Article
Biochemistry & Molecular Biology
Carlos Larque, Haydee Lugo-Martinez, Xiadany Mendoza, Monserrat Nochebuena, Luis Novo, Ricardo Vilchis, Guadalupe Sanchez-Bringas, Laura Ubaldo, Myrian Velasco, Rene Escalona
Summary: This study investigates the effects of paternal obesity on the metabolic and reproductive health of offspring. The results show that a high-fat diet led to weight gain, increased visceral fat, impaired glucose control, and reduced insulin sensitivity in the obese fathers. Additionally, the offspring of these obese fathers exhibited increased body weight, reduced sperm viability in males, and a decrease in the number of primordial follicles in females. These findings suggest that metabolic and reproductive issues can be inherited through the paternal line.
Article
Biochemistry & Molecular Biology
Prince K. K. Akowuah, Carolina Lema, Rolando E. E. Rumbaut, Alan R. R. Burns
Summary: Feeding mice with a high-fat/sucrose diet causes loss of corneal nerve function and impairs corneal wound healing. Changing to a low fat/sugar diet with enrichments in complex carbohydrates mitigates the reduction in nerve function, but its effect on corneal wound healing needs further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Tengteng Ji, Bing Fang, Fang Wu, Yaqiong Liu, Le Cheng, Yixuan Li, Ran Wang, Longjiao Zhu
Summary: The number of obese people is increasing worldwide due to high-fat diets causing excess energy intake. A 12-week dietary intervention study on high-fat diet-induced obese mice showed that changing the diet significantly reduced weight gain and subcutaneous adipose tissue weight. Diet change also affected lipolysis, lipogenesis, and the proportion of adipocyte stem cells in different fat tissues.
Article
Multidisciplinary Sciences
Woongjae Yoo, Jacob K. Zieba, Nora J. Foegeding, Teresa P. Torres, Catherine D. Shelton, Nicolas G. Shealy, Austin J. Byndloss, Stephanie A. Cevallos, Erik Gertz, Connor R. Tiffany, Julia D. Thomas, Yael Litvak, Henry Nguyen, Erin E. Olsan, Brian J. Bennett, Jeffrey C. Rathmell, Amy S. Major, Andreas J. Baumler, Mariana X. Byndloss
Summary: It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.
Article
Biochemistry & Molecular Biology
Mingming Li, Yang Xiao, Lianggui Xiao, Yu Li, Mengting Jia, Yu Sun, Tingli Pan, Lei Zhou, Yixing Li
Summary: With improvements in living standards, obesity has become an increasingly serious health issue. This study found that epigoitrin (EP) from Radix isatidis has significant potential in preventing and treating obesity. EP reduced fat accumulation, promoted glucose uptake and glycogen storage, increased energy production, and improved lipid and glucose metabolism disorders.
Article
Nutrition & Dietetics
Yu Ra Lee, Hye-Bin Lee, Mi-Jin Oh, Yoonsook Kim, Ho-Young Park
Summary: This study found that thyme extract can alleviate obesity and gut derangements caused by a high-fat diet. It can reduce weight gain and body fat percentage, regulate serum biomarkers associated with obesity, and improve intestinal barrier function and colon shortening. Additionally, thyme extract can alter the levels of metabolites.
Article
Food Science & Technology
Qianqian Zhou, Zihan Qu, Nanlan Wang, Huijuan Liu, Hongmei Yang, Huiqun Wang
Summary: SS intervention can regulate the intestinal flora of obese rats, promote weight loss and lipid reduction, and increase the expression of tight junction proteins in the intestinal epithelium.
FOOD SCIENCE & NUTRITION
(2023)
Article
Nutrition & Dietetics
Anandita Pal, Chien-Te Lin, Ilya Boykov, Emily Benson, Grahame Kidd, Kelsey H. Fisher-Wellman, P. Darrell Neufer, Saame Raza Shaikh
Summary: Diet-induced obesity impairs mitochondrial respiratory responses in activated splenic B cells, affecting their bioenergetic metabolism.
Review
Biochemistry & Molecular Biology
Natalia Ferreira Mendes, Carlos Poblete Jara, Ariane Maria Zanesco, Eliana Pereira de Araujo
Summary: Under high-fat feeding, the hypothalamus undergoes pro-inflammatory signaling activation, with recent data revealing microglial heterogeneity throughout the brain. The roles of microglial subpopulations in hypothalamic inflammation have been studied, but how each subset functions in response to inflammatory stimuli remains unclear. Novel experimental models have been developed to study the characteristics and roles of microglial subtypes, and transcriptomic data is being used to identify changes in hypothalamic microglial signature under short-term and long-term high-fat feeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Wei Song, Chen Song, Li Li, Tianyi Wang, Jinhong Hu, Lina Zhu, Tianli Yue
Summary: The study found that three Lactobacillus strains have inhibitory effects on obesity induced by high-fat diet, reducing weight gain and adipose accumulation, while also improving hepatic steatosis. These probiotics also regulated serum lipid levels and adipocytokines, and altered the diversity of gut microbiota.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tingwei Wang, Yongli Ye, Jian Ji, Shuang Zhang, Xingxing Yang, Jiayuan Xu, Jia-Sheng Wang, Zhiyuan Chen, Bangen Xia, Hongfang Shen, Ruowei Xia, Wenqin Shi, Xiulan Sun
Summary: Astilbin consumption has significant anti-obesity and anti-inflammatory effects in high-fat diet mice. It improves gut microbial dysbiosis, enhances intestinal carbohydrate and lipid metabolism, and protects the integrity of the intestinal barrier. Astilbin is a potential prebiotic for the prevention of gut-liver axis damage and metabolic disruption in obese individuals.
Article
Biochemistry & Molecular Biology
Sven H. Rouschop, Samantha J. Snow, Urmila P. Kodavanti, Marie-Jose Drittij, Lou M. Maas, Antoon Opperhuizen, Frederik J. van Schooten, Alexander H. Remels, Roger W. Godschalk
Summary: The study found that a perinatal obesogenic, high-fat diet exacerbated ozone-induced changes in pulmonary oxidant status and molecular control of mitophagy in female rat offspring, while responses were similar for male offspring regardless of diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aden Geonhee Lee, Sora Kang, Hye Ji Yoon, Suyeol Im, Seung Jun Oh, Youngmi Kim Pak
Summary: This study comprehensively investigated the distribution and physiological effects of microplastics (MPs) using in silico, in vitro, and in vivo approaches. The results showed that styrene exhibited the highest binding affinity for immune cells. Furthermore, oral administration of fluorescent-labeled PS-MPs to high-fat diet-induced obese mice led to the co-existence of MPs with immune cells in the blood, exacerbating impaired glucose metabolism and insulin resistance and promoting systemic inflammation. Additionally, MPs were detected throughout the brain, with increased activation of microglia in the hypothalamus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Yu Wang, Xuyang Gao, Xiaoyou Chen, Qiang Li, Xinrui Li, Junxing Zhao
Summary: Sea buckthorn powder intake has a preventive effect on high-fat diet-induced obesity, reducing body weight, fat mass, and circulating lipid levels, and improving insulin sensitivity. Additionally, it alleviates hepatic steatosis and lipid accumulation, exhibits anti-inflammatory capacity in white adipose tissue, promotes thermogenesis in brown adipose tissue, and induces beige adipocyte formation.
Article
Chemistry, Applied
Moon Ho Do, Hye-Bin Lee, Mi-Jin Oh, Hyunjhung Jhun, Sang Yoon Choi, Ho-Young Park
Summary: In high fat diet-induced obese mice, the polysaccharide fraction of radish greens showed anti-obesity activity by reducing weight gain and body fat percentage. This effect was achieved through improving gut barrier function, modulating gut microbiota, and regulating lipid metabolism.
Article
Endocrinology & Metabolism
Rikako Sagara, Tomoaki Inoue, Noriyuki Sonoda, Chieko Yano, Misato Motoya, Hironobu Umakoshi, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The study investigated the relationship between cortisol levels and diastolic dysfunction in patients with diabetes mellitus, revealing a positive correlation between cortisol concentration and LVDD in diabetic patients, suggesting that elevated cortisol levels may increase the risk of developing diastolic dysfunction in diabetic patients.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Shunsuke Katsuhara, Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Yayoi Matsuda, Norifusa Iwahashi, Hiroki Kaneko, Masatoshi Ogata, Tazuru Fukumoto, Eriko Terada, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The study used Mendelian randomization to demonstrate the association of cortisol with reduced muscle strength and mass, suggesting the impact of cortisol on the development of sarcopenia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Shigeki Tashiro, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Miho Kurokawa, Koji Imoto, Akifumi Kuwano, Motoi Takahashi, Hideo Suzuki, Motoyuki Kohjima, Masaki Kato, Yoshihiro Ogawa
Summary: In this study, it was found that Pirfenidone can attenuate APAP-induced liver injury by suppressing TUNEL-positive necrosis through blocking JNK phosphorylation. Simultaneous TUNEL and vital PI staining are useful for distinguishing APAP-induced necrosis from typical oncotic necrosis. Pirfenidone shows potential as a new option for preventing APAP-induced liver injury and holds value for further research and clinical applications.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kazuhide Matsumoto, Nao Fujimori, Yoshitaka Hata, Yosuke Minoda, Masatoshi Murakami, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Takamasa Oono, Eikichi Ihara, Kohei Nakata, Masafumi Nakamura, Takeo Yamamoto, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa
Summary: This study investigated the clinical characteristics of ampullary neuroendocrine neoplasms (NENs) and found distinct differences between ampullary NENs and pancreatic NENs, such as higher incidences of NEC and cholangitis in ampullary NENs. Furthermore, the study discovered identifiable distinctions between ampullary NETs and NECs through endoscopic findings.
DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa
Summary: This study investigated the region-specific role of the M-3 receptor in gastrointestinal motility using a novel positive allosteric modulator (PAM-369). The results showed that PAM-369 selectively potentiated the M-3 receptor without agonistic or antagonistic activity and increased small intestinal transit in mice. However, it had no effect on colonic transit. This study provides the first direct evidence of the different functional roles of the M-3 receptor between the small intestine and colon.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Endocrinology & Metabolism
Norifusa Iwahashi, Hironobu Umakoshi, Tsugio Seki, Celso E. Gomez-Sanchez, Kuniaki Mukai, Makoto Suematsu, Yuta Umezawa, Mototsugu Oya, Takeo Kosaka, Masahide Seki, Yutaka Suzuki, Yutaka Horiuchi, Yoshihiro Ogawa, Koshiro Nishimoto
Summary: This study analyzed the gene expression characteristics of aldosterone-producing cell clusters (APCCs) in the adrenal cortex at single-cell resolution. The findings suggest that some zona glomerulosa (ZG) cells remodel to become APCCs. This has important implications for understanding the development of APCCs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Tatsuki Ogasawara, Yoichi Fujii, Nobuyuki Kakiuchi, Yusuke Shiozawa, Ryuichi Sakamoto, Yoshihiro Ogawa, Katsuki Ootani, Etsuro Ito, Tomoaki Tanaka, Kenichiro Watanabe, Yusaku Yoshida, Noriko Kimura, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa
Summary: Mutated EPAS1 plays a key role in positive selection under hypoxic environments in the pathogenesis of CCHD-PPGL, particularly in patients with multifocal tumors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Erina Eto, Yasutaka Maeda, Noriyuki Sonoda, Naoki Nakashima, Kunihisa Kobayashi, Ryoichi Takayanagi, Yoshihiro Ogawa, Toyoshi Inoguchi
Summary: This study found an association between serum total bilirubin levels and the progression of diabetic nephropathy and end-stage kidney disease. Patients with lower bilirubin levels were more likely to experience progressive renal decline and end-stage kidney disease. Serum total bilirubin levels may be useful in identifying high-risk patients for end-stage kidney disease.
Article
Surgery
Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa
Summary: Mucosal incision-assisted biopsy (MIAB) is a safe procedure with minimal impact on postoperative prognosis for sampling gastric subepithelial lesions (SELs). MIAB releases some tumor cells after damaging the SEL's pseudocapsule, but it does not significantly affect the 5-year disease-free survival rate.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Gastroenterology & Hepatology
Akihisa Ohno, Nao Fujimori, Toshiya Abe, Masafumi Nakamura, Yoshihiro Ogawa
Article
Peripheral Vascular Disease
Shintaro Sakaguchi, Ryuji Okamoto, Chisa Inoue, Masaharu Akao, Kohei Kamemura, Isao Kurihara, Yoshiyu Takeda, Youichi Ohno, Nobuya Inagaki, Hiromi Rakugi, Takuyuki Katabami, Mika Tsuiki, Akiyo Tanabe, Kouichi Tamura, Satoshi Fujita, Yutaka Yano, Kaoru Dohi, Mitsuhide Naruse
Summary: This study investigated the factors associated with comorbid atrial fibrillation (AF) and cardiovascular events in patients with primary aldosteronism (PA), as well as the effect of PA treatment. The study found that age, sex, cardiothoracic ratio, and history of coronary artery disease and heart failure were associated with AF, and PA patients with AF had a higher frequency of cardiovascular events. After PA treatment, AF, in addition to age, duration of hypertension, body mass index, and chronic kidney disease, was an independent prognostic factor for cardiovascular events. The incidence of cardiovascular events was lower in PA patients with AF compared to AF patients without PA.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
Hiroki Kaneko, Hironobu Umakoshi, Tazuru Fukumoto, Norio Wada, Takamasa Ichijo, Shohei Sakamoto, Tetsuhiro Watanabe, Yuki Ishihara, Tetsuya Tagami, Masatoshi Ogata, Norifusa Iwahashi, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The clinical practice guideline emphasizes the importance of confirmatory tests for primary aldosteronism in order to avoid unnecessary adrenal venous sampling for false-positive cases. However, the study found that a combination of multiple confirmatory tests did not yield better results than individual tests in predicting subtypes of primary aldosteronism.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mitsuru Esaki, Eikichi Ihara, Yorinobu Sumida, Hiroyuki Fujii, Shunsuke Takahashi, Kazuhiro Haraguchi, Tsutomu Iwasa, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa
Summary: This study aimed to compare the treatment outcomes of hybrid endoscopic submucosal dissection (H-ESD) and conventional endoscopic submucosal dissection (C-ESD) for small early gastric neoplasms (EGNs). The results showed that H-ESD had significantly shorter procedure time than C-ESD, with comparable curability and safety. Therefore, H-ESD could be a good option for the endoscopic treatment of small EGNs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Hematology
Shojiro Haji, Motoaki Shiratsuchi, Akiko Takamatsu, Mariko Tsuda, Hiroki Muta, Toru Masuda, Yasuhiro Nakashima, Yoshihiro Ogawa
Summary: Non-invasive reactive hyperemia peripheral arterial tonometry (RH-PAT) can predict transplantation-related complications in hematopoietic stem cell transplantation (HSCT). Endothelial dysfunction is associated with the occurrence of thrombotic microangiopathy and acute graft-versus-host disease (aGVHD).
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Masatoshi Murakami, Nao Fujimori, Akihisa Ohno, Kazuhide Matsumoto, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Takamasa Oono, Toshiya Abe, Noboru Ideno, Naoki Ikenaga, Kohei Nakata, Masafumi Nakamura, Kousei Ishigami, Yoshihiro Ogawa
Summary: This study reveals the outcomes after neoadjuvant chemotherapy (NAC) and the characteristics of unresected cases. The study finds that the neutrophil to lymphocyte ratio (NLR) is a predictive factor for operability after NAC.