Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Clinical Neurology
Jieqiong Liu, Wenjing Tang, Lei Hou, Jing Wang, Rongfei Wang, Yaofen Zhang, Zhao Dong, Ruozhuo Liu, Shengyuan Yu
Summary: This study identified alterations in gut microbiota in Chinese Han migraine patients with IBS, but no correlation was found between gut microbiota and the clinical characteristics of migraine.
FRONTIERS IN NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
Nayoung Kwak, Hankil Lee, Beom Kyung Kim, Yun Mi Yu, Hye-Young Kang
Summary: This study found that the risk of subsequent IBS occurrence following SSRI use was high in patients who initially took a heavy SSRI dose and those who did not have a history of psychiatric drug use.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Clinical Neurology
Xing Huang, Jie Liu, Jinzhi Cong, Xinhua Zhang
Summary: This study suggests that the glutamate transporter gene SLC1A1 may be involved in the development of OCD in the Han population. Different genotypes and haplotypes were found to be associated with different types of OCD, providing some clues for studying the pathogenesis of OCD.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Cell Biology
Sandra Mohr, Nikola Fritz, Christian Hammer, Cristina Martinez, Sabrina Berens, Stefanie Schmitteckert, Verena Wahl, Malin Schmidt, Lesley A. Houghton, Miriam Goebel-Stengel, Maria Kabisch, Dorothea Gotze, Irina Milovac, Mauro D'Amato, Tenghao Zheng, Ralph Roth, Hubert Monnikes, Felicitas Engel, Annika Gauss, Jonas Tesarz, Martin Raithel, Viola Andresen, Thomas Frieling, Jutta Keller, Christian Pehl, Christoph Stein-Thoringer, Gerard Clarke, Paul J. Kennedy, John F. Cryan, Timothy G. Dinan, Eamonn M. M. Quigley, Robin Spiller, Caroll Beltran, Ana Maria Madrid, Veronica Torres, Edith Perez de Arce, Wolfgang Herzog, Emeran A. Mayer, Gregory Sayuk, Maria Gazouli, George Karamanolis, Lejla Kapur-Pojskic, Mariona Bustamante, Raquel Rabionet, Xavier Estivil, Andre Franke, Wolfgang Lieb, Guy Boeckxstaens, Mira M. Wouters, Magnus Simren, Gudrun A. Rappold, Maria Vicario, Javier Santos, Rainer Schaefert, Justo Lorenzo-Bermejo, Beate Niesler
Summary: This study identified genetic single nucleotide polymorphisms (SNPs) associated with irritable bowel syndrome (IBS), particularly with constipation-predominant IBS (IBS-C) in females. Validation in patients and controls from eight countries confirmed the association of the tagging SNP rs2020938 with female IBS-C. Further experiments demonstrated the functional relevance of rs2020938 in differential SLC6A4 expression in the jejunum and stool consistency.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Multidisciplinary Sciences
Kenjiro Matsumoto, Kana Takata, Daisuke Yamada, Haruki Usuda, Koichiro Wada, Maaya Tada, Yoshiyuki Mishima, Shunji Ishihara, Syunji Horie, Akiyoshi Saitoh, Shinichi Kato
Summary: Juvenile social defeat stress (SDS) exposure in mice leads to social avoidance, anxiety, depression, and visceral hypersensitivity. The number of 5-HT-containing cells and calcitonin gene-related peptide-positive neurons in the colon increases, while gut microbiota remains largely similar. Responses to stress are exacerbated in the juvenile SDS group, suggesting later onset of IBS-like symptoms.
SCIENTIFIC REPORTS
(2021)
Review
Integrative & Complementary Medicine
Guan-ru Chen, Xiao-fang Xie, Cheng Peng
Summary: Irritable bowel syndrome (IBS) is a common and difficult-to-treat disease, and Chinese medicine has shown remarkable efficacy and advantages in its treatment. This review summarizes the literature on the treatment of IBS with Chinese medicine, highlighting the latest treatment methods and underlying mechanisms. The primary methods of Chinese medicine treatment for IBS are herbal prescriptions, acupuncture, and moxibustion, with potential mechanisms involving the regulation of the enteric nervous system, alleviation of visceral hypersensitivity, stability of intestinal flora, and regulation of the immune system.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Medicine, General & Internal
Alexandra Aupetit, Sebastien Grigioni, Horace Roman, Moise Coeffier, Amelie Breant, Clotilde Hennetier, Najate Achamrah
Summary: This study found a significant association between irritable bowel syndrome (IBS), eating disorders (ED), and endometriosis. The prevalence of IBS and ED in patients with endometriosis was higher than in the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Cezary Chojnacki, Aleksandra Blonska, Paulina Konrad, Marcin Chojnacki, Marcin Podogrocki, Tomasz Poplawski
Summary: This study aimed to evaluate the urinary excretion of selected tryptophan metabolites in patients with IBS-C and IBS-D. It was found that changes in tryptophan metabolism occurred in both groups of IBS patients compared to the control group. The 5-HIAA level was correlated with abdominal symptoms and anxiety in IBS-D patients, while the concentration of kynurenines (KYN, QA) in urine was higher in IBS-C patients and correlated with depression.
Article
Immunology
Meng Feng, Shuping Zhou, Tong Liu, Yong Yu, Qinghong Su, Xiaofan Li, Min Zhang, Xiao Xie, Tingting Liu, Wei Lin
Summary: IL-35 is an essential regulatory factor in autoimmune uveitis, and its specific SNP sites change may be correlated to disease susceptibility and clinical symptoms, especially in patients with Vogt-Koyanagi-Harada syndrome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Linlin Liu, Yi Hu, Yumei Lu, Liping Hu, Changqing Gao, Shengjie Nie
Summary: Epigenetic alterations of the SLC6A4 gene are related to the pathophysiology of schizophrenia, with higher methylation levels observed especially in male patients.
NEUROSCIENCE LETTERS
(2022)
Article
Multidisciplinary Sciences
Aleksandra Grozic, Keaton Coker, Christopher M. Dussik, Marya S. Sabir, Zhela Sabir, Arianna Bradley, Lin Zhang, Jin Park, Steven Yale, Ichiro Kaneko, Maryam Hockley, Lucinda A. Harris, Tisha N. Lunsford, Todd R. Sandrin, Peter W. Jurutka
Summary: This study aimed to identify potential biomarkers and unique gene expression patterns that define the pathological state of irritable bowel syndrome (IBS). Gene expression profiling of colonic tissue samples from 29 participants, including IBS patients and healthy controls, revealed 858 differentially expressed genes potentially characteristic of IBS. After screening and analysis, seven putative IBS biomarkers, including genes involved in serotonin metabolism, were identified.
Article
Medicine, Research & Experimental
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura
Summary: Phlorizin was found to improve visceral hypersensitivity and colonic hyperpermeability in IBS models by inhibiting SGLT2, and these effects were mediated via the AMPK, NO, and opioid pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)