Article
Oncology
Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman, Claire M. Wells
Summary: This study found that prostate cancer cells have the ability to spontaneously form invadopodia and degrade extracellular matrix, leading to invasion and metastasis in vivo. Circulating tumor cells from patients also exhibited similar characteristics, supporting the role of invadopodia activity in prostate cancer progression.
Article
Biochemistry & Molecular Biology
Tingyu Wu, Yanshuang Zhang, Qing Han, Xin Lu, Yirui Cheng, Jiachen Chen, Jianjun Sha, Weiliang Xia
Summary: This study reveals that Klotho beta (KLB) is upregulated in prostate cancer and its expression level is positively correlated with malignant phenotype. KLB reduces exosomes secretion through a Rab8a-dependent mechanism, thereby promoting prostate cancer progression.
Review
Oncology
Andrew Hartley, Imran Ahmad
Summary: PPAR gamma plays an important role in prostate cancer progression and its splice variants may have different effects. While it is a potential target for therapy, the clinical use of drugs targeting PPAR gamma is limited by their associated side effects.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Motuma Yigezu Daba, Zhijie Fan, Qinyu Li, Xianglin Yuan, Bo Liu
Summary: Prostate cancer is the most commonly diagnosed cancer in men, and finding new prognostic biomarkers and potential therapeutic targets is crucial. Calcium signaling is involved in the progression of prostate cancer and the development of treatment resistance, with calcium channels playing a significant role in these processes. Modulating these calcium channels through pharmacological means has been suggested as a practical approach.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marley J. Binder, Alister C. Ward
Summary: The metzincin superfamily plays a significant role in the progression of prostate cancer, with members potentially influencing the disease in both positive and negative ways. Further research is needed to understand their mechanisms of action and how they can be utilized as prognostic indicators or molecular targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Joanna Dulinska-Litewka, Dominik Felkle, Kacper Dykas, Zuzanna Handziuk, Marta Krzysztofik, Bartosz Gasiorkiewicz
Summary: The role of cyclins in hormone-dependent neoplasms, especially breast cancer, is crucial. However, cyclins in prostate cancer are less studied, particularly the role of other cyclins that requires further investigation. Recent studies have shown that cyclins not only regulate the cell cycle but also interact with other signaling pathways. The androgen signaling axis plays a significant role in prostate cancer progression and interferes with cyclin pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Ahmed S. Doghish, Ahmed Ismail, Hesham A. El-Mahdy, Mohamed A. Elkady, Mahmoud A. Elrebehy, Al-Aliaa M. Sallam
Summary: Prostate cancer is a major cause of cancer-related deaths, and miRNA plays a key role in its initiation and progression, serving as potential biomarkers for early diagnosis and personalized treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Mengke Zhu, Chao Wei, Haijiang Wang, Shangning Han, Lindi Cai, Xiaowen Li, Xinhua Liao, Xiangming Che, Xuqi Li, Lin Fan, Guanglin Qiu
Summary: This study investigates the effects and underlying mechanism of SIRT1 on autophagy and malignant biological behavior of gastric cancer cells under conditions of glucose deprivation. Results show that SIRT1 regulates the activity of FoxO1 and upregulates the expression of Rab7 through deacetylation, thereby affecting autophagy in gastric cancer cells. Decreasing the expression of SIRT1, FoxO1 or Rab7 significantly inhibits autophagy levels, increases sensitivity to glucose deprivation, and enhances the inhibition of proliferation, migration, and invasion, as well as apoptosis in gastric cancer cells induced by glucose deprivation.
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Article
Cell Biology
Jia Hu, Xueliang Ding, Shaobo Tian, Yanan Chu, Zhibo Liu, Yuqin Li, Xiaoqiong Li, Guobin Wang, Lin Wang, Zheng Wang
Summary: TRIM39, upregulated in colorectal cancer tissues, plays a crucial role in promoting cancer progression by regulating autophagy pathway and p53 degradation, establishing a functional relationship between autophagy and CRC progression.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Su Jung Oh-Hohenhorst, Tobias Lange
Summary: In this review, the dual roles of microRNAs in promoting and suppressing metastasis in prostate cancer are summarized, focusing on their impact on invasion, migration, and epithelial-to-mesenchymal transition. MicroRNAs have the potential to serve as therapeutic targets for metastatic prostate cancer and as biomarkers for metastasis and therapeutic response.
Review
Biochemistry & Molecular Biology
Mai K. L. Nguyen, Jaimy Jose, Mohamed Wahba, Marc Bernaus-Esque, Andrew J. Hoy, Carlos Enrich, Carles Rentero, Thomas Grewal
Summary: Cancer cells undergo metabolic adaptions to meet their increased bioenergetic needs, including an increased demand for cholesterol. They uptake cholesterol from low-density lipoproteins (LDL) and distribute it from late endosomes/lysosomes (LE/Lys) to other organelles to promote cancer growth and spread. Understanding the regulation of cholesterol transporters and related proteins in LE/Lys is important for developing treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yongjun Quan, Xiaodong Zhang, William Butler, Zhen Du, Mingdong Wang, Yuexin Liu, Hao Ping
Summary: The dysregulation of androgen receptor signaling is crucial in prostate cancer progression, and targeting N-cadherin may overcome resistance to hormone therapy. N-cadherin collaborates with c-Jun and NDRG1 to promote CRPC progression through EMT, providing insights into potential therapeutic strategies for advanced prostate cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Oncology
Hao Liang, Yang Liu, Jiao Guo, Maoyang Dou, Xiaoyi Zhang, Liyong Hu, Jun Chen
Summary: Prostate cancer is a common malignant cancer of the male genitourinary system. Immunotherapy has shown initial success in the treatment of advanced prostate cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Osama A. A. Mohamed, Heba S. Tesen, Marwa Hany, Aya Sherif, Maya Magdy Abdelwahab, Muhammed H. Elnaggar
Summary: Prostate cancer is the second most common cancer in men and the fifth leading cause of cancer death worldwide. Hypoxic microenvironment of prostate cancer drives hypoxia-inducible factors (HIFs) to mediate cell adaptations to hypoxia. HIFs regulate various signaling pathways and promote tumor progression, metastasis, and transformation in prostate cancer.
MOLECULAR BIOLOGY REPORTS
(2023)