Article
Neurosciences
Ya-Dong Li, Yan-Jia Luo, Ze-Ka Chen, Luis Quintanilla, Yoan Cherasse, Libo Zhang, Michael Lazarus, Zhi-Li Huang, Juan Song
Summary: Adult hippocampal neurogenesis is critical for memory and emotion processing. Researchers have found that chronic patterned optogenetic stimulation of SuM neurons in the hypothalamus promotes neurogenesis and modulates behavior. SuM neurons are highly responsive to environmental novelty.
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Leonidas M. A. Richter, Julijana Gjorgjieva
Summary: This study investigates the impact of deprivation-induced synaptic changes on excitatory and inhibitory firing rates. It reveals that a single interneuron subtype can only co-modulate the firing rates together, while independent modulation observed in experiments requires strong feedback from a second interneuron subtype.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Bianca Pierattini, Sabrina D 'Agostino, Carlotta Bon, Omar Peruzzo, Andrej Alendar, Azzurra Codino, Gloria Ros, Francesca Persichetti, Remo Sanges, Piero Carninci, Claudio Santoro, Stefano Espinoza, Luca Pandol, Paola Valentini, Stefano Gustincich
Summary: SINEUPs are natural and synthetic antisense long non-coding RNAs (lncRNAs) that selectively enhance translation of target mRNAs. This is achieved by increasing their association with polysomes through two RNA domains: an embedded inverted SINEB2 element and an antisense region. It has been found that SINEUPs are N6-methyladenosine (m6A) modified by the METTL3 enzyme, and this modification is necessary for their activity.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biology
Isabella Farhy-Tselnicker, Matthew M. Boisvert, Hanqing Liu, Cari Dowling, Galina A. Erikson, Elena Blanco-Suarez, Chen Farhy, Maxim N. Shokhirev, Joseph R. Ecker, Nicola J. Allen
Summary: Research has shown that astrocytes regulate the formation and function of neuronal synapses during development through multiple signals, with some signals showing differential temporal and layer-enriched expression, regulated by neuronal activity. Alterations in astrocyte signaling lead to changes in the expression of synapse-regulating genes and synaptic development. Single-nucleus RNA sequencing identified groups of astrocytic genes regulated by neuronal and astrocyte activity, as well as a cassette of genes that show layer-specific enrichment. It highlights the importance of coordinated signaling between astrocytes and neurons in the development of cortical circuits.
Article
Multidisciplinary Sciences
Lauren C. Panzera, Ben Johnson, Josiah A. Quinn, In Ha Cho, Michael M. Tamkun, Michael B. Hoppa
Summary: Research indicates that Kv2.1 channels play a crucial role in facilitating ER calcium uptake during electrical activity in neurons, which is related to synaptic transmission. Loss of the Kv2.1 channel can disrupt synaptic vesicle fusion during stimulation, while its non-conducting role can link ER calcium uptake with electrical activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Agnieszka Grabowska, Hanna Sas-Nowosielska, Bartosz Wojtas, Dagmara Holm-Kaczmarek, Elzbieta Januszewicz, Yana Yushkevich, Iwona Czaban, Pawel Trzaskoma, Katarzyna Krawczyk, Bartlomiej Gielniewski, Ana Martin-Gonzalez, Robert Kuba Filipkowski, Krzysztof Hubert Olszynski, Tytus Bernas, Andrzej Antoni Szczepankiewicz, Malgorzata Alicja Sliwinska, Tambudzai Kanhema, Clive R. Bramham, Grzegorz Bokota, Dariusz Plewczynski, Grzegorz Marek Wilczynski, Adriana Magalska
Summary: Spatial chromatin organization is crucial for transcriptional regulation in neurons and is influenced by activity-induced chromatin condensation, histone modifications, and rearrangements in chromosome territories and nuclear speckles. HDAC1 plays a key role in this process.
Article
Neurosciences
Xiao-Wei Li, Yi Ren, Dong-Qing Shi, Lei Qi, Fang Xu, Yanyang Xiao, Pak-Ming Lau, Guo-Qiang Bi
Summary: Acetylcholine (ACh) affects neural circuit dynamics by inhibiting excitatory synaptic transmission and enhancing neuronal excitability through muscarinic signaling pathways. It suppresses evoked reverberation at low to moderate doses, while high doses result in longer duration of reverberation and increased spontaneous activity. These effects are mediated by muscarinic, but not nicotinic receptors, and can be simulated through changes in excitatory postsynaptic currents (EPSCs) and the excitability of single cells.
NEUROSCIENCE BULLETIN
(2023)
Article
Biophysics
Leonid P. Savtchenko, Kaiyu Zheng, Dmitri A. Rusakov
Summary: Research has shown that in obstacle-filled media, the permeability of ion diffusion decreases with stronger external electric fields. The dependence of this phenomenon increases with lower medium porosity and decreases with radial electric fields compared to homogenous fields.
BIOPHYSICAL JOURNAL
(2021)
Article
Immunology
Chihiro Kurematsu, Masato Sawada, Masaki Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, Mami Matsumoto, Hisashi Oishi, Hiroyuki Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, Truc Quynh Thai, Shinichi Kohsaka, Nobuhiko Ohno, Maki K. Yamada, Masato Asai, Masahiro Sokabe, Junichi Nabekura, Kenichi Asano, Masato Tanaka, Kazunobu Sawamoto
Summary: This study demonstrates the involvement of phosphatidylserine (PS) in the synaptic pruning and functional maturation of adult-born neurons in the olfactory bulb and hippocampus. Using an inducible transgenic mouse model, the researchers found that impaired microglial spine pruning and altered electrophysiological properties of adult-born neurons occurred when PS exposure was masked by a dominant-negative form of milk fat globule-EGF-factor 8 (MFG-E8). These findings highlight the significance of PS in microglial pruning and the maturation of adult-born neurons.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Neurosciences
Trine Waage Rygvold, Christoffer Hatlestad-Hall, Torbjorn Elvsashagen, Torgeir Moberget, Stein Andersson
Summary: This study aimed to replicate previous findings of visual SRM in healthy adults and integrate visual and auditory stimuli in the same recording session. Results showed that high-frequency visual stimulation is a viable probe into LTP-like synaptic plasticity in the human visual cortex, while auditory SRM may rely on different mechanisms and did not show significant cross-modal correlations with visual SRM. Further research on non-invasive LTP-like synaptic plasticity should focus on optimizing paradigms within the visual modality.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Jaime Caballero-Insaurriaga, Jose A. Pineda-Pardo, Ignacio Obeso, Antonio Oliviero, Guglielmo Foffani
Summary: This study combined transcranial static magnetic field stimulation (tSMS) with resting-state functional MRI (fMRI) to investigate corticostriatal activity and found that tSMS can noninvasively modulate corticostriatal activity in humans. The results showed that the supplementary motor area (SMA) is the main region with functional connectivity to the striatum, and tSMS can modulate local activity in the SMA, adjacent sensorimotor cortex, and motor striatum. The findings also indicated that the tSMS-induced modulation of striatal activity can be primarily explained by a change in the shared activity between the modulated motor cortical areas and the motor striatum. These results suggest that corticostriatal activity can be targeted, monitored, and modulated noninvasively in humans.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Rehabilitation
Laura A. Baehr, Laura A. Frey-Law, Margaret Finley
Summary: This scoping review examines the evidence on using quantitative sensory testing to evaluate psychophysical changes related to physical activity in adult populations. The findings suggest that quantitative sensory testing can be an effective measurement tool for assessing neuromodulation related to physical activity.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Cell Biology
Yu Wu, Xinyou Lv, Haiting Wang, Kai Qian, Jinjun Ding, Jiejie Wang, Shushan Hua, Tiancheng Sun, Yiting Zhou, Lina Yu, Shuang Qiu
Summary: Neuronal activity induces retrograde translocation and nuclear accumulation of endosomal adaptor APPL1, which is necessary for the regulation of gene transcription and maintenance of hippocampal late-phase long-term potentiation. These results illustrate an APPL1-mediated pathway that contributes to the modulation of synaptic plasticity via coupling neuronal activity with chromatin remodeling.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paula Tena-Morraja, Guillem Rique-Pujol, Claudia Muller-Sanchez, Manuel Reina, Ofelia M. Martinez-Estrada, Francesc X. Soriano
Summary: Synaptic activity in the central nervous system consumes the most energy. New research reveals that an episode of synaptic activity increases mitochondrial bioenergetics by inducing the expression of iron metabolism genes, resulting in enhanced cellular and mitochondrial iron uptake. The study suggests a coordinated expression of synaptic plasticity programs and energy demands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yong-Jun Liu, Elizabeth E. Spangenberg, Bryan Tang, Todd C. Holmes, Kim N. Green, Xiangmin Xu
Summary: Microglia play a crucial role in sculpting neuronal circuit connectivity and regulating subsequent functional activity in the adult cortex. Depletion of microglia increases synaptic connections and enhances neural activities, which recover following re-population of adult microglia.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Otorhinolaryngology
N. Rosskothen-Kuhl, R. -B. Illing
Article
Audiology & Speech-Language Pathology
Till F. Jakob, Nicole Rosskothen-Kuhl, Robert-Benjamin Illing
Article
Neurosciences
A. -K. Rauch, N. Rosskothen-Kuhl, R. -B. Illing
Article
Neurosciences
Nicole Rosskothen-Kuhl, Heika Hildebrandt, Ralf Birkenhaeger, Robert-Benjamin Illing
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Nicole Rosskothen-Kuhl, Robert-Benjamin Illing
Article
Neurosciences
Nicole Rosskothen-Kuhl, Robert-Benjamin Illing
Article
Neurosciences
Till F. Jakob, Robert-Benjamin Illing, Nicole Rosskothen-Kuhl
Article
Acoustics
Kongyan Li, Chloe H. K. Chan, Vani G. Rajendran, Qinglin Meng, Nicole Rosskothen-Kuhl, Jan W. H. Schnupp
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2019)
Article
Neurosciences
Mina Sadeghi Najafabadi, Longtu Chen, Kelsey Dutta, Ashley Norris, Bin Feng, Jan W. H. Schnupp, Nicole Rosskothen-Kuhl, Heather L. Read, Monty A. Escabi
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Biology
Nicole Rosskothen-Kuhl, Alexa N. Buck, Kongyan Li, Jan W. H. Schnupp
Summary: The study demonstrates that neonatally deafened rats provided with precisely synchronized CI stimulation in adulthood can be trained to localize ITDs and show physiological sensitivity to ITDs. This contrasts sharply with prelingually deaf human CI patients who often fail to develop a useful sensitivity to ITDs, raising questions about the reasons behind the usually poor binaural outcomes for current CI patients.
Article
Audiology & Speech-Language Pathology
Alexa N. Buck, Nicole Rosskothen-Kuhl, Jan W. H. Schnupp
Summary: This study characterized ITD sensitivity and tuning of inferior colliculus neurons under bilateral CI stimulation of neonatally deafened and hearing experienced rats. The research found that while both groups showed similar levels of ITD sensitivity, there were evident differences in tuning curve shapes, with auditory experience influencing the shapes. Despite profound hearing loss, rats demonstrated highly precise innate ITD sensitivity, suggesting that lateralization encoding is present even without auditory experience.
Article
Biophysics
Andreas Weltin, Jochen Kieninger, Gerald A. Urban, Sarah Buchholz, Susan Arndt, Nicole Rosskothen-Kuhl
Summary: This study developed an electrochemical method to turn the platinum stimulation microelectrodes of cochlear implants into electrochemical sensors. In vitro and in vivo experiments demonstrated the effectiveness and stability of this method. This research is significant for advancing implant functionality, long-term monitoring, and investigating electrode degradation in cochlear implant patients in situ.
BIOSENSORS & BIOELECTRONICS
(2022)
Proceedings Paper
Computer Science, Theory & Methods
A. Weltin, J. Kieninger, G. A. Urban, S. Arndt, N. Rosskothen-Kuhl
Summary: This study demonstrates the conversion of cochlear implant electrodes into electrochemical sensors for measuring oxygen levels. The ultimate goal is to improve the function and longevity of implants.
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2021)
Article
Neurosciences
Nicole Rosskothen, Ingeborg Hirschmueller-Ohmes, Robert-Benjamin Illing