Review
Chemistry, Analytical
Niharika G. Jha, Daphika S. Dkhar, Sumit K. Singh, Shweta J. Malode, Nagaraj P. Shetti, Pranjal Chandra
Summary: To combat pathogens or tumors, antimicrobial or antineoplastic drugs have been developed, however, cells have evolved mechanisms to resist such drugs. Microorganisms or cancer cells that exhibit resistance to multiple drugs are known as multidrug-resistant (MDR) cells. The drug resistance status of a cell can be determined through analyzing genotypic and phenotypic changes caused by physiological and biochemical alterations. Conventional methods for determining drug resistance status have drawbacks, and biosensors with low detection limit have been engineered as an alternative solution.
Review
Biochemistry & Molecular Biology
Tam Thuy Lu Vo, Dain Shin, Eunyoung Ha, Ji Hae Seo
Summary: This review examines the harmful effects of drug abuse on the blood-brain barrier (BBB), with a focus on the mechanisms through which it damages the neurovascular unit (NVU). Understanding the relationships between drug abuse, BBB integrity, and NVU function may lead to the discovery of new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yi Yan, Xiao-Yu Liu, An Lu, Xiang-Yu Wang, Lin-Xia Jiang, Jian-Cheng Wang
Summary: RNA-based therapy is a promising strategy for disease treatment, and recent advances in non-viral delivery systems have shown potential in protecting RNA, facilitating cell internalization, and controlled release of therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Bo Zhang, Junqiao Zhang, Zhengzhong Kang, Lijun Liang, Yingchun Liu, Qi Wang
Summary: Through molecular dynamics simulation, it was found that P-glycoprotein has a multidrug resistance feature, with similar binding free energy to different drugs, correlating with the size of drugs but showing no obvious correlation with the polarity of drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Microbiology
Elisabeth Hodille, Charlotte Genestet, Thomas Delque, Luna Ruffel, Yvonne Benito, Isabelle Fredenucci, Jean-Philippe Rasigade, Gerard Lina, Oana Dumitrescu
Summary: The MDR/MTB ELITe MGB (R) Kit shows high specificity for MTB detection and the ability to detect RIF/INH resistance, with easy integration in laboratory workflow.
Article
Engineering, Biomedical
Mengchang Xu, Fenglin Liu, Wenhu Zhou, Binsheng He, Songwen Tan
Summary: In this study, two-phase enteric-coated granules of aspirin and L-glutamate compound were constructed using extrusion spheronization method and fluidized bed coating. The quality analysis and optimization of the compound were conducted, resulting in granules with good sphericity and dissolution. The quality evaluation and preliminary stability of the compound met commercial requirements, and it should be stored in a sealed cool place.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Tuyelee Das, Uttpal Anand, Swaroop Kumar Pandey, Charles R. Ashby, Yehuda G. Assaraf, Zhe-Sheng Chen, Abhijit Dey
Summary: This article discusses the main cause of cancer chemotherapy resistance, which is multidrug resistance. The mechanisms of resistance to paclitaxel and docetaxel are explored, including alterations in microtubule-protein interactions and the expression of multidrug efflux transporters. Additionally, various pharmacological modulations and herbal formulations for reversing paclitaxel resistance are discussed, indicating a new era in modern medicine to combat multidrug resistance in cancer patients.
DRUG RESISTANCE UPDATES
(2021)
Article
Neurosciences
Phetcharawan Lye, Enrrico Bloise, Stephen G. G. Matthews
Summary: Infectious pathogen-associated molecular patterns (PAMPs) significantly modify the expression and function of multidrug resistance (MDR) transporters in human fetal brain endothelial cells (hfBECs), potentially leading to altered trajectories of fetal brain development.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Review
Biochemical Research Methods
Boao Xia, Charles Sebesta, Sangsin Lee, Vishnu Nair, Xuan Zhao, Samantha Coffler, Jacob T. Robinson, Jerzy O. Szablowski
Summary: The 'biohybrid' approach combines synthetic materials, genetically encoded proteins or cells, and optical, acoustic, and magnetic energy sources to improve interfacing with the nervous system and achieve enhanced spatial, temporal, cell-type, and molecular precision.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Swamini Saini, Mansi Balhara, Debjani Dutta, Surabhi Chaudhuri, Shamik Ghosh, Kabir Sardana
Summary: Dermatomycosis is a common superficial fungal infection. The combination of plant-based extract and existing antifungal drugs shows potential as an alternative therapy to minimize resistance.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Asma Akram, Mateen Izhar, Asim Saifullah, Sameen Binte Ali
Summary: This study found a high percentage of PVL positive Staph aureus in pus samples from children, indicating the need for treatment of both patients and their close contacts to control its spread.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Dahua Fan, Yongkai Cao, Meiqun Cao, Yajun Wang, Yongliang Cao, Tao Gong
Summary: Cancer remains a highly lethal disease but current cancer therapies lack tumor-targeted specificity, resulting in undesired side effects. Recent advances in nanotechnology have led to the development of nanocarriers with tumor-specific targeting, but most nanocarriers lack hierarchical targeting capability and their therapeutic efficacy is compromised. This review discusses current and prospective strategies in the design of tumor-targeted nanomedicines and highlights the latest progress in hierarchical targeting technologies to maximize therapeutic outcomes.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Shangjun Liu, Xia Li
Summary: The mode of drug delivery plays a crucial role in the efficacy of cancer treatment. Microcapsules and mesoporous silica nanoparticles have gained wide attention as drug carriers. The intelligent drug release system allows for on-off control of drug release based on specific signals, and is created by encapsulating drugs with polymers. By changing the environment, the microstructure of the intelligent polymer can reversibly switch from hydrophilic to hydrophobic, enabling the construction of drug release systems that respond to different stimulation signals.
2023 3RD ASIA-PACIFIC CONFERENCE ON COMMUNICATIONS TECHNOLOGY AND COMPUTER SCIENCE, ACCTCS
(2023)
Article
Environmental Sciences
Sharofiddin Yuldashev, Nargiza Parpieva, Salikhdjan Alimov, Laziz Turaev, Khasan Safaev, Kostyantyn Dumchev, Jamshid Gadoev, Oleksandr Korotych, Anthony D. Harries
Summary: Uzbekistan has scaled up the use of rapid molecular diagnostic tests for drug-resistant tuberculosis, leading to a significant increase in patients with laboratory-confirmed XDR-TB. The number of patients with laboratory-confirmed MDR-TB remained stable, with potential second-line drug resistance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nanoscience & Nanotechnology
Ahmad Gholami, Biuck Habibi, Amir Abbas Matin, Naser Samadi
Summary: Controlled drug release systems can improve the effectiveness of drug therapy by modifying the release profile, biodistribution, stability, and solubility of drugs, minimizing the side effects of anticancer drugs.
NANOMEDICINE JOURNAL
(2021)
Article
Materials Science, Ceramics
Ziyu Ding, Yinghong Tang, Lei Liu, Zeliang Ding, Yimin Tan, Quanguo He
Summary: This study investigates the influence of the introduced TamOn-TiO2/TiO2/Ti multi-interlayer on the microstructure, adhesive, mechanical, and anti-corrosion properties of reactive sputtered tantalum oxide coatings. The inserted multiple interlayers reduce the residual stress in the coating, couple the mechanical performance between the layer and the substrate, and block the continuous growth of penetrating defects in a film with columnar structure. The results provide a workable approach for improving the properties of the tantalum oxide coating on Ti6Al4V alloy for medical applications.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Physical
Yanping Wei, Liangyuan Yao, Yiyong Wu, Xia Liu, Jinxia Feng, Jianhua Ding, Kanghua Li, Quanguo He
Summary: In this study, an electrochemical sensor based on FeMoO4 loaded graphene oxide composites was prepared for the ultrasensitive detection of Acyclovir in nanomolar concentrations. The sensor exhibited a linear relationship between the oxidation peak current and Acyclovir concentration in the range of 0.1-10 mu M and 10-100 mM, with a detection limit of 20 nM. The sensor also showed good recoveries and accuracy in nanomolarity for the analysis of Acyclovir drug samples.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Materials Science, Ceramics
Ziyu Ding, Qianhong Yuan, Hao Wang, Yinghong Tang, Yimin Tan, Quanguo He
Summary: A Nb2O5/Mg gradient coating was synthesized on AZ31 magnesium alloy through magnetron sputtering, which showed improved mechanical, anti-wear, and anti-corrosion properties. The coating had an amorphous columnar structure and a gradual change in chemical composition, reducing residual stress and increasing compactness. Compared to a Nb2O5 single-layer film, the gradient coating exhibited increased adhesion, hardness, elastic modulus, and reduced wear rate. Moreover, it showed better corrosion resistance. This study provides a strategy for enhancing ceramic coatings on magnesium alloy for medical applications.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Kanghua Li, Yang Xiao, Yuchi Zhao, Yonghui Xia, Jianhua Ding, Quanguo He, Juan Ling, Guangli Li
Summary: In this study, a novel metal-free voltammetric sensor was developed using carboxyl-functionalized carbon nanomaterials for sensitive detection of the harmful synthetic dye Rhodamine B (RhB). The sensor showed low detection limit, excellent selectivity and stability, and achieved good recovery in tomato sauce samples.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wenming Li, Jingyun Xiao, Liangyuan Yao, Yanping Wei, Jinsong Zuo, Weili Zeng, Jianhua Ding, Quanguo He
Summary: In this study, a ZrMo2O8-MWCNTs composite was synthesized and used for the electrochemical detection of ADV. The sensor showed a great improvement in the electrochemical response to ADV compared to single-material modified electrodes. It was successfully tested in serum and urine, and demonstrated advantages of simple preparation, fast response, and good reproducibility.
Article
Chemistry, Applied
Peihong Deng, Yanping Wei, Wei Li, Shuting Shi, Chuanqin Zhou, Junhua Li, Liangyuan Yao, Jianhua Ding, Quanguo He
Summary: In this study, a sensitive electrochemical sensor using MnO2 nanoparticles functionalized carboxylated multi-walled carbon nanotubes (MnO2-c-MWCNTs) was prepared for the determination of curcumin. The synthesized materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The electrochemical behavior and reaction mechanism of curcumin on the modified electrode were investigated in detail. The sensor showed high sensitivity (3.30 mu A mu M-1 cm(-1)) and a low detection limit of 6.0 nM, as well as good anti-interference ability and stability. It was successfully applied for the accurate and rapid determination of curcumin in commercial food samples, demonstrating its practical potential.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Applied
Yanping Wei, Yiyong Wu, Jinxia Feng, Jun Liu, Yaling Tian, Jingyun Xiao, Quanguo He
Summary: In this study, a pod-like Ce2Mo3O13 was prepared and used to construct a highly sensitive molecularly imprinted sensor for the detection of ponceau 4 R at nanomolar concentrations. The results showed that the electrochemical response of the MIPs/Ce2Mo3O13-MWCNTs/GCE hybridized electrode was stronger than the non-molecularly imprinted ones, indicating a synergistic effect from the combination of Ce2Mo3O13-MWCNTs and modification to the electrode.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Materials Science, Multidisciplinary
Quanguo He, Bing Wang, Jing Liang, Jun Liu, Bo Liang, Guangli Li, Yaohang Long, Gongyou Zhang, Hongmei Liu
Summary: The environment is crucial for human survival, but human activities have led to increasing pollutants in drinking water, food, and the environment, posing a significant threat to human health. Therefore, there is a need for fast and effective monitoring of environmental compound concentrations in samples. Electrochemical sensors have great potential for online monitoring of specific pollutants in complex environments due to their high sensitivity, selectivity, low cost, simplicity, and accuracy, making them a hot research topic. With the development of portable electronic technology, portable electrochemical sensing systems have seen significant growth in various fields. This paper provides a systematic review of portable electrochemical sensors used for environmental pollutant analysis and summarizes the current research direction, aiming to inspire researchers with new ideas and perspectives.
MATERIALS TODAY ADVANCES
(2023)
Article
Chemistry, Inorganic & Nuclear
Chuanqin Zhou, Shuting Shi, Yanping Wei, Aiting Chen, Nana Tang, Jingsong Zuo, Quanguo He, Peihong Deng
Summary: In this study, hollow tubular manganese-cobalt sulfide (MnS/Co3S4) hybrids were synthesized and anchored on graphene oxide (GO) using a hydrothermal method and ultrasonic dispersion. The resulting nanocomposites were drop-coated onto a glassy carbon electrode (GCE) to construct a sensitive sensor for acetaminophen (AC) detection. The electrochemical performance of the MnS/Co3S4-ERGO/GCE was evaluated, showing excellent electrocatalytic activity for AC oxidation. The method demonstrated high accuracy for AC determination in commercial tablets and human serum samples, with satisfactory recoveries.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Shuting Shi, Yanping Wei, Jinxia Feng, Chuanqin Zhou, Jinsong Zuo, Liangyuan Yao, Jianhua Ding, Kanghua Li, Quanguo He
Summary: A bismuth oxide-carboxylated multi-walled carbon nanotube/glassy carbon electrode (Bi2O3-CMWCNTs/GCE) was prepared for the detection of the flavonoid drug baicalein. The in-situ synthesis of Bi2O3 on the surface of CMWCNTs resulted in a simple and efficient Bi2O3-CMWCNTs composite. The electrochemical sensing performance of the composite electrode surface was characterized and the optimal detection conditions of baicalein on Bi2O3-CMWCNTs/GCE were investigated.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Analytical
Yonghui Xia, Guangli Li, Yuefang Zhu, Quanguo He, Changping Hu
Summary: Graphitic-like carbon nitride/graphene oxide composite nanosheets (g-C3N4/GO) were synthesized and used for simultaneous determination of uric acid (UA) and dopamine (DA). The g-C3N4/GO exhibited improved electrical conductivity, selective oxidation capacity and electrocatalytic activity. The modified glassy carbon electrode (GCE) showed excellent electrocatalytic activity for UA and DA with a wide linear detection range and low detection limits. The g-C3N4/GO/GCE also demonstrated good reproducibility, selectivity and stability.
MICROCHEMICAL JOURNAL
(2023)
Review
Engineering, Environmental
Chuanqin Zhou, Jinxia Feng, Yaling Tian, Yiyong Wu, Quanguo He, Guangli Li, Jun Liu
Summary: Organophosphorus pesticides (OPPs) have significant impacts on ecological chains and food chains, thus effective non-enzymatic methods for residue analysis are important. Non-enzymatic nanosensors constructed with nanomaterials provide specificity, selectivity, and cost-effectiveness. The challenges and prospects in this field are discussed, and non-enzymatic sensors will facilitate food and ecosystem monitoring and safeguarding.
ENVIRONMENTAL SCIENCE-ADVANCES
(2023)
Review
Food Science & Technology
Jinsong Zuo, Jinxia Feng, Marcelo Gonsalves Gameiro, Yaling Tian, Jing Liang, Yingying Wang, Jianhua Ding, Quanguo He
Summary: The global pandemic has increased online food purchases, which has led to higher demand on the food supply chain. RFID technology is important and applicable to smart food packaging, enhancing food quality and safety.
Article
Chemistry, Multidisciplinary
Ziyu Ding, Qianhong Yuan, Hao Wang, Yinghong Tang, Yimin Tan, Quanguo He
Summary: In this study, a Nb2O5/Nb2O5-Mg/Mg multilayer coating was prepared on the surface of AZ31 magnesium alloy to improve its mechanical, tribological, and anticorrosion performance. Compared to a Nb2O5 monolayer coating, the multilayer coating exhibited significantly higher adhesion and damage resistance.
Article
Engineering, Environmental
Guangli Li, Chun Yang, Quanguo He, Jun Liu
Summary: Global environmental pollution and energy depletion are two major problems threatening human existence. The construction of Ag-based heterostructures in photocatalytic applications shows great potential for addressing these environmental and energy issues. This review summarizes the construction and photocatalytic performance of various Ag-based heterostructures, with a focus on their role in environmental remediation and energy storage. The challenges and prospects of Ag-based heterostructures, particularly Ag-based Z-scheme heterostructures, are also discussed.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
