Article
Biochemistry & Molecular Biology
Ana B. Segarra, Isabel Prieto, Inmaculada Banegas, Magdalena Martinez-Canamero, Ana B. Villarejo, German Dominguez-Vias, Marc de Gasparo, Manuel Ramirez-Sanchez
Summary: The study analyzed the activity of aminopeptidases in pituitary and adrenal glands of untreated and treated rats, showing substantial differences between glands, strains, and treatments. Positive correlations were predominant in the pituitary of WKY and in the adrenals of SHR, with additional mechanisms influencing systolic blood pressure in WKY or SHR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
YunLei Wang, Tong Zhang, YuGe Zhang, Yan Yu, Fan Bai, HaoJie Zhang, YaFei Chi
Summary: This study investigated the effects of inverted photoperiods on blood pressure and carotid arteries in hypertensive rats, finding that inverted photoperiods increased blood pressure, carotid intima-media thickness, and led to carotid arterial thrombosis and atherosclerotic plaque formation. The adverse consequences were more pronounced in spontaneously hypertensive rats compared to the control group.
JOURNAL OF HYPERTENSION
(2021)
Article
Cell Biology
Filipy Borghi, Camila Lidiane Morais, Carolina Silva, Priscila Cristina da Silva, Dora Maria Grassi-Kassisse
Summary: This study found that RAAS blockers had little effect on glycerol and lactate production in WIS and WKY adipocytes, while glycerol in SHR was affected by the blockers; NOR induced an increase in glycerol in adipocytes from all strains, but lipolytic activity decreased in SHR.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Yingying Yang, Quan Zhang, Jialiang Ren, Qingfeng Zhu, Lixin Wang, Yongzhi Zhang, Zuojun Geng
Summary: This study aimed to investigate the synergistic effects of hypertension and aging on brain morphology, especially in terms of gray matter atrophy. The results revealed interactive effects on tissue volumes, with the most pronounced gray matter atrophy observed in elderly SHRs. Specific brain regions, including the septal region, bilateral caudate putamen, hippocampus, and others, were identified as vulnerable to combined effects of hypertension and aging. Additionally, an inverted-U trajectory of volume change in SHRs was observed, with an increase in volume at the early phase followed by a decline in the late phase.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Romulo B. dos Santos, Lucas V. de C. Oliveira, Emerson P. Sena, Damiao P. de Sousa, Antonio L. M. Maia Filho, Renato Nery Soriano, Luciano da S. Lopes, Luiz G. S. Branco, Aldeidia P. de Oliveira, Helio C. Salgado, Joao Paulo J. Sabino
Summary: The study demonstrates that rose oxide can act as an antihypertensive agent by acutely promoting hypotension and bradycardia in spontaneously hypertensive rats. In Wistar rats, RO doses did not significantly affect hemodynamic parameters, while in SHR, RO reduced mean arterial pressure and prevented an increase in low frequency power.
Article
Physiology
Christopher L. Langdale, Danielle Degoski, Philip H. Milliken, Warren M. Grill
Summary: The spontaneously hypertensive rats may have bladder hypersensitivity that persists even after capsaicin desensitization.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Cell Biology
Nevena Dragasevic, Maja Savic, Katarina Mihajlovic, Vladimir Zivkovic, Marijana Andjic, Nevena Draginic, Nebojsa Zdravkovic, Sergey Bolevich, Stefani Bolevich, Vladimir Jakovljevic, Tamara Nikolic Turnic
Summary: This study aimed to investigate the effects of various diuretics on the ischemia/reperfusion dysfunction of the heart in hypertensive rats. The results showed that treatment with hydrochlorothiazide, spironolactone, or indapamide reduced oxidative damage to the myocardium and mitigated left ventricular hypertrophy. However, there were no significant changes in blood pressure or ejection fraction. In addition, spironolactone had a cardiodepressant effect on spontaneously hypertensive rats.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Physiology
Oscar J. Parada-Parra, Arturo Hernandez-Cruz
Summary: Intracellular Ca2+ signaling and catecholamine exocytosis from adrenal chromaffin cells vary between different mammalian species. The effects of cyclopiazonic acid (CPA) on catecholamine secretion and Ca2+ signals differ in mouse and bovine chromaffin cells. In rat chromaffin cells, CPA strongly inhibits voltage-gated exocytosis and Ca2+ transients. The suppression of endoplasmic reticulum Ca2+ uptake through CPA inhibits catecholamine secretion in rat chromaffin cells, similar to what is observed in bovine chromaffin cells.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Anatomy & Morphology
Neringa Pauziene, Dalia Ranceviene, Kristina Rysevaite-Kyguoliene, Tomas Ragauskas, Hermanas Inokaitis, Ignas Sabeckis, Khrystyna Plekhanova, Olena Khmel, Dainius H. Pauza
Summary: This study aimed to examine the neurochemical alterations of intrinsic cardiac ganglionated nerve plexus triggered by arterial hypertension during ageing in spontaneously hypertensive rats. The results showed an increase in the amount of autonomic neural structures in hypertensive rats, supporting the role of complex cardiac neural relationships in the development of arterial hypertension.
JOURNAL OF ANATOMY
(2023)
Article
Biochemistry & Molecular Biology
Samuel Golas, Andrea Berenyiova, Miroslava Majzunova, Magdalena Drobna, Muobarak J. Tuorkey, Sona Cacanyiova
Summary: This study investigated the vasoregulatory role of PVAT and its interaction with endogenous and exogenous H2S in the TA of normotensive rats and SHRs. PVAT had an anticontractile effect but worsened endothelial-dependent vasorelaxation. H2S in SHRs had a pro-contractile effect, while in Wistar rats it decreased adrenergic receptor sensitivity. H2S produced by the vascular wall had a pro-relaxant effect in SHRs. Exogenous H2S induced stronger vasorelaxation in SHRs, especially in the presence of PVAT.
Article
Neurosciences
Agata Korlatowicz, Paulina Pabian, Joanna Solich, Magdalena Kolasa, Katarzyna Latocha, Marta Dziedzicka-Wasylewska, Agata Faron-Gorecka
Summary: This study focused on the selection of miRNAs that differentiate the Wistar Kyoto rat strain from the Wistar Han rat strain in the lateral habenula and medial habenula. The results showed significant miRNA expression differences in these two brain regions, which correlated with alterations in the expression of target transcripts. Notably, two genes, Slc12a5 and Htr7, were found to be altered in both regions and may serve as potential targets for the treatment of TRD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Silvia Liskova, Sona Cacanyiova, Martina Cebova, Andrea Berenyiova, Michal Kluknavsky, Andrea Micurova, Katarina Valachova, Ladislav Soltes, Iveta Bernatova
Summary: This study investigated the effects of a 10-day-long treatment with taxifolin (TAX) on spontaneously hypertensive rats (SHRs). TAX reduced blood pressure in SHRs and improved the vascular functions of femoral arteries. However, there was no effect on the vascular reactivity of thoracic aortas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Kristina Szmicsekova, Lenka Bies Pivackova, Zuzana Kilianova, L'ubica Slobodova, Peter Krenek, Anna Hrabovska
Summary: This study found that both acetylcholinesterase and butyrylcholinesterase are present in all parts of rat aorta, with more abundant mRNA expression of butyrylcholinesterase than acetylcholinesterase. Normotensive rats have higher aortic mRNA expression and activity of butyrylcholinesterase compared to spontaneously hypertensive rats.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Physiology
Danyelle S. Miotto, Aline Dionizio, Andre M. Jacomini, Anderson S. Zago, Marilia Afonso Rabelo Buzalaf, Sandra L. Amaral
Summary: This study showed that treatment with perindopril reduced systolic blood pressure and pulse wave velocity in spontaneously hypertensive rats. It also increased nitrite concentration and upregulated GDP dissociation inhibitors, potentially inhibiting the RhoA/Rho-kinase pathway and contributing to decreased arterial stiffness.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sayeman Islam Niloy, Yue Shen, Lirong Guo, Stephen T. O'Rourke, Chengwen Sun
Summary: This study reveals that dysfunction of BKCa channels in vascular smooth muscle cells (VSMCs) is related to abnormal proliferation and morphological changes in hypertension, possibly due to decoupling of IP3R-BKCa. Genetic disruption of IP3R-BKCa coupling increases VSMC proliferation, while infusion of the BKCa opener NS1619 attenuates vascular hypertrophy in hypertensive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Mai Hyoguchi, Satoshi Tajiri, Mitsuru Tanaka, Yoshinori Mine, Toshiro Matsui
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2016)
Article
Agriculture, Multidisciplinary
Vu Thi Hanh, Weilin Shen, Mitsuru Tanaka, Aino Siltari, Riita Korpela, Toshiro Matsui
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Review
Food Science & Technology
Mitsuru Tanaka
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI
(2017)
Article
Agriculture, Multidisciplinary
Ayano Shimizu, Takakazu Mitani, Sachi Tanaka, Hiroshi Fujii, Motohiro Maebuchi, Yusuke Amiya, Mitsuru Tanaka, Toshiro Matsui, Soichiro Nakamura, Shigeru Katayama
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Huu-Nghi Nguyen, Mitsuru Tanaka, Baorui Li, Tomoya Ueno, Hideki Matsuda, Toshiro Matsui
SCIENTIFIC REPORTS
(2019)
Review
Instruments & Instrumentation
Huu-Nghi Nguyen, Tae Hun Ham, Toshiro Matsui, Mitsuru Tanaka
SENSORS AND MATERIALS
(2019)
Article
Multidisciplinary Sciences
Mitsuru Tanaka, Shinya Dohgu, Genki Komabayashi, Hayato Kiyohara, Fuyuko Takata, Yasufumi Kataoka, Takashi Nirasawa, Motohiro Maebuchi, Toshiro Matsui
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Applied
Tae Hun Hahm, Mitsuru Tanaka, Huu-Nghi Nguyen, Ayaka Tsutsumi, Koichi Aizawa, Toshiro Matsui
Summary: The study used MALDI-MS imaging to visually investigate the intestinal absorption of acylated anthocyanins in rats, finding that acylated cyanidins can be absorbed intact through the intestinal OATP transporter. Deacylated anthocyanins, on the other hand, were found to be absorbed through both the glucose transporter 2 and OATP routes.
Article
Chemistry, Applied
Xiaojing Sheng, Satoshi Nagaoka, Marika Hashimoto, Yusuke Amiya, Masato Beppu, Kenichiro Tsukamoto, Emiko Yanase, Mitsuru Tanaka, Toshiro Matsui
Summary: Beta-conglycinin was orally administered to rats, and specific oligopeptides derived from the protein were identified in the blood plasma, indicating that beta-conglycinin could be the dietary source protein for these peptides found in the circulating bloodstream of rats.
Article
Chemistry, Analytical
Tae Hun Hahm, Toshiro Matsui, Mitsuru Tanaka
Summary: A fluorescence-assisted spraying method was developed to overcome the variability in matrix crystals and improve the reproducibility of analyte intensity in matrix-assisted laser desorption/ionization mass spectrometry imaging. The method utilized a fluorescent reagent, rhodamine 6G, to achieve a constant fluorescence intensity. The proposed method successfully quantified nifedipine and ferulic acid in a rat kidney section and visually determined the accumulation of ferulic acid in the kidney over time.
ANALYTICAL CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Xiaojing Sheng, Mitsuru Tanaka, Risa Katagihara, Marika Hashimoto, Satoshi Nagaoka, Toshiro Matsui
Summary: The study established a novel analytical assay for peptide metabolites from glycinin, using MALDI-MS combined with amine derivatization with coumarin. The use of coumarin derivatization under specific conditions led to improved MS detection of peptides, allowing for successful characterization of glycinin-derived metabolites in rats.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Tae Hun Hahm, Mitsuru Tanaka, Toshiro Matsui
Summary: Anthocyanins are natural color pigments found in plants, such as berries, vegetables, and grapes. They have various physiological effects and are considered promising functional food ingredients. However, the bioavailability of anthocyanins, especially their absorption behaviors, is still unclear.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Mitsuru Tanaka, Keishiro Arima, Tomotaka Takeshita, Yuri Kunitake, Naoto Ohno, Miho Imamura, Toshiro Matsui
Summary: In this study, a GCB-LDI-MS method was developed for the simultaneous detection of taste- and odor-active compounds. This method was able to detect compounds that could not be detected by conventional matrix-assisted-LDI-MS, and it was also capable of detecting a variety of taste-active compounds in liquid samples.
ACS APPLIED NANO MATERIALS
(2022)
Article
Food Science & Technology
Yuna Lee, Akihiro Nakano, Saya Nakamura, Kenta Sakai, Mitsuru Tanaka, Keisuke Sanematsu, Noriatsu Shigemura, Toshiro Matsui
Summary: This study aimed to develop a dipeptide with an agonistic effect on AdipoR1 in skeletal muscle, and found that Tyr-Pro was the most effective in promoting glucose uptake, likely through the activation of AMPK/Glut4 pathway in L6 myotubes. This dipeptide may directly interact with AdipoR1 as an agonist, as demonstrated by molecular dynamics simulations.
NPJ SCIENCE OF FOOD
(2021)
Article
Chemistry, Analytical
Mitsuru Tanaka