Article
Pharmacology & Pharmacy
Danni Wang, Mei Tian, Yong Fu, Yawei Sun, Liang Ding, Xiaoxin Zhang, Yue Jing, Guowen Sun, Yanhong Ni, Yuxian Song
Summary: The study found that Halofuginone can inhibit the migration and invasion of oral squamous cell carcinoma (OSCC) by targeting cancer-associated fibroblasts (CAFs), and is involved in this process through inhibiting MMP2 secretion and the TGF-beta/Smad2/3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leilei Wang, Yuxiong Su, Wing Shan Choi
Summary: The study showed that melatonin suppresses invasion and migration of OSCC cells by blocking the FGF19/FGFR4 pathway, suggesting a potential alternative for OSCCs prevention and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yoshiaki Tadokoro, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa
Summary: Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Cancer-associated fibroblasts (CAFs) play a critical role in tumor progression. This study investigated the effect of transcutaneous carbon dioxide (CO2) application on CAFs marker expression and tumor growth in OSCC.
Article
Dentistry, Oral Surgery & Medicine
Dan Yang, Dan Yang, Yuqing He, Jiaxin Liu, Yansong Song, Yu Zhou, Lu Jiang, Xin Zeng, Xiaoping Xu, Hao Xu, Jing Li, Hongxia Dan
Summary: The overexpression of MRTF-A/SRF was found to inhibit the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC) cells in vitro. High expression of SRF and its co-activator MRTF-A was associated with better prognosis in OSCC patients on the hard palate, alveolar ridge, and oral tongue. It was also observed that overexpression of MRTF-A/SRF inhibited the epithelial-mesenchymal transformation (EMT) of OSCC cells.
Article
Medicine, Research & Experimental
Xin Li, Weidong Yang
Summary: This study found that CLDN7 expression is low in OSCC tissues and that overexpression of CLDN7 inhibits the proliferation, invasion, and migration of OSCC cells. IRF2 was found to bind to the CLDN7 promoter and regulate its expression, also affecting the functions of OSCC cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yong Liu, Yuelin Liu, Yong Gao, Lei Wang, Hengliang Shi, Chengmin Xuan
Summary: This study identified the regulatory pathway of H19 and hsa-miR-338-3P in regulating NRP1 expression in GBM, which plays an important role in the disease.
Article
Oncology
Adjabhak Wongviriya, Richard M. Shelton, Paul R. Cooper, Michael R. Milward, Gabriel Landini
Summary: This study aimed to determine the involvement of S1PR2 in EGF-induced migration and invasion of OSCC lines, as well as any potential crosstalk between the two pathways. The results demonstrated that S1PR2 inhibition reduced EGF-induced migration, invasion, and Rac1 activity. However, S1PR2 activation did not enhance the effect of EGF on migration, invasion, or Rac1 activity. Additionally, EGF promoted S1P production through the upregulation of Sphk1.
CANCER CELL INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Xun Zhang, Yujue Wang, Xue Wang, Bingyu Zou, Jie Mei, Xue Peng, Zhao Wu
Summary: Our study revealed that miR-10a-5p in CAF-derived EVs promotes angiogenesis and tumorigenesis of cervical squamous cell carcinoma cells by inhibiting TBX5 and activating the Hedgehog signaling pathway. These findings suggest a novel therapeutic strategy targeting miR-10a-5p against CSCC.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Xinning Liu, Yanan Jiang, Hao Zhou, Xiaokun Zhao, Mingzhu Li, Zhuo Bao, Zitong Wang, Chenyang Zhang, Zhenliang Xie, Jimin Zhao, Zigang Dong, Kangdong Liu, Zhiping Guo
Summary: Esophageal squamous cell carcinoma (ESCC), a highly fatal upper gastrointestinal cancer, can be suppressed by dasabuvir, an FDA-approved drug for hepatitis C virus (HCV) treatment. Dasabuvir inhibits ESCC cell growth in a dose and time-dependent manner, arresting cell cycle progression. In vivo validation using patient-derived xenograft tumor models further confirmed the anti-tumor activity. Mechanistically, dasabuvir acts as a ROCK1 inhibitor, blocking the ROCK1/ERK signaling pathway and downregulating CDK4 and cyclin D1 expression.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Sarthak Tandon, Parveen Ahlawat, Sunil Pasricha, Sandeep Purohit, David K. Simson, Kiran Dobriyal, Preetha Umesh, Manindra Mishra, Lalit Kumar, Ahmad M. Karimi, M. Jwala, Munish Gairola
Summary: This study aimed to use Depth of invasion (DOI) as a cut-off to identify a discrete group within stage III oral tongue squamous cell carcinoma (OTSCC), finding that the deep group had significantly lower overall and relapse-free survival rates. The study suggests that DOI cut-off can be a significant predictor of OTSCC progression.
Article
Oncology
Zhigang Zhao, Shankun Zhao, Lianmin Luo, Qian Xiang, Zhiguo Zhu, Jiamin Wang, Yangzhou Liu, Jintai Luo
Summary: The study demonstrates a tumor-suppressive role of miR-199b-5p in invasion and metastasis of PCa by inhibiting DDR1 expression and EMT, leading to poor prognosis in patients. Additionally, the miR-199b-5p-DDR1-ERK signaling axis represents a novel mechanism for regulating EMT in PCa metastases.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Qiuyu Chen, Lingyun Zhang, Changshan Wan, Boli Yang, Xiangxu Kong, Xin Xu, Yu Gu, Chen Wang, Xiaotong Liu, Qian Ding, Lanping Zhu, Ying Li, Bangmao Wang, Weilong Zhong
Summary: The aim of this study was to investigate the role of transgelin (TAGLN) in the ferroptosis of esophageal squamous cell carcinoma (ESCC). TAGLN expression was negatively associated with ESCC prognosis. TAGLN overexpression inhibited the migration, invasion, viability, and proliferation of ESCC cells. TAGLN also promoted ferroptosis in ESCC by interacting with p53. These findings suggest that TAGLN may inhibit the malignant development of ESCC through the induction of ferroptosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Meifang Suo, Zhichen Lin, Dongfang Guo, Airong Zhang
Summary: Abnormal expression of hsa_circ_0056686 in cancer-associated fibroblasts (CAFs) promotes the proliferation and migration of uterine leiomyoma (ULM) cells and reduces endoplasmic reticulum stress (ERS)-induced apoptosis by sponging miR-515-5p.
Article
Anatomy & Morphology
Xiao-Qin Liu, Yao Yao, Jing-Wen Mu, Feng-Ying Yang
Summary: This study found that high cytoplasmic expression of Sema4A is related to T classification, clinical stage, and nodal metastasis of OSCC patients. Patients with low cytoplasmic Sema4A expression showed higher microvessel density (MVD) and poorer prognosis in OSCC. Over-expression of Sema4A can inhibit the invasion, migration, and angiogenesis abilities of oral squamous cell carcinoma cells.
Article
Endocrinology & Metabolism
Yuanxin Chen, Zhijie Huang, Jianjiang Zhao, Bo Jia
Summary: This study verified the effect of Fusobacterium nucleatum (F. nucleatum) in oral squamous cell carcinoma (OSCC) and explored the possible molecular mechanism. The abundance of F. nucleatum was found to be higher in OSCC compared to paracancerous tissues. F. nucleatum can regulate cell proliferation, migration, and invasion, and promote the progression of OSCC through CCL20.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sidi Zhang, Qianming Chen, Chao Yang, Jiayu Shi, Yansong Lin, Shijun Duan, Bing Shi, Zhonglin Jia
Summary: This study identified new potential SNPs around IRF6 associated with non-syndromic orofacial cleft (NSOC) in Western Han Chinese, and found that these SNPs have different transmission patterns and parent-of-origin effects in different subtypes, indicating their potential importance in the development of the disease.
Article
Dentistry, Oral Surgery & Medicine
Dikan Wang, Juan Fang, Shuqiong Wen, Qunxing Li, Jinming Wang, Lisa Yang, Wenxiao Dai, Huanzi Lu, Junyi Guo, Zhongyan Shan, Wenqiang Xie, Xiangqi Liu, Liling Wen, Jie Shen, Anxun Wang, Qianming Chen, Zhi Wang
Summary: The study explores two subsets of exhausted T cells, TCF1(+)Tex(prog) and TCF1(-)Tex(term), in head and neck squamous cell cancer (HNSCC). TCF1(-)Tex(term) represents a greater proportion of CD8(+)PD1(+)Tex and exhibits a polyfunctional phenotype associated with better survival. These cells are also accompanied by an increase in the proportion of regulatory T cells (Tregs) in the tumor immune microenvironment (TIME).
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Materials Science, Biomaterials
Tingting Ding, Jiajia Qi, Jingcheng Zou, Hongxia Dan, Hang Zhao, Qianming Chen
Summary: A novel hydrogel material with excellent antibacterial and adhesive properties was successfully synthesized in this study, which could be degraded within three days in vivo. The hydrogel also showed remarkable antioxidant capability, injectability, and good cytocompatibility, accelerating wound healing in mice.
BIOMATERIALS SCIENCE
(2022)
Letter
Dentistry, Oral Surgery & Medicine
Yilong Hao, Yao Yuan, Yining Li, Qianming Chen
Article
Biotechnology & Applied Microbiology
Zhiwei Jiang, Na Li, Qin Shao, Danji Zhu, Yuting Feng, Yang Wang, Mengjia Yu, Lingfei Ren, Qianming Chen, Guoli Yang
Summary: This study successfully isolated a new population of mesenchymal stem cells (PMSCs) from rat hard palates and fabricated scaffold-free 3D cell aggregates using light-controlled cell sheet technology. Transplantation of the PMSC aggregates significantly enhanced bone formation and implant osseointegration in vivo, demonstrating their potential as a powerful tool for tissue engineering.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xiaofei Yu, Yao Liu, Keqing Pan, Pei Sun, Jing Li, Lingyu Li, Qianming Chen, Zheng Sun
Summary: BRCA1 depletion increases oxidative damage and promotes the malignant phenotype in oral cancer. The NRF2-activator sulforaphane is a potential chemo-preventive agent for oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Maofeng Qing, Yu Zhou, Jiakuan Peng, Qianhui Shang, Jiaxin Deng, Xin Zeng, Hao Xu, Qianming Chen
Summary: This study aimed to investigate the expression of interleukin-6 (IL-6) family in local tissues of oral lichen planus (OLP) patients and its correlation with presentations and outcomes. The results showed that the expression of IL-6 family significantly increased in erosive type OLP patients. Additionally, IL-6 family factors were significantly increased in the recurrent erosion group compared to the persistent nonerosion group. Multiple regression analysis revealed that the increased expression of IL-6 family was closely related to clinical types and outcomes of OLP.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Infectious Diseases
Yufeng Wang, Haiwen Zhou, Wenmei Wang, Ning Duan, Zhixiao Luo, Hongbo Chai, Lu Jiang, Qianming Chen, Jinli Liu, Hong Hua, Zhimin Yan, Yuan Fan, Juanyong Xu, Xiaobing Guan, Hongjian Wang, Hongzhou Lu, Wenhui Lun, Wei Fei, Tong Zhang, Jizhi Zhao, Chunling Jia, Hui Kong, Xuemin Shen, Qing Liu, Weizhi Wang, Guoyao Tang
Summary: The study found that once-daily treatment with miconazole buccal tablets is as effective as systemic itraconazole capsules in Chinese patients with oropharyngeal candidiasis, and it has minimal side effects.
Article
Materials Science, Multidisciplinary
Tiannan Liu, Yuqi Du, Yujie Yan, Shaojuan Song, Jiajia Qi, Xin Xia, Xiaopei Hu, Qianming Chen, Jiang Liu, Xin Zeng, Hang Zhao
Summary: In this study, a pH-responsive dual-functional isoG-based supramolecular hydrogel with excellent stability and sustained release capability was successfully developed. Both in vitro and in vivo experiments demonstrated its biocompatibility, biodegradability, and significant inhibition of tumor growth. This is the first example of a pH-responsive dual-functional isoG-based supramolecular hydrogel integrating localized delivery and anti-cancer activity in one molecule.
Article
Dentistry, Oral Surgery & Medicine
Yansong Song, Ling Ren, Jiaxin Liu, Xin Zeng, Qianming Chen, Hongxia Dan
Summary: The core outcome set (COS) is a minimum set of outcomes that should be reported by all clinical trials in a specific health field. The use of COS in clinical studies can reduce heterogeneity, facilitate systematic review, and increase the utility of studies. The importance of COS in oral health has recently been recognized.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Article
Materials Science, Biomaterials
Shangxue Lei, Xiaopei Hu, Shaojuan Song, Yuting Zhang, Hang Zhao, Xiaoping Xu, Hongxia Dan
Summary: Catechins, extracted from green tea, have been proven to have excellent anti-HPV and anti-tumour properties, showing great potential in the treatment of HPV+ OSCC. However, their poor bioavailability, short half-lives, and stability issues hinder their clinical application. To overcome these shortcomings, a new injectable supramolecular hydrogel called CPBisoG was innovatively synthesized, which exhibited good stability, injectability, self-healing properties, biocompatibility, biodegradability, and therapeutic effects toward HPV+ OSCC in vitro and in vivo. It also showed selective inhibition against HPV+ OSCC cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Immunology
Xiaoting Deng, Ying Wang, Lu Jiang, Jing Li, Qianming Chen
Summary: Oral lichen planus (OLP) is a chronic immune inflammatory disease that affects the oral mucosa and has the potential to develop into oral squamous cell carcinoma (OSCC). The etiology of OLP is still unknown, but immune dysregulation may play a vital role in its pathogenesis. This review focuses on the relationship between OLP and its immune microenvironment, summarizing the current developments in immunology, functional cell types, crucial cytokines, and signaling pathways involved. The potential application of targeted immune microenvironment therapy for OLP is highlighted.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Surgery
You Zhang, Yuqi Wu, Dan Pan, Zhenyu Zhang, Lu Jiang, Xiaodong Feng, Yuchen Jiang, Xiaobo Luo, Qianming Chen
Summary: This study aimed to evaluate the diagnostic accuracy of narrow band imaging (NBI) for malignant transformations of potentially malignant disorders (OPMD) in the oral cavity. The results showed that defining IPCL II and above as a positive result demonstrated the highest diagnostic accuracy for OPMD malignant transformations.
FRONTIERS IN SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yahui Wang, Fan Tang, Zhiyong Li, Qianming Chen
Summary: This retrospective study investigated and compared the features of SBCs and ABCs of the jaw. The study found that SBCs and ABCs mostly occur in adolescents and young adults, are generally asymptomatic and found incidentally, and the final diagnosis depends on pathological examination. Curettage combined with bone grafting is the main treatment method.
Article
Dentistry, Oral Surgery & Medicine
Yansong Song, Na Liu, Lijie Gao, Dan Yang, Jiaxin Liu, Liang Xie, Hongxia Dan, Qianming Chen
Summary: This study revealed the association between human herpes simplex virus (HSV) infection and periodontitis. It found that HSV-1 infection was significantly associated with periodontitis and severe periodontitis, while HSV-2 infection was associated with severe periodontitis, periodontitis in 40-50-year-olds, and Mexican-Americans.
