Article
Immunology
Daniela Correia da Silva, Peter J. Jervis, Jose A. Martins, Patricia Valentao, Paula M. T. Ferreira, David M. Pereira
Summary: Inflammation and endoplasmic reticulum stress often occur together in chronic diseases. Fisetin, a dietary flavonol, has multiple bioactivities and may be used as a pharmacological approach against ER stress and inflammation. New derivatives of fisetin were synthesized and tested, some of which are more potent inhibitors of inflammation and ER stress signaling than the parent compound.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Lisa Dowling, Philip Jakeman, Catherine Norton, Maeve M. Skelly, Hamid Yousuf, Miranda G. Kiernan, Margaret Toomey, Sheila Bowers, Suzanne S. Dunne, J. Calvin Coffey, Colum P. Dunne
Summary: Crohn's disease is a global inflammatory bowel condition that differs from healthy population in terms of body fat distribution, specifically showing elevated gynoid fat and reduced android fat. There is a potential rationale to refer to Crohn's disease as a fatty intestine condition, similar to fatty liver conditions, which may require further investigation in a larger patient cohort.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Chuen-Mao Yang, Chien-Chung Yang, Wun-Hsin Hsu, Li-Der Hsiao, Hui-Ching Tseng, Ya-Fang Shih
Summary: Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of cardiac injury, inflammation, and apoptosis. TNF-alpha-induced CCL20 secretion in human cardiac fibroblasts is mediated through a TNFR1-dependent EGFR/p38 MAPK and JNK1/2/FoxO1 or NF-kappa B cascade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Hanan H. Ali, Balaji Bhaskar Maruthi Sridhar, Jason A. Rosenzweig
Summary: Houston watersheds are susceptible to microbial and chemical contamination. Environmental isolates of Klebsiella spp. were found to be more Pb-tolerant than reference strains, showing better growth and higher biofilm production when exposed to lead, potentially leading to increased environmental persistence and human disease risk.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Green & Sustainable Science & Technology
Kun Wu, Weijia Xu, Jian Lu, Chun Wang, Jinhui Liao, Xia He
Summary: This study found that calcium can increase methane production in the anaerobic digestion of FOG, with Ca(OH)2 being the most effective calcium source for enhancing methane production and a Ca2+/LCFAs = 0.5 being the most beneficial mole ratio.
Article
Environmental Sciences
Huifeng Yue, Xiaowen Yang, Xiaoyun Wu, Yuchai Tian, Pengchong Xu, Nan Sang
Summary: The ban on BPA has resulted in the increased use and detection of BPA analogs in the environment and organisms, which have been found to have adverse health effects. This study examined the effects of exposure to BPB and BPAF on ovarian tissue in CD-1 mice. Morphological changes were observed in the ovaries, and disturbances in biological processes were identified. The altered expression of genes and transcription factors associated with ovarian disease suggests that BPA analog exposure may be a risk factor for ovarian diseases.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cell Biology
Yu Li, Na-Chuan Luo, Xu Zhang, Tetsuya Hara, Chiaki Inadomi, Tao-Sheng Li
Summary: Prolonged exposure to oxygen induced mobilization and functional impairment of stem/progenitor cells, enhancing inflammatory responses to exacerbate cardiac I/R injury in healthy mice.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Helene Escalon, Didier Courbet, Chantal Julia, Bernard Srour, Serge Hercberg, Anne-Juliette Serry
Summary: The study revealed that more than 50% of food advertisements seen on television by children and adolescents were for HFSS products, with half of ads for D and E Nutri-Score products being aired during peak viewing hours in the evening.
Article
Endocrinology & Metabolism
Jose Fernando Garcia-Rodrigo, Georgina Ortiz, Oscar Fernando Martinez-Diaz, Janette Furuzawa-Carballeda, Xarubet Ruiz-Herrera, Fernando Macias, Maria G. Ledesma-Colunga, Gonzalo Martinez de la Escalera, Carmen Clapp
Summary: The hormone prolactin (PRL) has both proinflammatory and anti-inflammatory effects in rheumatoid arthritis (RA). This study found that PRL can modulate the proinflammatory actions of IL-1 beta and TNF-alpha in synovial fibroblasts, with opposite effects on the activation of the NF-kappa B signaling pathway. In vivo experiments confirmed these findings, showing that PRL can prevent the actions of IL-1 beta but may enhance the proinflammatory effect of TNF-alpha. These dual actions of PRL may help regulate joint inflammation in RA.
Article
Physiology
Akila L. Oliveira, Matheus L. Medeiros, Mariana G. de Oliveira, Caio Jordao Teixeira, Fabiola Z. Monica, Edson Antunes
Summary: This study found that MGO can cause bladder overactivity, and its mechanism is related to the activation of the AGE-RAGE-ROS signaling cascade and Rho kinase. Accumulation of MGO leads to an increase in AGEs levels, which in turn activates the RAGE-ROS signaling pathway, ultimately leading to bladder overactivity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
JinHeng Lin, Michael Taggart, Lee Borthwick, Andrew Fisher, Malcolm Brodlie, M. Flori Sassano, Robert Tarran, Michael A. Gray
Summary: The study found that cigarette smoke affects human airway smooth muscle cells by stimulating calcium influx through the neurogenic pain receptor channel TRPA1, leading to myosin light-chain phosphorylation. This may be an important link between cigarette smoke exposure and airway hyperresponsiveness.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Rundong Liu, Lin Bai, Mengchen Liu, Ruike Wang, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Guoyu Zhou, Fangfang Yu, Hui Huang
Summary: Lead and high-fat diets are co-occurring risk factors for cognitive impairment. This study found that combined exposure to lead and high-fat diets exacerbates cognitive deficits and affects synaptic plasticity through multiple signaling pathways. The study highlights the importance of evaluating the effects of mixed exposures on brain function in realistic environments and the need to modulate central pathways to prevent neurological disorders.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Medicinal
Marina Masetto Antunes, Guilherme Godoy, Laureane Nunes Masi, Rui Curi, Roberto Barbosa Bazotte
Summary: Both HCD and HFD diets induced inflammation in the prefrontal cortex, but hippocampus showed greater sensitivity to HFD. Proinflammatory cytokines IL-1 beta and TNF-alpha were found to be higher in specific brain regions following different diets, indicating potential impact on brain function and disorders.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Pathology
Guoqing Qian, Oluwaseun Adeyanju, Christudas Sunil, Steven K. Huang, Shi-You Chen, Torry A. Tucker, Steven Idell, Xia Guo
Summary: Obesity is a significant risk factor for lung disease development, but the impact of chronic high-fat and high-fructose diet-induced obesity on lung inflammation and subsequent pulmonary fibrosis is not well understood. This study reveals a previously unrecognized role of DOCK2 in regulating proinflammatory phenotype of LFs, potentiation of lung inflammation, and pulmonary fibrosis in chronic HFHF diet-caused obesity.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Environmental Sciences
Takuro Okamura, Masahide Hamaguchi, Yuka Hasegawa, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Ryoichi Sasano, Yuki Nakanishi, Hiroshi Seno, Hirohisa Takano, Michiaki Fukui
Summary: The study found that microplastics can cause metabolic disturbances, such as diabetes and nonalcoholic fatty liver disease, in mice on a high-fat diet. The results highlight the importance of reducing oral exposure to microplastics through environmental measures to improve metabolic disturbance under high-fat diet conditions.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)