Article
Immunology
Siyu Liu, Chang Xu, Fan Yang, Lu Zong, Yizu Qin, Yufeng Gao, Qian Su, Tuantuan Li, Ye Li, Yuanhong Xu, Meijuan Zheng
Summary: The antiviral response of NK cells and CD8(+) T cells is weak in patients with CHB, and the overexpression of Gal-9 contributes to NK cell dysfunction and CD8(+) T cell exhaustion. Blocking Gal-9 or TIM-3 can restore the function of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mao Li, Zi-xin Wan, Yue-yang Tang, Xin-hua Liang, Ya-ling Tang
Summary: Immunohistochemical staining was used to detect the expression of TIM-3, Gal-9, and CD160 in SACC and their correlation with clinicopathological characteristics. The results showed that overexpression of TIM-3 and CD160 were associated with SACC recurrence, while high expression of Gal-9 was correlated with pathological classification. The average percentage of TILs in SACC was 18.2%, with a higher occurrence in minor salivary glands. There were positive correlations observed between the expression of TIM-3, Gal-9, and CD160 in tumor cells and TILs. These findings suggest that the density of TILs and the expression of TIM-3, Gal-9, and CD160 could be potential therapeutic targets in SACC.
Article
Allergy
Martina Konantz, Margaret Williams, Tamara Merkel, Antonia Reiss, Stefan Dirnhofer, Sara C. Meyer, Peter Valent, Tracy I. George, Alexandar Tzankov, Karin Hartmann
Summary: This study found that serum levels of TIM-3 and galectin-9 are increased in patients with advanced systemic mastocytosis. Additionally, TIM-3 and galectin-9 are expressed in bone marrow infiltrates in mastocytosis. These findings suggest that TIM-3 and galectin-9 could be explored as diagnostic markers and potential therapeutic targets in systemic mastocytosis, particularly in advanced forms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Guanzhang Li, Ruoyu Huang, Wenhua Fan, Di Wang, Fan Wu, Fan Zeng, Mingchen Yu, You Zhai, Yuanhao Chang, Changqing Pan, Tao Jiang, Wei Yan, Hongjun Wang, Wei Zhang
Summary: The study revealed that 1p/19q chromosome deletion in gliomas is associated with activation of immune and inflammatory responses. The decreased expression level of CCAAT enhancer-binding protein alpha in samples with 1p/19q codeletion led to the downregulation of immune checkpoints Galectin-9 and TIM-3. The loss of chromosome 19q was identified as the main reason for promoting the antitumor immune response in gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Andrzejczak, Krzysztof Tupikowski, Anna Tomkiewicz, Bartosz Malkiewicz, Kuba Ptaszkowski, Aleksandra Domin, Tomasz Szydelko, Lidia Karabon
Summary: This study analyzed the influence of TIM-3 and LGALS9 polymorphisms on susceptibility to ccRCC and patient overall survival. The results indicate that variations within TIM-3 and LGALS9 genes are associated with ccRCC risk and OS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Qinyu Peng, Guoxin Zhang, Xiaodi Guo, Lijun Dai, Min Xiong, Zhaohui Zhang, Liam Chen, Zhentao Zhang
Summary: The Galectin-9/Tim-3 pathway plays a crucial role in the pathogenesis of Parkinson's disease by exacerbating microglial activation, neuroinflammation, oxidative stress, and dopaminergic neurodegeneration.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Jun Yao, Hui Li, Meisi Yan, Wei-Chao Chang, Jung-Mao Hsu, Jong-Ho Cha, Jennifer L. Hsu, Cheng-Wei Chou, Xian Sun, Yalan Deng, Chao-Kai Chou, Dihua Yu, Mien-Chie Hung
Summary: The study reveals that PD-1 contributes to exhausted T cell survival by binding to TIM-3 ligand Gal-9 and inhibiting Gal-9/TIM-3 induced cell death. Anti-Gal-9 therapy selectively expands intratumoral TIM-3(+) cytotoxic CD8 T cells and T-reg cells, while combination treatment with anti-Gal-9 and GITR agonist shows synergistic antitumor activity.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
JeongMin Sim, JeongMan Park, Suwan Kim, Sojung Hwang, KyoungSu Sung, Jung-Eun Lee, SeungHo Yang, Kyunggi Cho, SungHwan Lee, Jong-Seok Moon, JuWon Ahn, Jaejoon Lim
Summary: The expression of Tim-3/Gal-9 is associated with glioma malignancy and poor prognosis, and they regulate the formation and activation of the NLRC4 inflammasome. A blockade of Tim-3/Gal-9 may be beneficial in glioma therapy by reducing the inflammatory microenvironment through downregulating the NLRC4 inflammasome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Tixiao Wang, Jie Zhang, Na Li, Mengzhen Li, Shuaiya Ma, Siyu Tan, Xiaowei Guo, Zehua Wang, Zhuanchang Wu, Lifen Gao, Chunhong Ma, Xiaohong Liang
Summary: The spatial organization of immune cells within the tumor microenvironment (TME) plays a crucial role in anti-tumor immunity, tumor progression, and therapeutic response. Tim-3 is an immune checkpoint with potential as an immunotherapy target. This study examined the spatial distribution of Tim-3/Tim-3L in the TME and found that CD4 T cells were more accumulated in the tumor region and had a closer association with patient survival. CD4 T cells surrounding Tim-3L(+) cells expressed higher levels of Tim-3. Depletion of CD4 T cells abrogated the inhibition of tumor growth and metastasis mediated by Tim-3 blockade. These findings highlight the importance of CD4 T cells in Tim-3/Tim-3L-mediated immunosuppression and provide insights for Tim-3 targeted cancer immunotherapy.
Article
Parasitology
Hui Zhao, Yuyu Ma, Fengming Tian, Bin Li, Ning Xiao, Xiaojin Mo, Madinaimu Aibibula, Hongyue Min, Xuanlin Cai, Ting Zhang, Xiumin Ma
Summary: This study investigated the relationship between the Tim-3/Galectin-9 pathway and CD8+T cells in patients with AE. The findings suggest that the high expression of Tim-3 on CD8+T cell surfaces in AE patients may lead to an increase in CD8(+)CD28-T cells and related factors, while suppressing CTL and related factor expressions. This immune tolerance phenomenon may contribute to the persistent infections of Echinococcus multilocularis in AE patients.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Immunology
Huifang Xiong, Guohui Xue, Yuting Zhang, Shuang Wu, Qiaoyun Zhao, Rulin Zhao, Nanjin Zhou, Yong Xie
Summary: The study aimed to investigate the effects of Gal-9 on experimental colitis. The results showed that exogenous Gal-9 increased Tim-3 expression, inhibited the TLR4/NF-kappa B pathway, and alleviated TNBS-induced colitis in mice. However, it had no reducing effect on DSS-induced colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shaoyu Li, Yuejie Zhu, Song Wang, Yujiao Li, Nannan Pang, Mengting An, Fengbo Zhang, Jianbing Ding
Summary: This study investigated the role of Tim-3/Galectin-9 in persistent infection of Echinococcus multilocularis (Em) and found that this signaling pathway may be involved in the development of Em infection by regulating the production of Th1 and Th2 cytokines.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Zhifang Chen, Di Dong, Yuejie Zhu, Nannan Pang, Jianbing Ding
Summary: In HPV positive cervical cancer patients, high levels of Tim-3 and Galectin-9 are associated with disease progression by promoting Treg cells to inhibit the cytotoxic function of Th1 and CD8+ T cells. The Tim-3/Galectin-9 pathway may serve as a new immunotherapy target for patients with HPV positive cervical cancer.
Article
Medicine, General & Internal
Dorota Grazyna Boron, Aleksy Swietlicki, Michal Potograbski, Grazyna Kurzawinska, Przemyslaw Wirstlein, Daniel Boron, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz
Summary: This study investigated the changes in maternal serum levels of galectin-1 and galectin-9 in patients with preterm prelabor rupture of membranes (pPROM) compared to uncomplicated pregnancies. The results showed that low levels of galectin-1 were associated with the incidence of pPROM, while galectin-9 levels were not significantly correlated with pPROM. Further clinical studies on larger groups are needed to investigate the potential of galectin-1 and galectin-9 levels as markers for pPROM.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Hui Wang, Kangli Cao, Siyu Liu, Yuanhong Xu, Ling Tang
Summary: The study found that the frequency and absolute number of NK cells in patients with type 2 diabetes mellitus were significantly lower than in healthy individuals. The expression of surface receptors and cytokine production in NK cells were affected in patients, and correlated with high blood glucose levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Sarolta Szalai, Nelli Farkas, Bela Veszpremi, Jozsef Bodis, Kalman Kovacs, Balint Farkas
Summary: The study analyzed the effects of increased ionizing radiation emitted by the Chernobyl nuclear disaster on maternal and fetal outcomes in Hungary. Trends showed increasing rates of spontaneous and voluntary abortions, while there was a decreasing trend in late pregnancy losses during the study period. Ultimately, the data suggested that the nuclear catastrophe in 1986 did not lead to significant increases in pregnancy loss or congenital malformations in Hungary.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Endre Sulyok, Balint Farkas, Bernadett Nagy, Akos Varnagy, Kalman Kovacs, Jozsef Bodis
Summary: This article discusses the risks of excessive sodium intake on the development of cardiovascular and renal diseases, as well as the storage and dissociation of sodium in the skin interstitium. It also explores the cellular response to increased tissue sodium concentration and the protective role of endothelial glycocalyx in sodium retention. Furthermore, it highlights the involvement of oxygen free radicals in sodium-induced tissue damage and mentions some clinical entities associated with sodium/volume retention and oxidative stress.
Article
Obstetrics & Gynecology
Zoltan Nemeth, Szilard Kolumban, Roxana Schmidt, Peter Gubas, Kalman Kovacs, Balint Farkas
Summary: This study investigates the effectiveness of using a cube pessary for daily self-management of symptomatic pelvic organ prolapse (POP) and finds that it is a safe and effective long-term treatment for improving symptoms and quality of life.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Marta Hock, Istvan Tiringer, Eszter Ambrus, Zoltan Nemeth, Balint Farkas
Summary: The Hungarian version of the self-administered Australian Pelvic Floor Questionnaire (APFQ) has been translated, culturally adapted and validated in this study. The results indicate that the Hungarian version of APFQ is a reliable and valid instrument for evaluating symptom severity and impact of pelvic floor dysfunction on the quality of life of Hungarian women.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Immunology
Matyas Meggyes, David U. Nagy, Iyad Saad Al Deen, Borbala Parkanyi, Laszlo Szereday
Summary: This study found that CD8+ NKT cells are finely regulated during healthy human pregnancy, with significant differences compared to other NKT cell subsets.
IMMUNOLOGICAL INVESTIGATIONS
(2023)
Article
Public, Environmental & Occupational Health
Aida Hougaard Andersen, Zsolt Illes, Kirsten Kaya Roessler
Summary: This study investigates patients' experiences of existential communication with their physicians in the treatment of multiple sclerosis or chronic pain. Patients found it challenging when physicians focused only on medical aspects and neglected psychological and existential aspects of their illness. Patients needed a transition from dependency to autonomy for shared decision-making, and existential communication about transitional objects supported this transition.
JOURNAL OF RELIGION & HEALTH
(2023)
Review
Clinical Neurology
Christoph Mueller, Saskia Elben, Gregory S. Day, Pedro Alves, Julien Hebert, David F. Tang-Wai, Olga Holtmann, Raffaele Iorio, Daniela Perani, Maarten J. Titulaer, Niels Hansen, Thorsten Bartsch, Andreas Johnen, Zslot Illes, Leah Borm, Alice G. Willison, Heinz Wiendl, Sven G. Meuth, Stjepana Kovac, Jens Boelte, Nico Melzer
Summary: This study aims to investigate whether autoimmune limbic encephalitis (ALE) with different associated autoantibodies (AABs) exhibit distinct neuropsychological manifestations and respond differently to immunotherapy. The results show that ALE patients with AABs against LGI1, CASPR2, and GAD65 commonly have memory deficits, along with deficits in attention, executive functions, and psychological function. However, there is currently no definite evidence supporting the notion that different AAB-types of ALE have distinct neuropsychological manifestations and respond differently to immunotherapy.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Matyas Meggyes, Timoteus Feik, David U. Nagy, Beata Polgar, Laszlo Szereday
Summary: This study investigated the immunological consequences of improper placenta development in early-onset preeclampsia. The results showed that early-onset preeclampsia affects maternal immunotolerance against the fetus and alters the Th1 predominance developed by the mother's immune system. Significant differences were also found in the expression patterns of immune checkpoint receptors and ligands between early-onset preeclamptic and healthy pregnant women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Ching-Han Tsao, Wei-Chen Hsieh, Feng-Jen Lin, Ri-Yao Yang, Meng-Ting Chang, Maria Karmella Apaya, Lie -Fen Shyur, Liang-Yin Ke, Christos C. Zouboulis, Fu-Tong Liu
Summary: Sebaceous glands produce lipids that are crucial for maintaining the skin barrier. Galectin-12 protein has been found to regulate sebocyte differentiation and lipid production, playing a positive role in sebaceous lipid metabolism.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Feng-Jen Lin, Yun-Hsi Huang, Ching-Han Tsao, Wei-Chen Hsieh, Yuan-Hsin Lo, Christos C. Zouboulis, Hung-Lin Chen, Fu-Tong Liu
Summary: Sebaceous glands play a role in skin immune response and dysregulated lipid production may contribute to the progression of certain skin diseases. Galectin-12 is a factor that affects the immune response and regulates IL-4 signaling and endoplasmic reticulum stress in sebaceous glands.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sandor Pentek, Akos Varnagy, Balint Farkas, Peter Mauchart, Krisztina Godony, Timea Varjas, Tamas Koszegi, Peter Kaltenecker, Rita Jakabfi-Csepregi, Kalman Kovacs, Jozsef Bodis, Endre Sulyok
Summary: This study aimed to investigate the relationship between telomere length, telomerase activity, and oxidative DNA damage in IVF patients. The study found that telomere lengths were similar in granulosa cells and follicular fluid, but telomerase activity was significantly reduced and 8-OHdG levels were significantly elevated in follicular fluid. Additionally, high levels of 8-OHdG were associated with negative outcomes in IVF success and clinical pregnancies.
Article
Biochemistry & Molecular Biology
Barbara Sandor, Beata Csiszar, Gergely Galos, Simone Funke, Dora Kinga Kevey, Matyas Meggyes, Laszlo Szereday, Kalman Toth
Summary: This study investigated the hemorheological factors in newborns of early-onset preeclamptic mothers and healthy neonates during the early perinatal period. The results showed that preterm neonates had lower whole blood and plasma viscosity, as well as lower red blood cell aggregation parameters, suggesting better microcirculation at birth as an adaptation mechanism to the impaired uteroplacental circulation in preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Endre Sulyok, Balint Farkas, Jozsef Bodis
Summary: Based on epidemiological observations, Barker et al. proposed the hypothesis/concept that adverse intrauterine environment, including insufficient nutrient supply, chronic hypoxia, stress, and toxic substances, is a significant risk factor for the development of chronic diseases in adulthood. Fetus responds to the unfavorable environment with adaptive reactions, ensuring short-term survival, but initiating pathological processes leading to adult diseases. This review outlines major mechanisms, such as telomere dysfunction, epigenetic modifications, and cardiovascular-renal-endocrine-metabolic reactions, with a particular focus on the role of oxidative stress in fetal origin of adult diseases.
Review
Immunology
Fu-Tong Liu, Sean R. Stowell
Summary: Galectins can modulate immune cells by binding to glycosylated proteins and lipids on the cell surface, or intracellularly via carbohydrate-dependent or carbohydrate-independent interactions. This Review explores the diverse ways in which galectins affect immunity and discusses the opportunities and challenges in the field.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Matyas Meggyes, David U. Nagy, Timoteus Feik, Akos Boros, Beata Polgar, Laszlo Szereday
Summary: The study highlights the significance of immune checkpoint molecules in immune regulation during pregnancy. CD226 appears to be a crucial regulator, particularly in CD4(+) T and NKT cells, contributing to maternal immune tolerance in the late phase of pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)