested that neuronal depolarization, caused by Cl- efflux through GABA(A) receptors, leads to calcium influx and nitric oxide release.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Physics, Fluids & Plasmas
Tomoki Oyama, Shunichi Ishida, Kohei Maeyama, Taimei Miyagawa, Yohsuke Imai
Summary: The study focuses on the effects of clustered contractions propagating along a circular channel on fluid flow, finding that clustered contractions cause retrograde flow and fluid trapping in the upstream and downstream regions of the cluster. Flow rate is not proportional to the number of peristaltic waves, particularly for large contraction ratios.
PHYSICAL REVIEW FLUIDS
(2021)
Article
Gastroenterology & Hepatology
Ryan M. Cassidy, Erika M. Flores, Anh K. Trinh Nguyen, Sai S. Cheruvu, Rosa A. Uribe, Anne Marie Krachler, Max A. Odem
Summary: Researchers successfully annotated contraction events of gut motility, including the previously neglected phenomenon of anorectal contractions, using automated event detection analysis. However, challenges remain in discriminating contraction events based on intraluminal fluorescence under treatment conditions that disrupt functional motility.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Hiroyuki Nakamori, Kenta Noda, Retsu Mitsui, Hikaru Hashitani
Summary: The roles of enteric dopaminergic neurons in the generation of colonic peristalsis were investigated by studying the effects of various neurotransmitter blockers on peristaltic waves in rat colonic segments. Dopaminergic neurons appeared to facilitate nitrergic neurons via D-1-like receptors to stabilize asynchronous contractile activity resulting in the generation of colonic peristalsis.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Hiroyuki Nakamori, Koji Iida, Hikaru Hashitani
Summary: GLP-1 activates CGRP-containing intrinsic afferent neurons to accelerate colonic peristalsis. Short-chain fatty acids stimulate the secretion of endogenous GLP-1, resulting in an acceleration of colonic peristalsis.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Physiology
Hiroyuki Nakamori, Hikaru Hashitani
Summary: In the isolated segments of rat proximal colon, the dopamine reuptake inhibitor GBR 12909 causes dilation, while the D-1-like receptor antagonist SCH 23390 induces tonic constriction, suggesting that neurally released dopamine stimulates enteric inhibitory efferent neurons.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Biophysics
Changyong Li, Jie Xiao, Xiao Dong Chen, Yan Jin
Summary: Through numerical simulation, it was found that there is a fast pathway near the lesser curvature of the stomach when water is emptied, but this pathway disappears when the gastric contents include food boluses with different properties. Muscle contractions enhance the mixing of light food boluses and water, while heavy food boluses are distributed in the bottom layer.
JOURNAL OF BIOMECHANICS
(2021)
Article
Neurosciences
Tiaosi Xing, Giorgia Nanni, Cameron R. Burkholder, Kirsteen N. Browning, R. Alberto Travagli
Summary: A monosynaptic pathway connecting the substantia nigra pars compacta (SNpc) to neurons of the dorsal motor nucleus of the vagus (DMV) modulates the tone and motility of the proximal colon, and impairment of this pathway may contribute to colonic transit reduction and constipation.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Ophthalmology
Conceicao Lobo, Torcato Santos, Ines P. Marques, Maria H. Madeira, Ana Rita Santos, Joao Figueira, Jose Cunha-Vaz
Summary: This study characterizes the prevalence and progression of centre-involving diabetic macular oedema (CI-DMO) in minimal to moderate non-proliferative diabetic retinopathy using optical coherence tomography (OCT) and optical reflectivity ratios (OCT-Leakage) measurements of retinal fluid. The results show that subclinical CI-DMO and CI-DMO occur independently of the severity grading of retinopathy and exhibit a progressive increase in retinal extracellular fluid, which is associated with vision loss.
Article
Agriculture, Dairy & Animal Science
Giovanni Capuzzello, Lorenzo Viora, Elena Borelli, Nicholas N. Jonsson
Summary: This observational study aimed to describe the diurnal pattern of reticuloruminal contraction rate (RRCR) and the proportion of time spent ruminating by cattle, using two commercial devices equipped with triaxial accelerometers: an indwelling bolus (placed in the reticulum) and a neck collar. The three objectives of this study were firstly to determine whether the indwelling bolus provided observations consistent with RRCR as determined by clinical examination using auscultation and ultrasound, secondly to compare estimates of time spent ruminating using the indwelling bolus and a collar-based accelerometer, and finally to describe the diurnal pattern of RRCR using the indwelling bolus data.
JOURNAL OF DAIRY RESEARCH
(2023)
Article
Neurosciences
Ezidin G. Kaddumi, Dalal A. Shuqair, Samya A. Omoush, Wesam Abdel-Razaq, Hakam H. Alkhateeb
Summary: Infertility is a major concern for male patients following spinal cord injury, with severity of the injury impacting infertility. This study evaluated sperm parameters, locomotion scores, and hormonal changes in male rats with different degrees of SCI. Results showed a significant decrease in sperm count and motility following SCI, with no significant changes in serum hormonal levels.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Physiology
Yuko Kuwahara, Ikuo Kato, Toshio Inui, Yoshinori Marunaka, Atsukazu Kuwahara
Summary: Xenin25 has an inhibitory effect on the spontaneous circular muscle contractions in the rat distal colon, with postinhibitory spontaneous contractions at a higher frequency. The mechanism involves activation of neuronal NTSR1, transmitters from VIP and apamin-sensitive NO neurons, and NK1R to modulate the muscle contractions. Xenin25 is considered an important modulator of postprandial circular muscle contraction in the distal colon.
PHYSIOLOGICAL REPORTS
(2021)
Article
Physiology
Shin-Ichiro Karaki, Ryo Tanaka
Summary: PGs produced in colonic tissue inhibit the frequency and amplitude of giant contractions (GCs) of circular muscle in the rat middle colon through mediation by EP4 receptors expressed in smooth muscle cells.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Corrin Hulls, Roger G. Lentle, Gordon W. Reynolds, Patrick W. M. Janssen, Paul Chambers, Clement de Loubens
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2016)
Article
Mechanics
J. Gubspun, C. de Loubens, R. Trozzo, J. Deschamps, M. Georgelin, F. Edwards-Levy, M. Leonetti
FLUID DYNAMICS RESEARCH
(2017)
Article
Chemistry, Physical
Kaili Xie, Clement de Loubens, Frederic Dubreuil, Deniz Z. Gunes, Marc Jaeger, Marc Leonetti
Article
Biophysics
Vincent Mathieu, Clement de Loubens, Chloe Thomas, Maud Panouille, Albert Magnin, Isabelle Souchon
JOURNAL OF BIOMECHANICS
(2018)
Article
Physics, Fluids & Plasmas
Antoine Naillon, Clement de Loubens, William Chevremont, Samuel Rouze
PHYSICAL REVIEW FLUIDS
(2019)
Article
Gastroenterology & Hepatology
C. de Loubens, A. Dubreuil, R. G. Lentle, A. Magnin, N. El Kissi, J-L Faucheron
TECHNIQUES IN COLOPROCTOLOGY
(2020)
Article
Chemistry, Applied
Khadija Trigui, Clement De Loubens, Albert Magnin, Jean-Luc Putaux, Sami Boufi
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Applied
Alice Vilotte, Hugues Bodiguel, Komla Ako, Deniz Z. Gunes, Christophe Schmitt, Clement de Loubens
Summary: Research suggests that in high temperature conditions, WPI aggregation is limited by a nucleation step. When using a capillary flow method, larger aggregates can be formed in a shorter amount of time with less impact from slower thermalization.
FOOD HYDROCOLLOIDS
(2021)
Article
Engineering, Chemical
Mehdi Maleki, Clement de Loubens, Kaili Xie, Emeline Talansier, Hugues Bodiguel, Marc Leonetti
Summary: High throughput fabrication of microcapsules with uniform size and mechanical properties can be achieved using lab-scale emulsification equipment and complex shell assembly methods. By optimizing process parameters and developing strategies, desired elastic properties can be obtained based on the kinetics of shell assembly.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Chemistry, Physical
Revaz Chachanidze, Kaili Xie, Hanna Massaad, Denis Roux, Marc Leonetti, Clement de Loubens
Summary: Controlling the assembly of polyelectrolytes and surfactant at liquid-liquid interfaces is important for fabricating soft materials with specific physical properties. The kinetics and properties of the assembly process of a positively charged biopolymer, chitosan, with an anionic fatty acid at the water-oil interface were studied. The results revealed that the interfacial complexation is a multi-step process.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Physics, Fluids & Plasmas
Mehdi Maleki, Clement de Loubens, Hugues Bodiguel
Summary: Using absorbance measurements and a Couette cell, the volume fraction profiles of buoyant droplets were measured, and the normal stress in the vorticity direction was directly determined. It was found that the normal viscosity responsible for shear-induced droplet migration is independent of the capillary number.
PHYSICAL REVIEW FLUIDS
(2022)
Article
Mechanics
Midhun Puthumana Melepattu, Clement de Loubens
Summary: Physiological transport of fluid at small scales is often achieved by microscopic active fingerlike structures that induce non-symmetric flow to break the symmetry of creeping flow. However, symmetric oscillations of these microstructures can also generate irreversible flow on long time scales. Three-dimensional simulations showed that steady streaming flow (SSF) generated by oscillating fingerlike structures can induce mass transfers between the bulk and the periphery, with vortices at the tip of the villi playing a key role. Additionally, secondary vortices outside the steady boundary layer were observed, indicating the complexity of the flow phenomena.
Article
Materials Science, Multidisciplinary
Alice Vilotte, Clement de Loubens, Deniz Z. Gunes, Christophe Schmitt, Hugues Bodiguel
Summary: Using fractal protein aggregates as building blocks, porous fibers were produced by precisely controlling both hydrodynamic and physicochemical conditions. Different fiber states were observed by increasing calcium concentration.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biology
Faisal Ahmad, Stephane Tanguy, Alain Dubreuil, Albert Magnin, Jean-Luc Faucheron, Clement de Loubens
Summary: A mechanistic understanding of the physiological process of defaecation is important for improving medical care of patients with defaecation disorders. In this study, complex fluid dynamics modelling of video defaecography was used to analyze the velocity, pressure, and stress during the expulsion of soft stool-like materials. The findings showed that pressure gradient and the geometry of the anal canal play significant roles in the evacuation flow rate.
Article
Polymer Science
Hamza Mehdaoui, Hamid Ait Abderrahmane, Clement de Loubens, Faical Nait Bouda, Sofiane Hamani
Summary: This paper discusses the rheological behaviors of gel-based ophthalmic formulation spreading on the cornea surface, investigates the influence of rheological properties on the spreading, and proposes optimal values for efficient gel-based artificial tears.