Article
Medicine, General & Internal
Mohammed S. Al-Mogbel, Godfred A. Menezes, Mohamed T. Elabbasy, Manal M. Alkhulaifi, Ashfaque Hossain, Mushtaq A. Khan
Summary: This study evaluated the synergistic effects of bovine lactoferrin with conventional antibiotics against multidrug resistant bacterial pathogens. The results showed that bovine lactoferrin inhibited biofilm production of significant bacterial pathogens and had significant synergistic effects with antibacterial agents. This study provides valuable data on the potential of bovine lactoferrin combined with antibiotics against drug resistant pathogens.
MEDICINA-LITHUANIA
(2021)
Article
Biochemistry & Molecular Biology
Bei Wang, Jiayuan Zhao, Wenxin Lu, Yuanya Ma, Xusen Wang, Xiaoli An, Zengjie Fan
Summary: The development of a novel wound dressing with highly effective antibacterial and wound healing properties has been the focus of this study. Through a simple electrostatic interaction method, a novel and injectable hydrogel composed of lactoferrin and lithium magnesium silicate was synthesized. The physical and biological properties of the hydrogel were characterized and it was found to have good antibacterial properties and biocompatibility. The hydrogel was able to effectively promote wound healing in a rat skin wound model, achieving a much higher healing rate compared to other groups.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Fisheries
Sarahi Luna-Castro, Ivonne Ceballos-Olvera, Flaviano Benavides-Gonzalez, Zeferino Blanco-Martinez, Genaro Sanchez-Martinez, Maria de la Luz Vazquez-Sauceda, Mireya de la Garza
Summary: Lactoferrin, a cationic iron-binding glycoprotein, is used as a food supplement for humans and has potential as a microbicide, microbiostatic, and immunostimulant. Administering bovine lactoferrin to dairy animals can lead to physiological changes that enhance resistance to pathogens. Despite lack of consensus on how bovine lactoferrin affects fish physiology in vivo, in vitro assays suggest similarities to effects seen in mammals.
AQUACULTURE RESEARCH
(2022)
Article
Microbiology
Alessandra Pino, Tommaso Mazza, Maura-Ann H. Matthews, Stefano Castellana, Cinzia Caggia, Cinzia L. Randazzo, Gary A. Gelbfish
Summary: Gardnerella species are key players in the development and recurrence of Bacterial Vaginosis (BV), often showing high resistance to antibiotics. Bovine lactoferrin may be a potential candidate for treating Gardnerella species infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Food Science & Technology
Rahul Mehra, Rajat Singh, Varij Nayan, Harpal S. Buttar, Naveen Kumar, Shiv Kumar, Anuradha Bhardwaj, Ravinder Kaushik, Harish Kumar
Summary: Bovine colostrum is a highly concentrated supplement with potential benefits for preventing and managing a variety of health issues. Its components have shown promise in nutraceuticals and non-pharmacological therapies, influencing the immune system, gastrointestinal tract, and bone marrow stem cells.
Article
Chemistry, Applied
Ying Li, Lezhen Dong, Yahui Liu, Qin Chen, Zufang Wu, Lingyi Liu, Mohamed A. Farag, Lianliang Liu
Summary: The effects of covalent binding of protocatechuic acid (PA) and gallic acid (GA) to lactoferrin (LF) on the structure, functional, and antioxidant properties of the protein conjugate were investigated. The LF-PA/GA conjugates showed altered hydrodynamic diameter and zeta-potential, but their antioxidant activities remained unchanged.
Article
Biochemistry & Molecular Biology
Liang Wang, Yu-Lian Wang, Zi-Li Lv, En-peng Zhang, Ai-zhen Guo
Summary: By optimizing the design of bovine lactoferricin-derived peptide and constructing a recombinant expression vector, a stronger antibacterial activity against Staphylococcus aureus was obtained compared to natural bovine lactoferrin peptide under the same fermentation conditions. The effective expression of the optimized peptide was confirmed using SDS-PAGE electrophoresis, laying the foundation for improving the biological activities of antimicrobial peptides.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Aysel Aslanli, Maksim Domnin, Nikolay Stepanov, Elena Efremenko
Summary: The combined use of various antimicrobial peptides (AMPs) with enzymes that hydrolyze quorum sensing molecules is a leading approach in solving antimicrobial resistance. In this study, lactoferrin-derived AMPs were investigated as potential partners for combination with enzymes hydrolyzing lactone-containing QS molecules. The His(6)-OPH/Lfcin combination showed the most promising results in terms of stability and catalytic efficiency, demonstrating its potential as an effective antimicrobial agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aili Wang, Mengying Zhou, Qian Chen, Hui Jin, Gaochi Xu, Ruiyin Guo, Jianmin Wang, Ren Lai
Summary: With the increase in drug-resistant bacteria, the study and development of new antibacterial drugs have become important. This study found that three antimicrobial peptides derived from goat submandibular glands have potent antibacterial activity and low cytotoxicity against mammalian cells, making them potential candidates for the development of novel antibacterial agents.
Article
Agriculture, Dairy & Animal Science
Irene Ferri, Matteo Dell'Anno, Benedetta Canala, Stefano Magnaghi, Beatrice Petrali, Luciana Rossi
Summary: Insects are a promising alternative protein source for food and feed. This study found that using lactoferrin as a hydration source during the rearing of Tenebrio molitor larvae not only improved animal performance but also enhanced the nutritional and functional characteristics of the insect meals.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Marta Gomez-Gomez, Jorge Labella, Tomas Torres
Summary: This study presents the synthesis, electronic properties, and reactivity of borylated subphthalocyanines, which are prepared via Suzuki-Miyaura borylation with high yields. These compounds are easily purified, exhibit excellent stability, and serve as powerful starting materials for post-functionalization of SubPcs. This novel approach is more efficient than existing methods and enables the preparation of exotic SubPc dimeric species with promising properties for optoelectronic devices.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Engineering, Manufacturing
Wei Xiao, Bei Li, Jun Yan, Ling Wang, Xuewu Huang, Jiefeng Gao
Summary: Three dimensional graphene-based hybrid materials have attracted much interest and are being applied in various fields. These materials provide a framework for other functional materials and facilitate electron and mass transport during reactions. The synthesis methods, morphology, and applications of these hybrids are reviewed, with challenges and prospects discussed for future development.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2023)
Article
Food Science & Technology
Oguz Bayraktar, Charis M. Galanakis, Turki M. S. Aldawoud, Salam A. Ibrahim, Merve Deniz Kose, Mehmet Emin Uslu
Summary: The study demonstrates the potential use of waste eggshell membrane to adsorb bioactive compounds from olive leaf extract, designing functional biomaterials with bioactive properties, showing promising market prospects.
Article
Engineering, Chemical
Yuekang Zhang, Guangfa Zhang, Shuai Zhao, Ailin Gao, Jian Cui, Yehai Yan
Summary: With the development of economics and society, water pollution and shortage have become more severe. The design and fabrication of efficient 3D separation functional materials for water purification is still a challenge. 2D transition metal carbide/nitride materials, MXenes, offer a new platform for the creation of 3D water treatment materials. This review summarizes recent progress in MXene-based functional materials for wastewater treatment and water reclamation, highlighting their fabrication approaches and material performance.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Biophysics
Swarup Roy, Jong-Whan Rhim
Summary: In this study, zinc sulfide nanoparticles were successfully synthesized using a simple one-pot reaction method and integrated into pectin/agar-based functional composite films. The resulting films exhibited improved mechanical properties, UV protection, and strong antibacterial activity against E. coli and L. monocytogenes, making them ideal for active packaging applications. The transparency, hydrophobicity, water vapor barrier, and thermal properties of the films were maintained after the addition of the nanofillers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Energy & Fuels
Saruchi, Vaneet Kumar, Ayman A. Ghfar, Sadanand Pandey
Summary: A novel hydrogel was synthesized and its potential for adsorbing crude oil was investigated. The optimal parameters for maximum oil adsorption were determined through parametric variation. The synthesized hydrogel exhibited high affinity and efficiency for crude oil adsorption, as confirmed by characterization and adsorption isotherm analysis.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Review
Chemistry, Multidisciplinary
Neeraj Kumar, Rashi Gusain, Sadanand Pandey, Suprakas Sinha Ray
Summary: This review comprehensively analyzes the use of hydrogel nanocomposites for water treatment, focusing on adsorbent and photocatalysis techniques. It discusses the structure, classification, and synthesis methods of hydrogels, as well as their incorporation with functional nanoparticles. The review also critically examines the structure-property relationships of hydrogel nanocomposites, considering factors such as swelling characteristics, mechanical properties, and stimuli-responsiveness.
ADVANCED MATERIALS INTERFACES
(2023)
Review
Chemistry, Physical
Sounok Sengupta, Prathama Das, Samridhi Sharma, Monu Kumar Shukla, Rajesh Kumar, Rajiv Kumar Tonk, Sadanand Pandey, Deepak Kumar
Summary: A biocatalyst is an enzyme that speeds up or slows down chemical reactions and accelerates certain processes by a factor of 10^8. It is used as an anticancer agent because it activates drugs inside the tumor microenvironment while minimizing damage to healthy cells. Biocatalysts have been employed in the synthesis of various heterocyclic compounds and in nano drug delivery systems. The use of nano-biocatalysts for targeted tumor delivery not only facilitates tumor invasion, angiogenesis, and mutagenesis, but also provides insight into the expression and activity of numerous microenvironment-related markers.
Article
Chemistry, Multidisciplinary
Saruchi, Vaneet Kumar, Diksha A. Bhatt, Hamed. A. El-Serehy, Sadanand Pandey
Summary: The aim of this study was to synthesize a gum katira-silver nanoparticle-based bionanocomposite. The synthesized bionanocomposite was characterized using various techniques such as FTIR spectroscopy, FESEM, TGA, and TEM. The results showed the formation of AgNPs with a size range of 6-20 nm and the nanocomposite exhibited higher thermal stability than gum katira. The optimized nanocomposite showed a high swelling capacity and excellent adsorption efficiency for the removal of MR dye from wastewater.
FRONTIERS IN CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Akshansh Sharma, Devanshi Shambhwani, Sadanand Pandey, Jay Singh, Hauzel Lalhlenmawia, Murali Kumarasamy, Sachin Kumar Singh, Dinesh Kumar Chellappan, Gaurav Gupta, Parteek Prasher, Kamal Dua, Deepak Kumar
Summary: Carcinoma of the lungs is a deadly form of cancer with low survival rates. Nanotechnology offers potential solutions, through nanoscale theranostic agents, to improve drug delivery, enhance therapeutic efficacy, and enable early detection and targeted therapy. Various types of nanoparticles, such as liposomes, dendrimers, and gold nanoparticles, have been successfully studied for therapeutic applications in lung carcinoma. This review provides a comprehensive overview of the overexpressed receptors in lung cancer and the targeting approaches of nanoparticles.
Review
Chemistry, Analytical
Mehrab Pourmadadi, Ali Moammeri, Amin Shamsabadipour, Yasamin Farahanian Moghaddam, Abbas Rahdar, Sadanand Pandey
Summary: Diagnosing early-stage cancers is crucial for saving lives and reducing mortality rates. Detection of the cancer antigen CA-125 is a key step in the treatment of certain cancers, such as ovarian cancer. This review discusses various optical and electrochemical methods for detecting CA-125, compares their performance and sensitivity, investigates commercial detection kits, and evaluates their applicability and accuracy.
Review
Chemistry, Analytical
Akash Kumaran, Nathan Jude Serpes, Tisha Gupta, Abija James, Avinash Sharma, Deepak Kumar, Rupak Nagraik, Vaneet Kumar, Sadanand Pandey
Summary: With the increasing shift of molecular tests to on-site testing, there is a growing demand for nucleic acid-based diagnostic tools in point-of-care systems. CRISPR-based biosensors offer a promising approach to nucleic acid detection and can be combined with various readout methods for on-site analysis. This review explores the integration of the CRISPR Cas system with traditional biosensing readout methods and amplification technologies, as well as its potential in detecting viral and bacterial diseases. It also discusses the development of CRISPR biosensors during the COVID-19 pandemic and the challenges and future prospects of CRISPR Cas systems in point-of-care testing.
Article
Materials Science, Composites
Anita Shekhawat, Ravin Jugade, Vaishnavi Gomase, Shashikant Kahu, Saravanan Dhandayutham, Sadanand Pandey
Summary: Cellulose-Sn(IV) (CSn) biocomposite was synthesized by incorporating Sn(IV) into the cellulose matrix using microwave irradiation.The prepared CSn composite exhibited adsorption capacity of 16.64 mg/g for As(III) removal at pH 7.0.Freundlich isotherm and pseudo-second-order kinetic model were found to be suitable for the adsorption process. The adsorption mechanism of As(III) was not limited to diffusion process only, and chloride ions decreased the percentage removal of As(III). The CSn material showed greener aspect with gradual decrease in percentage removal during adsorption-desorption cycles and could be applicable for larger sample volumes.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Article
Green & Sustainable Science & Technology
Mehrab Pourmadadi, Mojdeh Mirshafiei, Fatemeh Yazdian, Behnam Rasekh, Mahsa Zamani, Ali Mansouri, Abbas Rahdar, Sadanand Pandey
Summary: Despite progress, corrosion in oil and gas pipelines remains a concern due to industrial failures, environmental and economic damages. This study investigates the effects of seawater containing microorganisms on internal corrosion of pipelines. It reports the corrosion behavior of carbon steel exposed to seawater from the Persian Gulf containing sulfate-reducing bacteria, iron-reducing bacteria, and acid-producing bacteria. The results confirm the influence of microbial activity on corrosion products and electrochemical properties of steel.
ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Mehrab Pourmadadi, Amin Shamsabadipour, Ali Aslani, Mohammad Mahdi Eshaghi, Abbas Rahdar, Sadanand Pandey
Summary: A biosensor is an analytical tool that can specifically and sensitively detect biomarkers. Using biosensors in clinical settings allows reliable, precise, and quantitative measurements of biomarkers at low concentrations. Nanotechnology has greatly contributed to the design and fabrication of biosensors, offering advantages such as time-saving and the ability to perform onsite diagnosis using nanomaterials. This article provides a brief overview of recent biosensors that incorporate PVP as part of their structure.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Maryam Rajabzadeh-Khosroshahi, Mohammad Mahdi Eshaghi, Erfan Rahmani, Hamidreza Motasadizadeh, Rabia Arshad, Abbas Rahdar, Sadanand Pandey
Summary: In biomedical engineering, researchers are studying the modification of TiO2 (titania) to enhance its physiochemical properties. This comprehensive review focuses on the potential applications of nanoscale TiO2 and its nanocomposites in biomedical research, specifically in cancer therapeutics. The use of titania-based nanomaterials in biosensors, particularly in the electrochemical field, has been widely explored. Various bioimaging techniques, such as FL, PA, CT, PET, MR, and multi-mode imaging, have been evaluated for their applicability. Nanoscale titania has also emerged as a popular candidate for cancer treatment methods including phototherapy, chemotherapy, and microwave hyperthermia. Finally, a multifunctional nanoplatform combining different treatment methods has been developed for cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Composites
Pradip Nandanwar, Ravin Jugade, Vaishnavi Gomase, Anita Shekhawat, Apurva Bambal, Dhandayutham Saravanan, Sadanand Pandey
Summary: This study presents a composite material consisting of chitosan biopolymer and activated charcoal. The composite exhibits microporous structure and high adsorption capacities for both dyes in aqueous phase and CO2 in gaseous phase.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Article
Environmental Sciences
Sadanand Pandey, Sujeong Kim, Young Soo Kim, Deepak Kumar, Misook Kang
Summary: By using an environmentally friendly approach, LBG-s-AgNPs@g-C3N4 NS hybrid nanostructures were successfully fabricated. These nanostructures exhibit excellent antibacterial activity and can degrade hazardous dyes under visible light irradiation. Therefore, this study is of great importance for the health of aquatic life and humans.
ENVIRONMENTAL RESEARCH
(2024)
Article
Chemistry, Analytical
Vaneet Saruchi, Vaneet A. Kumar, Ayman Ghfar, Sadanand Pandey
Summary: This study synthesized a biodegradable hydrogel using a natural polysaccharide aloe vera as the backbone and vinyl monomer acrylic acid as the monomer, with ammonium persulfate-glutaraldehyde as the initiator-cross-linker system. Techniques like SEM, FT-IR, XRD, and EDS confirmed the grafting. The hydrogel showed maximum biodegradation of 90%, 94%, and 93% in soil burial, composting, and vermicomposting methods, respectively. It also exhibited extended water retention capacity and sustained release of dichlorvos pesticide.
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Rahmuddin Khan, Mohd. Aamir Mirza, Mohd Aqil, Thomson Santosh Alex, Nafis Raj, Nikhat Manzoor, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Zeenat Iqbal
Summary: This study developed a nanotherapeutic consisting of bioactives to improve the treatment outcomes of psoriasis.