Article
Pharmacology & Pharmacy
Chin-Li Chen, Chien-Chang Kao, Ming-Hsin Yang, Gang-Yi Fan, Juin-Hong Cherng, Chih-Wei Tsao, Sheng-Tang Wu, Tai-Lung Cha, En Meng
Summary: The study demonstrated that dextrose prolotherapy shows promising treatment results for IC/BPS, reducing bladder instability, frequent urination, improving glycosaminoglycan layer regeneration and bladder wall thickness, along with significantly enhancing CD44 receptor expression. Additionally, it reduced treatment frequency over time and improved EGF levels while reducing HGF, PIGF-1, and VEGF-D levels in patients with IC/BPS. The modulation of growth factors and cytokines suggests potential tissue remodeling effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jia-Fong Jhang, Cheng-Der Liu, Yung-Hsiang Hsu, Chien-Chin Chen, Hsiang-Chin Chen, Yuan-Hong Jiang, Wan-Chen Wu, Chih-Wen Peng, Hann-Chorng Kuo
Summary: In this study, EBV persistence and reactivation were detected in the B cells of HIC bladders, suggesting the involvement of EBV infection in bladder inflammation. Nerve hyperplasia and upregulation of BDNF were also observed in HIC bladders, with the origin of BDNF found to be EBV-infected B cells. Knockdown of BDNF in EBV-infected B cells inhibited cell proliferation and viability, while implantation of BDNF-depleted EBV-infected B cells abrogated tissue inflammation and nerve hyperplasia, providing insights into the mechanisms underlying the involvement of EBV-infected B cells in HIC pathogenesis.
JOURNAL OF PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Emad A. Hindi, Craig J. Williams, Leo A. H. Zeef, Filipa M. Lopes, Katie Newman, Martha M. M. Davey, Nigel W. Hodson, Emma N. Hilton, Jennifer L. Huang, Karen L. Price, Neil A. Roberts, David A. Long, Adrian S. Woolf, Natalie J. Gardiner
Summary: The study found wide-ranging gene expression changes in the bladders of diabetic rats, including genes regulating extracellular matrix and neural molecules. The reduced birefringent collagen and significant decrease in tissue stiffness in diabetic rat bladders may contribute to voiding dysfunction in diabetic individuals.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Zhenming Zheng, Jintao Hu, Wenshuang Li, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Yousheng Yao
Summary: This study used 16S rRNA sequencing and untargeted metabolomics techniques to analyze the urinary microbial and metabolite profiles of IC/BPS patients and healthy controls. The results showed differential genera and metabolites associated with the inflammatory response of IC/BPS, including Lactobacillus as a protective bacterium and Sphingomonas as a pathogenic factor. The metabolite theophylline may also play a role in downregulating the inflammatory response of IC/BPS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study found significantly higher levels of urinary cytokines and chemokines in patients with IC/BPS, which were closely associated with bladder conditions and treatment outcomes.
Article
Biology
Jing-Dung Shen, Szu-Ju Chen, Huey-Yi Chen, Kun-Yuan Chiu, Yung-Hsiang Chen, Wen-Chi Chen
Summary: The treatment of urinary bladder dysfunction requires an understanding of bladder function, involving physiology, pathology, and psychology. Various animal models are available for studying bladder disorders, ranging from rodents to non-human primates. These models can help in studying different bladder disorders, such as overactive bladder or incontinence, according to facility, priority, and disease.
Article
Medicine, General & Internal
Hung-Yu Lin, Jian-He Lu, Shu-Mien Chuang, Kuang-Shun Chueh, Tai-Jui Juan, Yi-Chang Liu, Yung-Shun Juan
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic bladder disorder characterized by suprapubic pain and discomfort during bladder filling, accompanied by lower urinary tract symptoms. The diagnosis of IC/BPS is still not standardized, but cystoscopy and bladder biopsy can determine the presence of ulcers. The pathophysiology of IC/BPS may involve chronic inflammation, autoimmune disorders, and other factors. Biomarkers in urine and serum specimens could be useful for the diagnosis of IC/BPS.
Article
Urology & Nephrology
Jung Hyun Shin, Bosik Kang, Myung-Soo Choo
Summary: The study found that the features of HLs in IC patients were not associated with subjective symptoms, but inflammatory changes in HLs were a predictive factor for IC recurrence and associated with frequent urgency episodes and smaller bladder capacity.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Pedro Abreu-Mendes, Beatriz Araujo-Silva, Ana Charrua, Francisco Cruz, Rui Pinto
Summary: This study suggests that daily silodosin can be an effective and well-tolerated treatment for refractory BPS/IC female patients. Additionally, stress coping levels may be associated with symptom improvement.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Zhinoos Taidi, Tommy Zhou, Kate H. Moore, Kylie J. Mansfield, Lu Liu
Summary: Inflammatory conditions of the urinary bladder are associated with urothelial damage and loss of function. The purinergic P2X7 receptor plays a role in such inflammatory conditions and may be a new therapeutic target for bladder inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Hee Seo Son, Hana Yoon, Hye Sun Lee, Jang Hwan Kim
Summary: Adding hydrodistension (HD) to transurethral fulguration (TUF) tends to be more effective in controlling pain in Hunner-type IC/BPS compared to TUF alone, indicating the potential role of normal-appearing background areas in the pain of IC/BPS.
WORLD JOURNAL OF UROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jin Li, Xianyanling Yi, Jianzhong Ai
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease with a negative impact on quality of life. Diagnoses and treatments are still unsatisfactory, calling for new approaches. This study aims to provide a comprehensive overview of IC/BPS research, promoting progress in diagnosis, treatment, and prognosis. The complexity of IC/BPS and emerging evidence call for further studies to optimize management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yuan-Ju Lee, Shang-Jen Chang, Hsiu-Ying Lin, En Meng, Jeff S. Chueh, Chi-Shin Tseng
Summary: This follow-up study assessed the long-term effects of pentosan polysulfate sodium (PPS) monotherapy on recurrent urinary tract infections (UTIs). The study found that PPS significantly reduced the recurrence of UTIs and improved the quality of life for women with recurrent UTI during the 2-year follow-up period.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study analyzed the differences in urinary cytokines and chemokines between different subtypes of interstitial cystitis/bladder pain syndrome (IC/BPS), particularly ulcer (HIC) and non-ulcer subtypes. The results showed that elevated urine levels of IL-8, CXCL10, BDNF, IL-6, and RANTES may indicate the presence of HIC. These findings suggest that urinary biomarkers may be useful for discriminating HIC patients from controls.
Article
Surgery
Yung Tai Chen, Hsin-Chih Yeh, Hsiang-Ying Lee, Po-Fan Hsieh, Eric Chieh-lung Chou, Yao-Chou Tsai, Jian-Hua Hong, Chao-Yuan Huang, Yuan-Hong Jiang, Yu-Khun Lee, Jen-Shu Tseng, Chih-Chin Yu, Bing-Juin Chiang, Thomas Y. Hsueh, Chia-Chang Wu, Chung-You Tsai
Summary: This study retrospectively reviewed the treatment outcomes of endoscopic management for clinically localized UTUC in Taiwan, and found that endoscopic treatment is safe and effective in this area. Early salvage radical nephroureterectomy (RNU) is necessary for UTUC refractory to endoscopic management in order to prevent UTUC-related mortality.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Lori A. A. Birder, Hann-Chorng Kuo
Summary: The aim of this study was to investigate the expression levels of sensory receptors, inflammatory proteins, and pro-apoptotic proteins in the urothelium of non-Hunner's interstitial cystitis (NHIC) bladders of patients with different clinical and cystoscopic phenotypes. The study concluded that IC/BPS patients with frequency and bladder pain complaints have higher levels of urothelial sensory receptors, and inflammatory and pro-apoptotic proteins. The expression levels of these sensory receptors, inflammatory proteins, and pro-apoptotic proteins are not significantly different among IC/BPS bladders with different conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jia-Fong Jhang, Cheng-Der Liu, Yung-Hsiang Hsu, Chien-Chin Chen, Hsiang-Chin Chen, Yuan-Hong Jiang, Wan-Chen Wu, Chih-Wen Peng, Hann-Chorng Kuo
Summary: In this study, EBV persistence and reactivation were detected in the B cells of HIC bladders, suggesting the involvement of EBV infection in bladder inflammation. Nerve hyperplasia and upregulation of BDNF were also observed in HIC bladders, with the origin of BDNF found to be EBV-infected B cells. Knockdown of BDNF in EBV-infected B cells inhibited cell proliferation and viability, while implantation of BDNF-depleted EBV-infected B cells abrogated tissue inflammation and nerve hyperplasia, providing insights into the mechanisms underlying the involvement of EBV-infected B cells in HIC pathogenesis.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Hsin Chen, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: Urinary oxidative stress biomarkers can be used to diagnose and predict the occurrence of detrusor overactivity (DO) in women with urodynamic stress incontinence (USI). Combined with voided volume, the diagnostic accuracy can be improved.
Review
Medicine, General & Internal
Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: Botulinum toxin A (BoNT-A) has been widely used in urological functional disorders such as neurogenic detrusor overactivity (NDO), overactive bladder (OAB), lower urinary tract dysfunction, and interstitial cystitis/bladder pain syndrome (IC/BPS). The chronic inflammation in OAB and IC/BPS can be reduced by inhibiting sensory peptides with BoNT-A, leading to symptom improvement. Although not approved by FDA for IC/BPS, intravesical BoNT-A injection is recommended as the fourth line therapy. Experimental trials are being conducted to explore alternative delivery methods and minimize adverse events. This article reviews the current research on BoNT-A in OAB and IC/BPS.
TZU CHI MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Wei-Hsin Chen, Yu Khun Lee, Hann-Chorng Kuo, Jen-Hung Wang, Yuan-Hong Jiang
Summary: This study examined the outcomes of robot-assisted radical prostatectomy (RaRP) in high-risk and very high-risk prostate cancer patients. The results showed that high-risk/very high-risk patients without adjuvant treatment had worse biochemical recurrence-free survival compared to those with adjuvant treatment. However, the combination of RaRP and adjuvant treatment resulted in comparable biochemical recurrence-free survival for high-risk/very high-risk patients and below high-risk patients. Additionally, high-risk/very high-risk patients had higher rates of stress urinary incontinence at postoperative week 1 and month 1 compared to below high-risk patients, but there was no significant difference in incontinence rates between the two groups from postoperative 3 months to 12 months.
Article
Biochemistry & Molecular Biology
Jia-Fong Jhang, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: This study investigated the role of urinary biomarkers in discriminating different bladder and bladder outlet dysfunctions in women with frequency-urgency syndrome. The results showed that there were significant variations in the urinary levels of inflammatory, neurogenic, and oxidative stress biomarkers among patients with different urodynamic subtypes. These findings suggest that the presence of varying bladder inflammation and oxidative stress conditions may have an impact on treatment outcomes in women with frequency-urgency syndrome.
Review
Medicine, Research & Experimental
Siyu Wu, Rong Li, Yuanhong Jiang, Jiazheng Yu, Jianyi Zheng, Zeyu Li, Mingyang Li, Kerong Xin, Yang Wang, Zhenqun Xu, Shijie Li, Xiaonan Chen
Summary: Liquid biopsy is an accurate method for determining molecular profiles in urothelial carcinoma (UC). It has the potential to play a crucial role in early diagnosis, treatment monitoring, and prognosis prediction, thereby contributing to precision medicine in UC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: This review summarizes the recent results of clinical trials and studies on medication for OAB and explores the underlying pathophysiology of OAB. Antimuscarinic agents and beta-3 adrenoceptor agonists are feasible as first-line treatments. Combination therapy can improve therapeutic efficacy for patients who do not respond well to full-dose antimuscarinics or mirabegron. Intravesical BoNT-A injection is effective for refractory OAB. For patients who do not respond to initial pharmacotherapies, investigating the underlying pathophysiology and adding appropriate medications, such as alpha 1-blockers or anti-inflammatory agents, is recommended. Patient education on behavioral modifications and therapies should always be provided.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study aimed to analyze urinary biomarkers in men with lower urinary-tract symptoms (LUTS) and distinguish interstitial cystitis/bladder pain syndrome (IC/BPS) from other lower urinary-tract dysfunctions (LUTDs) through characteristic urinary biomarker levels. The results showed that urinary TNF-α and eotaxin levels can be used as biomarkers to differentiate IC/BPS from other LUTD subgroups in men with LUTS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Jiazheng Yu, Siyu Wu, Rong Li, Yuanhong Jiang, Jianyi Zheng, Zeyu Li, Mingyang Li, Kerong Xin, Xiaojiao Guan, Shijie Li, Xiaonan Chen
Summary: Antibody-drug conjugates (ADCs) combine the cytotoxicity of small-molecule drugs with antibody targeting and have become a new hotspot in the research and development of anti-tumor antibody drugs. This article summarizes impressive advancements in new clinical trials and clinical data on ADCs for the treatment of urothelial carcinoma at the 2023 ASCO-GU Cancers Symposium.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Letter
Oncology
Yuanhong Jiang, Siyu Wu, Rong Li, Jiazheng Yu, Jianyi Zheng, Zeyu Li, Mingyang Li, Kerong Xin, Zhenqun Xu, Shijie Li, Xiaonan Chen
Summary: Numerous novel therapeutic agents and clinical trials for castration-resistant prostate cancer (CRPC) were presented at the 2023 ASCO-GU Cancers Symposium. Radionuclide drug conjugates (RDC), specifically 177Lu/111In-J591 and 225Ac-J591, showed improved efficacy in treating CRPC patients. Other promising approaches included dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors, PSCA-directed CAR-T cell immunotherapy, and AKTi-CAPltello-280 protein kinase inhibitor. We have summarized the latest CRPC treatment strategies and clinical trial advancements from the 2023 ASCO-GU Cancers Symposium.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Wei-Hsin Chen, Wan-Ru Yu, Jia-Fong Jhang, Yuan-Hong Jiang, Hann-Chorng Kuo
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Wei-Hsin Chen, Yuan-Hong Jiang, Hann-Chorng Kuo
JOURNAL OF UROLOGY
(2023)
Article
Mathematics, Applied
Yuanhong Jiang, Qiaoqiao Ding, Yu Guang Wang, Pietro Lio, Xiaoqun Zhang
Summary: This paper proposes a new backbone neural network called vision graph U-Net (VGU-Net), which constructs multi-scale graph structures to extract long-range self-similarity information in images. By replacing CNNs with graph convolution networks, it allows an interpretation of long-range interactions. The VGU-Net achieves remarkable performance in reconstruction and segmentation tasks.
INVERSE PROBLEMS AND IMAGING
(2023)
