Article
Biochemistry & Molecular Biology
Eisaku Ogawa, Tomohiro Edamitsu, Hidetaka Ohmori, Kazuyoshi Kohu, Mineo Kurokawa, Hiroshi Kiyonari, Masanobu Satake, Ryuhei Okuyama
Summary: This study reveals the important roles of Runx1 and Runx3 in keratinocyte differentiation, where they directly inhibit the expression of keratin 1 and keratin 10 genes during the differentiation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y. Feng, Kiran Mahajan, Nupam P. Mahajan
Summary: This study reveals a new mechanism of inhibiting androgen synthesis by phosphorylated SREBF1 protein, which affects the development and treatment of prostate cancer.
NATURE COMMUNICATIONS
(2023)
Article
Ophthalmology
Aya Motoyoshi, Fuminori Saitoh, Tomohiro Iida, Hiroki Fujieda
Summary: The proliferative and neurogenic potential of retinal Muller glia after injury varies widely across species. This study reveals that nestin plays a critical role in regulating the proliferative response of rat Muller glia after retinal injury, while this response is not observed in mice. The findings highlight the importance of cross species analysis to understand the molecular mechanisms of injury response in the mammalian retina.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Hirotaka Iijima, Gabrielle Gilmer, Kai Wang, Allison C. Bean, Yuchen He, Hang Lin, Wan-Yee Tang, Daniel Lamont, Chia Tai, Akira Ito, Jeffrey J. Jones, Christopher Evans, Fabrisia Ambrosio
Summary: Matrix stiffening is a key characteristic of aged tissues. In this study, the authors found that an aged (stiff) matrix causes epigenetic repression of the gene encoding alpha-Klotho, a longevity factor, leading to chondrocyte dysfunction, which is a major cause of osteoarthritis. Exposing aged chondrocytes to a soft matrix restores a more youthful phenotype and enhances cartilage integrity. These findings highlight the importance of age-related biophysical alterations in extracellular matrix and have implications for the broader field of aging research.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hongsen Liu, Tao Wei, Lin Sun, Tingting Wu, Fuqiang Li, Jianlei Zhao, Jinmeng Chu, Fei Wang, Yong Cai, Jingji Jin
Summary: The NSL HAT complex plays a role in regulating gene expression through histone acetylation, particularly affecting the transcription factor YY1, which is involved in cell proliferation, biological adhesion, and metabolic processes. MOF and NSL3 are involved in the regulation of YY1 and the downstream target gene cell division cycle 6. The NSL HAT complex may recognize specific DNA-binding sites in the promoter region of target genes for transcriptional regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xinxin Li, Huiwen Zhou, Ling Cheng, Niannian Ma, Baofeng Cui, Wenfei Wang, Yongjia Zhong, Hong Liao
Summary: This study identified the key gene GmNN1 that regulates soybean nodulation and leaf nitrogen nutrition, and found that manipulating this gene enhances soybean nodulation, plant growth, and nitrogen nutrition. The study further revealed the molecular dialogue between shoots and root nodulating symbionts, shedding new insights into the shoot-to-root signaling required for communication between host plants and symbionts.
Article
Cell Biology
Siyuan Yin, Ru Song, Jiaxu Ma, Chunyan Liu, Zhenjie Wu, Guoqi Cao, Jian Liu, Guang Zhang, Huayu Zhang, Rui Sun, Aoyu Chen, Yibing Wang
Summary: In this study, the researchers investigated the role of RAMP1, a component of the CGRP receptor, in promoting the proliferation of mouse skin fibroblasts. They found that RAMP1 overexpression increased MSF proliferation through the G alpha i3-PKA-CREB-YAP axis. This finding provides valuable insights into the function of RAMP1 and suggests that targeting this pathway could be an attractive and accurate approach for skin wound treatment.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Engineering, Biomedical
Xinman Song, Kazuto Okabe, Yuya Ohta, Go Ohara, Naoto Toyama, Qi Chang, Yilin Wang, Hideharu Hibi
Summary: FAM20B plays a crucial role in osteogenic differentiation and bone formation on titanium surfaces. Depletion of FAM20B inhibits the formation of a PG-rich layer between bone cells and titanium surfaces, reduces MSC osteogenesis signaling pathway, and decreases the expression of osteogenic marker genes.
ACTA BIOMATERIALIA
(2023)
Article
Neurosciences
Junhua Li, Lin Wang, Qinhua Zeng, Jing He, Qing Tang, Kejian Wang, Guiqiong He
Summary: This study investigates the role of MKP-1 in regulating microglia phenotype and inflammatory factor release in Alzheimer's disease (AD). The findings suggest that MKP-1 can modulate microglia phenotype and inflammatory factor release in AD through the p38 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Retraction
Oncology
Wenying Zhuo, Dengdi Hu, Xihua Chen, Tian Zhang
Summary: lncRNA LINC01638 plays an oncogenic role in colorectal adenocarcinoma by interacting with RUNX2, leading to the promotion of cancer cell proliferation. Upregulation of LINC01638 in plasma distinguishes colorectal adenocarcinoma at early stages from healthy controls.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Cell Biology
Mikiko Nagashima, Peter F. Hitchcock
Summary: Zebrafish have remarkable regenerative potential, with the ability to regenerate almost all tissues and organs. In the zebrafish brain and retina, radial glia can reprogram into stem-like cells to repair damaged tissues. Inflammation plays a crucial role in regulating the process of retinal regeneration, affecting the quiescence, division, and survival of the cells involved.
Article
Cell Biology
Shanshan Huang, Yaqi Li, Jinhua Hu, Li Li, Zhen Liu, Hui Guo, Bailing Jiang, Jun Chen, Junhe Li, Xiaojun Xiang, Jun Deng, Jianping Xiong
Summary: PWAR6 is identified as a frequently down-regulated lncRNA in PDAC, associated with multiple clinical outcomes. Cell-based and in vivo studies confirm the anti-tumour role of PWAR6 in PDAC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jie Huang, Yan Li, Dingwei Xu, Xiao Zhang, Xiaoyang Zhou
Summary: In this study, it was found that the expression of RUNX1 was upregulated in LF mice, and RUNX1 knockdown alleviated CCl4-induced LF. RUNX1 silencing reduced the viability and migration of HSCs. Besides, as a transcription factor, RUNX1 bound to the promoter of USP9X and regulated the expression of USP9X. USP9X, a deubiquitination enzyme, was found to be upregulated in LF mice. Silencing of USP9X reduced the viability and migration of HSCs, thereby inhibiting LF.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shu Somemura, Takanori Kumai, Kanaka Yatabe, Chizuko Sasaki, Hiroto Fujiya, Hisateru Niki, Kazuo Yudoh
Summary: The study indicates that mechanical stress can upregulate Glut1 while downregulating SIRT1 and upregulating Runx2 in osteoblasts but not in chondrocytes. This suggests that the interplay between Glut1, SIRT1, and Runx2 plays a crucial role in mediating the cellular responses to mechanical loading in osteoblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ludivine C. Litzler, Astrid Zahn, Kiersten L. Dionne, Adrien Sprumont, Silvana R. Ferreira, Michael R. F. Slattery, Stephen P. Methot, Anne-Marie Patenaude, Steven Hebert, Nisha Kabir, Poorani Ganesh Subramani, Seolkyoung Jung, Stephane Richard, Claudia L. Kleinman, Javier M. Di Noia
Summary: Protein arginine methyltransferase 1 (PRMT1) is upregulated via Myc and mTORC1 during positive selection and plays a critical role in transcription. Deleting Prmt1 compromises antibody affinity maturation by hampering proliferation and cycling of GCBC. Moreover, Prmt1 restricts plasma cell differentiation and this function is co-opted by B cell lymphoma cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Nimmi Baby, Nithyakalyani Alagappan, Shaikali Thameem Dheen, Sreedharan Sajikumar
Article
Neurosciences
Genevieve Saw, Kumar Krishna, Neelima Gupta, Tuck Wah Soong, Karthik Mallilankaraman, Sreedharan Sajikumar, S. Thameem Dheen
Review
Engineering, Biomedical
Rita Hameister, Charanjit Kaur, Shaikali Thameem Dheen, Christoph H. Lohmann, Gurpal Singh
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Materials Science, Biomaterials
Ganesh Kumar Meenashisundaram, Niyou Wang, Silambarasan Maskomani, Shenglu Lu, Senthil Kumar Anantharajan, Shaikali Thameem Dheen, Sharon Mui Ling Nai, Jerry Ying Hsi Fuh, Jun Wei
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Biology
Ananya Dasgupta, Yu Jia Lim, Krishna Kumar, Nimmi Baby, Ka Lam Karen Pang, Amrita Benoy, Thomas Behnisch, Sreedharan Sajikumar
Article
Biochemistry & Molecular Biology
Kumar Krishna-K, Nimmi Baby, Radha Raghuraman, Sheeja Navakkode, Thom Behnisch, Sreedharan Sajikumar
Review
Engineering, Biomedical
Niyou Wang, Jerry Ying Hsi Fuh, S. Thameem Dheen, A. Senthil Kumar
Summary: Bone defects and diseases can have severe consequences, but orthopedic implants and scaffolds help in the treatment by promoting bone growth. Metallic and metallic oxide nanoparticles offer unique properties that can enhance orthopedic implants and scaffolds, but their potential toxicity to cells and tissues needs to be carefully considered.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Materials Science, Biomaterials
Niyou Wang, Silambarasan Maskomani, Ganesh Kumar Meenashisundaram, Jerry Ying Hsi Fuh, Shaikali Thameem Dheen, Senthil Kumar Anantharajan
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Olivia J. J. Scully, Sukanya Shyamasundar, Ken Matsumoto, S. Thameem Dheen, George W. W. Yip, Boon Huat Bay
Summary: Breast carcinoma is the most prevalent cancer in women globally, and its development and progression involve complex genetic and molecular mechanisms. Challenges such as metastasis and drug resistance limit the prognosis of breast cancer, leading to the constant search for better treatment regimes and novel molecular therapeutic targets. C1QBP, a promising molecular target, has been implicated in breast carcinogenesis. This study demonstrates the role of C1QBP in breast cancer progression, specifically in cancer cell growth, and highlights its potential as a target for future breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yue Li, S. Thameem Dheen, Fengru Tang, Yumin Luo, Ran Meng, Tay Sam Wah Samuel, Lan Zhang
Summary: This study investigated the miRNA expression profiles in the hippocampal areas of mice before and after pilocarpine-induced status epilepticus (SE) and predicted the downstream proteins and related pathways. The results showed that the miRNA expression patterns were closely related to epileptogenesis in different time points and subfields. These findings contribute to a better understanding of the mechanisms underlying epilepsy.
Article
Cell Biology
Sukanya Shyamasundar, Seshadri Ramya, Deepika Kandilya, Dinesh Kumar Srinivasan, Boon Huat Bay, Suraiya Anjum Ansari, S. Thameem Dheen
Summary: Maternal diabetes is associated with increased risk of neurodevelopmental disorders in offspring. Hyperglycemia alters expression of genes and microRNAs in neural stem cells, including downregulation of methyl-CpG-binding protein-2 (Mecp2). miR-26b-5p controls Mecp2 expression and affects neurite outgrowth and synaptogenesis. These findings suggest that maternal diabetes disrupts synaptogenesis through miR-26b-5p/Mecp2 pathway, potentially leading to neurodevelopmental disorders.
Review
Engineering, Biomedical
Niyou Wang, Jerry Ying Hsi Fuh, S. Thameem Dheen, A. Senthil Kumar
Summary: With the continuous improvement of nanoparticle synthesis methods, it is possible to better meet the needs of different applications and enhance their widespread use.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Cell & Tissue Engineering
R. Hameister, C. H. Lohmann, S. T. Dheen, G. Singh, C. Kaur
BONE & JOINT RESEARCH
(2020)
Article
Cell Biology
Rita Hameister, Christoph H. Lohmann, S. Thameem Dheen, Gurpal Singh, Charanjit Kaur
HISTOLOGY AND HISTOPATHOLOGY
(2020)